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Non-apoptotic Cell Death / Necrosis
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ALX-430-149 Revised 23-Jun-08
7BIO
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SYNONYMS (2’Z, 3’E)-7-Bromoindirubin-3’-monoxime
MLS2156
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Non-apoptotic Cell Death / Necrosis
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ALX-430-149-M005   5 mg 80.00 USD Add To Cart
ALX-430-149-M025   25 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C16H10BrN3O2
MW: 356.2
PURITY: ≥95% (1H-NMR)
APPEARANCE: Dark brown solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Induces a rapid caspase-independent cell death process distinct from apoptosis. Demonstrated selective inhibition of aurora kinase B (IC50=4.6µM) and aurora kinase C (IC50=0.7µM) whereas the homologeous aurora kinase A is poorly inhibited.
Product Specific Literature References
3’-Substituted 7-halogenoindirubins, a new class of cell death inducing agents: Y. Ferandin, et al.; J. Med. Chem. 49, 4638 (2006) Abstract
7-Bromoindirubin-3’-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2006) Abstract
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007) Abstract
7-Bromoindirubin-3’-oxime uncovers a serine protease-mediated paradigm of necrotic cell death: J. Ribas, et al.; Biochem. Pharmacol. 76, 39 (2008) Abstract
Related Products
Further Categories Containing This Product:
Aurora / Related Products
 
 
ALX-630-093 Revised 23-Jul-08
Aflatoxin B1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-093-M001   1 mg 28.00 USD Add To Cart
ALX-630-093-M005   5 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C17H12O6
MW: 312.3
CAS NUMBER: 1162-65-8
MERCK INDEX: 14: 180
RTECS: GY1925000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to yellow powder.
SOLUBILITY: Soluble in DMSO (20mg/ml) or methylene chloride (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: VERY TOXIC. MAY BE CARCINOGENIC. MAY BE TERATOGENIC.

Product Description
Naturally occuring mycotoxin produced by many species of Aspergillus. Metabolized by the liver to the reactive intermediate aflatoxin M1. Exposure may produce acute necrosis, cirrhosis and carcinoma of the liver. Induces DNA damage.
Product Specific Literature References
Molecular dosimetry of aflatoxin exposure: contribution to understanding the multifactorial etiopathogenesis of primary hepatocellular carcinoma with particular reference to hepatitis B virus: C.P. Wild, et al.; Environ. Health Perspect. 99, 115 (1993) Abstract
A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China: G.S. Qian, et al.; Cancer Epidemiol. Biomarkers Prev. 3, 3 (1994) Abstract
Aflatoxin B1 induced lacI mutation in liver and kidney of transgenic mice C57BL/6N: effect of phorone: H. Autrup, et al.; Mutagenesis 11, 69 (1996) Abstract
Activation and detoxication of aflatoxin B1: F.P. Guengerich, et al.; Mutat. Res. 402, 121 (1998), (Review) Abstract
Hyperplasia, partial hepatectomy, and the carcinogenicity of aflatoxin B1: B.D. Roebu; J. Cell. Biochem. 91, 242 (2004), (Review) Abstract
Aflatoxin B1-induced DNA damage and its repair: L. L. Bedard & T. E. Massey; Cancer Lett. 241, 174 (2006), (Review) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Non-apoptotic Cell Death / Necrosis • Plant Research Reagents / Related Products
 
 
ALX-630-103 Revised 04-Sep-08
Aflatoxin B2
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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ALX-630-103-M001   1 mg 55.00 USD Add To Cart
ALX-630-103-M005   5 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C17H14O6
MW: 314.3
CAS NUMBER: 7220-81-7
MERCK INDEX: 14: 180
RTECS: GY1722000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methylene chloride (5mg/ml), DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE CARCINOGENIC. VERY TOXIC.

Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Aflatoxin B2: Chemical Identity and Biological Activity: S.B. Chang, et al.; Science 142, 1191 (1963) Abstract
Accumulation of only aflatoxin B2 by a strain of Aspergillus flavus: H.W. Schroeder & W.W. Carlton; Appl. Microbiol. 25, 146 (1973) Abstract
In vitro metabolism of aflatoxin B2 by animal and human liver: B.D. Roebuck, et al.; Cancer Res. 38, 999 (1978) Abstract
Interaction of aflatoxin B2 with rat liver DNA and histones in vivo: J.D. Groopman, et al.; Carcinogenesis 2, 1371 (1981) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Non-apoptotic Cell Death / Necrosis • Plant Research Reagents / Related Products
 
 
ALX-630-104 Revised 24-Sep-08
Aflatoxin G1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-104-M001   1 mg 65.00 USD Add To Cart
ALX-630-104-M005   5 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C17H12O7
MW: 328.3
CAS NUMBER: 1165-39-5
MERCK INDEX: 14: 181
RTECS: LV1720000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to yellow powder.
SOLUBILITY: Soluble in DMSO (10mg/ml), methylene chloride (5mg/ml) or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: VERY TOXIC. MAY BE CARCINOGENIC.

Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Mutagenic effect of aflatoxin G1 in comparison with B1: M.M. el-Zawahri, et al.; J. Environ. Pathol. Toxicol. Oncol. 10, 45 (1990) Abstract
Identification of an aflatoxin G1-serum albumin adduct and its relevance to the measurement of human exposure to aflatoxins: G. Sabbioni & C.P. Wild; Carcinogenesis 12, 97 (1991) Abstract
Effects of sterigmatocystin, deoxynivalenol and aflatoxin G1 on apoptosis of human peripheral blood lymphocytes in vitro: X.M. Sun, et al.; Biomed. Environ. Sci. 15, 145 (2002) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Non-apoptotic Cell Death / Necrosis • Carcinogens & Tumor Promoters Other Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Plant Research Reagents / Related Products
 
 
ALX-630-106 Revised 20-Jun-08
Aflatoxin G2
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-106-M001   1 mg 150.00 USD Add To Cart
ALX-630-106-M005   5 mg 600.00 USD Add To Cart
Product Specification
FORMULA: C17H14O7
MW: 330.3
CAS NUMBER: 7241-98-7
MERCK INDEX: 14: 181
RTECS: LV1700000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in methylene chloride (5mg/ml), DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE CARCINOGENIC. VERY TOXIC.

Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Combining Ability for Resistance to Field Aflatoxin Accumulation in Maize Grain: D.P. Gorman, et al.; Plant Breeding 109, 296 (1992)
Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential: J.J. Wong & D.P. Hsieh; PNAS 73, 2241 (1976) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Plant Research Reagents / Related Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Non-apoptotic Cell Death / Necrosis
 
 
ALX-630-095 Revised 29-Oct-08
Aflatoxin M1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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ALX-630-095-MC01   0.1 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C17H12O7
MW: 328.3
CAS NUMBER: 6795-23-9
MERCK INDEX: 14: 182
RTECS: GY1880000
SOURCE/HOST: Isolated from Aspergillus flavus.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methylene chloride (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE CARCINOGENIC. MAY BE MUTAGENIC. VERY TOXIC.

Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin. Hydroxylated metabolite of aflatoxin B1. Maximum absorbance (λmax) at 228, 264 and 360nm.
Product Specific Literature References
Production and characterization of monoclonal antibodies against aflatoxin M1: N.A. Woychik, et al.; Appl. Environ. Microbiol. 48, 1096 (1984) Abstract; Full Text
Comparative binding and sequence interaction specificities of aflatoxin B1, aflatoxicol, aflatoxin M1, and aflatoxicol M1 with purified DNA: K. Marien, et al.; J. Biol. Chem. 262, 7455 (1987) Abstract; Full Text
Presence of aflatoxin M1 in commercial ultra-high-temperature-treated milk.: J.L. Blanco, et al.; Appl. Environ. Microbiol. 54, 1622 (1988) Abstract; Full Text
Distribution and stability of aflatoxin M1 during processing, ripening and storage of Telemes cheese: A. Govaris, et al.; Food Addit. Contam. 18, 437 (2001) Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Non-apoptotic Cell Death / Necrosis • Plant Research Reagents / Related Products
 
 
ALX-380-002 Revised 03-Apr-08
Cyclosporin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Immunomodulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-002-M100   100 mg 46.00 USD Add To Cart
ALX-380-002-5100   5x100 mg 190.00 USD Add To Cart
ALX-380-002-G001   1 g 290.00 USD Add To Cart
ALX-380-002-5001   5x1 g 1'150.00 USD Add To Cart
Product Specification
FORMULA: C62H111N11O12
MW: 1202.6
CAS NUMBER: 59865-13-3
MERCK INDEX: 14: 2752
RTECS: GZ4120000
SOURCE/HOST: Isolated from Fusarium solani.
PURITY: ≥99% (Assay)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol, 100% ethanol, acetone or petroleum ether; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE TERATOGENIC. TOXIC. MAY BE CARCINOGENIC.

Product Description
Antibiotic. Potent immunosuppressor. Widely used after organ transplantation. Binds to cytosolic proteins of the cyclophilin family. Cyclosporin A-cyclophilin complexes block protein phosphatase 2B (PP2B; calcineurin), a key enzyme in T cell activation. As a result of the calcineurin inhibition, cyclosporine A blocks various cellular processes such as activation of T cells and expression of several lymphokines (especially IL-2). Inhibits cytochrome c release from mitochondria. Inhibits nitric oxide (NO) synthesis.
Product Specific Literature References
Cyclosporin A and C-New metabolites from Trichodermapolysporum (Link ex Pers.) Rifai: Dreyfuss M., et al.; Europ. J. appl. Microbiol. 3, 125 (1976)
Immunosuppression for organ grafting - observations on cyclosporin A: R. Y. Calne; Immunol. Rev. 46, 113 (1976), Review Abstract
Immunological actions of cyclosporin A in rheumatoid arthritis: D. Yocum; Br. J. Rheumatol. 32, 38 (1993), Review Abstract
Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury: A.P. Halestrap, et al; Mol. Cell. Biochem. 174, 167 (1997), Review Abstract
New aspects of cyclosporin a mode of action: from gene silencing to gene up-regulation: L. Mascarell & P. Truffa-Bachi; Mini Rev. Med. Chem. 3, 205 (2003), Review Abstract
Rationale for T cell inhibition by cyclosporin A in major autoimmune diseases: G.F. Ferraccioli, et al.; Ann. N. Y. Acad. Sci. 1051, 658 (2005), Review Abstract
Further Categories Containing This Product:
MPTP [Mitochondrial Transition Pore] / Related Products • Antibiotics - Nitric Oxide Pathway Modulators • Antibiotics - Apoptosis Inducers & Inhibitors • Non-apoptotic Cell Death / Necrosis
 
