ALEXIS Biochemicals: POBN (high purity)

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ALX-430-141

Revised 14-Nov-06

BMPO (high purity)
SYNONYMS	5-tert-Butoxycarbonyl-5-methyl-1-pyrroline-N-oxide (high purity)
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Spin Traps, Spin Probes & Spin Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-141-M010		10 mg	70.00 USD
ALX-430-141-M050		50 mg	280.00 USD

Product Specification

FORMULA:	C₁₀H₁₇NO₃
MW:	199.3
PURITY:	≥99% (¹H-NMR, EPR)
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from moisture.

Product Description

Nitrone spin trap for the specific in vivo or in vitro detection of short-lived superoxide, hydroxyl and thiyl radicals. Forms distinguishable adducts which can be measured by EPR spectroscopy. Unlike with DMPO, the superoxide adduct does not decay into a hydroxyl adduct and it has a much longer half-life (t_1/2=23min). Low paramagnetic impurities. No further purification required.

Product Specific Literature References

Synthesis and biochemical applications of a solid cyclic nitrone spin trap: a relatively superior trap for detecting superoxide anions and glutathiyl radicals: H. Zhao, et al.; Free Radic. Biol. Med. 31, 599 (2001) Abstract
Spin traps: in vitro toxicity and stability of radical adducts: N. Khan, et al.; Free Radic. Biol. Med. 34, 1473 (2003) Abstract
Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence: H. Zhao, et al.; PNAS 102, 5727 (2005) Abstract
Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species: H. Shi, et al.; Arch. Biochem. Biophys. 437, 59 (2005) Abstract

ALX-430-131

Revised 16-Oct-08

CAT1H . hydrochloride
SYNONYMS	1-Hydroxy-2,2,6,6-tetramethylpiperidin-4-yl-trimethylammonium chloride . HCl
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Spin Traps, Spin Probes & Spin Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-131-M010		10 mg	65.00 USD
ALX-430-131-M050		50 mg	195.00 USD
ALX-430-131-M250		250 mg	450.00 USD

Product Specification

FORMULA:	C₁₂H₂₆N₂O . 2HCl
MW:	214.4 . 72.9
APPEARANCE:	Colorless crystalline solid.
PURITY DETAIL:	Paramagnetic impurities ≤0.01% (EPR).
SOLUBILITY:	Soluble in water, methanol or 100% ethanol.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from moisture.

Product Description

Cyclic hydroxylamine spin probe for in vivo, intraperitoneal and intravenous injections. Lifetime of more than 4 hours in blood plasma, in cells and tissue. Allows quantitative measurements of extracellular O2^•– and quantification of intracellular O2^•– in cells and tissue samples and in vivo O2^•– detection.

Product Specific Literature References

Role of extracellular superoxide dismutase in hypertension: M.C. Gongora, et al.; Hypertension 48, 473 (2006) Abstract; Full Text
Measurement of reactive oxygen species in cardiovascular studies: S. Dikalov, et al.; Hypertension 49, 717 (2007) Abstract
Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction: T.J. Guzik, et al.; J. Exp. Med. 204, 2449 (2007) Abstract; Full Text
Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis: A.K. Doughan & S.I. Dikalov; Antioxid. Redox Signal. 9, 1825 (2007) Abstract

ALX-430-089

Revised 19-Sep-06

CDMIO . potassium salt
SYNONYMS	4-Carboxy-2,2-dimethyl-2H-imidazole-1-oxide . K
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Spin Traps, Spin Probes & Spin Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-089-M010		10 mg	15.00 USD
ALX-430-089-M050		50 mg	45.00 USD

Product Specification

FORMULA:	C₆H₇N₂O₃.K
MW:	156.1 . 39.1
APPEARANCE:	White crystals.
SOLUBILITY:	Soluble in water, 100% ethanol and DMSO.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

Water soluble, non-cell permeable spin trap. Stable against reduction by vitamin C and thiols.

