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ALX-450-001
Revised 23-Jul-08
A23187 (free acid)
SYNONYMS
Calcium Ionophore A23187
Calcimycin
Antibiotic A23187
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Ionophores
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-450-001-M001
1 mg
28.00 USD
ALX-450-001-M005
5 mg
65.00 USD
ALX-450-001-M010
10 mg
92.00 USD
ALX-450-001-M025
25 mg
195.00 USD
ALX-450-001-M050
50 mg
350.00 USD
ALX-450-001-5001
5x1 mg
80.00 USD
Product Specification
FORMULA:
C
29
H
37
N
3
O
6
MW:
523.6
CAS NUMBER:
52665-69-7
MERCK INDEX:
14:
1639
RTECS:
DM4676000
SOURCE/HOST:
Isolated from
Streptomyces chartreusis
.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methylene chloride; slightly soluble in water. Solubilize in DMSO or ethanol prior to preparing aqueous solutions of very low concentrations.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
In aqueous systems product may aggregate over time.
HANDLING:
Protect from light. In aqueous systems, the product aggregates over time.
HAZARD:
IRRITANT.
Product Description
Antibiotic possessing weak
in vitro
antimicrobial activity against gram positive bacteria and fungi. Divalent cation ionophore commonly used to increase intracellular Ca
2+
levels in intact cells.
Product Specific Literature References
A23187: a divalent cation ionophore:
P. W. Reed & H. A. Lardy; J. Biol. Chem.
247
, 6970 (1972)
Abstract
Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria:
D.T. Wong, et al.; Arch. Biochem. Biophys.
156
, 578 (1973)
Abstract
Biological applications of ionophores:
B.C. Pressman; Annu. Rev. Biochem.
45
, 501 (1976), (Review)
Abstract
Molecular mechanisms of endothelium-mediated vasodilation:
R.R. Fiscus; Semin. Thromb. Hemost.
14 Suppl
, 12 (1988), (Review)
Abstract
Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species: 1740, 481 (2005):
T. Przygodzki, et al.; Biochim. Biophys. Acta
1740
, 481 (2005)
Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
•
Respiratory Chain Other Products
•
Antibiotics - ATPase Inhibitors
ALX-380-075
Revised 03-Apr-08
Antimycin A
SYNONYMS
Antipiricullin
Virosin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Apoptosis Inducers & Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-380-075-M005
5 mg
20.00 USD
ALX-380-075-M010
10 mg
33.00 USD
Product Specification
CAS NUMBER:
1397-94-0
MERCK INDEX:
14:
714 (A1) & 715 (A3)
RTECS:
CD0350000
SOURCE/HOST:
Isolated from
Streptomyces sp
. Mixture of antimycin A's.
APPEARANCE:
White to faint yellow powder.
SOLUBILITY:
Soluble in 100% ethanol (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Antibiotic. Induces apoptosis, which is not prevented by the presence of Bcl-2. Inhibits mitochondrial electron transport specifically between cytochromes b and c1.
Product Specific Literature References
The isolation and properties of antimycin A:
B. R. Dunshee, et al.; J. Am. Chem. Soc.
71
, 2436 (1949)
The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity:
M.L. Campo, et al.; J. Biol. Chem.
267
, 8123 (1992)
Abstract
;
Full Text
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3:
S.P. Tzung, et al.; Nat. Cell Biol.
3
, 183 (2001)
Abstract
Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A:
K.M. Kim, et al.; Biochemistry
40
, 4911 (2001)
Abstract
Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis
:
D. Liu & Z. Huang; Apoptosis
6
, 453 (2001)
Abstract
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3:
S.P. Tzung, et al.; Nat. Cell. Biol.
3
, 183 (2001)
Abstract
Oligomycin and antimycin A prevent nitric oxide-induced apoptosis by blocking cytochrome C leakage:
N. Dairaku, et al.; J. Lab. Clin. Med.
143
, 143 (2004)
Abstract
An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis:
W.H. Park, et al.; J. Cell. Biochem.
102
, 98 (2007)
Abstract
Further Categories Containing This Product:
Bcl-2 Family Modulators
•
Respiratory Chain Other Products
ALX-380-207
Revised 03-Apr-08
Apoptolidin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Apoptosis Inducers & Inhibitors
Ordering Information
Product Numbers:
Format:
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ALX-380-207-MC01
0.1 mg
290.00 USD
Product Specification
FORMULA:
C
58
H
96
O
21
MW:
1129.4
CAS NUMBER:
194874-06-1
SOURCE/HOST:
Isolated from
Amicolatopsis
sp. MST-AS5912.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
HARMFUL.
