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Src Family Kinases / Related Products
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ALX-385-021 Revised 23-Oct-07
4'-Amino-6-hydroxyflavone
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SYNONYMS Aminogenistein
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavones
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ALX-385-021-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C15H11NO3
MW: 253.3
PURITY: ≥95%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibitor of the p56lck protein-tyrosine kinase.
Product Specific Literature References
Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues: M. Cushman, et al.; J. Med. Chem. 34, 798 (1991) Abstract
Expression of p56lck in B-cell neoplasias: A. Von Knethen, et al.; Leuk. Lymphoma 26, 551 (1997) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • Src Family Kinases / Related Products • Kinases in T Cell Signal Transduction / Related Products
 
 
ALX-270-181 Revised 28-Jul-08
Damnacanthal
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SYNONYMS 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
PRODUCT LINE Immunology
PRODUCT CATEGORY Kinases in T Cell Signal Transduction / Related Products
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ALX-270-181-M001   1 mg 165.00 USD Add To Cart
Product Specification
FORMULA: C16H10O5
MW: 282.3
CAS NUMBER: 477-84-9
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow to orange solid.
SOLUBILITY: 10mg/ml soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Potent and selective inhibitor of p56lck tyrosine kinase activity. Inhibition of p56lck by damnacanthal appears to be reversible, not time-dependent and not significantly affected by the presence of sulfhydryl reagents.
Product Specific Literature References
S. Nonomura; J. Pharm. Soc. Jpn. 75, 219 (1955)
N.R. Ayyangar, et al.; Tetrahedron 6, 331 (1959)
Effects of three compounds extracted from Morinda lucida on Plasmodium falciparum: K.Koumaglo, et al.; Planta Medica 58, 533 (1992) Abstract
Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia: T. Hiramatsu, et al.; Cancer Lett. 73, 161 (1993) Abstract
Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity: C.R. Faltynek, et al.; Biochemistry 34, 12404 (1995) Abstract
Further Categories Containing This Product:
Src Family Kinases / Related Products • Tyrosine Kinase Inhibitors
 
 
ALX-350-057 Revised 20-Feb-08
Emodin
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SYNONYMS 6-Methyl-1,3,8-trihydroxyanthraquinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-057-M025   25 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C15H10O5
MW: 270.2
CAS NUMBER: 518-82-1
MERCK INDEX: 14: 3561
RTECS: CB7920600
SOURCE/HOST: Isolated from Frangula bark.
PURITY: ≥96% (HPLC)
APPEARANCE: Orange to red solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or 1N dilute aqueous ammonia; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Inhibitor of p56lck tyrosine kinase. Has mutagenic and genotoxic effects, mainly in bacterial systems. Anticancer agent. Exhibits anti-proliferative effects in various cancer cell lines by efficient induction of apoptosis. Has inhibitory effects on angiogenic and metastasis regulatory processes. Anti-inflammatory compound. Suppresses NF-κB activation. 
Product Specific Literature References
Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum: H. Jayasuriya, et al.; J. Nat. Prod. 55, 696 (1992) Abstract
Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor: T.C.K. Chan, et al.; BBRC 193, 1152 (1993) Abstract
Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent: G. Srinivas, et al.; Med. Res. Rev. 27, 591 (2007), (Review) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • Other Toxins • Src Family Kinases / Related Products • Kinases in T Cell Signal Transduction / Related Products • Natural Products - Anti-inflammatory Agents • Natural Products - NF-kB Pathway Inhibitors • Natural Products - Antitumor Reagents • Natural Products - Apoptosis Inducers & Inhibitors • NF-kB Pathway Inhibitors
 
 
ALX-270-425 Revised 10-Apr-08
Indirubin-3’-(2,3-dihydroxypropyl)oximether
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SYNONYMS E804
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Src Family Kinases / Related Products
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ALX-270-425-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C19H17N3O4
MW: 351.4
PURITY: ≥96% (1H-NMR)
FORMULATION: Dark red solid.
SOLUBILITY: Soluble in DMSO (1M).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of c-Src (IC50=0.43µM) blocking downstream STAT3 signalling. Induces apoptosis in human cancer cells.
Product Specific Literature References
Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells: S. Nam, et al.; PNAS 102, 5998 (2005) Abstract
Further Categories Containing This Product:
JAK / STAT Signalling Pathway Other Products • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-804-564 Revised 10-Jun-08
Monoclonal Antibody to Fyn (FYN-01)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Src Family Kinases / Related Products
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ALX-804-564-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: FYN-01
ISOTYPE: Mouse IgG
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant of human Fyn (aa 7-176).
SPECIFICITY: Recognizes human and mouse Fyn. Detects a band of ~59kDa by immunoprecipitation.
APPLICATION: Immunocytochemistry
Immunoprecipitation: Preparation of cell lysate: 30 min. on ice (orbital incubator) in lysis buffer containing N-dodecyl-β-D-maltoside (Prod. No. ALX-500-007) (20mM TRIS-Cl, 100mM sodium chloride, pH 8.2, 1% laurylmaltoside, 50mM sodium fluoride); positive control J77 T-cell lysate.
Western Blot (1:500)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies • Natural Killer T [NKT] Cells / Related Products
 