Product Specific Literature References

2H-imidazole-N-oxides as spin traps: S.I. Dikalov, et al.; Bull. Russ. Acad. Sci. 41, 834 (1992)
Spin trapping of O-, C-, and S-centered radicals and peroxynitrite by 2H-imidazole-1-oxides: S.I. Dikalov, et al.; BBRC 218, 616 (1996) Abstract

ALX-430-117

Revised 16-May-08

CMH . hydrochloride
SYNONYMS	1-Hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine . HCl
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Spin Traps, Spin Probes & Spin Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-117-M010		10 mg	65.00 USD
ALX-430-117-M050		50 mg	195.00 USD
ALX-430-117-M250		250 mg	450.00 USD

Product Specification

FORMULA:	C₁₀H₁₉NO₃ . HCl
MW:	201.3 . 36.5
PURITY:	≥99% (EPR)
APPEARANCE:	White to off-white crystalline powder.
SOLUBILITY:	Soluble in DMSO, 100% ethanol, methanol or water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

Analog of CPH (Prod. No. ALX-430-078) with higher cell permeability and 3-fold better reactivity with superoxide. Has been used to study intracellular production of superoxide radicals in plasma, endothelial cells and isolated hearts.

Product Specific Literature References

Detection of superoxide with new cyclic hydroxylamine CMH in plasma, cells and isolated heart: B. Fink & S. Dikalov; Free Radical Biol. Med. 33, S366 (2002)
Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion: J. Hwang, et al.; J. Biol. Chem. 278, 47291 (2003) Abstract; Full Text
Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase: N. Kuzkaya, et al.; Biochem. Pharmacol. 70, 343 (2005) Abstract
Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases: S.C. Dudley, Jr., et al.; Circulation 112, 1266 (2005) Abstract
Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice: A. Dikalova, et al.; Circulation 112, 2668 (2005) Abstract
Measurement of reactive oxygen species in cardiovascular studies: S. Dikalov, et al.; Hypertension 49, 717 (2007) Abstract
Production of extracellular superoxide by human lymphoblast cell lines: comparison of electron spin resonance techniques and cytochrome C reduction assay: S.I. Dikalov, et al.; Biochem. Pharmacol. 73, 972 (2007) Abstract; Full Text

Related Products

ALX-430-078

CPH . hydrochloride

ALX-430-078

Revised 10-Nov-06

CPH . hydrochloride
SYNONYMS	1-Hydroxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine . HCl
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Spin Traps, Spin Probes & Spin Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-078-M010		10 mg	65.00 USD
ALX-430-078-M050		50 mg	195.00 USD
ALX-430-078-M250		250 mg	450.00 USD

Product Specification

FORMULA:	C₉H₁₇NO₃ . HCl
MW:	187.2 . 36.5
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO, 100% ethanol, methanol or water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

Effective, cell permeable and non-toxic spin trap for the detection of superoxide radical and peroxynitrite, both in vitro and in vivo. Resistant to reduction by vitamin C and thiols.

Product Specific Literature References

Spin trapping of superoxide radicals and peroxynitrite by 1-hydroxy-3- carboxy-pyrrolidine and 1-hydroxy-2,2,6, 6-tetramethyl-4-oxo-piperidine and the stability of corresponding nitroxyl radicals towards biological reductants: S. Dikalov, et al.; BBRC 231, 701 (1997) Abstract
Quantification of superoxide radicals and peroxynitrite in vascular cells using oxidation of sterically hindered hydroxylamines and electron spin resonance: S. Dikalov, et al.; Nitric Oxide 1, 423 (1997) Abstract
Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: effect of vitamin C: S. Dikalov, et al.; Free Radic. Biol. Med. 27, 170 (1999) Abstract
A new approach for extracellular spin trapping of nitroglycerin-induced superoxide radicals both in vitro and in vivo: B. Fink, et al.; Free Radic. Biol. Med. 28, 121 (2000) Abstract
Noninvasive diagnostic tool for inflammation-induced oxidative stress using electron spin resonance spectroscopy and an extracellular cyclic hydroxylamine: S.I. Dikalov, et al.; Arch. Biochem. Biophys. 402, 218 (2002) Abstract
Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase: N. Kuzkaya, et al.; J. Biol. Chem. 278, 22546 (2003) Abstract; Full Text
Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase: N. Kuzkaya, et al.; Biochem. Pharmacol. 70, 343 (2005) Abstract
Indoxyl sulfate induces complex redox alterations in mesangial cells: A.K. Gelasco & J.R. Raymond; Am. J. Physiol. Renal Physiol. 290, F1551 (2006) Abstract

ALX-430-120

Revised 02-Nov-07

DEDPI
SYNONYMS	4-(Dimethylamino)-2-ethyl-5,5-dimethyl-2-pyridine-4-yl-2,5-dihydro-1H-imidazol-1-oxyl
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Spin Traps, Spin Probes & Spin Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-120-M010		10 mg	60.00 USD
ALX-430-120-M050		50 mg	210.00 USD

Product Specification

FORMULA:	C₁₄H₂₁N₄O
MW:	261.3
PURITY:	≥99% (HPLC; EPR)
APPEARANCE:	Orange crystalline solid.
SOLUBILITY:	Highly soluble in DMSO, methanol or 100% ethanol; moderately soluble in water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

pH-sensitive nitroxide for in vivo studies. The presence of two ionizable groups in the side-chains extends the range of pH sensitivity. The relatively high solubility in water and broad range of pH-sensitivity makes the probe particularly suitable for pH monitoring in stomach using non-invasive low-field EPR techniques.