Product Description
Originally isolated from
Nocardiopsis
sp. Antibiotic. Potent and highly selective apoptosis inducer in several cancer cell lines. F
0
F
1
-ATPase inhibitor.
Product Specific Literature References
Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp:
J.W. Kim, et al.; J. Antibiot. (Tokyo)
50
, 6628 (1997)
Abstract
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase:
A.R. Salomon, et al.; PNAS
97
, 14766 (2000)
Abstract
;
Full Text
Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase:
A.R. Salomon, et al.; Chem. Biol.
8
, 71 (2001)
Abstract
;
Full Text
Apoptolidin: induction of apoptosis by a natural product:
P.T. Daniel, et al.; Angew. Chem. Int. Ed. Engl.
45
, 872 (2006)
Abstract
Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues:
P.A. Wender, et al.; Org. Lett.
8
, 589 (2006)
Abstract
Further Categories Containing This Product:
Natural Products - ATPase Inhibitors
•
Antitumor Agents (Apoptosis Inducers)
•
Antitumor Antibiotics
•
Respiratory Chain Other Products
ALX-380-108
Revised 03-Apr-08
Atpenin A5
SYNONYMS
3-[(2
S
,4
S
,5
R
)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1
H
)-pyridinone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Antifungal
Ordering Information
Product Numbers:
Format:
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ALX-380-108-C250
250 µg
90.00 USD
Product Specification
FORMULA:
C
15
H
21
Cl
2
NO
5
MW:
366.2
CAS NUMBER:
119509-24-9
RTECS:
CJ8800000
SOURCE/HOST:
Produced by
Penicillium
sp.
PURITY:
≥85% (HPLC)
APPEARANCE:
Colorless oil.
SOLUBILITY:
Soluble in DMSO, methanol or 100% ethanol; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antibiotic. Potent and specific inhibitor of mitochondrial complex II (succinate-ubiquinone oxidoreductase).
Product Specific Literature References
Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological properties:
S. Omura, et al.; J. Antibiot.
41
, 1769 (1988)
Abstract
The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp:
H. Kumagai, et al.; J. Antibiot.
43
, 1553 (1990)
Abstract
Mechanism of action of atpenin B on Raji cells:
K. Oshino, et al.; J. Antibiot.
43
, 1064 (1990)
Abstract
Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase):
H. Miyadera, et al.; PNAS
100
, 473 (2003)
Abstract
Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction:
R. Horsefield, et al.; J. Biol. Chem.
281
, 7309 (2006)
Abstract
;
Full Text
General Information
MANUFACTURER
Fungal strain courtesy of the Kitasato Institute, Tokyo.
Further Categories Containing This Product:
Respiratory Chain Other Products
ALX-385-029
Revised 08-Apr-08
4’-Bromoflavone
SYNONYMS
4’-Bromo-2-phenylbenzopyran
4’-Bromo-2-phenyl-4
H
-1-benzopyran-4-one
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Flavonoids/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-385-029-G001
1 g
90.00 USD
Product Specification
FORMULA:
C
15
H
9
BrO
2
MW:
301.1
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
IRRITANT.
Product Description
Chemopreventive compound. Potent inducer of phase II detoxifying enzymes. Quininone reductase and glutathione S-transferase in cell culture and different tissues of rats. Aryl hydrocarbon hydroxylase inducer.
Product Specific Literature References
Simple vs. complex inheritance of inducible aryl hydrocarbon hydroxylase in mouse tissues:
K. Burki, et al.; Biochem. Genet.
13
, 417 (1975)
Abstract
Cancer chemopreventive activity mediated by 4’-bromoflavone, a potent inducer of phase II detoxification enzymes:
L.L. Song, et al.; Cancer Res.
59
, 578 (1999)
Abstract
Further Categories Containing This Product:
Respiratory Chain Other Products
•
Natural Products - Chemopreventive Agents
ALX-380-058
Revised 03-Apr-08
Citrinin
SYNONYMS
Antimycin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-380-058-M001
1 mg
15.00 USD
ALX-380-058-M005
5 mg
60.00 USD
ALX-380-058-M010
10 mg
105.00 USD
ALX-380-058-M025
25 mg
210.00 USD
Product Specification
FORMULA:
C
13
H
14
O
5
MW:
250.3
CAS NUMBER:
518-75-2
MERCK INDEX:
14:
2327
SOURCE/HOST:
Isolated from
Penicillium citrinum
.
