ALEXIS Biochemicals: 4’-Bromoflavone

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Anthocyanidins

Chalcones

Polyphenols Other Products

ALX-385-008

Revised 13-Mar-08

Apigenin
SYNONYMS	4',5,7-Trihydroxyflavone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavones

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-008-M010		10 mg	35.00 USD
ALX-385-008-M050		50 mg	105.00 USD

Product Specification

FORMULA:	C₁₅H₁₀O₅
MW:	270.2
CAS NUMBER:	520-36-5
MERCK INDEX:	14: 730
SOURCE/HOST:	Synthetic.
PURITY:	≥90% (HPLC)
APPEARANCE:	Light yellow to slightly brown powder.
SOLUBILITY:	Soluble in diluted potassium hydroxide or DMSO; slightly soluble in 100% ethanol (hot). Insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	IRRITANT.

Product Description

Antioxidant flavonoid. Has chemopreventive and antitumor properties. Induces apoptosis. Inhibits the proliferation of malignant tumor cells by G2/M arrest. MAP kinase (MAPK/ERK) inhibitor. Inhibits hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression.

Product Specific Literature References

Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells: C. Chaumontet, et al.; Carcinogenesis 15, 2325 (1994) Abstract
Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells: F. Sato, et al.; BBRC 204, 578 (1994) Abstract
Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes: M.L. Kuo and N.C. Yang; BBRC 212, 767 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression: V. Trochon, et al.; Int. J. Cancer 85, 691 (2000) Abstract
Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma: R. Torkin, et al.; Mol. Cancer Ther. 4, 1 (2005) Abstract
Apigenin and cancer chemoprevention: progress, potential and promise: D. Patel, et al.; Int. J. Oncol. 30, 233 (2007), (Review) Abstract
Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression: J. Fang, et al.; Carcinogenesis 28, 858 (2007) Abstract
Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells: S. Shukla & S. Gupta; Cell Cycle 6, 1102 (2007) Abstract
Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation: C. Nicholas, et al.; J. Immunol. 179, 7121 (2007) Abstract

Further Categories Containing This Product:

MAPK Pathway Inhibitors • Hypoxia-inducible Factor [HIF] / Related Products • Natural Products - Protein Kinase Inhibitors • VEGFs & VEGF-Rs Other Products • Natural Products for Angiogenesis Research • Natural Products - Chemopreventive Agents • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Apoptosis Inducers & Inhibitors • Antitumor Agents (Anti-proliferative) • Natural Products - Antitumor Reagents • Natural Products - Antioxidants

ALX-385-009

Revised 03-Apr-08

Chrysin
SYNONYMS	5,7-Dihydroxyflavone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavones

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-009-G001		1 g	15.00 USD

Product Specification

FORMULA:	C₁₅H₁₀O₄
MW:	254.2
CAS NUMBER:	480-40-0
MERCK INDEX:	14: 2256
RTECS:	LK8329050
PURITY:	≥96%
APPEARANCE:	Yellow to tan solid.
SOLUBILITY:	Soluble in pyridine or alkaline solutions; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Antioxidant flavonoid. Shows anti-inflammatory and antitumor properties. Inhibits hypoxia-inducible factor-1α (HIF-1α). Induces apoptosis.

Product Specific Literature References

Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells: K.J. Woo, et al.; Biochem. Biophys. Res. Commun. 325, 1215 (2004) Abstract
Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase: M.S. Weng, et al.; Biochem. Pharmacol. 69, 1815 (2005) Abstract
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism:: Y.J. Moon, et al.; Toxicol. In Vitro 20, 187 (2006), (Review) Abstract
Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis: B. Fu, et al.; Mol. Cancer Ther. 6, 220 (2007) Abstract

Further Categories Containing This Product:

Hypoxia-inducible Factor [HIF] / Related Products • Natural Products - Anti-inflammatory Agents • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antitumor Reagents • Natural Products - Antioxidants

ALX-385-010

Revised 08-Apr-08

(±)-Naringenin
SYNONYMS	(±)-4',5,7-Trihydroxyflavanone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavanones

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-010-G001		1 g	15.00 USD

Product Specification

FORMULA:	C₁₅H₁₂O₅
MW:	272.3
CAS NUMBER:	67604-48-2
MERCK INDEX:	14: 6424
PURITY:	≥95%
APPEARANCE:	Light yellow to tan powder.
SOLUBILITY:	Soluble in 100% ethanol; almost insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.

Product Description

Antioxidant flavonoid. Has anti-inflammatory and antitumor properties. Induces apoptosis. Stimulates DNA repair following oxidative damage. Inhibits the activity of phosphoinositide 3-kinase (PI(3)K).

