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Glutamate Receptors (Metabotropic) / Related Products
You are here: Product Lines > Neurobiology > Excitatory Amino Acids & Receptors > Glutamate Receptors (Metabotropic) / Related Products
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ALX-106-023 Revised 13-Dec-02
5-Hydroxy-L-tryptophan
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-106-023-M500   500 mg 20.00 USD Add To Cart
Product Specification
FORMULA: C11H12N2O3
MW: 220.2
CAS NUMBER: 56-69-9
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Serotonin precursor.
Further Categories Containing This Product:
Special Amino Acids • Glutamate Receptors (Metabotropic) / Related Products
 
 
ALX-106-024 Revised 14-Oct-08
O-Phospho-L-serine
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SYNONYMS L-Phosphoserine
L-Serine-O-phosphate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-106-024-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C3H8NO6P
MW: 185.1
CAS NUMBER: 407-41-0
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Store tightly sealed. Use fresh solutions.

Product Description
L-AP4 agonist. Competitive NMDA antagonist. Has affinity for type IV, but not type I, metabotropic glutamate receptor.
Product Specific Literature References
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes: W.E. Klunk, et al.; J. Neurochem. 56, 1997 (1991) Abstract
Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor: C. Thomsen & P.D. Suzdak; Neuroreport 4, 1099 (1993) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis: K. Borodezt & S.R. D'Mello; J. Neurosci. Res. 53, 531 (1998) Abstract
Further Categories Containing This Product:
Special Amino Acids • Glutamate Receptors (Metabotropic) / Related Products
 
 
ALX-550-005 Revised 16-Feb-05
trans-1,2-homo-ACPD
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SYNONYMS (±)-trans-1-Amino-1-carboxycyclopentane-2-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-005-M005   5 mg 48.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Selective antagonist for group II mGluRs.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-006 Revised 16-Feb-05
trans-1,3-homo-ACPD
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SYNONYMS (±)-trans-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-006-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.


(1R,3S)-homo-ACPD
Product Description
Equimolar mixture of (1R,3S)-homo-ACPD (Prod. No. ALX-550-008) and (1S,3R)-homo-ACPD (Prod. No. ALX-550-007). Selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-007 Revised 26-Apr-07
(1S,3R)-homo-ACPD
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SYNONYMS (1S,3R)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-007-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Active isomer of trans-1,2-homo-ACPD (Prod. No. ALX-550-006). Highly selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-008 Revised 24-Feb-05
(1R,3S)-homo-ACPD
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SYNONYMS (1R,3S)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-008-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in diluted sodium hydroxide solution.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

(1R,3S)-homo-ACPD
Product Description
Inactive isomer of trans-1,3-homo-ACPD (Prod. No. ALX-550-006).
Product Specific Literature References
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-009 Revised 24-Nov-04
cis-1,3-homo-ACPD
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SYNONYMS (±)-cis-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-009-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
Product Description
Equimolar mixture of (1R,3R)-homo-ACPD (Prod. No. ALX-550-010) and (1S,3S)-homo-ACPD (Prod. No. ALX-550-011). Selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-010 Revised 16-Feb-05
(1R,3R)-homo-ACPD
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SYNONYMS (1R,3R)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-010-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
Active isomer of cis-1,3-homo-ACPD (Prod. No. ALX-550-009) Selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-011 Revised 24-Nov-04
(1S,3S)-homo-ACPD
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SYNONYMS (1S,3S)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-011-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Isomer of cis-1,3-homo-ACPD (Prod. No. ALX-550-009). Partial agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-017 Revised 17-Jan-05
cis-ACPD
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SYNONYMS (±)-1-Aminocyclopentane-cis-1,3-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-017-M005   5 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C7H11NO4
MW: 173.2
CAS NUMBER: 39026-63-6
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

(1S,3S)-ACPD
(1R,3R)-ACPD
Product Description
Potent NMDA agonist. Equimolar mixture of (1R,3R)-ACPD (Prod. No. ALX-550-018) and (1S,3S)-ACPD (Prod. No. ALX-550-019).
Product Specific Literature References
Receptors for the excitatory amino acids in the mammalian central nervous system: H. McLennan; Prog. Neurobiol. 20, 251 (1983) Abstract
Structure/activity relations of N-methyl-D-aspartate receptor ligands as studied by their inhibition of [3H]D-2-amino-5-phosphonopentanoic acid binding in rat brain membranes: H.J. Olverman, et al.; Neuroscience 26, 17 (1988) Abstract
In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects: D.D. Schoepp, et al.; J. Neurochem. 56, 1789 (1991) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • Excitatory Amino Acids
 
 
ALX-550-018 Revised 03-Mar-05
(1R,3R)-ACPD
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SYNONYMS (1R,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-018-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C7H11NO4
MW: 173.2
CAS NUMBER: 111900-33-5
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

(1R,3R)-ACPD
Product Description
Active isomer of cis-ACPD (Prod. No. ALX-550-017). Potent and specific NMDA receptor agonist.
Product Specific Literature References
Receptors for the excitatory amino acids in the mammalian central nervous system: H. McLennan; Prog. Neurobiol. 20, 251 (1983) Abstract
Synthesis, resolution, and absolute configuration of the isomers of the neuronal excitant 1-amino-1,3-cyclopentanedicarboxylic acid: K. Curry, et al.; J. Med. Chem. 31, 864 (1988) Abstract
Differences in agonist and antagonist activities for two indices of metabotropic glutamate receptor-stimulated phosphoinositide turnover: R. Mistry & R.A. Challiss; Br. J. Pharmacol. 117, 1735 (1996) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • Excitatory Amino Acids
 
 
ALX-550-020 Revised 11-Mar-08
trans-ACPD
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SYNONYMS (±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid