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ALX-430-069
Revised 31-Oct-08
MnTBAP chloride
SYNONYMS
Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-430-069-M010
10 mg
20.00 USD
ALX-430-069-M050
50 mg
60.00 USD
Product Specification
FORMULA:
C
48
H
28
MnN
4
O
8
Cl
MW:
879.2
PURITY:
≥97% (EA, MS)
APPEARANCE:
Black crystalline powder.
SOLUBILITY:
Dissolve at 0.1M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light and moisture.
Product Description
Cell permeable SOD mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO).
Product Specific Literature References
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo:
K.M. Faulkner, et al.; J. Biol. Chem.
269
, 23471 (1994)
Abstract
;
Full Text
A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro:
B.J. Day, et al.; J. Pharm. Exp. Ther.
275
, 1227 (1995)
Abstract
Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger:
C. Szabó, et al.; FEBS Lett.
381
, 82 (1996)
Abstract
Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation:
P. Ghafourifar, et al.; J. Biol. Chem.
274
, 31185 (1999)
Abstract
;
Full Text
Reactive oxygen species regulate activation-induced T cell apoptosis::
D.A. Hildeman, et al.; Immunity
10
, 735 (1999)
Abstract
Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen.:
S. Kotamraju, et al.; J. Biol. Chem.
275
, 33585 (2000)
Abstract
;
Full Text
Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols:
R. Motterlini, et al.; J. Biol. Chem.
275
, 13613 (2000)
Abstract
;
Full Text
Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis:
H. Dussmann, et al.; J. Biol. Chem.
278
, 12645 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
•
Superoxide Dismutases [SODs] / Related Products
ALX-430-070
Revised 05-Mar-08
MnTMPyP . pentachloride
SYNONYMS
Manganese (III) tetrakis (1-methyl-4-pyridyl)porphyrin . 5Cl
-
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
Ordering Information
Product Numbers:
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Size:
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ALX-430-070-M010
10 mg
20.00 USD
ALX-430-070-M050
50 mg
50.00 USD
Product Specification
FORMULA:
C
44
H
36
MnN
8
Cl
5
MW:
909.0
PURITY:
≥95%
APPEARANCE:
Black crystalline powder.
SOLUBILITY:
Soluble in water or aqueous buffers (e.g. 0.1M TRIS-HCl, pH 9.0 containing 1mM EDTA (>50mg/ml) or PBS, pH 7.2 (4mg/ml)).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Prepare solutions immediately before experiments. We recommend using fresh preparations each day.
Product Description
Cell permeable SOD mimetic. Catalyzes the dismutation of O
2
-
even in the presence of excess EDTA.
Product Specific Literature References
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo:
K.M. Faulkner, et al.; J. Biol. Chem.
269
, 23471 (1994)
Abstract
;
Full Text
A cationic manganic porphyrin inhibits uptake of paraquat by Escherichia coli:
S.I. Liochev & I. Fridovich; Arch. Biochem. Biophys.
321
, 271 (1995)
Abstract
Superoxide scavenging by Mn(II/III) tetrakis (1-methyl-4-pyridyl) porphyrin in mammalian cells:
P.R. Gardner, et al.; Arch. Biochem. Biophys.
325
, 20 (1996)
Abstract
The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium- 2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic:
Batinic-Haberle, et al.; J. Biol. Chem.
273
, 24521 (1998)
Abstract
;
Full Text
Molecular actions of a Mn(III)Porphyrin superoxide dismutase mimetic and peroxynitrite scavenger: reaction with nitric oxide and direct inhibition of NO synthase and soluble guanylyl cyclase:
S. Pfeiffer, et al.; Mol. Pharmacol.
53
, 795 (1998)
Abstract
SODs are involved in the regulation of ICAM-1 expression in human melanoma and endothelial cells:
R. Morandini, et al.; Cell. Mol. Biol. (Noisy-le-grand)
45
, 1053 (1999)
Abstract
Effects of superoxide dismutase mimetics on the activity of nitric oxide in rat aorta:
A. MacKenzie, et al.; Br. J. Pharmacol.
127
, 1159 (1999)
Abstract
Inducible nitric oxide synthase-derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure:
A.A. Miller, et al.; Br. J. Pharmacol.
131
, 29 (2000)
Abstract
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Superoxide Dismutases [SODs] / Related Products
ALX-430-076
Revised 03-Oct-08
Cobalt (III) Protoporphyrin IX chloride
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
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ALX-430-076-M025
25 mg
80.00 USD
Product Specification
FORMULA:
C
34
H
32
CoN
4
O
4
. Cl
MW:
654.5
PURITY:
≥95% (TLC)
APPEARANCE:
Dark purple solid.
SOLUBILITY:
Soluble in acidic or basic aqueous solutions at pH between 8.5-9.0. Once in solution pH can be adjusted to physiological pH.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light and moisture.
ALX-340-037
Revised 08-Jul-08
8(S)-HETE
SYNONYMS
8-Hydroxy-[S-(E,Z,Z,Z)]-5,9,11,14-eicosatetraenoic acid
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Hydroxy, Hydroperoxy & Oxo Fatty Acids / Related Products
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ALX-340-037-C025
25 µg
165.00 USD
Product Specification
FORMULA:
C
20
H
32
O
3
MW:
320.5
CAS NUMBER:
98462-03-4
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na
2
CO
3
(2mg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months in other organic solvents when stored at -20°C. Keep aqueous solutions on ice and use within 12 hours.
HANDLING:
Protect from light and oxygen.
Product Description
Activator of PPARα. Activates mouse skin protein kinase C (PKC).
Product Specific Literature References
Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin:
M.A. Hughes & A.R. Brash; Biochim. Biophys. Acta
1081
, 347 (1991)
Abstract
In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites:
H.H. Lo, et al.; Lipids
29
, 547 (1994)
Abstract
Differential activation of peroxisome proliferator-activated receptors by eicosanoids:
K. Yu, et al.; J. Biol. Chem.
270
, 23975 (1995)
Abstract
;
Full Text
Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans:
Y. Guan, et al.; Am. J. Physiol.
273
, F1013 (1997)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PPAR Agonists
•
PKC Activators
ALX-270-308
Revised 10-Apr-08
Sirtinol
SYNONYMS
Sir Two Inhibitor Naphthol
2-[(2-Hydroxynaphthalen-1-yl-methylene)amino]-N-(1-phenethyl)benzamide
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Sirtuins / Related Products
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Product Numbers:
Format:
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ALX-270-308-M001
1 mg
53.00 USD
ALX-270-308-M005
5 mg
160.00 USD
Product Specification
FORMULA:
C
26
H
22
N
2
O
2
MW:
394.5
PURITY:
≥97% (HPLC)
APPEARANCE:
Off-white to yellow crystals.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Relatively unstable in aqueous solution, especially at acidic pH.
HANDLING:
Protect from light.
Product Description
Specific cell permeable inhibitor of the sirtuin family of NAD-dependent deacetylases (ySir2: IC
50
=48µM; hSIRT1: IC
50
=131µM; hSIRT2: IC
50
=58µM) with no effect on human HDAC1. Reported to inhibit Sir2p transcriptional silencing activity
in vivo
(IC
50
=25µM) and NAD-dependent histone deacetylase activity of purified recombinant yeast Sir2p (IC
50
=70µM) and hSIRT2 (IC
50
=40µM)
in vitro
.
Product Specific Literature References
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening:
C.M. Grozinger, et al.; J. Biol. Chem.
276
, 38837 (2001)
Abstract
;
Full Text
Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity
:
C.E. Koering, et al.; EMBO Rep.
