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Nitric Oxide Pathway Other Products
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ALX-430-020 Revised 13-Nov-08
Zaprinast
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SYNONYMS 1,4-Dihydro-5-[2-propoxyphenyl]-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one
M&B 22,948
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-020-M010   10 mg 30.00 USD Add To Cart
ALX-430-020-M050   50 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C13H13N5O2
MW: 271.3
CAS NUMBER: 37762-06-4
PURITY: ≥98%
APPEARANCE: White to tan powder.
SOLUBILITY: Soluble in 1M sodium hydroxide, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.11mg/ml), DMSO (10mg/ml) or 100% ethanol (5 mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT.

Product Description
Phosphodiesterase (PDE) inhibitor.
Product Specific Literature References
Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M&B 22,948: P.G. Gillespie and J.A. Beavo; Mol. Pharmacol. 36, 773 (1989) Abstract
Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors: J.A. Beavo & D.H. Reifsnyder; TIPS 11, 150 (1990) Abstract
The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung: F. Burns, et al.; Biochem. J. 283, 487 (1992) Abstract
Cyclic nucleotide phosphodiesterases from frog atrial fibers: isolation and drug sensitivities: C. Lugnier, et al.; Am. J. Physiol. 262, H654 (1992) Abstract
Zaprinast increases cyclic GMP levels in plasma and in aortic tissue of rats: R.L. Dundore, et al.; Eur. J. Pharmacol. 249, 293 (1993) Abstract
Reversal of nitroglycerin tolerance in vitro by the cGMP- phosphodiesterase inhibitor zaprinast: E.D. Pagani, et al.; Eur. J. Pharmacol. 243, 141 (1993) Abstract
The nitric oxide--cyclic GMP pathway and synaptic depression in rat hippocampal slices: C.L. Boulton, et al.; Eur. J. Neurosci. 6, 1528 (1994) Abstract
The PDE inhibitor zaprinast enhances NO-mediated protection against vascular leakage in reperfused lungs: H. Schutte, et al.; Am. J. Physiol. Lung Cell Mol. Physiol. 279, L496 (2000) Abstract; Full Text
Phosphodiesterase 5 inhibitor, zaprinast, selectively increases cerebral blood flow in the ischemic penumbra in the rat brain: F. Gao, et al.; Neurol. Res. 27, 638 (2005) Abstract
Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35: Y. Taniguchi, et al.; FEBS Lett. 580, 5003 (2006) Abstract
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Nitric Oxide Pathway Other Products
 
 
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