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ALX-400-023
Revised 19-Apr-06
Gadolinium (III) chloride . hexahydrate
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Monocytes & Macrophages Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-400-023-M100
100 mg
15.00 USD
ALX-400-023-M500
500 mg
25.00 USD
Product Specification
FORMULA:
GdCl
3
. 6H
2
O
MW:
263.6 . 108.1
CAS NUMBER:
13450-84-5
MERCK INDEX:
14:
4326
PURITY:
≥99%
APPEARANCE:
White crystals or chunks.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Packaged under inert gas. Hygroscopic.
HAZARD:
IRRITANT.
Product Description
Inhibits macrophages.
Product Specific Literature References
Inhibition of macrophages with gadolinium chloride abrogates ozone- induced pulmonary injury and inflammatory mediator production:
K.J. Pendino, et al.; Am. J. Respir. Cell Mol. Biol.
13
, 125 (1995)
Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
ALX-201-198
Revised 15-Mar-05
G-CSF (human) (recombinant)
SYNONYMS
Granulocyte-colony Stimulating Factor (human) (recombinant)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Granulocyte Colony-Stimulating Factor [G-CSF] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-198-C010
10 µg
125.00 USD
Product Specification
MW:
~18.8kDa.
SOURCE/HOST:
Produced in
E. coli.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In PBS, pH7.4.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-850-309
Revised 06-Oct-08
sHLA-G ELISA Kit
PRODUCT LINE
Immunology
PRODUCT CATEGORY
MHC Proteins & Human Leukocyte Antigens [HLA] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-850-309-KI01
1 Kit
1'431.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Goat
Sheep
Dog
Monkey
SENSITIVITY:
1U/ml (range 1.95 to 125U/ml)
QUANTITY:
For 96 wells (~80 tests)
APPLICATION:
For the quantitative determination of soluble human HLA-G (leukocyte antigen-G) in plasma, serum, cell culture supernatant and other body fluids. Cross-reacts strongly with bovine, dog, goat, monkey, rabbit and sheep HLA-G. Cross-reacts weakly with cat HLA-G.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
General Information
MANUFACTURER
Manufactured by Exbio/BioVendor.
Further Categories Containing This Product:
ELISA & EIA Kits
ALX-522-078
Revised 26-Aug-08
LAG-3 (human):Fc (human) (recombinant)
SYNONYMS
Lymphocyte Activation Gene-3 (human):Fc (human) (recombinant)
FDC Protein (human):Fc (human) (recombinant)
CD223 (human):Fc (human) (recombinant)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Dendritic Cells [DC]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-078-C050
50 µg
360.00 USD
Product Specification
MW:
~80kDa (SDS-PAGE).
SOURCE/HOST:
Produced in CHO cells. The sequence coding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1.
CONCENTRATION:
0.5mg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. In PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
SPECIFICITY:
Binds to human, mouse and monkey MHC class II.
BIOLOGICAL ACTIVITY:
Inhibits binding of MAb to LAG-3 (human) to LAG-3. Induces maturation of human dendritic cells.
APPLICATION:
Flow Cytometry: Detection of MHC class II molecules in combination with fluorescently labelled Ab to IgG1.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
CD4/major histocompatibility complex class II interaction analyzed with CD4- and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins
:
B. Huard, et al.; Eur. J. Immunol.
25
, 2718 (1995)
Abstract
T cell major histocompatibility complex class II molecules down-regulate CD4+ T cell clone responses following LAG-3 binding
:
B. Huard, et al.; Eur. J. Immunol.
26
, 1180 (1996)
Abstract
Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223)
:
S. Andreae, et al.; J. Immunol.
168
, 3874 (2002)
Abstract
;
Full Text
LAG-3 (CD223) reduces macrophage and dendritic cell differentiation from monocyte precursors:
S. Buisson and F. Triebel; Immunology
114
, 369 (2005)
Abstract
A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors:
F. Triebel, et al.; Cancer Lett.
235
, 147 (2006)
Abstract
A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells:
C. Brignone, et al.; J. Immunol.
179
, 4202 (2007)
Abstract
General Information
The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4 [1]. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa) [1,2]. The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome [3]. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses [4].
