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Nitric Oxide Pathway
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ALX-620-054 Revised 11-Oct-06
4AF DA
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SYNONYMS 4-Aminofluorescein diacetate
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide & NOS Detection / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-620-054-M001   1 mg 136.00 USD Add To Cart
Product Specification
FORMULA: C24H17NO7
MW: 431.4
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Negative control compound for the fluorescent probes DAF-2 (Prod. No. ALX-620-052) and DAF-2 DA (Prod. No. ALX-620-056).
Product Specific Literature References
Direct evidence of NO production in rat hippocampus and cortex using a new fluorescent indicator: DAF-2 DA: H. Kojima, et al.; Neuroreport 9, 3345 (1998) Abstract
Further Categories Containing This Product:
Dyes / Stains / Fluorescent Probes / Fluorescent Labels
 
 
ALX-270-073 Revised 15-Dec-06
1400W . dihydrochloride
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SYNONYMS N-(3-(Aminomethyl)benzyl)acetamidine . 2HCl
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-073-M005   5 mg 50.00 USD Add To Cart
ALX-270-073-M025   25 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C10H15N3 . 2HCl
MW: 177.3 . 73.0
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Hygroscopic.

Product Description
Highly selective inhibitor of inducible nitric oxide synthase (iNOS/NOS II) in vitro and in vivo.
Product Specific Literature References
1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo: E.P. Garvey, et al.; J. Biol. Chem. 272, 4959 (1997) Abstract; Full Text
Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor: L.L. Thomsen, et al.; Cancer Res. 57, 3300 (1997) Abstract
Actions of isoform-selective and non-selective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon: F. Laszlo & B.J.R. Whittle; Eur. J. Pharmacol. 334, 99 (1997) Abstract
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol. 58, 1026 (2000) Abstract; Full Text
Nitric oxide synthases: structure, function and inhibition: W.K. Alderton, et al.; Biochem. J. 357, 593 (2001), Review Abstract; Full Text
Nitric Oxide Ameliorates Hydrophobic Bile Acid-induced Apoptosis in Isolated Rat Hepatocytes by Non-mitochondrial Pathways: E. Gumpricht, et al.; J. Biol. Chem. 277, 25823 (2002) Abstract; Full Text
Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms: R. Fedorov, et al.; J. Biol. Chem. 278, 45818 (2003) Abstract; Full Text
Increased vasoconstriction to noradrenaline by 1400W, inhibitor of iNOS, in rats with streptozotocin-induced diabetes: X. Cheng & C.C. Pang; Eur. J. Pharmacol. 484, 263 (2004) Abstract
1400W, a potent selective inducible NOS inhibitor, improves histopathological outcome following traumatic brain injury in rats: M. Jafarian-Tehrani, et al.; Nitric Oxide 12, 61 (2005) Abstract
Addition of nitric oxide donor S-nitroso-N-acetylcysteine to selective iNOS inhibitor 1400W further improves contractile function in reperfused skeletal muscle: J.U. Barker, et al.; Microsurgery 25, 338 (2005) Abstract
Effects of 1400W, a potent selective inducible NOS inhibitor, on histamine- and leukotriene D4-induced relaxation of isolated guinea pig nasal mucosa: Y. Chiba, et al.; Nitric Oxide 15, 142 (2006) Abstract
 
 
ALX-450-001 Revised 23-Jul-08
A23187 (free acid)
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SYNONYMS Calcium Ionophore A23187
Calcimycin
Antibiotic A23187
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Ionophores
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-450-001-M001   1 mg 28.00 USD Add To Cart
ALX-450-001-M005   5 mg 65.00 USD Add To Cart
ALX-450-001-5001   5x1 mg 80.00 USD Add To Cart
ALX-450-001-M010   10 mg 92.00 USD Add To Cart
ALX-450-001-M025   25 mg 195.00 USD Add To Cart
ALX-450-001-M050   50 mg 350.00 USD Add To Cart
Product Specification
FORMULA: C29H37N3O6
MW: 523.6
CAS NUMBER: 52665-69-7
MERCK INDEX: 14: 1639
RTECS: DM4676000
SOURCE/HOST: Isolated from Streptomyces chartreusis.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methylene chloride; slightly soluble in water. Solubilize in DMSO or ethanol prior to preparing aqueous solutions of very low concentrations.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: In aqueous systems product may aggregate over time.
HANDLING: Protect from light. In aqueous systems, the product aggregates over time.
HAZARD: IRRITANT.

