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ALX-210-427 Revised 23-Oct-08
Polyclonal Antibody to Nampt/Visfatin (human) (CT)
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SYNONYMS anti-Nicotinamide Phosphoribosyltransferase (human) PAb (CT)
anti-PBEF1 (human) PAb (CT)
anti-Pre-B-Cell Colony Enhancing Factor 1 (human) PAb (CT)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Visfatin / Nampt / PBEF / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-427-C100   100 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Synthetic peptide corresponding to aa 413-431 (V413FKDPVADPNKRSKKGRLS431) of human Nampt/visfatin.
SPECIFICITY: Recognizes human Nampt/visfatin. Weakly cross-reacts with mouse Nampt/visfatin.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:5’000)
Immunohistochemistry (paraffin sections)
Western Blot (1:2’000-1:5’000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Specific Literature References
Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis: M.A. Nowell, et al.; Arthritis Rheum. 54, 2084 (2006) Abstract; Full Text
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
NAD+ Metabolism / Related Products • Polyclonal Antibodies
 
 
ALX-210-428 Revised 23-Oct-08
Polyclonal Antibody to Nampt/Visfatin (mouse)
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SYNONYMS anti-Nicotinamide Phosphoribosyltransferase (mouse) PAb
anti-PBEF1 (mouse) PAb
anti-Pre-B-Cell Colony Enhancing Factor 1 (mouse) PAb
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Visfatin / Nampt / PBEF / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-428-C100   100 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant mouse Nampt/visfatin.
SPECIFICITY: Recognizes mouse Nampt/visfatin. Weakly cross-reacts with human Nampt/visfatin.
APPLICATION: ELISA (direct and indirect: 1:2'000-1:5'000).
Western Blot (1:2'000-1:5'000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
NAD+ Metabolism / Related Products • Polyclonal Antibodies
 
 
ALX-210-434 Revised 23-Oct-08
Polyclonal Antibody to Nampt/Visfatin (rat)
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SYNONYMS anti-Nicotinamide Phosphoribosyltransferase (rat) PAb
anti-PBEF1 (rat) PAb
anti-Pre-B-Cell Colony Enhancing Factor 1 (rat) PAb
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Visfatin / Nampt / PBEF / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-434-C100   100 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant rat Nampt/visfatin.
SPECIFICITY: Recognizes human (weak) and rat Nampt/visfatin.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:5’000)
Western Blot (1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
NAD+ Metabolism / Related Products • Polyclonal Antibodies
 
 
ALX-210-961 Revised 05-Aug-08 New product
Polyclonal Antibody to AROS (human) (AT135)
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SYNONYMS anti-Active Regulator of SIRT1 (human) PAb (AT135)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Sirtuins / Related Products
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ALX-210-961-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human AROS (aa 2-136)
SPECIFICITY: Recognizes human AROS.
APPLICATION: Western blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
SIRT1 is a member of the silent information regulator 2 (Sir2) family. It is an NAD+-dependent deacetylase protein that functions in cell death / survival, senescence, and endocrine signaling. It is also involved in the increase of life span following caloric restriction [1]. Recently, the first direct activator of SIRT1 has been described: AROS (active regulator of SIRT1) [2]. This nuclear protein of 142 amino acids interacts with SIRT1 and enhances SIRT1-mediated deacetylation of p53.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Sirtuins: Sir2-related NAD-dependent protein deacetylases: B.J. North & E. Verdin; Genome Biol. 5, 224 (2004) Abstract; Full Text
[2] Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity: E.J. Kim, et al.; Mol. Cell 28, 277 (2007) Abstract
Related Products
Further Categories Containing This Product:
NAD+ Metabolism / Related Products • Polyclonal Antibodies • p53 Other Products
 
