© 2008 Alexis Corporation
You are here:
Product Lines
>
Signal Transduction
>
Receptors
>
Receptor Tyrosine Kinases / Related Products
>
EGF / EGF Receptor [EGFR] Kinase / Related Products
> EGFR Kinase Inhibitors
ALX-350-256
Revised 07-Oct-08
(+)-Aeroplysinin-1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-256-M001
1 mg
70.00 USD
Product Specification
FORMULA:
C
9
H
9
Br
2
NO
3
MW:
339.0
CAS NUMBER:
28656-91-9
SOURCE/HOST:
Isolated from
Aplysina aerophoba
.
PURITY:
≥97%
APPEARANCE:
Oil.
SOLUBILITY:
Soluble in 100% ethanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Displays cytostatic and cytotoxic activity. Inhibitor of EGFR kinase. Shows antiangiogenic activity.
Product Specific Literature References
Aeroplysinin-1, an antibacterial bromo-compound from the sponge Verongia aerophoba:
E. Fattorusso, et al.; J. Chem. Soc.
1
, 16 (1972)
Abstract
Cytostatic activity of aeroplysinin-1 against lymphoma and epithelioma cells:
M.H. Kreuter, et al.; Z. Naturforsch. [C]
44
, 680 (1989)
Abstract
Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1:
M.H. Kreuter, et al.; Comp. Biochem. Physiol. B
97
, 151 (1990)
Abstract
Production of the cytostatic agent aeroplysinin by the sponge Verongia aerophoba in in vitro culture:
M.H. Kreuter, et al.; Comp. Biochem. Physiol.
101C
, 183 (1992)
Abstract
Antibiotic and cytotoxic activity of brominated compounds from the marine sponge Verongia aerophoba:
R. Teeyapant, et al.; Z. Naturforsch. [C]
48
, 939 (1993)
Abstract
Cytotoxicity and mode of action of aeroplysinin-1 and a related dienonefrom the sponge Aplysina aerophoba:
A. Koulman, et al.; J. Nat. Prod.
59
, 591 (1996)
Abstract
Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge:
S. Rodriguez-Nieto, et al.; FASEB J.
16
, 261 (2002)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
EGFR Kinase Inhibitors
Natural Products with Antibiotic Activity
Natural Products - Antitumor Reagents
Natural Products for Angiogenesis Research
Marine Natural Products
ALX-270-313
Revised 03-Mar-05
BPIQ-I
SYNONYMS
8-[(3-Bromophenyl)amino]-3-methyl-3
H
-imidazo[4,5-γ]-quinazoline
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
EGFR Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-313-M001
1 mg
140.00 USD
Product Specification
FORMULA:
C
16
H
12
BrN
5
MW:
354.2
PURITY:
≥95%
APPEARANCE:
Off white to yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC
50
=25 pM).
Product Specific Literature References
Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor:
G.W. Rewcastle, et al.; J. Med. Chem.
39
, 918 (1996)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
ALX-270-338
Revised 03-Mar-05
BPIQ-II
SYNONYMS
8-[(3-Bromophenyl)amino]-1
H
-imidazo[4,5-γ]-quinazoline
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
EGFR Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-338-M001
1 mg
140.00 USD
Product Specification
FORMULA:
C
15
H
10
BrN
5
MW:
340.2
PURITY:
≥98%
APPEARANCE:
Pale pink solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC
50
=8pM).
Product Specific Literature References
Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor
:
G.W. Rewcastle, et al.; J. Med. Chem.
39
, 918 (1996)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
ALX-350-246
Revised 07-Oct-08
Butein
SYNONYMS
2',3,4,4'-Tetrahydroxychalcone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-246-M010
10 mg
190.00 USD
Product Specification
FORMULA:
C
15
H
12
O
5
MW:
272.3
CAS NUMBER:
487-52-5
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO (>50mg/ml) or methanol; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep cool and dry under inert gas.
IDENTITY:
Identity determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Plant polyphenol. Specific tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor and p60
c-
src
. Potent antioxidant and anti-inflammatory agent. Inhibits glutathione reductase and rat liver glutathione S-transferase. Activator of human deacetylase SIRT1. Inhibits aromatase, showing chemopreventive properties. Directly inhibits IKK.