 
ALX-804-479 Revised 10-Jun-08
Monoclonal Antibody to Lck (human) (LCK-01)
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PRODUCT LINE Immunology
PRODUCT CATEGORY Kinases in T Cell Signal Transduction / Related Products
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ALX-804-479-C100   100 µg 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: LCK-01
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE)
FORMULATION: Liquid. Affinity purified antibody in PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 22-36 of human Lck.
SPECIFICITY: Recognizes human Lck. Does not cross-react with mouse Lck.
APPLICATION: Flow Cytometry
Immunocytochemistry
Immunoprecipitation
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Incorporation of leucocyte GPI-anchored proteins and protein tyrosine kinases into lipid-rich membrane domains of COS-7 cells: M. Cebecauer, et al.; BBRC 243, 706 (1998) Abstract
A potential role for protein tyrosine kinase p56(lck) in rheumatoid arthritis synovial fluid T lymphocyte hyporesponsiveness: P. Romagnoli, et al.; Int. Immunol. 13, 305 (2001) Abstract; Full Text
Further Categories Containing This Product:
Autoimmunity & Self Tolerance Other Products • Src Family Kinases / Related Products • Monoclonal Antibodies
 
 
ALX-804-561 Revised 29-Nov-04
Monoclonal Antibody to Lck-interacting Molecule (human) (LIME-10)
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SYNONYMS anti-LIME (human) MAb (LIME-10)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-804-561-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: LIME-10
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml.
PURITY: >95% (SDS-PAGE).
FORMULATION: Liquid. Protein A affinity purified antibody in PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 281-296 of human LIME (Lck-interacting molecule).
SPECIFICITY: Recognizes human LIME.
APPLICATION: Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling: N. Brdickova, et al.; J. Exp. Med. 198, 1453 (2003) Abstract
Further Categories Containing This Product:
Src Family Kinases / Related Products • Monoclonal Antibodies
 
 
ALX-804-560 Revised 30-May-05
Monoclonal Antibody to Lck-interacting Molecule (human) (LIME-06)
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SYNONYMS anti-LIME (human) MAb (LIME-06)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-804-560-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: LIME-06
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE).
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant intracellular fragment corresponding to aa 141-295 of human LIME (Lck-interacting molecule).
SPECIFICITY: Recognizes human LIME.
APPLICATION: Immunoprecipitation
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling: N. Brdickova, et al.; J. Exp. Med. 198, 1453 (2003) Abstract
Further Categories Containing This Product:
Src Family Kinases / Related Products • Monoclonal Antibodies
 
 
ALX-804-565 Revised 10-Jun-08
Monoclonal Antibody to Lyn (LYN-01)
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PRODUCT LINE Immunology
PRODUCT CATEGORY Kinases in T Cell Signal Transduction / Related Products
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ALX-804-565-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: LYN-01
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml.
PURITY: >95% (SDS-PAGE).
FORMULATION: Liquid. Protein A affinity purified antibody in PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant human Lyn (aa 8-238).
SPECIFICITY: Recognizes human, mouse and rat Lyn.
APPLICATION: Immunocytochemistry
Immunoprecipitation
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
Thy-1-mediated activation of rat mast cells: the role of Thy-1 membrane microdomains: L. Draberova, et al.; Immunology 87, 141 (1996) Abstract
Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors: M. Amoui, et al.; Eur. J. Immunol. 27, 321 (1997) Abstract
Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation: M. Kovarova, et al.; Mol. Cell. Biol. 21, 8318 (2001) Abstract
Further Categories Containing This Product:
Src Family Kinases / Related Products • Monoclonal Antibodies
 
 
ALX-804-316 Revised 04-Jun-08
Monoclonal Antibody to Src (phosphorylated) (pTyr416) (9A6)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Src Family Kinases / Related Products
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ALX-804-316-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: 9A6
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN: Synthetic peptide corresponding to a portion of src phosphorylated at Tyr416.
SPECIFICITY: Recognizes human, mouse and rat src phosphorylated at Tyr416. Does not cross-react with non-phosphorylated form of src nor with unrelated tyrosine-phosphorylated proteins.
APPLICATION: Flow Cytometry
Immunocytochemistry
Western Blot (1µg/ml for AP/BCIP/NBT (MTT) detection; 0.1µg/ml for HRPO/ECL detection).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
Product Specific Literature References
Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases: B. Viviani, et al.; J. Neurosci. 23, 8692 (2003) Abstract; Full Text
Further Categories Containing This Product:
Phospho-specific Antibodies • Monoclonal Antibodies
 
 
ALX-210-827 Revised 18-Oct-07
Polyclonal Antibody to Lck (human)
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PRODUCT LINE Immunology
PRODUCT CATEGORY Kinases in T Cell Signal Transduction / Related Products
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ALX-210-827-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Contains 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 38-57 (R38NGSEVRDPLVTYEGSNPPA57) of human Lck.
SPECIFICITY: Recognizes human Lck.
APPLICATION: Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
The structure of the mu/ps