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Nitric Oxide Donors
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ALX-420-019 Revised 14-Dec-06
N-Acetyl-D,L-penicillamine disulfide
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SYNONYMS AP-SS
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Donors
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ALX-420-019-M001   1 mg 40.00 USD Add To Cart
ALX-420-019-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C14H24N2O6S2
MW: 380.5
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in DMSO or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Degradation product of S-nitroso-N-acetyl-D,L-penicillamine (SNAP) (Prod. No. ALX-420-003).
Product Specific Literature References
The nitric oxide-cyclic GMP pathway and synaptic depression in rat hippocampal slices: C.L. Boulton, et al.; Eur. J. Neurosci. 6, 1528 (1994) Abstract
Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor: P.M. Gross, et al.; Neuropharmacology 33, 915 (1994) Abstract
 
 
ALX-430-126 Revised 18-Jul-08
Angeli's Salt
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SYNONYMS Hyponitric acid . disodium salt
Sodium α-oxyhyponitrite
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Donors
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ALX-430-126-M010   10 mg 82.00 USD Add To Cart
Product Specification
FORMULA: N2O3 . 2Na
MW: 76.0 . 46.0
CAS NUMBER: 13826-64-7
PURITY: ≥99%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Highly soluble in water; also soluble in 0.01M sodium hydroxide.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C. Alkaline solutions (in 0.01M NaOH) are stable and can be stored at 0°C for one day. The half-life in 0.1M PBS, pH 7.4 is 2.3 min. at 37°C. The decomposition at pH 5 is nearly instantaneous.
HANDLING: Protect from light, oxygen and moisture.

Product Description
Nitric oxide (NO) donor. The stoichiometry of NO release is 0.54 mole per mole of Angeli’s Salt. The EC50 for relaxation of norepinephrine-constricted rabbit aorta is 0.59µM.
Product Specific Literature References
Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects: C.M. Maragos, et al.; J. Med. Chem. 34, 3242 (1991) Abstract
Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO: J.M. Fukuto, et al.; BBRC 196, 707 (1993) Abstract
Angeli’s salt and spinal motor neuron injury: A.J. Vaananen, et al.; Free Radic. Res. 38, 271 (2004) Abstract
Nitroxyl triggers Ca2+ release from skeletal and cardiac sarcoplasmic reticulum by oxidizing ryanodine receptors: E. Cheong, et al.; Cell. Calcium 37, 87 (2005) Abstract
Neurotoxicity of nitroxyl: insights into HNO and NO biochemical imbalance: S.J. Hewett, et al.; Free Radic. Biol. Med. 39, 1478 (2005) Abstract
Mechanism of aerobic decomposition of Angeli’s salt (sodium trioxodinitrate) at physiological pH: K.M. Miranda, et al.; JACS 127, 722 (2005) Abstract
Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo: K.M. Miranda, et al.; J. Med. Chem. 48, 8220 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To initiate the release of nitric oxide, add the alkaline solution of Angeli’s Salt to an excess of pH 7.0-7.4 buffer.
 