Product Specific Literature References
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects:
E. Aizu, et al.; Carcinogenesis
7
, 1809 (1986)
Abstract
Protective effects of hydroxychalcones on free radical-induced cell damage:
S. Sogawa, et al.; Biol. Pharm. Bull.
17
, 251 (1994)
Abstract
Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation:
C.C. Yit & N.P. Das; Cancer Lett.
82
, 65 (1994)
Abstract
Inhibitory effects of plant polyphenols on rat liver glutathione S-transferase:
K. Zhang & N.P. Das; Biochem. Pharmacol.
47
, 2063 (1994)
Abstract
Endothelium-dependent relaxation of rat aorta by butein, a novel cyclic AMP-specific phosphodiesterase inhibitor:
S.M. Yu, et al.; Eur. J. Pharmacol.
280
, 69 (1995)
Abstract
Butein (3,4,2',4'-tetrahydroxychalcone) ameliorates experimantal anti-glomerular basement membrane antibody-associated glomerulonephritis (3):
K. Hayashi, et al.; Eur. J. Pharmacol.
316
, 297 (1996)
Abstract
Inhibition of glutathione reductase by plant polyphenols:
K. Zhang, et al.; Biochem. Pharmacol
54
, 1047 (1997)
Abstract
Butein, a specific protein tyrosine kinase inhibitor:
E.-B. Yang, et al.; BBRC
245
, 435 (1998)
Abstract
Antioxidant properties of butein isolated from Dalbergia odorifera:
Z.J. Cheng, et al.; Biochim. Biophys. Acta
1392
, 291 (1998)
Abstract
Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells:
K. Iwashita, et al.; Biosci. Biotechnol. Biochem.
64
, 1813 (2000)
Abstract
Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells:
N.Y. Kim, et al.; Pharmacol. Toxicol.
88
, 261 (2001)
Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
:
K.T. Howitz, et al.; Nature
425
, 191 (2003)
Abstract
The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase:
Y. Wang, et al.; Life Sci.
77
, 39 (2005)
Abstract
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue:
M.K. Pandey, et al.; J. Biol. Chem.
282
, 17340 (2007)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
Natural Products - Anti-inflammatory Agents
EGFR Kinase Inhibitors
Glutathione / Related Products
Chalcones
Phosphodiesterases / Related Products
Natural Products - Chemopreventive Agents
Glutathione S-Transferase
Sirtuins / Related Products
Natural Products - Antioxidants
IkB Kinases [IKKs] / Related Products
ALX-270-314
Revised 04-Dec-07
CL-387,785
SYNONYMS
EKI-785
N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
EGFR Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-314-M001
1 mg
130.00 USD
Product Specification
FORMULA:
C
18
H
13
BrN
4
O
MW:
381.2
PURITY:
≥98% (HPLC)
APPEARANCE:
Off-white to yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic. Protect from light. Packaged under inert gas.
Product Description
Irreversibly inhibits EGF-stimulated autophosphorylation of tyrosine residues in the epidermal growth factor receptor (EGFR)
in vivo
(IC
50
=250-490pM) and blocks EGF-mediated growth.
Product Specific Literature References
Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785)
:
C.M. Discafani, et al.; Biochem. Pharmacol.
57
, 917 (1999)
Abstract
ALX-270-316
Revised 12-Jan-07
Compound 56
SYNONYMS
4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
EGFR Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-316-C500
500 ΅g
135.00 USD
Product Specification
FORMULA:
C
18
H
18
BrN
3
O
2
MW:
388.3
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
MAY BE MUTAGENIC. HARMFUL.
Product Description
Potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC
50
=6pM).
Product Specific Literature References
Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor:
A.J. Bridges, et al.; J. Med. Chem.
39
, 267 (1996)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
ALX-350-028
Revised 12-Sep-08
Curcumin (high purity)
SYNONYMS
1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Diferuloylmethane
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-028-M010
10 mg
15.00 USD
ALX-350-028-M050
50 mg
60.00 USD
ALX-350-028-M250
250 mg
240.00 USD
Product Specification
FORMULA:
C
21
H
20
O
6
MW:
368.4
CAS NUMBER:
458-37-7
MERCK INDEX:
14:
2673
SOURCE/HOST:
Isolated from turmeric (
Curcuma longa
).
PURITY:
≥98.5% (Note: This highly purified product is free of demethoxy- and bis-demethoxycurcumin and does not contain 30-40% bioactive impurities)
APPEARANCE:
Orange-yellow crystalline powder.