Product Specific Literature References

Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Naringenin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes: A. W. Harmon & Y. M. Patel; BBRC 305, 229 (2003) Abstract
The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells: K. Gao, et al.; J. Nutr. Biochem. 17, 89 (2006) Abstract
Naringenin-induced apoptosis via activation of NF-kappaB and necrosis involving the loss of ATP in human promyeloleukemia HL-60 cells: S. Kanno, et al.; Toxicol. Lett. 166, 131 (2006) Abstract
Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages: S. Hirai, et al.; Life Sci. 81, 1272 (2007) Abstract

Further Categories Containing This Product:

Natural Products - Other Signal Transduction Pathway Modulators • Active Substances from Fruit and Vegetables • Phosphoinositide 3-kinase [PI(3)K] / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Anti-inflammatory Agents • Natural Products - Antitumor Reagents • Natural Products - Antioxidants • DNA Repair Other Products

ALX-385-011

Revised 05-Apr-08

(±)-Hesperetin
SYNONYMS	(±)-3',5,7-Trihydroxy-4'-methoxyflavanone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavanones

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-011-G001		1 g	21.00 USD

Product Specification

FORMULA:	C₁₆H₁₄O₆
MW:	302.3
CAS NUMBER:	520-33-2
MERCK INDEX:	14: 4670
PURITY:	≥95% (HPLC)
APPEARANCE:	Off-white to yellow powder.
SOLUBILITY:	Soluble in 100% ethanol; slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. Suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.

Product Specific Literature References

Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats: H. K. Kim, et al.; Clin. Chim. Acta 327, 129 (2003) Abstract
Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin: J. Cho; Arch. Pharm. Res. 29, 699 (2006) Abstract
Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin: J. Y. Kim, et al.; Aging Cell 5, 401 (2006) Abstract
Hesperetin Induced G1-Phase Cell Cycle Arrest in Human Breast Cancer MCF-7 Cells: Involvement of CDK4 and p21: E.J. Choi; Nutr. Cancer 59, 115 (2007) Abstract

Further Categories Containing This Product:

Cell Cycle Blockers & Inhibitors / Related Products • Active Substances from Fruit and Vegetables • NF-kB Pathway Inhibitors • Natural Products - Antioxidants • Natural Products - Anti-inflammatory Agents • Natural Products - NF-kB Pathway Inhibitors

ALX-385-012

Revised 19-Nov-07

Myricetin
SYNONYMS	3,3',4',5,5',7-Hexahydroxyflavone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavonols

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-012-M010		10 mg	35.00 USD
ALX-385-012-M050		50 mg	140.00 USD

Product Specification

FORMULA:	C₁₅H₁₀O₈
MW:	318.2
CAS NUMBER:	529-44-2
MERCK INDEX:	14: 6332
RTECS:	LK8646000
PURITY:	≥97%
APPEARANCE:	Light yellow-green crystals.
SOLUBILITY:	Soluble in alcohol; slightly soluble in water (warm); insoluble in acetic acid.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HANDLING:	Protect from light.

Product Description

Antioxidant flavonoid. Has antitumor and chemopreventive properties. Anti-inflammatory. Inhibits NF-κB activation.

Product Specific Literature References

Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Biological effects of myricetin: K. C. Ong & H. E. Khoo; Gen. Pharmacol. 29, 121 (1997), (Review) Abstract
In vitro cytotoxicity of glyco-S-nitrosothiols. a novel class of nitric oxide donors: H. Babich & H.L. Zuckerbraun; Toxicol. In Vitro 15, 181 (2001) Abstract
Suppression of TNFalpha-mediated NFkappaB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells: S. H. Tsai, et al.; J. Cell Biochem. 74, 606 (1999) Abstract
Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells: C.H. Ko, et al.; Mol. Cancer Ther. 4, 281 (2005) Abstract
Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade: C.H. Ko, et al.; Biochem. Pharmacol. 69, 913 (2005) Abstract
Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity: J. Lu, et al.; Cancer Res. 66, 4410 (2006) Abstract
Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1: K.W. Lee, et al.; Carcinogenesis 28, 1918 (2007) Abstract

Further Categories Containing This Product:

Active Substances from Fruit and Vegetables • NF-kB Pathway Inhibitors • Natural Products - Chemopreventive Agents • Natural Products - Antitumor Reagents • Natural Products - Antioxidants • Natural Products - Anti-inflammatory Agents • Natural Products - NF-kB Pathway Inhibitors

ALX-385-013

Revised 16-Jun-08

Malvidin chloride
SYNONYMS	3,4',5,7-Tetrahydroxy-3',5'-dimethoxyflavylium chloride
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Anthocyanidins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-013-M010		10 mg	260.00 USD

Product Specification

FORMULA:	C₁₇H₁₅O₇Cl
MW:	366.8
CAS NUMBER:	643-84-5
MERCK INDEX:	14: 5715
RTECS:	LK9900000
PURITY:	≥97%
APPEARANCE:	Reddish brown to black powder.
SOLUBILITY:	Soluble in 100% ethanol; slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light. Hygroscopic.