 
ALX-101-004 Revised 03-Aug-07
L-Arginine
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SYNONYMS H-L-Arg-OH
PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY L-Amino Acids
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ALX-101-004-G025   25 g 17.00 USD Add To Cart
Product Specification
FORMULA: C6H14N4O2
MW: 174.2
CAS NUMBER: 74-79-3
MERCK INDEX: 14: 780
RTECS: CF1934200
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Specific Literature References
L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation: R.M.J. Palmer, et al.; BBRC 153, 1251 (1988) Abstract
Vascular endothelial cells synthesize nitric oxide from L-arginine: R.M.J. Palmer, et al.; Nature 333, 664 (1988) Abstract
Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides: H.H.H.W. Schmidt, et al.; Science 255, 721 (1992) Abstract
The importance of L-arginine metabolism in melanoma: an hypothesis for the role of nitric oxide and polyamines in tumor angiogenesis: M. Joshi; Free Radic. Biol. Med. 22, 573 (1997), (Review) Abstract
L-arginine increases UVA cytotoxicity in irradiated human keratinocyte cell line: potential role of nitric oxide: C. Didier, et al.; FASEB J. 13, 1817 (1999) Abstract; Full Text
L-Arginine supplementation enhances diabetic wound healing: involvement of the nitric oxide synthase and arginase pathways: M.B. Witte, et al.; Metabolism 51, 1269 (2002) Abstract
Pharmacokinetics and pharmacodynamics of L-arginine in rats: a model of stimulated neuronal nitric oxide synthesis: E.L. Heinzen & G.M. Pollack; Brain Res. 989, 67 (2003) Abstract
L-arginine regulates neuronal nitric oxide synthase production of superoxide and hydrogen peroxide: P. Tsai, et al.; Biochem. Pharmacol. 69, 971 (2005) Abstract
Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide: S. Saleh & E. El-Demerdash; Basic Clin. Pharmacol. Toxicol. 97, 91 (2005) Abstract
General Information
Physiological precursor for the formation of nitric oxide (NO) by nitric oxide synthase (NOS). Enhances the release of NO.
Further Categories Containing This Product:
Arginine & Arginases / Related Products • Nitric Oxide Donors
 
 
ALX-430-148 Revised 24-May-07
BNN3
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SYNONYMS N,N’-Dimethyl-N,N’-dinitroso-p-phenylenediamine
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Donors
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ALX-430-148-M001   1 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C8H10N4O2
MW: 194.2
CAS NUMBER: 6947-38-2
PURITY: ≥98% (HPLC)
APPEARANCE: White to pale yellow solid.
SOLUBILITY: Soluble in DMSO (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 2 years after receipt when stored at -20°C. Keep stock solution on ice and use in one day.
HANDLING: Protect from light.

Product Description
Cell permeable, photolabile NO donor (λem (max): ~300nm). Produces two NO molecules per molecule of BNN3 upon irradiation (300-360nm) with a xenon lamp or laser flashlight. Causes photo-induced vasorelaxation in rat aortic strips.
Product Specific Literature References
Bis-N-nitroso-caged nitric oxides: photochemistry and biological performance test by rat aorta vasorelaxation: S. Namiki, et al.; Bioorg. Med. Chem. 7, 1695 (1999) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

NO Release Protocol

1. Prepare 1mM BNN3 stock solution in DMSO.
2. Add an appropriate volume of BNN3 stock solution to an organ bath containing a rat aortic strip
    incubated in Krebs-Ringer solution* at 37ºC. The final concentration of BNN3 should be 1µM.
3. Incubate the strip for 30 min. and wash with Krebs-Ringer solution* to remove BNN3.
4. Irradiate the aortic strip with 300 to 360nm UV light while recording its tension.

*Krebs-Ringer solution: 113mM NaCl, 4.8mM KCl, 25mM NaHCO3, 1.4mM KH2PO4, 2.2mM CaCl2, 1.4mM MgSO4 and 5.5mM glucose.
 
 
ALX-420-034 Revised 24-Jun-04
N-Cyclopropyl-N'-hydroxyguanidine . hydrochloride
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PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Donors
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ALX-420-034-M001   1 mg 35.00 USD Add To Cart
ALX-420-034-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C4H9N3O . HCl
MW: 115.1 . 36.5
PURITY: >95% (TLC, 1H-NMR, 13C-NMR)
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic.