Product Description
Antibiotic possessing weak in vitro antimicrobial activity against gram positive bacteria and fungi. Divalent cation ionophore commonly used to increase intracellular Ca2+ levels in intact cells.
Product Specific Literature References
A23187: a divalent cation ionophore: P. W. Reed & H. A. Lardy; J. Biol. Chem. 247, 6970 (1972) Abstract
Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria: D.T. Wong, et al.; Arch. Biochem. Biophys. 156, 578 (1973) Abstract
Biological applications of ionophores: B.C. Pressman; Annu. Rev. Biochem. 45, 501 (1976), (Review) Abstract
Molecular mechanisms of endothelium-mediated vasodilation: R.R. Fiscus; Semin. Thromb. Hemost. 14 Suppl, 12 (1988), (Review) Abstract
Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species: 1740, 481 (2005): T. Przygodzki, et al.; Biochim. Biophys. Acta 1740, 481 (2005) Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products • Respiratory Chain Other Products • Antibiotics - ATPase Inhibitors
 
 
ALX-270-420 Revised 11-Sep-07
ABH . ammonium salt
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SYNONYMS 2(S)-Amino-6-boronohexanoic acid . NH4
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Arginine & Arginases / Related Products
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ALX-270-420-M001   1 mg 60.00 USD Add To Cart
ALX-270-420-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C6H13BNO4 . NH4
MW: 174.0 . 18.0
PURITY: ≥95.0% (1H-NMR)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY:

Solutions are stable for 6 months when stored at -20°C.
HANDLING: Hygroscopic. After reconstitution, prepare aliquots and store at -20°C.

Product Description
Potent and specific inhibitor of arginase. Does not inhibit NO synthases.
Product Specific Literature References
Inhibition of Mn2+ 2-arginase by borate leads to the design of a transition state analog inhibitor, 2(S)-amino-6-boronohexanoic acid: R. Baggio, et al.; J. Am. Chem. Soc. 119, 8107 (1997)
Biochemical and functional profile of a newly developed potent and isozyme-selective arginase inhibitor: R. Baggio, et al.; J. Pharmacol. Exp. Ther. 290, 1409 (1999) Abstract; Full Text
Arginase-boronic acid complex highlights a physiological role in erectile function: J.D. Cox, et al.; Nat. Struct. Biol. 6, 1043 (1999) Abstract
Classical and slow-binding inhibitors of human type II arginase: D.M. Colleluori and D.E. Ash; Biochemistry (Mosc). 40, 9356 (2001) Abstract
Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction: T.J. Bivalacqua, et al.; BBRC 283, 923 (2001) Abstract
Arginase expression and modulation of IL-1beta-induced nitric oxide generation in rat and human islets of Langerhans: P. Stickings, et al.; Nitric Oxide 7, 289 (2002) Abstract
Arginase and autoimmune inflammation in the central nervous system: L. Xu, et al.; Immunology 110, 141 (2003) Abstract; Full Text
Role of arginase in the male and female sexual arousal response: N.N. Kim, et al.; J. Nutr. 134, 2873S (2004) Abstract; Full Text
Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response: L. Di Costanzo, et al.; PNAS 102, 13058 (2005) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Note: Contains ~14% ammonium chloride. This does not affect activity, but must be taken into account for calculation of concentrations.
 