 
ALX-380-282 Revised 19-Mar-08
Cyclosporin C
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SYNONYMS Thr2-cyclosporin A
7-L-Threonine-cyclosporin A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Immunomodulators
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ALX-380-282-M001   1 mg 50.00 USD Add To Cart
ALX-380-282-M005   5 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C62H111N11O13
MW: 1218.6
CAS NUMBER: 59787-61-0
MERCK INDEX: 14: 2752
SOURCE/HOST: Isolated from Fusarium solani.
PURITY: ≥95% (HPLC)
APPEARANCE: Colorless to off-white crystalline solid.
SOLUBILITY: Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE CARCINOGENIC. TOXIC. MAY BE TERATOGENIC.

Product Description
Potent immunosuppressor.
Product Specific Literature References
Cyclosporin A and C-New metabolites from Trichodermapolysporum (Link ex Pers.) Rifai: M. Dreyfuss, et al.; Europ. J. Appl. Microbiol. 3, 125 (1976)
[The structure of cyclosporin c (author’s transl)]: R. Traber, et al.; Helv. Chim. Acta 60, 1247 (1977) Abstract
Dosage, timing, and route of administration of cyclosporin A and nonimmunosuppressive derivatives of dihydrocyclosporin A and cyclosporin C against Schistosoma mansoni in vivo and in vitro: L.H. Chappell, et al.; Antimicrob. Agents Chemother. 31, 1567 (1987) Abstract
Cyclosporin C is the main antifungal compound produced by Acremonium luzulae: M. Moussaif, et al.; Appl. Environ. Microbiol. 63, 1739 (1997) Abstract; Full Text
Cyclosporin C(2) and C(0) concentration monitoring in stable, long-term heart transplant recipients receiving metabolic inhibitors: J.E. Ray, et al.; J. Heart Lung Transplant. 22, 715 (2003) Abstract
Further Categories Containing This Product:
Non-apoptotic Cell Death / Necrosis
 
 
ALX-380-286 Revised 08-Apr-08
Cyclosporin H
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SYNONYMS Csh-cyclosporin
5-(N-Methyl-D-valine)-cyclosporin A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Immunomodulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-286-M001   1 mg 80.00 USD Add To Cart
ALX-380-286-M005   5 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C62H111N11O12
MW: 1202.6
CAS NUMBER: 83602-39-5
SOURCE/HOST: Isolated from Fusarium solani.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE TERATOGENIC. TOXIC. MAY BE CARCINOGENIC.

Product Description

Immunologically inactive. Does not bind to immunophilin. Potent inhibitor of tumor promoting phorbol ester TPA/PMA (Prod. No. ALX-445-004) in mouse skin in vivo. Potent inhibitor of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. Potent and selective antagonist of formyl peptide receptor. Inhibits formyl peptide-induced superoxide formation.

Product Specific Literature References
The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC 150, 545 (1988) Abstract
Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation: K. Wenzel-Seifert, et al.; J. Immunol. 147, 1940 (1991) Abstract
Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E: K. Wenzel-Seifert & R. Seifert; J. Immunol. 150, 4591 (1993) Abstract
Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine: A. de Paulis, et al.; J. Allergy Clin. Immunol. 98, 152 (1996) Abstract
Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor: A.L. Stenfeldt, et al.; Inflammation 30, 224 (2007) Abstract
Further Categories Containing This Product:
MPTP [Mitochondrial Transition Pore] / Related Products • Antibiotics - Apoptosis Inducers & Inhibitors • CAM Kinase Inhibitors • Antibiotics - Nitric Oxide Pathway Modulators • Non-apoptotic Cell Death / Necrosis
 
 
ALX-420-027 Revised 26-Mar-08
DMNQ
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SYNONYMS 2,3-Dimethoxy-1,4-naphthoquinone
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-027-M005   5 mg 68.00 USD Add To Cart
ALX-420-027-M010   10 mg 115.00 USD Add To Cart
ALX-420-027-M025   25 mg 225.00 USD Add To Cart
Product Specification
FORMULA: C12H10O4
MW: 218.2
CAS NUMBER: 6956-96-3
PURITY: ≥99%
APPEARANCE: Yellow crystalline solid.
SOLUBILITY: Soluble in acetone, DMSO or methanol.