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ALX-450-001
Revised 23-Jul-08
A23187 (free acid)
SYNONYMS
Calcium Ionophore A23187
Calcimycin
Antibiotic A23187
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Ionophores
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-450-001-M001
1 mg
28.00 USD
ALX-450-001-M005
5 mg
65.00 USD
ALX-450-001-5001
5x1 mg
80.00 USD
ALX-450-001-M010
10 mg
92.00 USD
ALX-450-001-M025
25 mg
195.00 USD
ALX-450-001-M050
50 mg
350.00 USD
Product Specification
FORMULA:
C
29
H
37
N
3
O
6
MW:
523.6
CAS NUMBER:
52665-69-7
MERCK INDEX:
14:
1639
RTECS:
DM4676000
SOURCE/HOST:
Isolated from
Streptomyces chartreusis
.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methylene chloride; slightly soluble in water. Solubilize in DMSO or ethanol prior to preparing aqueous solutions of very low concentrations.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
In aqueous systems product may aggregate over time.
HANDLING:
Protect from light. In aqueous systems, the product aggregates over time.
HAZARD:
IRRITANT.
Product Description
Antibiotic possessing weak
in vitro
antimicrobial activity against gram positive bacteria and fungi. Divalent cation ionophore commonly used to increase intracellular Ca
2+
levels in intact cells.
Product Specific Literature References
A23187: a divalent cation ionophore:
P. W. Reed & H. A. Lardy; J. Biol. Chem.
247
, 6970 (1972)
Abstract
Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria:
D.T. Wong, et al.; Arch. Biochem. Biophys.
156
, 578 (1973)
Abstract
Biological applications of ionophores:
B.C. Pressman; Annu. Rev. Biochem.
45
, 501 (1976), (Review)
Abstract
Molecular mechanisms of endothelium-mediated vasodilation:
R.R. Fiscus; Semin. Thromb. Hemost.
14 Suppl
, 12 (1988), (Review)
Abstract
Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species: 1740, 481 (2005):
T. Przygodzki, et al.; Biochim. Biophys. Acta
1740
, 481 (2005)
Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
•
Respiratory Chain Other Products
•
Antibiotics - ATPase Inhibitors
ALX-430-021
Revised 17-Jan-05
N-Acetyl-N-acetoxy-4-chlorobenzenesulphonamide
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
Nitric Oxide Pathway Other Products
Ordering Information
Product Numbers:
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ALX-430-021-M005
5 mg
40.00 USD
Product Specification
FORMULA:
C
10
H
10
ClNO
5
S
MW:
291.7
PURITY:
≥98%
APPEARANCE:
White crystals.
SOLUBILITY:
Soluble in DMSO or DMF; slightly soluble in methanol; not soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Nitroxyl (HNO) releasing compound in neutral solution. Release of nitric oxide was not detected. Potent vasorelaxant. Powerful inhibitor of aldehyde dehydrogenase.
Product Specific Literature References
Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase:
M.J.C. Lee, et al.; J. Med. Chem.
35
, 3648 (1992)
Abstract
N,O-diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties:
J.M. Fukuto, et al.; BBRC
187
, 1367 (1992)
Abstract
ALX-480-001
Revised 13-Jul-06
Adenosine 5'-diphosphate . disodium salt
SYNONYMS
ADP . 2Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
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ALX-480-001-G001
1 g
45.00 USD
ALX-480-001-G005
5 g
160.00 USD
Product Specification
FORMULA:
C
10
H
13
N
5
O
10
P
2
. 2Na
MW:
471.2 . 46.0
CAS NUMBER:
16178-48-6
MERCK INDEX:
14:
154
SOURCE/HOST:
Isolated from yeast.
PURITY:
≥
95%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Slight degradation to AMP may occur during storage.
HANDLING:
Protect from moisture.
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
ALX-480-002
Revised 12-Apr-07
Adenosine 5'-diphosphate . potassium salt
SYNONYMS
ADP . K
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-480-002-G001
1 g
45.00 USD
ALX-480-002-G005
5 g
180.00 USD
Product Specification
FORMULA:
C
10
H
14
N
5
O
10
P
2
. K
MW:
426.2 . 39.1
CAS NUMBER:
72696-48-1
MERCK INDEX:
14:
154
SOURCE/HOST:
Isolated from yeast.
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Slight degradation to AMP may occur during prolonged storage.
HANDLING:
Protect from moisture.
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
ALX-340-004
Revised 18-Aug-08
Arachidonic acid
SYNONYMS
5Z,8Z,11Z,14Z-Eicosatetraenoic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Arachidonic Acid / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-340-004-M100
100 mg
147.00 USD
Product Specification
FORMULA:
C
20
H
32
O
2
MW:
304.5
CAS NUMBER:
506-32-1
MERCK INDEX:
14:
765
RTECS:
CE6675000
CONCENTRATION:
100mg/ml
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol containing 0.1% BHT.
SOLUBILITY:
100mg/ml soluble in DMSO or dimethyl formamide; sparingly soluble in basic aqueous buffers (1.7mg/ml). To prevent oxidation, the solvent should be purged with an inert gas.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C. Keep aqueous solutions on ice and use within 12 hours.
HANDLING:
Protect from light and oxygen.
HAZARD:
TOXIC.
Product Description
Precursor to a large family of eicosanoids. Activator for several protein kinase C (PKC) isotypes.
Product Specific Literature References
Arachidonic acid metabolism:
P. Needleman, et al.; Ann. Rev. Biochem.
55
, 69 (1986)
Abstract
Kinetic analysis of the Ca2+-dependent, membrane-bound, macrophage phospholipase A2 and the effects of arachidonic acid:
M.D. Lister, et al.; J. Biol. Chem.
263
, 7506 (1988)
Abstract
;
Full Text
Characterization of the L-arginine:nitric oxide pathway in human platelets:
M.W. Radomski, et al.; Br. J. Pharmacol.
101
, 325 (1990)
Abstract
The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet-derived growth factor:
A.J.R. Habenicht, et al.; Nature
345
, 634 (1990)
Abstract
The control of free arachidonic acid levels:
R.D. Burgoyne & A. Morgan; TIBS
15
, 365 (1990)
Abstract
A unique pool of free arachidonate serves as substrate for both cyclooxygenase and lipoxygenase in platelets:
F. Chevy, et al.; Lipids
26
, 1080 (1991)
Abstract
Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids:
J.W. Han, et al.; Science
252
, 576 (1991)
Abstract
Arachidonic acid as a second messenger. Interactions with a GTP-binding protein of human neutrophils:
S.B. Abramson, et al.; J. Immunol.
147
, 231 (1991)
Abstract
The immediate activator of the NADPH oxidase is arachidonate not phosphorylation:
Henderson, et al.; Eur. J. Biochem.
211
, 157 (1993)
Abstract
Nitric oxide and arachidonic acid modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia:
G. Khurana & M.R. Bennett; Br. J. Pharmacol.
109
, 480 (1993)
Abstract
Arachidonic acid-induced Ca2+ release from isolated sarcoplasmic reticulum:
C. Dettbarn & P. Palade; Biochem. Pharmacol.
45
, 1301 (1993)
Abstract
Covalent binding of arachidonate to G protein alpha subunits of human platelets:
H. Hallak, et al.; J. Biol. Chem.
269
, 4713 (1994)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PKC Activators
•
Nitric Oxide Pathway Other Products
•
Fatty Acids
ALX-440-008
Revised 30-Oct-06
L-Biopterin
SYNONYMS
6-Biopterin
2-Amino-6-[(1
R
,2
S
)-1,2-dihydroxypropyl]-4(1
H
)-pteridinone
2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine
L-
erythro
-6-(1,2-Dihydroxypropyl)pterin
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
Nitric Oxide Pathway Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-440-008-M025
25 mg
90.00 USD
ALX-440-008-M100
100 mg
270.00 USD
Product Specification
FORMULA:
C
9
H
11
N
5
O
3
MW:
237.2
CAS NUMBER:
22150-76-1
MERCK INDEX:
14:
1229
RTECS:
UO3506000
PURITY:
≥98%
APPEARANCE:
White to pale yellow powder.
SOLUBILITY:
Soluble in 1 N sodium hydroxide or 1N hydrogen chloride; very slightly soluble in water (0.7mg/ml) (ultrasonication). To obtain concentrated solutions, ammonium hydroxide should be added.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 2 years after receipt when stored at -20°C.
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
ALX-202-034
Revised 13-Dec-04
Calcineurin (bovine brain)
SYNONYMS
Calmodulin Binding Protein (bovine brain)
Protein Phosphatase 2B (bovine brain)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PP2B [Calcineurin] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-202-034-U100
100 U
590.00 USD
Product Specification
CAS NUMBER:
9025-75-6
EC:
3.1.3.16
MERCK INDEX:
14:
1640
SOURCE/HOST:
Isolated from bovine brain.
FORMULATION:
Lyophilized powder containing ~1% protein (Lowry) and 0.5% EGTA, buffer salts and stabilizers.
SPECIFIC ACTIVITY:
~2'500-5'000U/mg protein. One unit causes a 50% inhibition of the activated phosphodiesterase activity when assayed with 2 units of activator and 0.1mM Ca
2+
in an enzyme coupled system at 30°C, pH 7.5.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Enzymes
•
Natural Proteins
•
Nitric Oxide Pathway Other Products
ALX-200-089
Revised 18-Mar-08
Ceruloplasmin (human)
SYNONYMS
Ferroxidase (human)
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
Nitric Oxide Pathway Other Products
Ordering Information
Product Numbers:
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ALX-200-089-M001
1 mg
210.00 USD
Product Specification
MW:
~134kDa
CAS NUMBER:
9031-37-2
EC:
1.16.3.1
MERCK INDEX:
14:
2006
SOURCE/HOST:
Isolated from human plasma.
CONCENTRATION:
1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Plasma has been tested negative for HBsAg and for antibodies to HIV and HCV.
FORMULATION:
Lyophilized from 50mM potassium phosphate, pH 6.8, containing 100mM potassium chloride, 20mM ε-aminocaproic acid and 5mM EDTA.
RECONSTITUTION:
Reconstitute with water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Description
Serum copper transport and iron-oxidizing protein. Expressed in plasma at concentrations of 1-5µM. Contains six copper centers and is known to oxidize amines in a process coupled to the reduction of molecular oxygen. Has ferroxidase activity that is responsible for the oxidation of ferrous iron to its ferric form, which is necessary for efficient iron efflux from the cell (e.g. during hypoxia). Has previously been considered a target for nitric oxide (NO) and an inhibitor of endothelial nitric oxide synthase (eNOS/NOS III). Catalyzes S-nitrosothiol formation in cell culture media. Is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis.
Product Specific Literature References
The reaction of nitric oxide with ceruloplasmin:
R. Wever, et al.; Biochim. Biophys. Acta
302
, 236 (1973)
Abstract
Copper transport: an overview:
E.D. Harris; Proc. Soc. Exp. Biol. Med.
196
, 130 (1991)
Abstract
Ceruloplasmin inhibits carbonyl formation in endogenous cell proteins:
J.A. Krsek-Staples & R.O. Webster; Free Radic. Biol. Med.
14
, 115 (1993)
Abstract
Antioxidant protection against organic and inorganic oxygen radicals by normal human plasma: the important primary role for iron-binding and iron-oxidising proteins:
J.M. Gutteridge & G.J. Quinlan; Biochim. Biophys. Acta
1156
, 144 (1993)
Abstract
Inhibition of endothelial nitric-oxide synthase by ceruloplasmin:
A. Bianchini, et al.; J. Biol. Chem.
274
, 20265 (1999)
Abstract
;
Full Text
The reactions of copper proteins with nitric oxide:
J. Torres and M.T. Wilson; Biochim. Biophys. Acta
1411
, 310 (1999)
Abstract
Role of ceruloplasmin in macrophage iron efflux during hypoxia:
J. Sarkar, et al.; J. Biol. Chem.
278
, 44018 (2003)
Abstract
;
Full Text
Does oxidative stress change ceruloplasmin from a protective to a vasculopathic factor?:
N. Shukla, et al.; Atherosclerosis
187
, 238 (2006)
Abstract
Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis:
S. Shiva, et al.; Nat. Chem. Biol.
2
, 486 (2006)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P00450:
Ceruloplasmin (human) [Precursor]
Further Categories Containing This Product:
Natural Proteins
•
Serum Proteins Other Products
ALX-370-007
Revised 09-Sep-08
Corticosterone
SYNONYMS
(11β)-11,21-Dihydroxypregn-4-ene-3,20-dione
Reichstein's Substance H
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Glucocorticoids & Glucocorticoid Receptors / Related Products
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ALX-370-007-M050
50 mg
18.00 USD
Product Specification
FORMULA:
C
21
H
30
O
4
MW:
346.5
CAS NUMBER:
50-22-6
MERCK INDEX:
14:
2538
RTECS:
GM7650000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to light yellow solid.
SOLUBILITY:
Soluble in 100% ethanol (50mg/ml) or dioxane (20mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
MAY BE TERATOGENIC. IRRITANT.
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products
•
Nitric Oxide Pathway Other Products
ALX-440-009
Revised 20-Nov-06
7,8-Dihydro-L-biopterin
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
Nitric Oxide Pathway Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-440-009-M010
10 mg
38.00 USD
ALX-440-009-M050
50 mg
152.00 USD
Product Specification
FORMULA:
C
9
H
13
N
5
O
3
MW:
239.2
CAS NUMBER:
6779-87-9
PURITY:
≥98%
APPEARANCE:
Light yellow powder.
SOLUBILITY:
Slightly soluble in water (2mg/ml, 22°C, ultrasonication).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Solutions should be prepared by oxygen free water and stored at -20°C immediately. Product is unstable in acidic solutions.
HANDLING:
Hygroscopic.
ALX-400-023
Revised 19-Apr-06
Gadolinium (III) chloride . hexahydrate
