Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
> Protein Synthesis, Modification & Degradation
Autophagy / Related Products
Mono(ADP-ribosyl)transferases / Related Products
Ubiquitin & Proteasome
Posttranslational Modification
Protein Synthesis
Vesicles & Membrane Trafficking
Protein Synthesis, Modification & Degradation Other Products
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items
180-200
of 608
Page 10
of 31
Select Page:
<<
6
7
8
9
10
11
12
13
14
15
>>
ALX-210-708
Revised 30-Jun-06
Polyclonal Antibody to 14-3-3 (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
14-3-3 Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-708-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.1mg/ml
PURITY DETAIL:
Protein A-affinity purified IgG.
FORMULATION:
Liquid. In 0.05M sodium phosphate buffer containing 0.1% sodium azide and 0.2% gelatin.
IMMUNOGEN:
Synthetic peptide corresponding to aa 221-242 of 14-3-3 protein family members.
SPECIFICITY:
Recognizes human 14-3-3 protein family members.
APPLICATION:
Western Blot (2.5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Do not freeze.
General Information
General Literature References
[1]
14-3-3 proteins. Hot numbers in signal transduction:
P.D. Burbelo and A. Hall; Curr. Biol.
5
, 95 (1995)
Abstract
[2]
Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins:
D.H. Jones, et al.; FEBS Lett.
368
, 55 (1995)
Abstract
[3]
14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins:
A. Aitken, et al.; TIBS
17
, 498 (1992), (Review)
Abstract
[4]
Evolutionary conservation of the 14-3-3 protein:
G.J. Martens, et al.; BBRC
184
, 1456 (1992)
Abstract
[5]
Expression and structural analysis of 14-3-3 proteins:
D.H. Jones, et al.; D.H. Jones, et al.
245
, 375 (1995)
Abstract
[6]
Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies :
H. Martin, et al.; J. Neurochem.
63
, 2259 (1994)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-745
Revised 19-Mar-07
Polyclonal Antibody to Phosphatidylinositol-4-phosphate 5-kinase-Iγ
SYNONYMS
anti-PIP5K-Iγ PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-745-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
2mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 622-641 (A
622
SDEEDAPSTDIYFPTDERS
641
) of C-terminal mouse PIP5K-Iγ (phosphatidylinositol-4-phosphate 5-kinase-Iγ).
SPECIFICITY:
Recognizes two alternative splicing forms (87 and 90kDa) of human and mouse PIP5K-Iγ.
APPLICATION:
Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections)
Western Blot (1:1'000)
QUALITY CONTROL:
Western blot on mouse spleen and mouse brain lysates.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-032
.
Product Specific Literature References
Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family:
H. Ishihara, et al.; J. Biol. Chem.
273
, 8741 (1998)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-747
Revised 18-Sep-08
Polyclonal Antibody to Phosphoinositide 3-kinase p110δ (human)
SYNONYMS
anti-PI(3)K p110δ (human) PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphoinositide 3-kinase [PI(3)K] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-747-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1026-1044 (S
1026
WKTKVNWLAHNVSKDNRQ
1044
) of the C-terminal domain of human PI(3)K p110δ (phosphoinositide 3-kinase p110δ)
.
SPECIFICITY:
Recognizes human PI(3)K p110δ. Detects a band of ~110kDa by Western blot.
APPLICATION:
Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections)
Western Blot (1:1'000)
QUALITY CONTROL:
Western blot on human T cell line Jurkat.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-034
.
General Literature References
p110delta, a novel phosphoinositide 3-kinase in leukocytes:
B. Vanhaesebroeck, et al.; PNAS
94
, 4330 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-768
Revised 11-Apr-06
Polyclonal Antibody to p51A
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
p53 Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-768-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
2mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 424-446 (E
424
PRRETPKQSDVFFRHSKPPNRS
446
) of C-terminal human p51A.
SPECIFICITY:
Recognizes human and mouse p51A. Detects a band of ~54kDa by Western blot. Does not cross-react with p51B.
APPLICATION:
Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections)
Western Blot (1:1'000)
QUALITY CONTROL:
Western blot on mouse thymus, mouse heart and human T cell line Jurkat.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-040
.
