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ER-Golgi Intermediate Compartment [ERGIC] / Related Products
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ALX-201-269 Revised 18-Mar-08
Calreticulin (rabbit) (recombinant)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calreticulin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-269-C025   25 µg 170.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1.2mg/ml
PURITY: ≥99%
FORMULATION: Liquid. In 100mM HEPES, pH 7.5, containing 150mM NaCl and 5mM CaCl2.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Delineation of the lectin site of the molecular chaperone calreticulin: S.P. Thomson and D.B. Williams; Cell Stress Chaperones 10, 242 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P15253: Calreticulin (rabbit)
Further Categories Containing This Product:
ER-Golgi Intermediate Compartment [ERGIC] / Related Products • Recombinant Proteins / Fusion Proteins • Endoplasmatic Reticulum Stress
 
 
ALX-804-601 Revised 20-Jun-08
Monoclonal Antibody to BAP31 (A1/182)
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SYNONYMS anti-BCR-associated Protein BAP31 MAb (A1/182)
anti-p28 BAP31 MAb (A1/182)
anti-CDM MAb (A1/182)
anti-DXS1357E MAb (A1/182)
anti-6C6-AG Tumor-associated Antigen MAb (A1/182)
PRODUCT LINE Immunology
PRODUCT CATEGORY B Cell Receptor [BCR] & Co-Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-601-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Monkey
CLONE: A1/182
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml after reconstitution.
FORMULATION: Lyophilized. Protein G-affinity purified and gel filtrated (FPLC).
RECONSTITUTION: Reconstitute with 100µl PBS containing 0.1% sodium azide.
IMMUNOGEN: BAP31 (BCR associated protein BAP031) from Vero monkey cells.
SPECIFICITY: Recognizes human and monkey BAP31.
APPLICATION: ELISA
Flow Cytometry
Immunocytochemistry (1:1’000)
Immunohistochemistry (frozen sections)
Immunoprecipitation (2µl)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
The recycling pathway of protein ERGIC-53 and dynamics of the ER-Golgi intermediate compartment: J. Klumperman, et al.; J. Cell Sci. 111, 3411 (1998) Abstract; Full Text
A novel direct interaction of endoplasmic reticulum with microtubules: D.R. Klopfenstein, et al.; EMBO J. 17, 6168 (1998) Abstract; Full Text
Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment: D.R. Klopfenstein, et al.; J. Cell Biol. 153, 1287 (2001) Abstract; Full Text
Proteomics of endoplasmic reticulum-golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46: L. Breuza, et al.; J. Biol. Chem. 279, 47242 (2004) Abstract; Full Text
Capturing protein interactions in the secretory pathway of living cells: B. Nyfeler, et al.; PNAS 102, 6350 (2005) Abstract; Full Text
The Cargo Receptors Surf4, Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)-53, and p25 Are Required to Maintain the Architecture of ERGIC and Golgi: S. Mitrovic, et al.; Mol. Biol. Cell 19, 1976 (2008) Abstract
General Information
BAP31 (B cell receptor-associated protein 31) is an integral protein of the ER membrane that forms a large hetero-oligomeric complex with the related BAP29. The cytosolic domain of BAP31 contains two identical caspase recognition sites that are preferentially cleaved by initiator caspases, including caspase-8. After activation of cell surface death receptors, human BAP31 is cleaved into a membrane-embedded fragment called p20, which induces apoptosis when expressed ectopically. The p20 fragment can mediate Ca2+-dependent apoptotic cross-talk between the ER and mitochondria, stimulating cytochrome c release. In addition to its role in apoptosis, BAP31 is a component of the ER quality control compartment and functions as a cargo receptor for ER export of transmembrane proteins such as cellubrevin, MHC class I molecules, and cytochrome P450 2C2.
General Literature References
Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria: M. Nguyen, et al.; Mol. Cell. Biol. 20, 6731 (2000) Abstract; Full Text
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol: D.G. Breckenridge, et al.; J. Cell. Biol. 160, 1115 (2003) Abstract; Full Text
Bap31 Is an Itinerant Protein that Moves between the Peripheral ER and a Juxtanuclear Compartment Related to ER-associated Degradation: Y. Wakana, et al.; Mol. Biol. Cell 19, 1825 (2008) Abstract; Full Text
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • ER-Golgi Intermediate Compartment [ERGIC] / Related Products • Monoclonal Antibodies • Cell Death / Apoptosis / Autophagy Other Products
 