SOLUBILITY:
Soluble in acetic acid or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
Product Description
Dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase. Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Antioxidant. Inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), disrupting the binding of NQO1 to wild type p53 inducing ubiquitin-independent degradation of p53 and inhibits p53-mediated apoptosis in normal thymocytes and myeloid leukemic cells.
Product Specific Literature References
Modification of certain inflammation-induced biochemical changes by curcumin:
R. Srivastava & R.C. Srimal; Indian J. Med. Res.
81
, 215 (1985)
Abstract
Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones:
D.L. Flynn, et al.; Prostagl. Leukotr. Med.
22
, 357 (1986)
Abstract
Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells:
L. Korutla & R. Kumar; Biochim. Biophys. Acta
1224
, 597 (1994)
Abstract
Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages:
I. Brouet & H. Okshima; BBRC
206
, 533 (1995)
Abstract
Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin:
J.N. Commandeur & N.P. Vermeulen; Xenobiotica
26
, 667 (1996)
Abstract
Nitric oxide scavenging by curcuminoids:
Sreejayan & M.N. Rao; J. Pharm. Pharmacol.
49
, 105 (1997)
Abstract
Inhibitory effects of curcumin on tumorigenesis in mice:
M.T. Huang, et al.; J. Cell. Biochem. (Suppl.)
27
, 26 (1997)
Abstract
In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties:
M.M. Chan, et al.; Biochem. Pharmacol.
55
, 1955 (1998)
Abstract
Effect of curcumin on the production of nitric oxide by cultured rat mammary gland:
M. Onoda & H. Inano; Nitric Oxide
4
, 505 (2000)
Abstract
Suppression of nitric oxide oxidation to nitrite by curcumin is due to the sequestration of the reaction intermediate nitrogen dioxide, not nitric oxide:
B.D. Johnston & E.G. DeMaster; Nitric Oxide
8
, 231 (2003)
Abstract
Biological properties of curcumin-cellular and molecular mechanisms of action:
B. Joe, et al.; Crit. Rev. Food Sci. Nutr.
44
, 97 (2004), (Review)
Abstract
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects:
M.E. Egan, et al.; Science
304
, 600 (2004)
Abstract
Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin:
P. Tsvetkov, et al.; PNAS
102
, 5535 (2005)
Abstract
Immunomodulatory effects of curcumin:
V.S. Yadav, et al.; Immunopharmacol. Immunotoxicol.
27
, 485 (2005)
Abstract
Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases:
S. Bengmark; JPEN J. Parenter. Enteral. Nutr.
30
, 45 (2006), (Review)
Abstract
Curcumin is an inhibitor of p300 histone acetylatransferase:
M.G. Marcu, et al.; Med. Chem.
2
, 169 (2006)
Abstract
Multiple biological activities of curcumin: a short review:
R.K. Maheshwari, et al.; Life Sci.
78
, 2081 (2006), (Review)
Abstract
Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1:
M.K. Bae, et al.; Oncol. Rep.
15
, 1557 (2006)
Abstract
Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells:
Z. Wang, et al.; Cancer
106
, 2503 (2006)
Abstract
Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species:
M. Panchatcharam, et al.; Mol. Cell Biochem.
290
, 87 (2006)
Abstract
Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia:
K.K. Jung, et al.; Life Sci.
79
, 2022 (2006)
Abstract
The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats:
T. Morimoto, et al.; J. Clin. Invest.
118
, 868 (2008)
Abstract
;
Full Text
Further Categories Containing This Product:
Other Natural Products for Cancer Research
Cell Cycle Blockers & Inhibitors / Related Products
Lipoxygenases / Related Products
EGFR Kinase Inhibitors
Natural Products - Protein Kinase Inhibitors
Respiratory Chain Other Products
Natural Products - Immunomodulators
Natural Products - NF-kB Pathway Inhibitors
Natural Products - Antioxidants
Glutathione S-Transferase
Natural Products - Nitric Oxide Pathway Modulators
Active Substances from Fruit and Vegetables
COX Inhibitors
Polyphenols Other Products
Natural Products for Angiogenesis Research
Natural Products - Apoptosis Inducers & Inhibitors
NF-kB Pathway Inhibitors
ALX-270-281
Revised 28-Sep-06
Daphnetin
SYNONYMS
7,8-Dihydroxycoumarin
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
EGFR Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-281-M005
5 mg
25.00 USD
ALX-270-281-M025
25 mg
95.00 USD
Product Specification
FORMULA:
C
9
H
6
O
4
MW:
178.1
CAS NUMBER:
486-35-1
RTECS:
GN6382600
PURITY:
≥97%
APPEARANCE:
White to rose powder.
SOLUBILITY:
Soluble in 100% ethanol, methanol or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Inhibitor of protein kinases. EGF receptor tyrosine kinase (IC
50
=7.87΅M), PKA (IC
50
=9.33΅M), PKC (IC
50
=25.01΅M). Antioxidant. Antimalarial agent.
Product Specific Literature References
Daphnetin: a novel antimalarial agent with in vitro and in vivo activity:
Y.Z. Yang, et al.; Am. J. Trop. Med. Hyg.
46
, 15 (1992)
Abstract
Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor:
E.B. Yang, et al.; BBRC
260
, 682 (1999)
Abstract
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
PKA Inhibitors
Malaria / Related Products
Tyrosine Kinase Inhibitors
ALX-270-263
Revised 03-Apr-08
(-)-Epigallocatechin gallate
SYNONYMS
EGCG
(2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[
2H
]-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate)
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antioxidants
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-263-M010
10 mg
20.00 USD
ALX-270-263-M050
50 mg
60.00 USD
Product Specification
FORMULA:
C
22
H
18
O
11
MW:
458.4
CAS NUMBER:
989-51-5
MERCK INDEX:
14:
3526
SOURCE/HOST:
Isolated from green tea.
PURITY:
≥98% (HPLC)
APPEARANCE:
Off-white to yellow powder.
SOLUBILITY:
Soluble in 100% ethanol, dimethyl formamide or DMSO; slightly soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stock solutions in DMSO are stable for up to 3 months when stored at -20°C.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Keep under inert gas. Protect from light.
Product Description
Antitumor reagent. Antioxidant. Protects cells from lipid peroxidation and DNA damage induced by reactive free radicals. Inhibits inducible nitric oxide synthase (iNOS; NOS II). Chemopreventive anticancer agent. Induces apoptosis in human cancer cell lines. Inhibits MAP kinase mediated signalling pathways. Inhibits angiogenesis. Inhibits telomerase and DNA methyltransferase. Anti-inflammatory agent.
Product Specific Literature References
Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin:
M.T. Huang, et al.; Carcinogenesis
13
, 947 (1992)
Abstract
Inhibition of 12-O-tetradecanoylphorbol-13-acetate and other skin tumor-promoter-caused induction of epidermal interleukin-1 alpha mRNA and protein expression in SENCAR mice by green tea polyphenols:
S.K. Katiyar, et al.; J. Invest. Dermatol.
105
, 394 (1995)
Abstract
Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate:
S. Liao, et al.; Cancer Lett.
96
, 239 (1995)
Abstract
Inhibition of N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach:
T. Yamane, et al.; Cancer Res.
55
, 2081 (1995)
Abstract
(-)-Epigallocatechin gallate, a polyphenolic tea antioxidant, inhibits peroxynitrite-mediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine:
E.S. Fiala, et al.; Experientia
52
, 922 (1996)
Abstract
Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells:
N. Ahmad, et al.; J. Natl. Cancer Inst.
89
, 1881 (1997)
Abstract
Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea:
M.M. Chan, et al.; Biochem. Pharmacol.
54
, 1281 (1997)
Abstract
(-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB:
Y.L. Lin & J.K. Lin; Mol. Pharmacol.
52
, 465 (1997)
Abstract
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins:
I. Naasani, et al.; BBRC
249
, 391 (1998)
Abstract
Epigallocatechin suppression of proliferation of vascular smooth muscle cells: correlation with c-jun and JNK
:
L.H. Lu, et al.; Br. J. Pharmacol.
124
, 1227 (1998)
Abstract
ESR study on the structure-antioxidant activity relationship of tea catechins and their epimers:
Q. Guo, et al.; Biochim. Biophys. Acta
1427
, 13 (1999)
Abstract
Pharmacokinetics of the green tea derivative, EGCG, by the topical route of administration in mouse and human skin:
K. Dvorakova, et al.; Cancer Chemother. Pharmacol.
43
, 331 (1999)
Abstract
Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin:
S.K. Katiyar, et al.; Photochem. Photobiol.