General Information
p51 is a member of the p53 tumor suppressor gene family, which is induced by DNA damage and/or stress stimuli, causing cells to undergo G1-arrest or apoptotic death. Unlike ubiquitous expression of p53, expression of p51 is restricted to a limited number of tissues. The p51 gene encodes two major splicing variants, p51A (448 aa protein with a molecular weight of 50.9kDa) and p51B (641 aa protein with a molecular weight of 71.9kDa), a human homolog of rat Ket. p51A and p51B differ in their carboxyl-terminal structure.
BACKGROUND/TECHNICAL INFORMATION
Most of the p51A protein in Jurkat and K562 tumor cell lines is degraded.
General Literature References
Cloning and functional analysis of human p51, which structurally and functionally resembles p53:
M. Osada, et al.; Nature Med.
4
, 839 (1998)
Abstract
Human p53-p51 (p53-related) fusion protein: a potent BAX transactivator:
S. Ikawa, et al.; Jpn. J. Cancer Res.
90
, 596 (1999)
Abstract
p53 family genes: structural comparison, expression and mutation:
S. Ikawa, et al.; Cell Death Differ.
6
, 1154 (1999)
Abstract
p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression:
P. Ruiz-Lozano, et al.; Cell Growth Differ.
10
, 295 (1999)
Abstract
;
Full Text
Failure of viral oncoproteins to target the p53-homologue p51A:
J. Roth & M. Dobbelstein; J. Gen. Virol.
80
, 3251 (1999)
Abstract
;
Full Text
Mutational analysis of p51A/TAp63gamma, a p53 homolog, in non-small cell lung cancer and breast cancer
:
M. Sunahara, et al.; Oncogene
18
, 3761 (1999)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-769
Revised 11-Apr-06
Polyclonal Antibody to p51B
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
p53 Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-769-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
2mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 623-641(N
623
FDMDARRNKQQRIKEEGE
641
) of C-terminal human p51B.
SPECIFICITY:
Recognizes human and mouse p51B. Detects a band of ~75kDA by Western blot. Does not cross-react with p51A.
APPLICATION:
Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections)
Western Blot (1:1'000)
QUALITY CONTROL:
Western blot on mouse lung and human K562 cell line. As expected, some of the p51B is degraded in the tumor cell line K562.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-041
.
General Information
p51 is a member of the p53 tumor suppressor gene family, which is induced by DNA damage and/or stress stimuli, causing cells to undergo G1-arrest or apoptotic death. Unlike ubiquitous expression of p53, expression of p51 is restricted to a limited number of tissues. The p51 gene encodes two major splicing variants, p51A (448 aa protein with a molecular weight of 50.9kDa) and p51B (641 aa protein with a molecular weight of 71.9kDa), a human homolog of rat Ket. p51A and p51B differ in their carboxyl-terminal structure.
General Literature References
Cloning and functional analysis of human p51, which structurally and functionally resembles p53 :
M. Osada, et al.; Nat. Med.
4
, 839 (1998)
Abstract
Human p53-p51 (p53-related) fusion protein: a potent BAX transactivator :
S. Ikawa, et al.; Jpn. J. Cancer Res.
90
, 596 (1999)
Abstract
p53 family genes: structural comparison, expression and mutation :
S. Ikawa, et al.; Cell Death Differ.
6
, 1154 (1999)
Abstract
Failure of viral oncoproteins to target the p53-homologue p51A:
J. Roth & M. Dobbelstein; J. Gen. Virol.
80
, 3251 (1999)
Abstract
;
Full Text
p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression :
P. Ruiz-Lozano, et al.; Cell Growth Differ.
10
, 295 (1999)
Abstract
;
Full Text
Mutational analysis of p51A/TAp63gamma, a p53 homolog, in non-small cell lung cancer and breast cancer
:
M. Sunahara, et al.; Oncogene
18
, 3761 (1999)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-770
Revised 11-Apr-06
Polyclonal Antibody to pp36 (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphoinositide 3-kinase [PI(3)K] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-770-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
2mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 29-49 (C
29
HRLPGSYDSTSSDSLYPRGI
49
) of the N-terminal extracellular domain of human pp36.
SPECIFICITY:
Recognizes human pp36. Detects a band of ~40kDa by Western blot.
APPLICATION:
Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections)
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-042
.