 
ALX-350-255 Revised 03-Apr-08
(+)-cis,trans-Abscisic acid
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SYNONYMS (S)-5-(1-Hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl)-3-methyl-[2Z,4E]-pentadienoic acid
(+)-cis,trans ABA
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Plant Research Reagents
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ALX-350-255-C500   500 µg 90.00 USD Add To Cart
ALX-350-255-M001   1 mg 160.00 USD Add To Cart
ALX-350-255-M005   5 mg 620.00 USD Add To Cart
Product Specification
FORMULA: C15H20O4
MW: 264.3
CAS NUMBER: 21293-29-8
MERCK INDEX: 14: 11
SOURCE/HOST: Isolated from Curvularia lunata.
PURITY: ≥97%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in ethanol or DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Natural and active isomer of the abscission accelerating plant hormone.
Product Specific Literature References
Metabolism and physiology of abscisic acid: J.A.D. Zeevaart & R.A. Creelman; Annu. Rev. Plant Physiol. Plant Mol. Biol. 39, 439 (1988), (Review)
Molecular responses to drought and cold stress: K. Shinozaki & K. Yamaguchi-Shinozaki; Curr. Opin. Biotechnol. 7, 161 (1996), (Review) Abstract
Abscisic acid and signal transduction: J. Leung & J. Giraudat; Annu. Rev. Plant Physiol. Plant Mol. Biol. 49, 199 (1998), (Review)
ABA signal transduction: E. Grill & A. Himmelbach; Curr. Opin. Plant Biol. 1, 412 (1998), (Review) Abstract
Signal transduction networks and the biology of plant cells: M.J. Chrispeels, et al.; Biol. Res. 32, 35 (1999), (Review) Abstract
Abscisic acid: A.M. Hetherington; Curr. Biol. 9, R390 (1999), (Review) Abstract
Regulation of abscisic acid-induced stomatal closure and anion channels by guard cell AAPK kinase: J. Li, et al.; Science 287, 300 (2000) Abstract
Mitogen-activated protein kinase and abscisic acid signal transduction: S. Heimovaara-Dijkstra, et al.; Results Probl. Cell Differ. 27, 131 (2000) Abstract
Relay and control of abscisic acid signaling: A. Himmelbach, et al.; Corr. Opin. Plant Biol. 6, 470 (2003), Review Abstract
Nitric oxide induced by hydrogen peroxide mediates abscisic acid-induced activation of the mitogen-activated protein kinase cascade involved in antioxidant defense in maize leaves: A. Zhang, et al.; New Phytol. 175, 36 (2007) Abstract
Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger: S. Bruzzone, et al.; PNAS 104, 5759 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Nitric Oxide Pathway Modulators • Plant Research Reagents / Related Products
 
 
ALX-430-021 Revised 17-Jan-05
N-Acetyl-N-acetoxy-4-chlorobenzenesulphonamide
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PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Pathway Other Products
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ALX-430-021-M005   5 mg 40.00 USD Add To Cart
Product Specification
FORMULA: C10H10ClNO5S
MW: 291.7
PURITY: ≥98%
APPEARANCE: White crystals.
SOLUBILITY: Soluble in DMSO or DMF; slightly soluble in methanol; not soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Nitroxyl (HNO) releasing compound in neutral solution. Release of nitric oxide was not detected. Potent vasorelaxant. Powerful inhibitor of aldehyde dehydrogenase.
Product Specific Literature References
Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase: M.J.C. Lee, et al.; J. Med. Chem. 35, 3648 (1992) Abstract
N,O-diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties: J.M. Fukuto, et al.; BBRC 187, 1367 (1992) Abstract
 
 
ALX-420-019 Revised 14-Dec-06
N-Acetyl-D,L-penicillamine disulfide
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SYNONYMS AP-SS
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Donors
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ALX-420-019-M001   1 mg 40.00 USD Add To Cart
ALX-420-019-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C14H24N2O6S2
MW: 380.5
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in DMSO or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Degradation product of S-nitroso-N-acetyl-D,L-penicillamine (SNAP) (Prod. No. ALX-420-003).
Product Specific Literature References
The nitric oxide-cyclic GMP pathway and synaptic depression in rat hippocampal slices: C.L. Boulton, et al.; Eur. J. Neurosci. 6, 1528 (1994) Abstract
Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor: P.M. Gross, et al.; Neuropharmacology 33, 915 (1994) Abstract
 
 
ALX-480-001 Revised 13-Jul-06
Adenosine 5'-diphosphate . disodium salt
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SYNONYMS ADP . 2Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
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ALX-480-001-G001   1 g 45.00 USD Add To Cart
ALX-480-001-G005   5 g 160.00 USD Add To Cart
Product Specification
FORMULA: C10H13N5O10P2 . 2Na
MW: 471.2 . 46.0
CAS NUMBER: 16178-48-6
MERCK INDEX: 14: 154
SOURCE/HOST: Isolated from yeast.
PURITY: ≥95%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Slight degradation to AMP may occur during storage.
HANDLING: Protect from moisture.

Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
 
 
ALX-480-002 Revised 12-Apr-07
Adenosine 5'-diphosphate . potassium salt
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SYNONYMS ADP . K
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
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ALX-480-002-G001   1 g 45.00 USD Add To Cart
ALX-480-002-G005   5 g 180.00 USD Add To Cart
Product Specification
FORMULA: C10H14N5O10P2 . K
MW: 426.2 . 39.1
CAS NUMBER: 72696-48-1
MERCK INDEX: 14: 154
SOURCE/HOST: Isolated from yeast.
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Slight degradation to AMP may occur during prolonged storage.
HANDLING: Protect from moisture.

Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
 
 
ALX-850-323 Revised 31-Jul-08
ADMA Direct (human) ELISA Kit