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Protein Serine / Threonine Phosphatases Other Products
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ALX-350-003 Revised 23-May-08
Okadaic acid (high purity)
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SYNONYMS Halochondrine A (high purity)
9,10-Deepithio-9,10-didehydroacanthifolicin (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Okadaic Acids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-003-C025   25 µg 60.00 USD Add To Cart
ALX-350-003-C050   50 µg 110.00 USD Add To Cart
ALX-350-003-C100   100 µg 180.00 USD Add To Cart
ALX-350-003-M001   1 mg 990.00 USD Add To Cart
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Product Specification
FORMULA: C44H68O13
MW: 805.0
CAS NUMBER: 78111-17-8
MERCK INDEX: 14: 6819
RTECS: AA8227800
SOURCE/HOST: Isolated from Prorocentrum concavum by preparative flash, medium pressure and high performance liquid chromatography.
PURITY: ≥98% (HPLC)
APPEARANCE: White crystalline solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Use only fresh solutions.
HANDLING: Protect from light. Packaged under inert gas.
HAZARD: MAY BE CARCINOGENIC. HIGHLY IRRITANT. TOXIC.

Product Description
Potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A) in numerous cell types. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Non-phorbol type tumor promoter. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells, but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Tumor promoter. Has shown contractile effect on smooth muscle and heart muscle. Significantly increases cyclin B1 expression in adult neurons.
Product Specific Literature References
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate- type tumor promoter: M. Suganuma, et al.; PNAS 85, 1768 (1988) Abstract
Protein phosphatases come of age: P. Cohen & P.T.W. Cohen; J. Biol. Chem. 264, 21435 (1989) Abstract; Full Text
The structure and regulation of protein phosphatases: P. Cohen; Ann. Rev. Biochem. 58, 453 (1989) Abstract
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism: T.A. Haystead, et al.; Nature 337, 78 (1989) Abstract
Okadaic acid: a new probe for the study of cellular regulation: P. Cohen, et al.; TIPS 15, 98 (1990), (Review) Abstract
Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C: R. Gopalakrishna, et al.; BBRC 189, 950 (1992) Abstract
Protein phosphatase inhibitors okadaic acid and calyculin A alter cell shape and F-actin distribution and inhibit stimulus-dependent increases in cytoskeletal actin of human neutrophils: P. Kreienbuehl, et al.; Blood 80, 2911 (1992) Abstract
Site-specific dephosphorylation of smooth muscle myosin light chain kinase by protein phosphatases 1 and 2A: M. Nomura, et al.; Biochemistry 31, 11915 (1992) Abstract
Inhibition of apoptosis in human tumour cells by okadaic acid: Q. Song, et al.; J. Cell Physiol. 153, 550 (1992) Abstract
Okadaic acid enhances human T cell activation and phosphorylation of an internal substrate induced by phorbol myristate acetate: Y. Tada, et al.; Immunopharmacol. 24, 17 (1992) Abstract
Okadaic acid inhibits glucocorticoid-induced apoptosis in T cell hybridomas at its late stage: Y. Ohoka, et al.; BBRC 197, 916 (1993) Abstract
Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line: B.T. Gjertsen, et al.; J. Cell. Sci. 107, 3363 (1994) Abstract
Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A: K. Kiguchi, et al.; Cell Growth Differentiation 5, 995 (1994) Abstract
Unique features of the okadaic acid activity class of tumor promoters: H. Fujiki & M. Suganuma; J. Cancer Res. Clin. Oncol. 125, 150 (1999), Review Abstract
Okadaic acid: the archetypal serine/threonine protein phosphatase inhibitor: A.B. Dounay & C.J. Forsyth; Curr. Med. Chem. 9, 1939 (2002), Review Abstract
Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase: R. Tamaskovic, et al.; J. Biol. Chem. 278, 6710 (2003) Abstract; Full Text
Okadaic acid induced cyclin B1 expression and mitotic catastrophe in rat cortex: B. Chen, et al.; Neurosci. Lett. 406, 178 (2006) Abstract
 
 
ALX-350-010 Revised 02-Apr-08
Okadaic acid . ammonium salt (high purity)
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SYNONYMS Halochondrine A . Na (high purity)
9,10-Deepithio-9,10-didehydroacanthifolicin . Na (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Okadaic Acids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-010-C025   25 µg 55.00 USD Add To Cart
ALX-350-010-C100   100 µg 145.00 USD Add To Cart
ALX-350-010-M001   1 mg 980.00 USD Add To Cart
Product Specification
FORMULA: C44H67O13 . NH4
MW: 804.0 . 18.0
CAS NUMBER: 155716-06-6
SOURCE/HOST: Isolated from Prorocentrum concavum by preparative flash, medium pressure and high performance liquid chromatography. Salt form generated in aqueous ammonium hydroxide-methanol solution.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol, acetone, ethyl acetate or distilled water. Dissolve first in organic solvent before diluting in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Packaged under inert gas. Protect from light.
HAZARD: TOXIC. MAY BE CARCINOGENIC. HIGHLY IRRITANT.

Product Description
Salt form of okadaic acid (Prod. No. ALX-350-003), with slightly greater stability than the free acid after it is put into stock solution (in organic solvents). Potent inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). Potent tumor promotor and neurotoxin.
 
 
ALX-350-011 Revised 10-Apr-08
Okadaic acid . sodium salt (high purity)
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SYNONYMS Halochondrine A . sodium salt (high purity)
9,10-Deepithio-9,10-didehydroacanthifolicin . sodium salt (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Okadaic Acids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-011-C025   25 µg 58.00 USD Add To Cart
ALX-350-011-C100   100 µg 160.00 USD Add To Cart
ALX-350-011-M001   1 mg 980.00 USD Add To Cart
Product Specification
FORMULA: C44H67O13 . Na
MW: 804.0 . 23.0
CAS NUMBER: 209266-80-8
SOURCE/HOST: Isolated from Prorocentrum concavum by preparative flash, medium pressure and high performance liquid chromatography. Salt form generated in aqueous sodium hydroxide-methanol solution.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (1mg/ml), 100% ethanol, methanol, acetone, ethyl acetate or distilled water. Dissolve first in organic solvent before diluting in water. 
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HIGHLY IRRITANT. MAY BE CARCINOGENIC. TOXIC.

Product Description
Salt form of okadaic acid (Prod. No. ALX-350-003), with slightly greater stability than the free acid after it is put into stock solution (in organic solvents). Potent inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). Potent tumor promotor and neurotoxin.
 
 
ALX-350-063 Revised 22-Aug-08
Okadaic acid . potassium salt (high purity)
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SYNONYMS Halochondrine A . K (high purity)
9,10-Deepithio-9,10-didehydroacanthifolicin . K (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Okadaic Acids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-063-C050   50 µg 90.00 USD Add To Cart
ALX-350-063-C100   100 µg 140.00 USD Add To Cart
ALX-350-063-M001   1 mg 990.00 USD Add To Cart
Product Specification
FORMULA: C44H67O13 . K
MW: 804.0 . 39.1
CAS NUMBER: 155751-72-7
SOURCE/HOST: Isolated from Prorocentrum concavum.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol, acetone, ethyl acetate or distilled water. Dissolve first in organic solvent before diluting in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Packaged under inert gas.
HAZARD: TOXIC. MAY BE CARCINOGENIC. HIGHLY IRRITANT.

Product Description
Salt form of okadaic acid (Prod. No. ALX-350-003), with slightly greater stability than the free acid after it is put into stock solution (in organic solvents). Potent inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). Potent tumor promotor and neurotoxin.
General Information
BACKGROUND/TECHNICAL INFORMATION Isolated from Prorocentrum concavum by preparative flash, low pressure and high performance liquid chromatography. Salt form generated in aqueous potassium hydroxide - methanol solution.
 
 
ALX-380-041 Revised 08-Aug-08
Tautomycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-041-C025   25 µg 180.00 USD Add To Cart
ALX-380-041-C050   50 µg 235.00 USD Add To Cart
ALX-380-041-C100   100 µg 440.00 USD Add To Cart
Product Specification
FORMULA: C41H66O13
MW: 767.0
CAS NUMBER: 109946-35-2
RTECS: WX1000000
SOURCE/HOST: Isolated from Streptomyces spiroverticillatus.
PURITY: ≥90% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, ethyl acetate or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture.
HAZARD: VERY TOXIC.

Product Description
Cell permeable, potent protein phosphatase inhibitor. Apoptosis inducer. Mixture of two isomers.
Product Specific Literature References
A new antibiotic, tautomycin: X.C. Cheng, et al.; J. Antibiot. (Tokyo) 40, 907 (1987) Abstract
Comparison of the effect of tautomycin and phorbol ester on protein kinase C in a cell-free system: J. Magae, et al.; J. Antibiot. 42, 1290 (1989) Abstract
Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A: C. MacKintosh & S. Klumpp; FEBS Lett. 277, 137 (1990) Abstract
Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle: M.C. Gong, et al.; J. Biol. Chem. 267, 14662 (1992) Abstract; Full Text
Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity: M. Suganuma, et al.; Toxicon 30, 873 (1992) Abstract
Molecular shape analysis and activity of tautomycin, a protein phosphatase inhibitor: Y. Sugiyama, et al.; Bioorg. Med. Chem. Lett. 6, 3 (1996)
The apoptosis-inducing activity of the two protein phosphatase inhibitors, tautomycin and thyrsiferyl 23-acetate, is not due to the inhibition of protein phosphatases PP1 and PP2A: K. Kikuchi, et al.; Int. J. Mol. Med. 4, 395 (1999), Review Abstract
 
 
ALX-430-046 Revised 06-Dec-06
Permethrin
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SYNONYMS 3-Phenoxybenzyl (1R,S)-cis,trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclo-propanecarboxylate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Serine / Threonine Phosphatases Other Products
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ALX-430-046-M010   10 mg 18.00 USD Add To Cart
Product Specification
FORMULA: C21H20Cl2O3
MW: 391.3
CAS NUMBER: 52645-53-1
MERCK INDEX: 14: 7180
RTECS: GZ1255000
PURITY: Mixture of cis and trans isomers
APPEARANCE: Clear or whitish film adhered to inside of vial.
SOLUBILITY: Soluble in DMSO, 100% ethanol or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Type I pyrethroid. Structurally similar to the protein phosphatase 2B (calcineurin) inhibitors cypermethrin and deltamethrin, but only weakly active or inactive, depending on assay conditions. May be used as a negative control for cypermethrin (Prod. No. ALX-430-044) and deltamethrin (Prod. No. ALX-430-045).
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol 43, 1777 (1992) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-430-047 Revised 24-Feb-05
Resmethrin
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SYNONYMS 5-Benzyl-3-furylmethyl(1R,S)-cis,trans-chrysanthemate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Serine / Threonine Phosphatases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-047-M010   10 mg 25.00 USD Add To Cart
ALX-430-047-M025   25 mg 50.00 USD Add To Cart
ALX-430-047-M100   100 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C22H26O3
MW: 338.4
CAS NUMBER: 10453-86-8
PURITY: ≥90%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Type I pyrethroid. Weakly active negative control for studies of calcineurin inhibition by the more active type II pyrethroids.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-804-811 Revised 06-Jun-06
Monoclonal Antibody to Acidic Nuclear Phosphoprotein 32A (human) (RJ1)
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SYNONYMS anti-HLA-DR-associated Protein 1 (human) MAb (RJ1)
anti-PHAPI (human) MAb (RJ1)
anti-Acidic Nuclear Phosphoprotein pp32 (human) MAb (RJ1)
anti-PP2A Inhibitor Protein 1α (human) MAb (RJ1)
anti-I1αPP2A (human) MAb (RJ1)
anti-LANP (human) MAb (RJ1)
anti-ANP32A (human) MAb (RJ1)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Serine / Threonine Phosphatases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-811-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: RJ1
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human acidic nuclear phosphoprotein 32A.
SPECIFICITY: Recognizes human acidic nuclear phosphoprotein 32A.
APPLICATION: Immunocytochemistry (1:100-1:200; works on endogenous)
Immunoprecipitation (works on endogenous)
Western Blot (1:4'000; works on endogenous)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks: P.J. Beresford, et al.; J. Biol. Chem. 276, 43285 (2001) Abstract; Full Text
HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A: Z. Fan, et al.; Mol. Cell. Biol. 22, 2810 (2002) Abstract; Full Text
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A: Z. Fan, et al.; Nat. Immunol. 4, 145 (2003) Abstract
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor: Z. Fan, et al.; Cell 112, 659 (2003) Abstract
Granzyme a induces caspase-independent mitochondrial damage, a required first ste