Product Description

Antioxidant flavonoid. Antitumor compound. Induces cell cycle arrest in the G2/M-phase.

Product Specific Literature References

Further Categories Containing This Product:

Active Substances from Fruit and Vegetables • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products - Antitumor Reagents • Natural Products - Antioxidants • Natural Products for Cell Cycle Research

ALX-385-014

Revised 19-Nov-07

Pelargonidin chloride
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Anthocyanidins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-014-M005		5 mg	135.00 USD

Product Specification

FORMULA:	C₁₅H₁₁O₅Cl
MW:	306.7
CAS NUMBER:	134-04-3
MERCK INDEX:	14: 7071
PURITY:	≥97% (HPLC)
APPEARANCE:	Red to brown solid.
SOLUBILITY:	Soluble in 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Antioxidant flavonoid. Nitric oxide scavenger.

Product Specific Literature References

Flavonoids as scavengers of nitric oxide radical: S.A.B.E. Acker, et al.; BBRC 214, 755 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin: Y. Noda, et al.; J. Agric. Food Chem. 50, 166 (2002) Abstract
Antigenotoxic effects of the phytoestrogen pelargonidin chloride and the polyphenol chlorogenic acid: S.K. Abraham, et al.; Mol. Nutr. Food Res. 51, 880 (2007) Abstract

Further Categories Containing This Product:

Nitric Oxide Scavengers • Active Substances from Fruit and Vegetables • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Antioxidants

ALX-385-015

Revised 12-Aug-08

Peonidin chloride
SYNONYMS	3,4',5,7-Tetrahydroxy-3'-methoxyflavylium chloride
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Anthocyanidins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-015-M005		5 mg	280.00 USD

Product Specification

FORMULA:	C₁₆H₁₃O₆Cl
MW:	336.7
CAS NUMBER:	134-01-0
MERCK INDEX:	14: 7143
PURITY:	≥99% (HPLC)
APPEARANCE:	Beige to reddish-brown solid.
SOLUBILITY:	Soluble in 100% ethanol or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.

Product Description

Antioxidant flavonoid. Shows anti-inflammatory and chemopreventive properties.

Product Specific Literature References

Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Peonidin inhibits phorbol-ester-induced COX-2 expression and transformation in JB6 P+ cells by blocking phosphorylation of ERK-1 and -2: J.Y. Kwon, et al.; Ann. N. Y. Acad. Sci. 1095, 513 (2007) Abstract

Further Categories Containing This Product:

Natural Products - Chemopreventive Agents • Natural Products - Antioxidants • Natural Products - Anti-inflammatory Agents

ALX-385-016

Revised 02-Jun-08

Morin
SYNONYMS	2’,3,4’,5,7-Pentahydroxyflavone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavonols

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-016-G001		1 g	16.00 USD

Product Specification

FORMULA:	C₁₅H₁₀O₇
MW:	302.2
CAS NUMBER:	480-16-0
MERCK INDEX:	14: 6269
RTECS:	LK8749000
PURITY:	≥85%
APPEARANCE:	White to brown powder.
SOLUBILITY:	Soluble in methanol or 100% ethanol; slightly soluble in ether or acetic acid.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	IRRITANT.

Product Description

Antioxidant flavonoid. Shows anti-proliferative and antitumor properties. Induces apoptosis. Induces cell cycle arrest at the G2/M phase. Anti-inflammatory compound. Suppresses NF-κB activation. Induces lipid peroxidation and DNA strand breaks.

Product Specific Literature References

Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Lipid peroxidation and DNA damage induced by morin and naringenin in isolated rat liver nuclei: S. C. Sahu & G. C. Gray; Food Chem. Toxicol. 35, 443 (1997) Abstract
Morin inhibits the growth of human leukemia HL-60 cells via cell cycle arrest and induction of apoptosis through mitochondria dependent pathway: H.M. Kuo, et al.; Anticancer Res. 27, 395 (2007) Abstract
Morin (3,5,7,2’,4’-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosi: S.K. Manna, et al.; Clin. Cancer Res. 13, 2290 (2007) Abstract

Further Categories Containing This Product:

NF-kB Pathway Inhibitors • Natural Products - Anti-inflammatory Agents • Antitumor Agents (Anti-proliferative) • Natural Products - NF-kB Pathway Inhibitors