 
ALX-804-812 Revised 20-Jun-08
Monoclonal Antibody to BAP31 (CC-1)
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SYNONYMS anti-B Cell Receptor-associated Protein BAP31 MAb (CC-1)
anti-BCR-associated Protein BAP31 MAb (CC-1)
anti-p28 BAP31 MAb (CC-1)
anti-CDM Protein MAb (CC-1)
anti-6C6-AG Tumor-associated Antigen MAb (CC-1)
anti-DXS1357E MAb (CC-1)
PRODUCT LINE Immunology
PRODUCT CATEGORY B Cell Receptor [BCR] & Co-Receptors / Related Products
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ALX-804-812-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Goat
Sheep
Monkey
Others
CLONE: CC-1
ISOTYPE: Rat IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 0.5mg/ml
PURITY: >95% (SDS-PAGE)
FORMULATION: Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: Solubilized membranes of the IMR-32 human neuroblastoma cell line.
SPECIFICITY: Recognizes an epitope (aa 230-246) encompassing a caspase recognition site and the ER-homing motif (KKEE), present at the C-terminus of human, primate, bovine and hamster BAP31. Does not recognize mouse and rat BAP31.
APPLICATION: ELISA (capture)
Immunocytochemistry (1:1'000-1:10'000; works on endogenous)
Immunohistochemistry (frozen sections (1:1'000-1:10'000); works on endogenous)
Immunoprecipitation
Western Blot (1:1'000-1:6'000; works on endogenous).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Endoplasmic reticulum membrane-sorting protein of lymphocytes (BAP31) is highly expressed in neurons and discrete endocrine cells: H.A. Manley and V.A. Lennon; J. Histochem. Cytochem. 49, 1235 (2001) Abstract; Full Text
Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils: K. Zen, et al.; J. Biol. Chem. 279, 44924 (2004) Abstract; Full Text
Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules: J.J. Ladasky, et al.; J. Immunol. 177, 6172 (2006) Abstract
General Information
BAP31 (B cell receptor-associated protein 31) is an integral protein of the ER membrane that forms a large hetero-oligomeric complex with the related BAP29. The cytosolic domain of BAP31 contains two identical caspase recognition sites that are preferentially cleaved by initiator caspases, including caspase-8. After activation of cell surface death receptors, human BAP31 is cleaved into a membrane-embedded fragment called p20, which induces apoptosis when expressed ectopically. The p20 fragment can mediate Ca2+-dependent apoptotic cross-talk between the ER and mitochondria, stimulating cytochrome c release. In addition to its role in apoptosis, BAP31 is a component of the ER quality control compartment and functions as a cargo receptor for ER export of transmembrane proteins such as cellubrevin, MHC class I molecules, and cytochrome P450 2C2.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria: M. Nguyen, et al.; Mol. Cell. Biol. 20, 6731 (2000) Abstract; Full Text
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol: D.G. Breckenridge, et al.; J. Cell. Biol. 160, 1115 (2003) Abstract; Full Text
Bap31 Is an Itinerant Protein that Moves between the Peripheral ER and a Juxtanuclear Compartment Related to ER-associated Degradation: Y. Wakana, et al.; Mol. Biol. Cell 19, 1825 (2008) Abstract; Full Text
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • ER-Golgi Intermediate Compartment [ERGIC] / Related Products • Monoclonal Antibodies • Cell Death / Apoptosis / Autophagy Other Products
 