Product Description
Selective substrate for nNOS (NOS I). 70% nitric oxide (NO) formation for nNOS (NOS I), 26% for eNOS (NOS III) and <0.5% for iNOS (NOS II) as compared to NO formation using NG-Hydroxy-L-arginine (NOHA, Prod No. ALX-106-004) as a substrate.
Product Specific Literature References
Isoform-selective substrates of nitric oxide synthase: Q. Jia, et al.; J. Med. Chem. 46, 2271 (2003) Abstract
 
 
ALX-430-086 Revised 13-Dec-06
DD1
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SYNONYMS 3-Bromo-3,4,4-trimethyl-3,4-dihydrodiazete 1,2-dioxide
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Donors
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ALX-430-086-M010   10 mg 30.00 USD Add To Cart
ALX-430-086-M050   50 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C5H9BrN2O2
MW: 209.0
PURITY: ≥98%
APPEARANCE: Crystals.
SOLUBILITY: Soluble in DMSO, 100% ethanol or water (10mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Guanylyl cyclase activator. Cell permeable thiol-induced nitric oxide donor with strong vasodilator effects.
Product Specific Literature References
Kinetics of nitric oxide liberation by 3,4-dihydro-1,2-diazete 1,2- dioxides and their vasodilatory properties in vitro and in vivo: D.I. Utepbergenov, et al.; BBRC 214, 1023 (1995) Abstract
Thiol-induced nitric oxide release from 3-halogeno-3,4-dihydrodiazete 1,2-dioxides: I.A. Kirilyuk, et al.; J. Med. Chem. 41, 1027 (1998) Abstract
Geldanamycin leads to superoxide formation by enzymatic and non-enzymatic redox cycling. Implications for studies of Hsp90 and endothelial cell nitric-oxide synthase: S. Dikalov, et al.; J. Biol. Chem. 277, 25480 (2002) Abstract; Full Text
Inflammatory cytokines induce apoptosis of corneal endothelium through nitric oxide: P. Sagoo, et al.; Invest. Ophthalmol. Vis. Sci. 45, 3964 (2004) Abstract; Full Text
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
 
 
ALX-430-087 Revised 23-Feb-05
DD2
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SYNONYMS 3-Bromo-4-methyl-3,4-hexamethylene-3,4-dihydrodiazete 1,2-dioxide
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Donors
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ALX-430-087-M010   10 mg 30.00 USD Add To Cart
ALX-430-087-M050   50 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C7H11BrN2O2
MW: 235.1
PURITY: ≥98%
APPEARANCE: Crystals.
SOLUBILITY: Soluble in water (3.5mM), DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Guanylyl cyclase activator. Cell permeable thiol-induced nitric oxide donor with strong vasodilator effects.
Product Specific Literature References
Kinetics of nitric oxide liberation by 3,4-dihydro-1,2-diazete 1,2- dioxides and their vasodilatory properties in vitro and in vivo: D.I. Utepbergenov, et al.; BBRC 214, 1023 (1995) Abstract
Thiol-induced nitric oxide release from 3-halogeno-3,4-dihydrodiazete 1,2-dioxides: I.A. Kirilyuk, et al.; J. Med. Chem. 41, 1027 (1998) Abstract
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
 
 
ALX-430-034 Revised 31-Oct-08
DEA NONOate
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SYNONYMS DEA/NO
2-(N,N-Diethylamino)-diazenolate-2-oxide . diethylammonium salt
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Donors
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ALX-430-034-M010   10 mg 22.00 USD Add To Cart
ALX-430-034-M050   50 mg 55.00 USD Add To Cart
ALX-430-034-5005   5x5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C4H10N3O2 . C4H12N
MW: 132.1 . 74.1
CAS NUMBER: 56329-27-2
PURITY: ≥98%
APPEARANCE: White to yellow powder.
SOLUBILITY: Soluble in 100% ethanol (25mg/ml), DMSO (2mg/ml), dimethyl formamide (2mg/ml) or PBS, pH 7.2 (10mg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING: Packaged under inert gas. Hygroscopic. Protect from light and oxygen.
HAZARD: HARMFUL.