 
ALX-270-003 Revised 08-Aug-08
Diphenyleneiodonium chloride
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SYNONYMS Dibenziodolium chloride
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-003-M025   25 mg 85.00 USD Add To Cart
ALX-270-003-M100   100 mg 255.00 USD Add To Cart
Product Specification
FORMULA: C12H8ICl
MW: 314.5
CAS NUMBER: 4673-26-1
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: 10mg/ml soluble in DMSO (warm).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Binds strongly to flavoproteins and is thus a powerful and specific inhibitor of several important enzymes, including nitric oxide synthase (NOS), NADPH-ubiquinone oxidoreductase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Nitric oxide synthase, which shows significant homology with cytochrome P450 reductase, has shown to be irreversibly inhibited by this compound.
Product Specific Literature References
Specific labelling of a constituent polypeptide of bovine heart mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone reductase by the inhibitor diphenyleneiodonium: C.I. Ragan & D.P. Bloxham; Biochem. J. 163, 605 (1977) Abstract
The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages: J.T. Hancock & O.T.G. Jones; Biochem. J. 242, 103 (1987) Abstract
Indications to an NADPH oxidase as a possible pO2 sensor in the rat carotid body: H. Acker, et al.; FEBS Lett. 256, 75 (1989) Abstract
Purification and some properties of the 45 kDa diphenylene iodonium- binding flavoprotein of neutrophil NADPH oxidase: C.M. Yea, et al.; Biochem. J. 265, 95 (1990) Abstract
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs: D.J. Stuehr, et al.; FASEB J. 5, 98 (1991) Abstract
Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications: D.G. Tew; Biochemistry 32, 10209 (1993) Abstract
Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat: H. Kono, et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 280, G1005 (2001) Abstract
Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species: A.F. Mendes, et al.; Mediators Inflamm. 10, 209 (2001) Abstract
Preferential inhibition of the plasma membrane NADH oxidase (NOX) activity by diphenyleneiodonium chloride with NADPH as donor: D.J. Morre; Antioxid. Redox Signal 4, 207 (2002) Abstract
G2 cell cycle arrest, down-regulation of cyclin B, and induction of mitotic catastrophe by the flavoprotein inhibitor diphenyleneiodonium: R.M. Scaife; Mol. Cancer Ther. 3, 1229 (2004) Abstract
Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium: A. Balcerczyk, et al.; Biochem. Pharmacol. 69, 1263 (2005) Abstract
Selective and irreversible cell cycle inhibition by diphenyleneiodonium: R.M. Scaife; Mol. Cancer Ther. 4, 876 (2005) Abstract
Further Categories Containing This Product:
Oxygenases Other Products • Cytochrome P450 [CYP450] / Related Products • Respiratory Chain Other Products
 
 
ALX-270-308 Revised 10-Apr-08
Sirtinol
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SYNONYMS Sir Two Inhibitor Naphthol
2-[(2-Hydroxynaphthalen-1-yl-methylene)amino]-N-(1-phenethyl)benzamide
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Sirtuins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-308-M001   1 mg 53.00 USD Add To Cart
ALX-270-308-M005   5 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C26H22N2O2
MW: 394.5
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to yellow crystals.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Relatively unstable in aqueous solution, especially at acidic pH.
HANDLING: Protect from light.

Product Description
Specific cell permeable inhibitor of the sirtuin family of NAD-dependent deacetylases (ySir2: IC50=48µM; hSIRT1: IC50=131µM; hSIRT2: IC50=58µM) with no effect on human HDAC1. Reported to inhibit Sir2p transcriptional silencing activity in vivo (IC50=25µM) and NAD-dependent histone deacetylase activity of purified recombinant yeast Sir2p (IC50=70µM) and hSIRT2 (IC50=40µM) in vitro.
Product Specific Literature References
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening: C.M. Grozinger, et al.; J. Biol. Chem. 276, 38837 (2001) Abstract; Full Text
Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity: C.E. Koering, et al.; EMBO Rep. 3, 1055 (2002) Abstract; Full Text
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors: A. Mai, et al.; J. Med. Chem. 48, 7789 (2005) Abstract
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells: H. Ota, et al.; Oncogene 25, 176 (2006) Abstract
Further Categories Containing This Product:
NAD+ Metabolism / Related Products
 