BACKGROUND/TECHNICAL INFORMATION
Swiss Prot link P18627:
Lymphocyte activation gene-3 protein (human) (Precursor)
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
[1]
LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination:
F. Triebel; Trends Immunol.
24
, 619 (2003)
Abstract
[2]
A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors:
F. Triebel, et al.; Cancer Lett.
235
, 147 (2006)
Abstract
[3]
Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo:
C. Lienhardt, et al.; Eur. J. Immunol.
32
, 1605 (2002)
Abstract
[4]
Expression and release of LAG-3-encoded protein by human CD4+ T cells are associated with IFN-gamma production:
F. Annunziato, et al.; FASEB J.
10
, 769 (1996)
Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
•
CD Proteins
ALX-522-099
Revised 27-Mar-08
LAG-3 (mouse):Fc (mouse) (recombinant)
SYNONYMS
Lymphocyte Activation Gene-3 (mouse):Fc (mouse) (recombinant)
FDC Protein (mouse):Fc (mouse) (recombinant)
CD223 (mouse):Fc (mouse) (recombinant)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Dendritic Cells [DC]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-099-C050
50 µg
360.00 USD
ALX-522-099-C500
500 µg
1'600.00 USD
Product Specification
MW:
~180kDa (SPS-PAGE, nonreducing), ~80kDa (SPS-PAGE, reducing)
SOURCE/HOST:
Produced in CHO cells. The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH
2
-CH
3
).
CONCENTRATION:
0.5mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In PBS.
ENDOTOXIN CONTENT:
<1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY:
Binds to human and mouse MHC class II.
BIOLOGICAL ACTIVITY:
Induces maturation of mouse dendritic cells
in vitro
. Induces CD4 and CD8 antigen-specific T cells responses when coinjected
s.c.
in mice, together with the antigen.
APPLICATION:
Flow Cytometry
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at +4°C.
Product Specific Literature References
LAG-3 enables DNA vaccination to persistently prevent mammary carcinogenesis in HER-2/neu transgenic BALB/c mice:
P. Cappello, et al.; Cancer Res.
63
, 2518 (2003)
Abstract
;
Full Text
General Information
The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4 [1]. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa) [1,2]. The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome [3]. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses [4].
BACKGROUND/TECHNICAL INFORMATION
Swiss Prot link Q61790:
Lymphocyte activation gene-3 protein (mouse) (Precursor)
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
[1]
LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination:
F. Triebel; Trends Immunol.
24
, 619 (2003)
Abstract
[2]
A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors:
F. Triebel, et al.; Cancer Lett.
235
, 147 (2006)
Abstract
[3]
Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo:
C. Lienhardt, et al.; Eur. J. Immunol.
32
, 1605 (2002)
Abstract
[4]
Expression and release of LAG-3-encoded protein by human CD4+ T cells are associated with IFN-gamma production:
F. Annunziato, et al.; FASEB J.
10
, 769 (1996)
Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
•
CD Proteins
APO-54N-017
Revised 24-Jun-08
LAG-3, Soluble (human) Detection Set [For ELISA Application]
SYNONYMS
Lymphocyte Activation Gene-3, Soluble (human) Detection Set
FDC Protein, Soluble (human) Detection Set
CD223, Soluble (human) Detection Set
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Dendritic Cells [DC]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
APO-54N-017-KI01
1 Set
950.00 USD
Product Specification
SENSITIVITY:
0.05ng /ml (range 0 to 4ng/ml)
KIT/SET CONTAINS:
1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION:
For the quantitative determination of soluble human LAG-3 from biological fluids (serum and cell culture supernatant).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at +4°C.
Product Specific Literature References
Demonstration of antiglobulin activity in the synovial membrane of patients with rheumatoid arthritis and ankylosing spondylitis after pepsin treatment: real or artefact?
:
P.G. Davies, et al.; Ann. Rheum. Dis.
45
, 821 (1986)
Abstract
Preferential Th1 profile of T helper cell responses in X-linked (Bruton's) agammaglobulinemia
:
A. Amedei, et al.; Eur. J. Immunol.
31
, 1927 (2001)
Abstract
Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation:
C. Casati, et al.; J. Immunol.
180
, 3782 (2008)
Abstract
General Information
The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4 [1]. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa) [1,2]. The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome [3]. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses [4].