 
ALX-804-604 Revised 31-Oct-06
Monoclonal Antibody to CLIMP-63 (G1/296)
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SYNONYMS anti-ER Protein p63 MAb (G1/296)
anti-Cytoskeleton-linking Membrane Protein of 63kDa MAb (G1/296)
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY ER-Golgi Intermediate Compartment [ERGIC] / Related Products
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ALX-804-604-C100   100 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Monkey
CLONE: G1/296
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: >95%
PURITY DETAIL: Protein G-affinity purified and gel filtrated (FPLC).
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with 100µl PBS containing 0.1% sodium azide.
IMMUNOGEN: Human CLIMP-63 (cytoskeleton-linking membrane protein of 63kDa) from Caco-2 cells golgi membrane fraction.
SPECIFICITY: Recognizes human CLIMP-63. Cross-reacts with monkey CLIMP-63.
APPLICATION: ELISA
Flow Cytometry
Immunocytochemistry (1:1’000)
Immunohistochemistry (frozen sections)
Immunoprecipitation (2µl)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Description
The cytoskeleton-linking membrane protein of 62kDa (CLIMP-63) is a marker for the reticular subdomain of the rough endoplasmatic reticulum (ER) and is excluded from the outer nuclear membrane. Concentration of CLIMP-63 into patches may enhance microtubule binding on the cytosolic side and contribute to ER morphology by the formation of a protein scaffold in the lumen of the ER, linking the rough ER to microtubules.
Product Specific Literature References
Characterization of a novel 63 kDa membrane protein. Implications for the organization of the ER-to-Golgi pathway: A. Schweizer, et al.; J. Cell Sci. 104, 671 (1993) Abstract; Full Text
A reversibly palmitoylated resident protein (p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein: A. Schweizer, et al.; J. Cell Sci. 104, 685 (1993) Abstract; Full Text
Retention of p63 in an ER-Golgi intermediate compartment depends on the presence of all three of its domains and on its ability to form oligomers: A. Schweizer, et al.; J. Cell Biol. 126, 25 (1994) Abstract; Full Text
Reassessment of the subcellular localization of p63: A. Schweizer, et al.; J. Cell Sci. 108, 2477 (1995) Abstract; Full Text
A novel direct interaction of endoplasmic reticulum with microtubules: D.R. Klopfenstein, et al.; EMBO J. 17, 6168 (1998) Abstract; Full Text
Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment: D.R. Klopfenstein, et al.; J. Cell Biol. 153, 1287 (2001) Abstract; Full Text
Proteomics of endoplasmic reticulum-golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46: L. Breuza, et al.; J. Biol. Chem. 279, 47242 (2004) Abstract; Full Text
Further Categories Containing This Product:
Golgi Apparatus • Monoclonal Antibodies
 
 
ALX-804-602 Revised 19-Jun-08
Monoclonal Antibody to ERGIC-53 (G1/93)
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SYNONYMS anti-ER-Golgi Intermediate Compartment 53kDa Protein MAb (G1/93)
anti-LMAN1 MAb (G1/93)
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY ER-Golgi Intermediate Compartment [ERGIC] / Related Products
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ALX-804-602-C100   100 µg 346.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Pig
Monkey
CLONE: G1/93
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95%
PURITY DETAIL: Affinity purified (HYDRA column) and gel filtrated (FPLC).
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with 100µl PBS containing 0.1% sodium azide.
IMMUNOGEN: Human ERGIC-53 (ER-golgi intermediate compartment 53kDa protein) from Caco-2 cell golgi membrane fraction.
SPECIFICITY: Recognizes human ERGIC-53. Cross-reacts with pig and monkey ERGIC-53.
APPLICATION: ELISA
Flow Cytometry
Immunocytochemistry (1:1’000)
Immunohistochemistry (frozen sections)
Immunoprecipitation (2µl)
Western Blot (1:250)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Description
The ER-Golgi intermediate compartment (ERGIC) marker ERGIC-53 is a mannose-specific membrane lectin operating as a cargo receptor for the transport of glycoproteins from the ER to the ERGIC. ERGIC-53 can also be used for studying aspects of protein trafficking in the secretory pathway.
Product Specific Literature References
Identification, by a monoclonal antibody, of a 53-kD protein associated with a tubulo-vesicular compartment at the cis-side of the Golgi apparatus: A. Schweizer, et al.; J. Cell Biol. 107, 1643 (1988) Abstract; Full Text
The isolated ER-Golgi intermediate compartment exhibits properties that are different from ER and cis-Golgi: A. Schweizer, et al.; J. Cell Biol. 113, 45 (1991) Abstract; Full Text
A dual role for COOH-terminal lysine residues in pre-Golgi retention and endocytosis of ERGIC-53: F. Kappeler, et al.; J. Biol. Chem. 269, 6279 (1994) Abstract; Full Text
Targeting of protein ERGIC-53 to the ER/ERGIC/cis-Golgi recycling pathway: C. Itin, et al.; J. Cell Biol. 131, 57 (1995) Abstract; Full Text
ERGIC-53 is a functional mannose-selective and calcium-dependent human homologue of leguminous lectins: C. Itin, et al.; Mol. Biol. Cell 7, 483 (1996) Abstract; Full Text
The recycling of ERGIC-53 in the early secretory pathway. ERGIC-53 carries a cytosolic endoplasmic reticulum-exit determinant interacting with COPII: F. Kappeler, et al.; J. Biol. Chem. 272, 31801 (1997) Abstract; Full Text
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway: R. Halaban, et al.; J. Biol. Chem. 277, 14821 (2002) Abstract; Full Text
pH-induced conversion of the transport lectin ERGIC-53 triggers glycoprotein release: C. Appenzeller-Herzog, et al.; J. Biol. Chem. 279, 12943 (2004) Abstract; Full Text
Proteomics of endoplasmic reticulum-golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46: L. Breuza, et al.; J. Biol. Chem. 279, 47242 (2004) Abstract; Full Text
Capturing protein interactions in the secretory pathway of living cells: B. Nyfeler, et al.; PNAS 102, 6350 (2005) Abstract; Full Text
The Cargo Receptors Surf4, Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)-53, and p25 Are Required to Maintain the Architecture of ERGIC and Golgi: S. Mitrovic, et al.; Mol. Biol. Cell 19, 1976 (2008) Abstract
General Literature References
ERGIC-53 and traffic in the secretory pathway: H.P. Hauri, et al.; J. Cell Sci. 113, 587 (2000) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-210-126 Revised 07-Aug-07
Polyclonal Antibody to Calreticulin
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calreticulin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-126-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum containing 0.05% sodium azide.
IMMUNOGEN: Recombinant human calreticulin.
SPECIFICITY: Recognizes human, mouse, rat, rabbit and monkey calreticulin.
APPLICATION: Immunohistochemistry (1:100)
Immunocytochemistry
Immunoprecipitation
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Redistribution of intracellular Ca2+ stores during phagocytosis in human neutrophils: O. Stendahl, et al.; Science 265, 1439 (1994) Abstract
Cell surface calreticulin is a putative mannoside lectin which triggers mouse melanoma cell spreading: T.K. White, et al.; J. Biol. Chem. 270, 15926 (1995) Abstract; Full Text
Calreticulin interacts with newly synthesized human immunodeficiency virus type 1 envelope glycoprotein, suggesting a chaperone function similar to that of calnexin: A. Otteken & B. Moss; J. Biol. Chem. 271, 97 (1996) Abstract; Full Text
Further Categories Containing This Product:
ER-Golgi Intermediate Compartment [ERGIC] / Related Products • Endoplasmatic Reticulum Stress • Polyclonal Antibodies
 
 
ALX-210-171 Revised 03-Jun-05
Polyclonal Antibody to Calreticulin (CT)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calreticulin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-171-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Others
SOURCE/HOST: From chicken.
FORMULATION: Liquid. Contains 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 399-414 (D399EKEEDEEESPGQAKD414) of mouse calreticulin.
SPECIFICITY: Recognizes human, mouse, rat, rabbit, dog and hamster calreticulin. Detects a band of ~60kDa and and unidentified band of ~120kDa by Western blot.
APPLICATION: Western Blot.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-016.
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Related Products
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • ER-Golgi Intermediate Compartment [ERGIC] / Related Products • Polyclonal Antibodies
 
 
ALX-210-170/1 Revised 19-May-08
Polyclonal Antibody to Calreticulin (NT)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calreticulin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-170/1-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Others
SOURCE/HOST: From chicken.
CONCENTRATION: 1.1mg/ml 
PURITY DETAIL: Epitope-affinity purified IgY.
FORMULATION: Liquid. Contains 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 24-43 (K24EQFLDGDAWTNRWVESKHK43) of mouse calreticulin.
SPECIFICITY: Recognizes human, mouse, rat, dog and hamster calreticulin. Detects a band of ~60-66kDa by Western blot.
APPLICATION: Immunocytochemistry
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
BLOCKING PEPTIDE: For Blocking Peptide See Prod. No. ALX-153-017.
Product Images
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Related Products
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • ER-Golgi Intermediate Compartment [ERGIC] / Related Products • Polyclonal Antibodies
 
 
ALX-210-141 Revised 10-Jan-05
Polyclonal Antibody to KDEL/GRP78
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PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Stress & Heat Shock Proteins Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-141-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Others
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized. Purified IgG containing 0.05% sodium azide.
RECONSTITUTION: Reconstitute in PBS.
IMMUNOGEN: Synthetic peptide corresponding to aa 643-654 (CT643GEEDTSEKDEL654) of rat GRP