69
, 148 (1999)
Abstract
Antioxidant chemistry of green tea catechins. Identification of products of the reaction of (-)-epigallocatechin gallate with peroxyl radicals:
S. Valcic, et al.; Chem. Res. Toxicol.
12
, 382 (1999)
Abstract
Antimutagenic and anticarcinogenic activity of tea polyphenols:
Y. Kuroda & Y. Hara; Mutat. Res.
436
, 69 (1999)
Abstract
Inhibitory effect of green and black tea on tumor growth:
A.H. Conney, et al.; Proc. Soc. Exp. Biol. Med.
220
, 229 (1999)
Abstract
Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase
:
X. Wang & W. Tian; BBRC
288
, 1200 (2001)
Abstract
Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production
:
M.E. Waltner-Law, et al.; J. Biol. Chem.
277
, 34933 (2002)
Abstract
;
Full Text
The specificities of protein kinase inhibitors: an update:
:
J. Bain, et al.; Biochem. J.
371
, 199 (2003)
Abstract
;
Full Text
Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters
:
M.N. Vankemmelbeke, et al.; Eur. J. Biochem.
270
, 2394 (2003)
Abstract
Epigallocatechin-3-gallate, constituent of green tea, suppresses the LPS-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and NF-kappaB
:
S.C. Ahn, et al.; BBRC
313
, 148 (2004)
Abstract
Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases
:
J.F. Sah, et al.; J. Biol. Chem.
279
, 12755 (2004)
Abstract
Inhibition of c-Jun NH2-terminal kinase activity improves ischemia/reperfusion injury in rat lungs
:
M. Ishii, et al.; J. Immunol.
172
, 2569 (2004)
Abstract
A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation:
M. Lorenz, et al.; J. Biol. Chem.
279
, 6190 (2004)
Abstract
;
Full Text
Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants:
J.H. Chen, et al.; Am. J. Clin. Nutr.
80
, 742 (2004)
Abstract
;
Full Text
Neuroprotective effects of (-)-epigallocatechin gallate following hypoxia-ischemia-induced brain damage: novel mechanisms of action:
B.A. Sutherland, et al.; FASEB J.
19
, 258 (2005)
Abstract
;
Full Text
Tea flavanols inhibit angiotensin-converting enzyme activity and increase nitric oxide production in human endothelial cells:
I.A. Persson, et al.; J. Pharm. Pharmacol.
58
, 1139 (2006)
Abstract
General Literature References
Anticarcinogenic effects of (-)-epigallocatechin gallate
:
H. Fujiki, et al.; Prev. Med.
21
, 503 (1992), (Review)
Abstract
Absorption, metabolism and antioxidative effects of tea catechin in humans
:
T. Miyazawa; Biofactors
13
, 55 (2000), (Review)
Abstract
Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea
:
Y.D. Jung and L.M. Ellis; Int. J. Exp. Pathol.
82
, 309 (2001), (Review)
Abstract
Anti-invasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases
:
R. Benelli, et al.; Biol. Chem.
383
, 101 (2002), (Review)
Abstract
Further Categories Containing This Product:
Flavanols
NOS Inhibitors (NOS Induction & Enzyme Activity)
MAPK Pathway Inhibitors
Akt [PKB] / Related Products
EGFR Kinase Inhibitors
PKC Inhibitors
Telomerase / Related Products
Natural Products - Chemopreventive Agents
Fatty Acid Synthase [FAS] / Related Products
JNK [SAPK1] / Related Products
Natural Products - Protein Kinase Inhibitors
Active Substances from Fruit and Vegetables
Antitumor Agents (Enzyme Inhibitors)
Antitumor Agents (DNA Interaction & Gene Regulation)
Natural Products - Anti-inflammatory Agents
Natural Products - Antitumor Reagents
Natural Products for Angiogenesis Research
Natural Products - Nitric Oxide Pathway Modulators
Natural Products - Apoptosis Inducers & Inhibitors
Antitumor Agents (Apoptosis Inducers)
ALX-270-098
Revised 16-Nov-06
Erbstatin analog
SYNONYMS
Methyl 2,5-dihydroxycinnamate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
EGFR Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
