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Lipid Peroxidation
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Items 31 of 31
ALX-210-767 Revised 30-Sep-08
Polyclonal Antibody to (E)-4-Hydroxynonenal
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SYNONYMS anti-HNE PAb
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
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ALX-210-767-R100   100 µl 495.00 USD Add To Cart
Product Specification
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized. Neat serum containing 0.05% sodium azide.
RECONSTITUTION: Reconstitute with 100µl PBS.
IMMUNOGEN: Free recombinant HNE (E)-4-hydroxynonenal.
SPECIFICITY: Recognizes HNE-adducts.
APPLICATION: ELISA (1:1'000-1:10'000)
Immunohistochemistry (1:500-1:1'000)
Western Blot (1:500-1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes: K. Uchida, et al.; PNAS 90, 8742 (1993) Abstract
Formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma: K. Okamoto, et al.; Int. J. Cancer 58, 825 (1994) Abstract
Immunocytochemical detection of lipid peroxidation in phagosomes of human neutrophils: correlation with expression of flavocytochrome b: M.T. Quinn, et al.; J. Leukoc. Biol. 57, 415 (1995) Abstract
Characterization of epitopes recognized by 4-hydroxy-2-nonenal specific antibodies: K. Uchida, et al.; Arch. Biochem. Biophys. 324, 241 (1995) Abstract
Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease: A. Yoritaka, et al.; PNAS 93, 2696 (1996) Abstract
alpha-Phenyl-n-tert-butyl-nitrone attenuates hypoxic-ischemic white matter injury in the neonatal rat brain: S. Lin, et al.; Brain Res. 1007, 132 (2004) Abstract
Acquired Resistance to Acetaminophen Hepatotoxicity is Associated with Induction of Multidrug Resistance-Associated Protein 4 (Mrp4) in Proliferating Hepatocytes: L.M. Aleksunes, et al.; Toxicol. Sci. 104, 261 (2008) Abstract
Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes: K. Stadler, et al.; Free Radic. Biol. Med. Epub ahead of print, (2008) Abstract
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Further Categories Containing This Product:
Lipid Peroxidation • Polyclonal Antibodies
 
 
ALX-210-879 Revised 18-Jul-07
Polyclonal Antibody to Malondialdehyde
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SYNONYMS anti-MDA PAb
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-210-879-R100   100 µl 590.00 USD Add To Cart
Product Specification
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
IMMUNOGEN: Malondialdehyde (MDA) conjugated to a carrier protein.
SPECIFICITY: Recognizes MDA adducts.
APPLICATION: ELISA (1:1’000-1:10’000)
Immunohistochemistry (1:500-1:1’000)
Western blot (1:500-1:1’000)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Do not freeze, thaw or store diluted working solutions.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-881 Revised 04-Mar-05
Polyclonal Antibody to Acrolein
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-210-881-C100   100 µg 450.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Others
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
IMMUNOGEN: Acrolein conjugated to a carrier protein.
SPECIFICITY: Recognizes acrolein adducts. Slightly cross-reacts with malondialdehyde-BSA (cross-reactivity ratio=1:55 as determined with competitive ELISA test).
APPLICATION: ELISA (1:2'000-1:5'000).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Lyophilized powder is stable at least 2 years if stored at -20°C. Reconstitute with 100µl of distilled water if solution will be used entirely within 8 hours.
If stored at +4°C (stable for 2 months) reconstitute with 100µl distilled water containing 0.1% merthiolate.
If stored at -20°C (stable for at least 1 year) reconstitute with a mixture of distilled water/glycerol (v/v).
Antibody can be prediluted 10x in PBS containing 0.1% merthiolate.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-882 Revised 04-Mar-05
Polyclonal Antibody to Formaldehyde
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-210-882-R100   100 µl 450.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Others
SOURCE/HOST: From rat.
IMMUNOGEN: Formaldeyde conjuated to a carrier protein.
SPECIFICITY: Recognizes formaldehyde adducts.
APPLICATION: ELISA (1:2'000-1:5'000).
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-270-245 Revised 14-Feb-07
(E)-4-Hydroxynonenal
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SYNONYMS 4-HNE
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
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ALX-270-245-M005   5 mg 128.00 USD Add To Cart
Product Specification
FORMULA: C9H16O2
MW: 156.2
CAS NUMBER: 128946-65-6
RTECS: RA8510000
PURITY: ≥85% (HPLC) (precursor diethylacetal)
FORMULATION: Liquid. Solution in n-hexane.
SOLUBILITY: Soluble in DMSO (washed with nitrogen) or 100% ethanol.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Store solutions on ice and use within 6 hours of preparation.
HANDLING: Protect from light and oxygen. Keep under inert gas. Avoid freeze/thaw cycles.

Product Description
Among the aldehydes formed, 4-HNE is the major product of lipid peroxidation, and it has been suggested to play a major role in liver toxicity associated with lipid peroxidation. Prevents NF-κB activation and TNF expression by inhibiting IκB phosphorylation and subsequent proteolysis.
Product Specific Literature References
Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids: W.A. Pryor & N.A. Porter; Free Radic. Biol. Med. 8, 541 (1990) Abstract
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes: H. Esterbauer, et al.; Free Radic. Biol. Med. 11, 81 (1991) Abstract
Quantitation of 4-hydroxynonenal protein adducts: K. Uchida & E.R. Stadtman; Meth. Enzymol. 233, 371 (1994) Abstract
Histochemical detection of 4-hydroxynonenal protein in Alzheimer amyloid: Y. Ando, et al.; J. Neurol. Sci. 156, 172 (1998) Abstract
Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts: P.C. Burcham; Mutagenesis 13, 287 (1998) Abstract
Roles of lipid peroxidation in modulation of cellular signaling pathways, cell dysfunction, and death in the nervous system: J.N. Keller & M.P. Mattson; Rev. Neurosci. 9, 105 (1998) Abstract
4-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease: W.R. Markesbery and M.A. Lovell; Neurobiol. Aging 19, 33 (1998) Abstract
Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity: M.P. Mattson; TINS 21, 53 (1998) Abstract
Effects of 4-hydroxynonenal, a lipid peroxidation product, on dopamine transport and Na+/K+ ATPase in rat striatal synaptosomes: P. Morel, et al.; Neurochem. Int. 33, 531 (1998) Abstract
Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in thymocytes as an effective secondary antioxidative defense mechanism: W.G. Siems, et al.; J. Biochem. 123, 534 (1998) Abstract
Oxidative alterations in Alzheimer's disease: W.R. Markesbery & J.M. Carney; Brain Pathol. 9, 133 (1999) Abstract
4-Hydroxynonenal prevents NF-kappaB activation and tumor necrosis factor expression by inhibiting IkappaB phosphorylation and subsequent proteolysis: S. Page, et al.; J. Biol. Chem. 274, 11611 (1999) Abstract; Full Text
The lipid peroxidation product 4-hydroxynonenal impairs glutamate and glucose transport and choline acetyltransferase activity in NSC-19 motor neuron cells: W.A. Pedersen, et al.; Exp. Neurol. 155, 1 (1999) Abstract
The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules, and modifies cellular tubulin: M.D. Neely, et al.; J. Neurochem. 72, 2323 (1999) Abstract
Multidrug resistance protein MRP1 protects against the toxicity of the major lipid peroxidation product 4-hydroxynonenal: J. Renes, et al.; Biochem. J. 350, 555 (2000) Abstract
The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor kappa B in neurons: S. Camandola, et al.; Brain Res. Mol. Brain Res. 85, 53 (2000) Abstract
IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2- nonenal: C. Ji, et al.; J. Biol. Chem. 276, 18223 (2001) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION (E)-4-Hydroxynonenal-dimethylacetal (Prod. No. ALX-270-375) can be used for making a fresh preparation of HNE.
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Further Categories Containing This Product:
Lipid Peroxidation
 
 
ALX-270-253 Revised 18-Mar-08
Rosmarinic acid
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SYNONYMS (R)-α-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2E-propenyl]oxy]-3,4-dihydroxy-benzenepropanoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-253-M010   10 mg 20.00 USD Add To Cart
ALX-270-253-M050   50 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C18H16O8
MW: 360.3
CAS NUMBER: 537-15-5, 20283-92-5
SOURCE/HOST: Isolated from Rosmarinus officinalis.
PURITY: ≥98% (HPLC)
APPEARANCE: White to brown solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in PBS.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Naturally occurring polyphenolic compound with antioxidant and anti-inflammatory properties. Anticarcinogenic. Inhibitor of lipid peroxidation, TCR-induced T cell activation and proliferation.
Product Specific Literature References
Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid: H. Bult, et al.; Br. J. Pharmacol. 84, 317 (1985) Abstract
Complement-dependent stimulation of prostacyclin biosynthesis: inhibition by rosmarinic acid: M. Rampart, et al.; Biochem. Pharmacol. 35, 1397 (1986) Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes: Y. Kimura, et al.; J. Nat. Prod. 50, 392 (1987) Abstract
Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes: G.T. Liu, et al.; Biochem. Pharmacol. 43, 147 (1992) Abstract
Metabolism of rosmarinic acid in rats: T. Nakazawa & K. Ohsawa; J. Nat. Prod. 61, 993 (1998) Abstract
Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner: J. Won, et al.; Eur. J. Immunol. 33, 870 (2003) Abstract
Rosmarinic acid inhibits Ca2+-dependent pathways of T-cell antigen receptor-mediated signaling by inhibiting the PLC-gamma 1 and Itk activity: M.A. Kang, et al.; Blood 101, 3534 (2003) Abstract
Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model: N. Osakabe, et al.; Carcinogenesis 25, 549 (2004) Abstract
Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2): C. Renzulli, et al.; J. Appl. Toxicol. 24, 289 (2004) Abstract
Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro: S.S. Huang & R.L. Zheng; Cancer Lett. 239, 271 (2006) Abstract
Further Categories Containing This Product:
T Cell Regulation Other Products • Lipid Peroxidation • Active Substances from Fruit and Vegetables • Natural Products - Anti-inflammatory Agents • Polyphenols Other Products • Natural Products - Antitumor Reagents • Antitumor Agents (Anti-proliferative)
 
 
ALX-270-254 Revised 22-Sep-08
Carnosol
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SYNONYMS 1,3,4,9,10,10aS-Hexahydro-5,6-dihydroxy-1,1-dimethyl-7-isopropyl-2H-9S,4aR-(epoxymethano)phenanthren-12-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-254-M001   1 mg 60.00 USD Add To Cart
ALX-270-254-M005   5 mg 269.00 USD Add To Cart
Product Specification
FORMULA: C20H26O4
MW: 330.4
CAS NUMBER: 5957-80-2
SOURCE/HOST: Isolated from Rosmarinus officinalis.
PURITY: ≥96%
APPEARANCE: White to beige solid.
SOLUBILITY: Soluble in 100% ethanol (8mg/ml), DMSO (250mg/ml) or dimethyl formamide (35mg/ml); sparingly soluble in aqueous PBS, pH 7.2 (<30μg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING: Protect from light.

Product Description
Naturally occurring phenolic compound with antioxidant and anti-inflammatory properties. Suppresses nitric oxide (NO) production and inducible nitric oxide synthase (iNOS; NOS II) gene expression by inhibiting NF-κB activation. Inhibits lipid peroxidation. Antimicrobial. Anticarcinogenic. Inhibits cyclooxygenase-2 (COX-2).
Product Specific Literature References
Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid: O.I. Aruoma, et al.; Xenobiotica 22, 257 (1992) Abstract
Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production: M.M. Chan, et al.; Cancer Lett. 96, 23 (1995) Abstract
Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis: H. Haraguchi, et al.; Planta Med. 61, 333 (1995) Abstract
Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation: K. Singletary, et al.; Cancer Lett. 104, 43 (1996) Abstract
Development of in vitro models for cellular and molecular studies in toxicology and chemoprevention: K. Macé, et al.; Arch. Toxicol. Suppl. 20, 227 (1998) Abstract
Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages: A.H. Lo, et al.; Carcinogenesis 23, 983 (2002) Abstract
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma: O. Rau, et al.; Planta Med. 72, 881 (2006) Abstract
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis: K. Horiuchi, et al.; Biol. Pharm. Bull. 30, 287 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Chemopreventive Agents • Natural Products - NF-kB Pathway Inhibitors • Lipid Peroxidation • Active Substances from Fruit and Vegetables • Natural Products - Anti-inflammatory Agents • Natural Products - Nitric Oxide Pathway Modulators • COX Inhibitors
 
 
ALX-270-264 Revised 17-Apr-08
Carnosic acid
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-264-M010   10 mg 45.00 USD Add To Cart
ALX-270-264-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C20H28O4
MW: 332.4
CAS NUMBER: 3650-09-7
SOURCE/HOST: Isolated from Rosmarinus officinalis.
PURITY: ≥95%
APPEARANCE: Yellow powder.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Naturally occurring phenolic compound with antioxidant properties. Inhibits lipid peroxidation induced by NADH or NADPH oxidation. Peroxisome proliferator-activated receptor γ (PPARγ) activator. Anti-inflammatory. Antimicrobial.
Product Specific Literature References
Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. II. Isolation of carnosic acid and formation of other phenolic diterpenes: K. Schwarz & W. Ternes; Z. Lebensm. Unters. Forsch. 195, 99 (1992) Abstract
Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid: O.I. Aruoma, et al.; Xenobiotica 22, 257 (1992) Abstract
Radical intermediates and antioxidants: an ESR study of radicals formed on carnosic acid in the presence of oxidized lipids: M. Geoffroy, et al.; Free Radic. Res. 21, 247 (1994) Abstract
Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis: H. Haraguchi, et al.; Planta Med. 61, 333 (1995) Abstract
Rosemary components inhibit benzo[a]pyrene-induced genotoxicity in human bronchial cells: E.A. Offord, et al.; Carcinogenesis 16, 2057 (1995) Abstract
Chemiluminescence determination of the in vivo and in vitro antioxidant activity of RoseOx and carnosic acid: A.I. Kuzmenko, et al.; J. Photochem. Photobiol. B 48, 63 (1999) Abstract
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma: O. Rau, et al.; Planta Med. 72, 881 (2006) Abstract
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis: K. Horiuchi, et al.; Biol. Pharm. Bull. 30, 287 (2007) Abstract
Further Categories Containing This Product:
Lipid Peroxidation • Active Substances from Fruit and Vegetables • Natural Products with Antibiotic Activity • Natural Products - Anti-inflammatory Agents • PPAR Agonists
 
 
ALX-270-265 Revised 29-Jan-05
U-74389G
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SYNONYMS 21-(4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-pregna-1,4,9(11)-triene-3,20-dione . (Z)-2-butenedioate
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-270-265-M010   10 mg 15.00 USD Add To Cart
ALX-270-265-M050   50 mg 63.00 USD Add To Cart
Product Specification
FORMULA: C37H50N6O2 . C4H4O4
MW: 610.8 . 116.1
CAS NUMBER: 153190-29-5
PURITY: ≥98%
APPEARANCE: Crystalline solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol. Insoluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Store solutions of U-74389G on ice and use within 6 hours of preparation. We strongly recommend using fresh solution for each experiment. 
HANDLING: Hygroscopic.

Product Description
Lazaroid inhibitor of iron-dependent lipid peroxidation. Antioxidant.
Product Specific Literature References
Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells: A. Salahudeen, et al.; J. Am. Soc. Nephrol. 6, 1300 (1995) Abstract
21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers: F. Shi, et al.; Free Radic. Biol. Med. 19, 349 (1995) Abstract
Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation: G.M. Campo, et al.; J. Pharmacol. Exp. Ther. 277, 333 (1996) Abstract
Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G: A.M. Perna, et al.; Pharmacol. Res. 34, 25 (1996) Abstract
Comparison of various lazaroid compounds for protection against ischemic liver injury: N. Ishizaki, et al.; Transplantation 63, 202 (1997) Abstract
Protein oxidation biomarkers in hyperoxic lung injury in rats: effects of U-74389: S. Awasthi, et al.; Toxicol. Lett. 95, 47 (1998) Abstract
The 21-aminosteroid U-74389G reduces cerebral superoxide anion concentration following fluid percussion injury of the brain: R.H. Fabian, et al.; J. Neurotrauma 15, 433 (1998) Abstract
Novel 21-aminosteroid U-74389G inhibits low-density lipoprotein peroxidation induced by .OH and O2-. free radicals: A. Khalil, et al.; Life Sci. 63, 769 (1998) Abstract
Intrahippocampal injection of paraquat produces apoptotic cell death which is prevented by the lazaroid U74389G, in rats: D. Melchiorri, et al.; Life Sci. 62, 1927 (1998) Abstract
The lazaroid, U-74389G, inhibits inducible nitric oxide synthase activity, reverses vascular failure and protects against endotoxin shock:: D. Altavilla, et al.; Eur. J. Pharmacol. 369, 49 (1999) Abstract
Effect of lazaroid U-74389G and methylprednisolone on endotoxin-induced shock in mice: K. Fukuma, et al.; Surgery 12