PURITY:
≥98%
APPEARANCE:
Yellow crystals.
SOLUBILITY:
Soluble in 100% ethanol or dioxane. Insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Solutions change color with changes in pH from yellow (pH 4.6) to red (pH 9.9).
HAZARD:
TOXIC.
Product Description
Antibiotic. Induces mitochondrial permeability pore opening and inhibits respiration by interfering with complex I of the respiratory chain. Mycotoxin. Acts as nephrotoxin in all species in which it has been tested. Has been implicated as a cause of Balkan nephropathy and yellow rice fever in humans. Induces apoptosis.
Product Specific Literature References
Mechanism of citrinin-induced dysfunction of mitochondria. III. Effects on renal cortical and liver mitochondrial swelling:
G.M. Chagas, et al.; J. Appl. Toxicol.
15
, 91 (1995)
Abstract
Mycotoxins:
J.W. Bennett & M. Klich; Clin. Microbiol. Rev.
16
, 497 (2003)
Abstract
Citrinin induces apoptosis in HL-60 cells via activation of the mitochondrial pathway:
F.Y. Yu, et al.; Toxicol. Lett.
161
, 143 (2006)
Abstract
Citrinin induces apoptosis via a mitochondria-dependent pathway and inhibition of survival signals in embryonic stem cells, and causes developmental injury in blastocysts:
W.H. Chan; Biochem. J.
404
, 317 (2007)
Abstract
Further Categories Containing This Product:
Mycotoxins
•
Respiratory Chain Other Products
•
Antibiotics - Apoptosis Inducers & Inhibitors
ALX-350-335
Revised 14-Nov-07
Cochlioquinone A
SYNONYMS
Luteoleersin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
Ordering Information
Product Numbers:
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ALX-350-335-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
30
H
44
O
8
MW:
532.7
CAS NUMBER:
32450-25-2
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Shows antiangiogenic and nematocidal activities. Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of diacylglycerol acyltransferase, diacylglycerol kinase and NADH-ubiquinone reductase.
Product Specific Literature References
Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites:
J.M. Schaeffer, et al.; J. Antibiot. (Tokyo)
43
, 1179 (1990)
Abstract
Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi:
T. Fujioka, et al.; J. Antibiot. (Tokyo)
49
, 409 (1996)
Abstract
Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola:
H.J. Jung, et al.; Bioorg. Med. Chem.
11
, 4743 (2003)
Abstract
Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1:
H.B. Lee, et al.; J. Antibiot. (Tokyo)
56
, 967 (2003)
Abstract
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors/Related Products
•
Vitamins
•
NAD+ Metabolism/Related Products
ALX-350-341
Revised 14-Nov-07
Cochlioquinone B
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-350-341-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
28
H
40
O
6
MW:
472.6
CAS NUMBER:
32450-26-3
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of NADH-ubiquinone reductase. Phytotoxic agent inhibiting root growth.
Product Specific Literature References
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors/Related Products
•
Vitamins
•
NAD+ Metabolism/Related Products
ALX-350-028
Revised 21-May-08
Curcumin (high purity)
SYNONYMS
1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Diferuloylmethane
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products for Inflammation Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-028-M010
10 mg
15.00 USD
ALX-350-028-M050
50 mg
60.00 USD
ALX-350-028-M250
250 mg
240.00 USD
Product Specification
FORMULA:
C
21
H
20
O
6
MW:
368.4
CAS NUMBER:
458-37-7
MERCK INDEX:
14:
2673
SOURCE/HOST:
Isolated from turmeric (
Curcuma longa
).
PURITY:
≥98.5% (Note: This highly purified product does not contain 30-40% bioactive impurities)
APPEARANCE:
Orange-yellow crystalline powder.
SOLUBILITY:
Soluble in acetic acid or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
Product Description
Dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase. Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Antioxidant. Inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), disrupting the binding of NQO1 to wild type p53 inducing ubiquitin-independent degradation of p53 and inhibits p53-mediated apoptosis in normal thymocytes and myeloid leukemic cells.
Product Specific Literature References
Modification of certain inflammation-induced biochemical changes by curcumin:
R. Srivastava & R.C. Srimal; Indian J. Med. Res.
81
, 215 (1985)
Abstract
Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones:
D.L. Flynn, et al.; Prostagl. Leukotr. Med.
22
, 357 (1986)
Abstract
Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells:
L. Korutla & R. Kumar; Biochim. Biophys. Acta
1224
, 597 (1994)
Abstract
Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activate