General Information
pp36 is an adaptor protein that bridges proximal T-cell antigen receptor (TCR) signals to the activation of phosphoinositide turnover, Ras and perhaps other signaling pathways in T-cells. In natural killer cells perturbation of the low affinity Fc receptor (CD16) or the addition of target cells leads to the appearance of tyrosine phosphorylated pp36 and triggers its association with Grb2 and PLCγ-1. The amino acid sequence of human and rat pp36 also reveal potential motifs for the SH2 domains of Grb-2 and PLCγ-1, consistent with the proposed functions of pp36.
General Literature References
GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation
:
M. Sieh, et al.; Mol. Cell. Biol.
14
, 4435 (1994)
Abstract
Killer cell inhibitory receptor recognition of human leukocyte antigen (HLA) class I blocks formation of a pp36/PLC-gamma signaling complex in human natural killer (NK) cells
:
N.M. Valiante, et al.; J. Exp. Med.
184
, 2243 (1996)
Abstract
Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice K. Salojin, et al.; J. Exp. Med.
186
, 887 (1997)
Abstract
;
Full Text
CD16-mediated activation of phosphatidylinositol-3 kinase (PI-3K) in human NK cells involves tyrosine phosphorylation of Cbl and its association with Grb2, Shc, pp36 and p85 PI-3K subunit
:
C. Cerboni, et al.; Eur. J. Immunol.
28
, 1005 (1998)
Abstract
Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells
:
J.R. Weber, et al.; J. Exp. Med.
187
, 1157 (1998)
Abstract
;
Full Text
Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade
:
M.A. Purbhoo, et al.; PNAS
95
, 4527 (1998)
Abstract
;
Full Text
Further Categories Containing This Product:
Adaptor Proteins in T Cell Signal Transduction / Related Products
•
Polyclonal Antibodies
ALX-210-790
Revised 29-Sep-05
Polyclonal Antibody to SCAMP1
SYNONYMS
anti-Secretory Carrier Membrane Protein 1 PAb
PRODUCT LINE
Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY
Endocytosis
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-790-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-17 (M
1
SDFDSNPFADPDLNNP
17
C) of human SCAMP1 (secretory carrier membrane protein 1). This sequence is completely conserved in rat and pig SCAMP1.
SPECIFICITY:
Recognizes human, mouse and rat SCAMP 1. Detects a band of ~31kDa by Western blot.
APPLICATION:
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-167-026
.
Related Products
ALX-167-026
Blocking Peptide for PAb to SCAMP1 (rat) (Prod. No.
ALX-210-790
)
Further Categories Containing This Product:
Synaptic Proteins / Related Products
•
Golgi Apparatus
•
Polyclonal Antibodies
ALX-210-791
Revised 12-Jan-05
Polyclonal Antibody to VAMP-1
SYNONYMS
anti-Vesicle-associated Membrane Protein-1 PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Vesicle-associated Membrane Proteins [VAMPs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-791-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-18 (M
1
SAPAQPPAEGTEGAAPG
18
C) of rat VAMP-1 (vesicle associated membrane protein-1).
SPECIFICITY:
Recognizes human, mouse, rat and dog VAMP-1. Detects a band of ~15kDa by Western blot.
APPLICATION:
Immunoprecipitation
Western Blot (0.3µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-792
Revised 25-Feb-08
Polyclonal Antibody to VAMP-2
SYNONYMS
anti-Vesicle-associated Membrane Protein-2 PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Vesicle-associated Membrane Proteins [VAMPs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-792-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-18 (M
1
SATAATVPPAAPAGEGG
18
C) of mouse and rat VAMP-2 (vesicle-associated membrane protein-2).
SPECIFICITY:
Recognizes mouse and rat VAMP-2. Detects a band of ~19kDa by Western blot.
APPLICATION:
Immunoprecipitation
Western Blot (0.3µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-793
Revised 12-Jan-05
Polyclonal Antibody to Rab 3A
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Rab / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-793-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-18 (M
1
ASATDSRYGQKESSDQN
18
C) of human Rab 3A.
SPECIFICITY:
Recognizes human, mouse, rat, hamster and dog Rab 3A. Detects a band of ~21kDa by Western blot.
APPLICATION:
Immunoprecipitation
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Exocytosis
•
Polyclonal Antibodies
ALX-210-794
Revised 12-Jan-05
Polyclonal Antibody to Rab 3C (mouse)
