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ALX-350-366
Revised 03-Apr-08
Azaspiracid-1
SYNONYMS
AZA-1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Toxins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-350-366-C001
1 µg
180.00 USD
Product Specification
FORMULA:
C
47
H
71
NO
12
MW:
842.1
CAS NUMBER:
214899-21-5
SOURCE/HOST:
Islolated from marine mussel.
CONCENTRATION:
2μg/ml
PURITY:
≥95%
FORMULATION:
Liquid. In methanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HAZARD:
VERY TOXIC. MAY BE TERATOGENIC.
Product Description
Activator of JNK (c-Jun-N-terminal kinase). Cellular growth inhibitor and inducer of cytoskeletal alterations. Activator of caspases. Modulator of intracellular cAMP (cyclic adenosine monophosphate) and calcium levels. Inhibitor of cholesterol biosynthesis in human T lymphocyte cells. Potent teratogen to finfish. Cytotoxic to mammalian cells.
Product Specific Literature References
Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland:
E. Ito, et al.; Toxicon
38
, 917 (2000)
Abstract
Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets
:
Y. Roman, et al.; Cell. Signal.
14
, 703 (2002)
Abstract
Teratogenic effects of azaspiracid-1 identified by microinjection of Japanese medaka (Oryzias latipes) embryos
:
J.R. Coleman, et al.; Toxicon
45
, 881 (2005)
Abstract
Cytotoxic and cytoskeletal effects of azaspiracid-1 on mammalian cell lines
:
M.J. Twiner, et al.; Toxicon
45
, 891 (2005)
Abstract
Azaspiracids modulate intracellular pH levels in human lymphocytes
:
A. Alfonso, et al.; BBRC
346
, 1091 (2006)
Abstract
Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies
:
N. Vilarino, et al.; Chem. Res. Toxicol.
19
, 1459 (2006)
Abstract
The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1:
C. Vale, et al.; Cell Physiol. Biochem.
20
, 957 (2007)
Abstract
Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study
:
C. Vale, et al.; J. Med. Chem.
50
, 356 (2007)
Abstract
Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells
:
N. Vilarino, et al.; Biochem. Pharmacol.
74
, 327 (2007)
Abstract
Transcriptional profiling and inhibition of cholesterol biosynthesis in human T lymphocyte cells by the marine toxin azaspiracid
:
M.J. Twiner, et al.; Genomics
91
, 289 (2008)
Abstract
Further Categories Containing This Product:
MAPK Pathway Activators
•
Natural Products for Cytoskeletal Research
•
Natural Products - Other Signal Transduction Pathway Modulators
•
Caspases Other Products
•
cAMP Pathways Other Products
•
Marine Natural Products
ALX-350-367
Revised 31-Mar-08
Azaspiracid-2
SYNONYMS
AZA-2
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Toxins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-367-C001
1 µg
360.00 USD
Product Specification
FORMULA:
C
48
H
73
NO
12
MW:
855.5
CAS NUMBER:
265996-92-7
SOURCE/HOST:
Isolated from marine mussel.
CONCENTRATION:
2µg/ml
PURITY:
≥95%
APPEARANCE:
Liquid. In methanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HAZARD:
VERY TOXIC.
Product Description
Modulator of intracellular cAMP (cyclic adenosine monophosphate) and calcium levels.
Product Specific Literature References
Effects of Azaspiracids 2 and 3 on intracellular cAMP, [Ca2+], and pH
:
Y. Roman, et al.; Chem. Res. Toxicol.
17
, 1338 (2004)
Abstract
Azaspiracids modulate intracellular pH levels in human lymphocytes
:
A. Alfonso, et al.; BBRC
346
, 1091 (2006)
Abstract
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators
•
cAMP Pathways Other Products
•
Marine Natural Products
ALX-350-368
Revised 31-Mar-08
Azaspiracid-3
SYNONYMS
AZA-3
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Toxins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-368-C001
1 µg
540.00 USD
Product Specification
FORMULA:
C
46
H
69
NO
12
MW:
827.5
CAS NUMBER:
265996-93-8
SOURCE/HOST:
Isolated from marine mussel.
CONCENTRATION:
2µg/ml
PURITY:
≥95%
APPEARANCE:
Liquid. In methanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HAZARD:
VERY TOXIC.
Product Description
Modulator of intracellular cAMP (cyclic adenosine monophosphate), calcium and pH levels.
Product Specific Literature References
Effects of Azaspiracids 2 and 3 on intracellular cAMP, [Ca2+], and pH
:
Y. Roman, et al.; Chem. Res. Toxicol.
17
, 1338 (2004)
Abstract
Azaspiracids modulate intracellular pH levels in human lymphocytes
:
A. Alfonso, et al.; BBRC
346
, 1091 (2006)
Abstract
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators
•
cAMP Pathways Other Products
•
Marine Natural Products
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