 
ALX-350-028 Revised 12-Sep-08
Curcumin (high purity)
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SYNONYMS 1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Diferuloylmethane
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-028-M010   10 mg 15.00 USD Add To Cart
ALX-350-028-M050   50 mg 60.00 USD Add To Cart
ALX-350-028-M250   250 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C21H20O6
MW: 368.4
CAS NUMBER: 458-37-7
MERCK INDEX: 14: 2673
SOURCE/HOST: Isolated from turmeric (Curcuma longa).
PURITY: ≥98.5% (Note: This highly purified product is free of demethoxy- and bis-demethoxycurcumin and does not contain 30-40% bioactive impurities)
APPEARANCE: Orange-yellow crystalline powder.
SOLUBILITY: Soluble in acetic acid or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
Dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase. Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Antioxidant. Inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), disrupting the binding of NQO1 to wild type p53 inducing ubiquitin-independent degradation of p53 and inhibits p53-mediated apoptosis in normal thymocytes and myeloid leukemic cells.
Product Specific Literature References
Modification of certain inflammation-induced biochemical changes by curcumin: R. Srivastava & R.C. Srimal; Indian J. Med. Res. 81, 215 (1985) Abstract
Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones: D.L. Flynn, et al.; Prostagl. Leukotr. Med. 22, 357 (1986) Abstract
Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells: L. Korutla & R. Kumar; Biochim. Biophys. Acta 1224, 597 (1994) Abstract
Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages: I. Brouet & H. Okshima; BBRC 206, 533 (1995) Abstract
Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin: J.N. Commandeur & N.P. Vermeulen; Xenobiotica 26, 667 (1996) Abstract
Nitric oxide scavenging by curcuminoids: Sreejayan & M.N. Rao; J. Pharm. Pharmacol. 49, 105 (1997) Abstract
Inhibitory effects of curcumin on tumorigenesis in mice: M.T. Huang, et al.; J. Cell. Biochem. (Suppl.) 27, 26 (1997) Abstract
In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties: M.M. Chan, et al.; Biochem. Pharmacol. 55, 1955 (1998) Abstract
Effect of curcumin on the production of nitric oxide by cultured rat mammary gland: M. Onoda & H. Inano; Nitric Oxide 4, 505 (2000) Abstract
Suppression of nitric oxide oxidation to nitrite by curcumin is due to the sequestration of the reaction intermediate nitrogen dioxide, not nitric oxide: B.D. Johnston & E.G. DeMaster; Nitric Oxide 8, 231 (2003) Abstract
Biological properties of curcumin-cellular and molecular mechanisms of action: B. Joe, et al.; Crit. Rev. Food Sci. Nutr. 44, 97 (2004), (Review) Abstract
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects: M.E. Egan, et al.; Science 304, 600 (2004) Abstract
Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin: P. Tsvetkov, et al.; PNAS 102, 5535 (2005) Abstract
Immunomodulatory effects of curcumin: V.S. Yadav, et al.; Immunopharmacol. Immunotoxicol. 27, 485 (2005) Abstract
Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases: S. Bengmark; JPEN J. Parenter. Enteral. Nutr. 30, 45 (2006), (Review) Abstract
Curcumin is an inhibitor of p300 histone acetylatransferase: M.G. Marcu, et al.; Med. Chem. 2, 169 (2006) Abstract
Multiple biological activities of curcumin: a short review: R.K. Maheshwari, et al.; Life Sci. 78, 2081 (2006), (Review) Abstract
Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1: M.K. Bae, et al.; Oncol. Rep. 15, 1557 (2006) Abstract
Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells: Z. Wang, et al.; Cancer 106, 2503 (2006) Abstract
Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species: M. Panchatcharam, et al.; Mol. Cell Biochem. 290, 87 (2006) Abstract
Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia: K.K. Jung, et al.; Life Sci. 79, 2022 (2006) Abstract
The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats: T. Morimoto, et al.; J. Clin. Invest. 118, 868 (2008) Abstract; Full Text
Further Categories Containing This Product:
Other Natural Products for Cancer Research • Cell Cycle Blockers & Inhibitors / Related Products • Lipoxygenases / Related Products • EGFR Kinase Inhibitors • Natural Products - Protein Kinase Inhibitors • Respiratory Chain Other Products • Natural P