Product Specific Literature References

Grignard reagent addition to 5-alkylamino-4H-imidazole 3-oxides: synthesis of new pH-sensitive spin probes : T.G. Shevelev, et al.; Synthesis 2003, 871
Synthesis of the tetraethyl substituted pH-sensitive nitroxides of imidazole series with enhanced stability towards reduction: I.A. Kirilyuk, et al.; Org. Biomol. Chem. 2, 1025 (2004) Abstract
In vitro and in vivo measurement of pH and thiols by EPR-based techniques: V.V. Khramtsov, et al.; Antioxid. Redox Signal. 6, 667 (2004) Abstract
Nitroxides with two pK values--useful spin probes for pH monitoring within a broad range: I.A. Kirilyuk, et al.; Org. Biomol. Chem. 3, 1269 (2005) Abstract
Real-time monitoring of drug-induced changes in the stomach acidity of living rats using improved pH-sensitive nitroxides and low-field EPR techniques: D.I. Potapenko, et al.; J. Magn. Reson. 182, 1 (2006) Abstract

ALX-430-093

Revised 26-Jun-07

DEPMPO
SYNONYMS	5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide 2-Diethylphosphono-2-methyl-3,4-dihydro-2H-pyrrole 1-oxide (2-Methyl-3,4-dihydro-1-oxide-2H-pyrrol-2-yl)diethylphosphonate
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Spin Traps, Spin Probes & Spin Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-093-M050		50 mg	160.00 USD
ALX-430-093-M500		500 mg	1'120.00 USD

Product Specification

FORMULA:	C₉H₁₈NO₄P
MW:	235.2
CAS NUMBER:	157230-67-6
PURITY:	≥99%
APPEARANCE:	Colorless to light yellow oil.
SOLUBILITY:	Soluble in water or 100% ethanol.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-80°C
USE/STABILITY:	Unstable in solution. Reconstitute just prior to use.
HANDLING:	Hygroscopic. Protect from light and moisture.

Product Images

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Product Description

Most efficient spin trap for the in vitro and in vivo detection of O-, N-, S- and C-centered free radicals. Has a longer life-time than DMPO (Prod. No. ALX-430-090). Can distinguish between superoxide-dependent and independent mechanisms that lead to the hydroxyl radical. Less lipophilic (Kp=0.16) than DIPPMPO (Prod. No. ALX-430-119).

Product Specific Literature References

5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide: a new efficient phosphorylated nitrone for the in vitro and in vivo spin trapping of oxygen-centered radicals: C. Frejaville, et al.; J. Med. Chem. 38, 258 (1995) Abstract
Characterization of sulfur-centered radical intermediates formed during the oxidation of thiols and sulfite by peroxynitrite. ESR-spin trapping and oxygen uptake studies: H. Karoui, et al.; J. Biol. Chem. 271, 6000 (1996) Abstract
Use of spin-traps during war ischemia-reperfusion in rat liver: comparative effect on energetic metabolism studied using 31P nuclear magnetic resonance: M.C. Delmas-Beauvieux, et al.; Magma 5, 45 (1997) Abstract
Free radicals in rabbit retina under ocular hyperpressure and functional consequences: A. Muller, et al.; Exp. Eye Res. 64, 637 (1997) Abstract
Quantitative measurement of superoxide generation using the spin trap 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide: V. Roubaud, et al.; Anal. Biochem. 247, 404 (1997) Abstract
Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study: J. Vásquez-Vivar, et al.; FEBS Lett. 403, 127 (1997) Abstract
Quantitative measurement of superoxide generation and oxygen consumption from leukocytes using electron paramagnetic resonance spectroscopy: V. Roubaud, et al.; Anal. Biochem. 257, 210 (1998) Abstract
Evaluation of DEPMPO as a spin trapping agent in biological systems: K.J. Liu, et al.; Free Radic. Biol. Med. 26, 714 (1999) Abstract
Spin trapping of lipid radicals with DEPMPO-derived spin traps: detection of superoxide, alkyl and alkoxyl radicals in aqueous and lipid phase: K. Stolze, et al.; Free Radic. Biol. Med. 29, 1005 (2000) Abstract
Improved method for EPR detection of DEPMPO-superoxide radicals by liquid nitrogen freezing: M. Dambrova, et al.; Biochem. Biophys. Res. Commun. 275, 895 (2000) Abstract
Detection and removal of contaminating hydroxylamines from the spin trap DEPMPO, and re-evaluation of its use to indicate nitrone radical cation formation and S(N)1 reactions: S.K. Jackson, et al.; Free Radic. Biol. Med. 32, 228 (2002) Abstract
Deuterated analogues of the free radical trap DEPMPO: synthesis and EPR studies: J.L. Clement, et al.; Org. Biomol. Chem. 1, 1591 (2003) Abstract
Characterization of the high resolution ESR spectra of the methoxyl radical adducts of 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide (DEPMPO): S. Dikalov, et al.; Free Radic. Res. 37, 705 (2003) Abstract
ESR measurement of rapid penetration of DMPO and DEPMPO spin traps through lipid bilayer membranes: K. Anzai, et al.; Arch. Biochem. Biophys. 415, 251 (2003) Abstract
Nonradical mechanism of (bi)sulfite reaction with DEPMPO: cautionary note for SO3*- radical spin trapping: D.I. Potapenko, et al.; Free Radic. Biol. Med. 34, 196 (2003) Abstract
A new kinetic approach to the evaluation of rate constants for the spin trapping of superoxide/hydroperoxyl radical by nitrones in aqueous media: R. Lauricella, et al.; Org. Biomol. Chem. 2, 1304 (2004) Abstract
Kinetic analysis-based quantitation of free radical generation in EPR spin trapping: A. Samouilov, et al.; Anal. Biochem. 334, 145 (2004) Abstract
Detection of oxygen-centered radicals using EPR spin-trap DEPMPO: the effect of oxygen: M. Mojovic, et al.; Ann. N. Y. Acad. Sci. 1048, 471 (2005) Abstract
Detection of hydrogen atom adduct of spin-trap DEPMPO. The relevance for studies of biological systems: M. Mojovic, et al.; J. Chem. Inf. Model. 45, 1716 (2005) Abstract
Characterization of the high-resolution ESR spectra of superoxide radical adducts of 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide (DEPMPO) and 5,5-dimethyl-1-pyrroline N-oxide (DMPO). Analysis of conformational exchange: S. Dikalov, et al.; Free Radic. Res. 39, 825 (2005) Abstract
Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species: H. Shi, et al.; Arch. Biochem. Biophys. 437, 59 (2005) Abstract
The line asymmetry of electron spin resonance spectra as a tool to determine the cis:trans ratio for spin-trapping adducts of chiral pyrrolines N-oxides: the mechanism of formation of hydroxyl radical adducts of EMPO, DEPMPO, and DIPPMPO: M. Culcasi, et al.; Free Radic. Biol. Med. 40, 1524 (2006) Abstract
CLICK HERE for a complete literature overview:

ALX-400-003

Revised 25-May-07

Diethyldithiocarbamic acid . sodium salt . trihydrate (high purity)
SYNONYMS	DETC . 3H₂O (high purity) Diethyldithiocarbamate . 3H₂O (high purity)
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Spin Traps, Spin Probes & Spin Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-003-G005		5 g	17.00 USD
ALX-400-003-G025		25 g	27.00 USD

Product Specification

FORMULA:	C₅H₁₀NS₂ . Na . 3H₂O
MW:	148.3 . 23.0 . 54.0
CAS NUMBER:	20624-25-3
MERCK INDEX:	14: 3378
RTECS:	EZ6550000
PURITY:	≥99%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	HARMFUL.

Product Description

Nitric oxide (NO) spin-trapping reagent. Thiol and iron chelator. Inhibits induction of macrophage nitric oxide synthase (NOS). Has been shown to be an inhibitor of the nuclear transcription factor κB (NF-κB).

Product Specific Literature References

On-line detection of nitric oxide formation in liquid aqueous phase by electron paramagnetic resonance spectroscopy: P. Mordvintcev, et al.; Anal. Biochem. 199, 142 (1991) Abstract
NO accounts completely for the oxygenated nitrogen species generated by enzymic L-arginine oxygenation: A. Mülsch, et al.; Biochem. J. 288, 597 (1992) Abstract
Iron diethyldithiocarbamate as spin trap for nitric oxide detection: A.F. Vanin; Methods Enzymol. 301, 269 (1999), Review Abstract
Diethyldithiocarbamate inhibits induction of macrophage NO synthase: A. Mülsch, et al.; FEBS Lett. 321, 215 (1993) Abstract
The relationship between L-arginine-dependent nitric oxide synthesis, nitrite release and dinitrosyl-iron complex formation by activated macrophages: A. Vanin, et al.; Biochim. Biophys. Acta 1177, 37 (1993) Abstract
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells: R. Schreck, et al.; J. Exp. Med. 175, 1181 (1992) Abstract
In vivo spin trapping of nitric oxide generated in the small intestine, liver, and kidney during the development of endotoxemia: a time-course study: G. Wallis, et al.; Shock 6, 274 (1996) Abstract
Epr evidence of nitric oxide production by the regenerating rat liver: M. Obolenskaya, et al.; BBRC 202, 571 (1994) Abstract
EPR and laser flash photolysis studies of the reaction of nitric oxide with water soluble NO trap Fe(II)-proline-dithiocarbamate complex: S.V. Paschenko, et al.; BBRC 225, 577 (1996) Abstract
Complexes of Fe2+ with diethyldithiocarbamate or N-methyl-D-glucamine dithiocarbamate as traps of nitric oxide in animal tissues: comparative investigations: V.D. Mikoyan, et al.; Biochim. Biophys. Acta 1336, 225 (1997) Abstract
NO-dependent mechanisms of adaptation to hypoxia: I.Y. Malyshev, et al.; Nitric Oxide 3, 105 (1999) Abstract
Ex vivo EPR detection of nitric oxide in brain tissue: H. Fujii & L.J. Berliner; Magn. Reson. Med. 42, 599 (1999) Abstract
EPR spectroscopy of common nitric oxide - spin trap complexes: S. Nedeianu & T. Pali; Cell Mol. Biol. Lett. 7, 142 (2002) Abstract
EPR quantification of vascular nitric oxide production in genetically modified mouse models: J.P. Khoo, et al.; Nitric Oxide 10, 156 (2004) Abstract
Evaluation of lipid-based carrier systems and inclusion complexes of diethyldithiocarbamate-iron to trap nitric oxide in biological systems: N. Charlier, et al.; Magn. Reson. Med. 55, 215 (2006) Abstract

Further Categories Containing This Product:

NF-kB Pathway Inhibitors • NOS Inhibitors (NOS Induction & Enzyme Activity)

ALX-430-119

Revised 31-Jul-07

DIPPMPO
SYNONYMS	5-(Diisopropoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Spin Traps, Spin Probes & Spin Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-119-M050		50 mg	160.00 USD
ALX-430-119-M500		500 mg	1'120.00 USD

Product Specification

FORMULA:	C₁₁H₂₂NO₄P
MW:	263.3
PURITY:	≥98% (¹H-NMR)
APPEARANCE:	Colorless crystals.
SOLUBILITY:	Soluble in water, 100% ethanol or methylene chloride.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	-20°C
LONG TERM STORAGE:	-80°C
HANDLING:	Protect from light. Hygroscopic.

Product Description

Beside DEPMPO (Prod. No. ALX-430-093), most efficient spin trap for the in vitro and in vivo detection of O-, N-, S-, and C-centered free radicals. Has a longer life-time than DMPO (Prod. No. ALX-430-129). More lipophilic (Kp=2.1) than DEPMPO.

Product Specific Literature References

5-(Diisopropoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping properties: F. Chalier & P. Tordo; J. C. S. Perkin Trans. II 2002, 2110 Abstract
The line asymmetry of electron spin resonance spectra as a tool to determine the cis:trans ratio for spin-trapping adducts of chiral pyrrolines N-oxides: the mechanism of formation of hydroxyl radical adducts of EMPO, DEPMPO, and DIPPMPO : M. Culcasi, et al.; Free Radic. Biol. Med. 40, 1524 (2006) Abstract

ALX-430-088

Revised 13-Aug-08

DMPIO
SYNONYMS	2,2-Dimethyl-4-phenyl-2H-imidazole-1-oxide
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Spin Traps, Spin Probes & Spin Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-088-M010		10 mg	20.00 USD
ALX-430-088-M050		50 mg	70.00 USD

Product Specification

FORMULA:	C₁₁H₁₂N₂O
MW:	188.2
PURITY:	≥98% (GLC)
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in 100% ethanol, DMSO; only weakly soluble in water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
MELTINGPOINT:	108-109°C