3
, 1055 (2002)
Abstract
;
Full Text
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors:
A. Mai, et al.; J. Med. Chem.
48
, 7789 (2005)
Abstract
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells:
H. Ota, et al.; Oncogene
25
, 176 (2006)
Abstract
Further Categories Containing This Product:
NAD+ Metabolism / Related Products
ALX-350-335
Revised 14-Nov-07
Cochlioquinone A
SYNONYMS
Luteoleersin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
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ALX-350-335-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
30
H
44
O
8
MW:
532.7
CAS NUMBER:
32450-25-2
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Shows antiangiogenic and nematocidal activities. Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of diacylglycerol acyltransferase, diacylglycerol kinase and NADH-ubiquinone reductase.
Product Specific Literature References
Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites:
J.M. Schaeffer, et al.; J. Antibiot. (Tokyo)
43
, 1179 (1990)
Abstract
Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi:
T. Fujioka, et al.; J. Antibiot. (Tokyo)
49
, 409 (1996)
Abstract
Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola:
H.J. Jung, et al.; Bioorg. Med. Chem.
11
, 4743 (2003)
Abstract
Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1:
H.B. Lee, et al.; J. Antibiot. (Tokyo)
56
, 967 (2003)
Abstract
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products
•
NAD+ Metabolism / Related Products
•
Vitamins
ALX-350-341
Revised 14-Nov-07
Cochlioquinone B
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
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ALX-350-341-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
28
H
40
O
6
MW:
472.6
CAS NUMBER:
32450-26-3
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of NADH-ubiquinone reductase. Phytotoxic agent inhibiting root growth.
Product Specific Literature References
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products
•
NAD+ Metabolism / Related Products
•
Vitamins
ALX-460-008
Revised 02-Jun-06
Nicotinamide
SYNONYMS
Niacinamide
3-Pyridinecarboxylic amide
Vitamin PP
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NAD+ Metabolism / Related Products
Ordering Information
Product Numbers:
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ALX-460-008-G010
10 g
10.00 USD
Product Specification
FORMULA:
C
6
H
6
N
2
O
MW:
122.1
CAS NUMBER:
98-92-0
MERCK INDEX:
14:
6523
PURITY:
≥99%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water; also soluble in 100 % ethanol or glycerol; slightly soluble in chloroform; almost insoluble in ether or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
USE/STABILITY:
Susceptible to hydrolysis in acidic or alkaline solution.
HANDLING:
Protect from light.
HAZARD:
IRRITANT. MAY BE MUTAGENIC.
Further Categories Containing This Product:
Vitamins
•
DNA Repair Other Products
•
PARP Inhibitors
ALX-460-009
Revised 08-Jan-03
Nicotinic acid
SYNONYMS
Niacin
3-Pyridinecarboxylic acid
Vitamin B
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NAD+ Metabolism / Related Products
Ordering Information
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ALX-460-009-G010
10 g
13.00 USD
Product Specification
FORMULA:
C
6
H
5
NO
2
MW:
123.1
CAS NUMBER:
59-67-6
MERCK INDEX:
14:
6525
PURITY:
≥98% (HPLC)
SOLUBILITY:
Soluble in water or 96% ethanol (1g/100ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Further Categories Containing This Product:
Vitamins
ALX-480-003
Revised 10-Dec-04
NADP . disodium salt
SYNONYMS
β-Nicotinamide Adenine Dinucleotide Phosphate
β-NADP
Coenzyme II
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NAD+ Metabolism / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-480-003-M050
50 mg
20.00 USD
ALX-480-003-M250
250 mg
55.00 USD
ALX-480-003-G001
1 g
160.00 USD
Product Specification
FORMULA:
C
21
H
26
N
7
O
17
P
3
. 2Na
MW:
741.4 . 46.0
CAS NUMBER:
1184-16-3
MERCK INDEX:
14:
6348
PURITY:
≥97%
APPEARANCE:
Light yellow powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry. Protect from light.
Further Categories Containing This Product:
Adenosine Derivatives Other Products
ALX-480-004
Revised 06-Aug-08