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P18627:
LAG-3 (human)
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
[1]
LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination:
F. Triebel; Trends Immunol.
24
, 619 (2003)
Abstract
[2]
A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors:
F. Triebel, et al.; Cancer Lett.
235
, 147 (2006)
Abstract
[3]
Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo:
C. Lienhardt, et al.; Eur. J. Immunol.
32
, 1605 (2002)
Abstract
[4]
Expression and release of LAG-3-encoded protein by human CD4+ T cells are associated with IFN-gamma production:
F. Annunziato, et al.; FASEB J.
10
, 769 (1996)
Abstract
Related Products
ALX-522-099
LAG-3 (mouse):Fc (mouse) (recombinant)
ALX-522-078
LAG-3 (human):Fc (human) (recombinant)
ALX-804-805
Monoclonal Antibody to LAG-3 (human) (11E3)
ALX-804-806
Monoclonal Antibody to LAG-3 (human) (17B4)
Further Categories Containing This Product:
ELISA Sets
•
CD Kits & Sets
ALX-805-045
Revised 26-Jul-07
Monoclonal Antibody to CD83 (human) (1G11)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-805-045-C050
50 µg
210.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
1G11
ISOTYPE:
Rat IgG1
CONCENTRATION:
1.9mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.01% sodium azide.
IMMUNOGEN:
Recombinant human CD83 (extracellular domain).
SPECIFICITY:
Recognizes human CD83. The binding affinity strongly increases after deglycosylation of mature DC.
APPLICATION:
Flow Cytometry, Western blot.
Not
inhibitory to DC mediated T cell stimulation in mixed lymphocyte reactions.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Do not freeze/thaw.
Product Specific Literature References
The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells
:
M. Lechmann, et al.; J. Exp. Med.
194
, 1813 (2001)
Abstract
;
Full Text
Overexpression, purification, and biochemical characterization of the extracellular human CD83 domain and generation of monoclonal antibodies
:
M. Lechmann, et al.; Protein Exp. Purif.
24
, 445 (2002)
Abstract
Further Categories Containing This Product:
Dendritic Cells [DC]
•
Monoclonal Antibodies
ALX-805-044
Revised 10-Nov-04
Monoclonal Antibody to CD83 (human) (4B5)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-805-044-C050
50 µg
210.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
4B5
ISOTYPE:
Rat IgG2a
CONCENTRATION:
1.7mg/ml
FORMULATION:
Liquid. Protein G purified antibody in PBS containing 0.01% sodium azide.
IMMUNOGEN:
Recombinant human CD83 (extracellular domain).
SPECIFICITY:
Recognizes human CD83. Deglycosylated CD83 is only weakly recognized.
APPLICATION:
Flow Cytometry
Western Blot
Note:
NOT inhibitory to DC mediated T cell stimulation in mixed lymphocyte reactions.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Do not freeze/thaw.
Product Specific Literature References
The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells
:
M. Lechmann, et al.; J. Exp. Med.
194
, 1813 (2001)
Abstract
;
Full Text
Overexpression, purification, and biochemical characterization of the extracellular human CD83 domain and generation of monoclonal antibodies
:
M. Lechmann, et al.; Protein Exp. Purif.
24
, 445 (2002)
Abstract
Further Categories Containing This Product:
Dendritic Cells [DC]
•
Monoclonal Antibodies
ALX-804-661
Revised 13-Mar-08
Monoclonal Antibody to CLEC12B (human) (16)
SYNONYMS
anti-C-type Lectin Domain Family 12 Member B (human) MAb (16)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Monocytes & Macrophages Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-661-C100
100 µg
260.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
16
ISOTYPE:
Mouse IgG2a
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS, pH 7.4, containing 50% glycerol.
IMMUNOGEN:
Ba/F3 cells transfected with human CLEC12B.
SPECIFICITY:
Recognizes human CLEC12B.
APPLICATION:
ELISA (1µg/ml)
Flow Cytometry (10µg/ml)
Western Blot (1µg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least one year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Identification of CLEC12B, an Inhibitory Receptor on Myeloid Cells:
S.C. Hoffmann, et al.; J. Biol. Chem.
282
, 22370 (2007)
Abstract
Further Categories Containing This Product:
Immune Receptors Other Products
•
Monoclonal Antibodies
ALX-804-339
Revised 14-Nov-08
Monoclonal Antibody to GM-CSF (mouse) (MP1-22E9)
SYNONYMS
anti-Granulocyte-macrophage Colony Stimulating Factor (mouse) MAb (MP1-22E9)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Granulocyte-Macrophage Colony-Stimulating Factor [GM-CSF] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-339-C100
100 µg
259.00 USD
Product Specification