Product Description
Nitric oxide (NO) donor.
Product Specific Literature References
The Reaction of Nitrogen(II) Oxide with Diethylamine: R.S. Drago & F.E. Paulik; JACS 82, 96 (1960)
The Reaction of Nitrogen(II) Oxide with Various Primary and Secondary Amines: R.S. Drago & B.R. Karstetter; JACS 83, 1819 (1961)
Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects: C.M. Maragos, et al.; J. Med. Chem. 34, 3242 (1991) Abstract
DNA deaminating ability and genotoxicity of nitric oxide and its progenitors: D.A. Wink, et al.; Science 254, 1001 (1991) Abstract
New nitric oxide-releasing zwitterions derived from polyamines : J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993)
Peroxynitrite-mediated inactivation of heme oxygenases: R. Kinobe, et al.; BMC Pharmacol. 21, 4 (2004) Abstract; Full Text
Flavin-containing monooxygenase activity can be inhibited by nitric oxide-mediated S-nitrosylation: S.D. Ryu, et al.; Life Sci. 75, 2559 (2004) Abstract
A potential role for extracellular nitric oxide generation in cGMP-independent inhibition of human platelet aggregation: biochemical and pharmacological considerations: M.S. Crane, et al.; Br. J. Pharmacol. 144, 849 (2005) Abstract
Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients: J.S. Isenberg, et al.; Free Radic. Biol. Med. 40, 1028 (2006) Abstract
Nitric oxide mediates interactions between GABAA receptors and adenosine A1 receptors in the rat hippocampus: I.R. Fragata, et al.; Eur. J. Pharmacol. 543, 32 (2006) Abstract
Effect of endogenous and exogenous nitric oxide on calcium sparks as targets for vasodilation in rat cerebral artery: M. Mandala, et al.; Nitric Oxide 16, 104 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Dissociates to the free amine and nitric oxide in a pH-dependent manner following first order kinetics. To initiate the release of nitric oxide, add stock alkaline solution of DEA NONOate to excess buffer of pH 7.0 - 7.4. The half life in 0.1 M phosphate buffer, pH 7.4, is t½ = 16 min. at 22 -25 °C or t½= 2 min. at 37 °C. Liberates 1.5 mol of NO per mol of parent compound. Decomposition is nearly instantaneous at pH 5.0.
 
 
ALX-270-169 Revised 07-Dec-04
Dephostatin
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SYNONYMS 2,5-Dihydroxy-N-methyl-N-nitrosoaniline
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Tyrosine Phosphatases Other Products
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ALX-270-169-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C7H8N2O3
MW: 168.2
CAS NUMBER: 151606-30-3
SOURCE/HOST: Synthetic.
PURITY: ≥90%
APPEARANCE: Red to brown solid.
SOLUBILITY: Soluble in DMSO, chloroform or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Competitive protein tyrosine phosphatase inhibitor. Protein S-nitrosating reagent.
Product Specific Literature References
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy, isolation, and characterization: M. Imoto, et al.; J. Antibiot. 46, 1342 (1993) Abstract
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination: H. Kakeya, et al.; J. Antibiot. 46, 1716 (1993) Abstract
Synthesis and protein tyrosine phosphatase inhibitory activity of dephostatin analogs: T. Watanabe, et al.; J. Antibiot. 48, 1460 (1995) Abstract
Synthesis and Bioassay of a Protein Tyrosine Phosphatase Inhibitor, Dephostatin: L. Yu, et al.; Bioorg. Med. Chem. Lett. 5, 1003 (1995)
Further Categories Containing This Product:
Nitric Oxide Donors
 
 
ALX-430-014 Revised 13-May-08
DETA NONOate
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SYNONYMS NOC-18
DETA/NO
(Z)-1-[2-(2-Aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Donors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-014-M005   5 mg 30.00 USD Add To Cart
ALX-430-014-M025   25 mg 100.00 USD Add To Cart
ALX-430-014-5005   5x5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C4H13N5O2
MW: 163.2
CAS NUMBER: 146724-94-9
RTECS: KH2502500
PURITY: ≥97% (1H-NMR)
APPEARANCE: