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ALX-210-646
Revised 12-Oct-07
Polyclonal Antibody to Adiponectin Receptor 2 (human)
SYNONYMS
anti-AdipoR2 (human) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Adiponectin [ACRP30] / Related Products
Ordering Information
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ALX-210-646-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From goat.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope affinity-purified.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 11-40 (C
11
SRTPEPDIRLRKGHQLDGTRRGDND SHQG
40
) of human adiponectin receptor 2 (AdipoR2).
SPECIFICITY:
Recognizes human AdipoR2.
APPLICATION:
Immunocytochemistry (acetone fixed cells (1:400))
Immunohistochemistry (paraffin sections (1:250))
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-151-046
.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-647
Revised 12-Oct-07
Polyclonal Antibody to Adiponectin Receptor 2 (mouse)
SYNONYMS
anti-AdipoR2 (mouse) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-647-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From goat.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope affinity-purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 11-40 (C
11
TRTPEPDIRLRKGHQLDDTRGSNNDNYQG
40
) of mouse adiponectin receptor 2 (AdipoR2).
SPECIFICITY:
Recognizes mouse AdipoR2.
APPLICATION:
Immunocytochemistry (acetone fixed cells (1:400))
Immunohistochemistry (paraffin sections (1:250))
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-151-047
.
Product Images
Please click on thumbnails to enlarge.
Related Products
ALX-151-047
Blocking Peptide for PAb to Adiponectin Receptor 2 (mouse) (Prod. No.
ALX-210-647
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-147
Revised 27-Mar-08
Polyclonal Antibody to Adrenergic Receptor α2a
SYNONYMS
anti-Adrenoceptor α2a PAb
anti-Adrenoreceptor α2a PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-147-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.6mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 218-235 (R
218
IYQIAKRRTRV
PPSRRG
235
) of human AR α-2a (adrenergic receptor α-2a). This sequence is completely conserved in mouse, rat and pig AR α-2a.
SPECIFICITY:
Recognizes mouse and rat AR α-2a. Detects a band of ~45kDa by Western blot.
APPLICATION:
Immunohistochemistry (paraffin sections (1:1’000))
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-146
Revised 27-Mar-08
Polyclonal Antibody to Adrenergic Receptor α-1
SYNONYMS
anti-AR α-1 PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-210-146-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 339-349 (K
339
FSREKKAAKT
349
) of human AR α-1 (adrenergic receptor α-1).
SPECIFICITY:
Recognizes human, mouse, rat, zebrafish and
Drosophila
AR α-1. Detects a band of ~60kDa by Western blot.
APPLICATION:
Immunocytochemistry (1:1'000)
Western Blot (1:400)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-148
Revised 27-Mar-08
Polyclonal Antibody to Adrenergic Receptor β-1
SYNONYMS
anti-AR β-1 PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
Ordering Information
Product Numbers:
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ALX-210-148-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.4mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.5mg/ml sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 394-408 (H
394
GDRPRASGCLARAG
408
) of mouse AR β-1 (adrenergic receptor β-1).
SPECIFICITY:
Recognizes mouse and rat AR β-1. Detects a band of ~64kDa by Western blot.
APPLICATION:
Immunocytochemistry (1:500)
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-245
Revised 21-Nov-06
Polyclonal Antibody to Ah Receptor Nuclear Translocator 3
SYNONYMS
anti-ARNT3 PAb
anti-BMAL1 PAb
anti-Brain & Muscle ARNT-like 1 PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Aryl Hydrocarbon Receptor / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-210-245-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 582-594 (CD
582
MIDNDQG
SSSPS
594
) of mouse ARNT3 (Ah receptor nuclear translocator 3).
SPECIFICITY:
Recognizes human and hamster ARNT3.
APPLICATION:
Western Blot (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-152-023
.
General Information
Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein mediated autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-BMAL1 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK-BMAL1 has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian the timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.
Further Categories Containing This Product:
Circadian Transcriptional Regulators / Related Products
•
Polyclonal Antibodies
ALX-210-150
Revised 15-Oct-07
Polyclonal Antibody to Ah Receptor Nuclear Translocator (mouse)
SYNONYMS
anti-ARNT (mouse) PAb
anti-HIF-1β (mouse) PAb
anti-Hypoxia-inducible Factor 1β (mouse) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Aryl Hydrocarbon Receptor / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-150-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 771-789 (N
771
SYNNEEFPDLTMFPPFSE
789
) of human ARNT (Ah receptor nuclear translocator).
SPECIFICITY:
Recognizes mouse ARNT.
APPLICATION:
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Literature References
Cloning of a factor required for activity of the Ah (Dioxin) receptor
:
E. Hoffman, et al.; Science
252
, 954 (1991)
Abstract
Physiochemical and immunocytochemical analysis of the aryl hydrocarbon receptor nuclear translocation: characterization of two monoclonal antibodies to the ARNT
:
N.G. Hord and G. Perdew; Mol. Pharmacol.
46
, 618 (1994)
Abstract
cDNA cloning and tissue-specific expression of a novel basic helix/loop/helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear transporter
:
K. Hirose, et al.; Mol. Cell. Biol.
16
, 1706 (196)
Abstract
Expression of the aryl hydrocarbon receptor is regulated by serum and mitogenic growth factors in murine 3T3 fibroblasts
:
C. Vaziri, et al.; J. Biol. Chem.
271
, 25921 (1996)
Abstract
;
Full Text
Further Categories Containing This Product:
Hypoxia-inducible Factor [HIF] / Related Products
•
Polyclonal Antibodies
ALX-210-255
Revised 25-Sep-06
Polyclonal Antibody to AIB1 (human)
SYNONYMS
anti-Amplified in Breast Cancer 1 (human) PAb
anti-SRC-3 (human) PAb
anti-Steroid Receptor Coactivator-3 (human) PAb
anti-NCOA3 (human) PAb
anti-Nuclear Receptor Coactivator 3 (human) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Nuclear Receptor Coactivators / Related Products
Ordering Information
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Format:
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ALX-210-255-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 3-15 (G
3
LGENLDPLASDS
15
C) of human AIB1 (amplified in breast cancer 1).
SPECIFICITY:
Recognizes human AIB1. Detects a band of ~155kDa by Western blot.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-151-034
.
General Information
Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. AIB1 (Amplified In Breast Cancer-1) is a member of a growing family of transcriptional coactivator proteins which includes SRC-1 and GRIP1.
AIB1 has been shown to interact and stimulate transcriptional activity of the retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, progesterone, and peroxisome proliferator activated receptors. AIB1 also interacts with the transcriptional integrators CREB binding protein (CBP) and p300.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-226
Revised 17-Dec-07
Polyclonal Antibody to Akt
SYNONYMS
anti-PKB PAb
anti-Protein Kinase B PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Akt [PKB] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-226-C200
200 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic phosphopeptide corresponding to aa 302-314 (D
302
GATMKTpFCGTPE
314
) of mouse Akt (protein kinase B; PKB).
SPECIFICITY:
Recognizes the phosphorylated and non-phosphorylated form of human, mouse, rat and drosophila Akt. Detects a band of ~55kDa by Western blot.
APPLICATION:
Western Blot (10µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-039
.
Related Products
ALX-165-039
Blocking Peptide for PAb to Akt (mouse) (Prod. No.
ALX-210-226
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-534
Revised 27-Dec-06
Polyclonal Antibody to Akt (mouse)
SYNONYMS
anti-PKB (mouse) PAb
anti-Protein Kinase B (mouse) PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Akt [PKB] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-534-R100
100 µl
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
PURITY:
Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant mouse Akt (protein kinase B; PKB).
SPECIFICITY:
Recognizes mouse Akt. Does not cross-react with other species.
APPLICATION:
ELISA
Immunoprecipitation (5µl/700µl protein extracts)
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Polyclonal Antibodies
ALX-210-151
Revised 19-Mar-08
Polyclonal Antibody to Androgen Receptor
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Androgens & Androgen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-151-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Monkey
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human androgen receptor (aa 331-572).
SPECIFICITY:
Recognizes human, mouse, rat and monkey androgen receptor. Detects a band of ~110kDa by Western blot.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (paraffin sections, frozen sections) (1:100)
Immunoprecipitation
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
•
Tumor Markers
ALX-210-152/1
Revised 28-Feb-08
Polyclonal Antibody to Androgen Receptor
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Androgens & Androgen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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