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Items 18 of 18
ALX-270-449 Revised 20-Mar-07
2-Amino-4-methylpyridine
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SYNONYMS 2-Amino-4-picoline
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-270-449-G001   1 g 20.00 USD Add To Cart
Product Specification
FORMULA: C6H8N2
MW: 108.1
CAS NUMBER: 695-34-1
MERCK INDEX: 14: 466
RTECS: TJ5150000
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethylformamide or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 3 years after receipt when stored at -20°C.
HAZARD: TOXIC.

Product Description

Potent inhibitor of inducible nitric oxide synthase (iNOS; NOS II) both in vitro and in vivo. Analgesic agent.
Product Specific Literature References
2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo: W.S. Faraci, et al.; Br. J. Pharmacol. 119, 1101 (1996) Abstract
Analgesic activity of 2-amino-4-methylpyridine, a novel NO synthase inhibitor: E.R. Pettipher, et al.; Inflamm. Res. 46 Suppl 2, S135 (1997) Abstract
Inhibition of nitric oxide synthase aggravates cisplatin-induced nephrotoxicity: effect of 2-amino-4-methylpyridine: S.Y. Saad, et al.; Chemotherapy 48, 309 (2002) Abstract
Further Categories Containing This Product:
Analgesic / Anti-nociceptive Agents / Related Products
 
 
ALX-340-042 Revised 07-Jan-06
Arvanil
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SYNONYMS N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cannabinoid Receptor Agonists & Antagonists / Related Products
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ALX-340-042-M005   5 mg 25.00 USD Add To Cart
Product Specification
FORMULA: C28H41NO3
MW: 439.6
CAS NUMBER: 128007-31-8
PURITY: ≥98%
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep cool and dry.

Product Description
"Hybrid" activator of CB1 receptor (CB1: Ki=0.5µM; CB2: Ki=>15µM) and TRPV1 (Ki=0.3µM). Also inhibits anandamide uptake (IC50=3.6µM) and fatty acid amide hydrolase (FAAH) (IC50=3µM). Analgesic, vasodilatory and anti-inflammatory in vivo. Apoptosis inducer.
Product Specific Literature References
Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors: D. Melck, et al.; BBRC 262, 275 (1999) Abstract
Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide: V. Di Marzo, et al.; Eur. J. Pharmacol. 406, 363 (2000) Abstract
A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid: V. Di Marzo, et al.; J. Pharmacol. Exp. Ther. 300, 984 (2002) Abstract
The CB1/VR1 agonist arvanil induces apoptosis through an FADD/caspase-8-dependent pathway: R. Sancho, et al.; Br. J. Pharmacol. 140, 1035 (2003) Abstract
Evidence against the presence of an anandamide transporter: S.T. Glaser, et al.; PNAS 100, 4269 (2003) Abstract
Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease: E. de Lago, et al.; Brain Res. 1050, 210 (2005) Abstract
Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis: A.M. Malfitano, et al.; J. Neuroimmunol. 171, 110 (2006) Abstract
Further Categories Containing This Product:
Anandamide Uptake Inhibitors • Apoptosis Inducers & Inhibitors Other Products • TRPV1 Agonists and Antagonists / Related Products • Analgesic / Anti-nociceptive Agents / Related Products • Anti-inflammatory Agents Other Products • Fatty Acid Amide Hydrolase [FAAH] / Related Products
 
 
ALX-550-084 Revised 13-Dec-04
Carbamazepine
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SYNONYMS 5H-Dibenz[b,f]azepine-5-carboxamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Benzodiazepines / Related Products
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ALX-550-084-G001   1 g 10.00 USD Add To Cart
ALX-550-084-G005   5 g 30.00 USD Add To Cart
Product Specification
FORMULA: C15H12N2O
MW: 236.3
CAS NUMBER: 298-46-4
MERCK INDEX: 14: 1781
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in ethanol. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Anticonvulsant and analgesic.
Further Categories Containing This Product:
Analgesic / Anti-nociceptive Agents / Related Products • Autophagy Other Products
 
 
ALX-350-353 Revised 16-Jun-08
Chlorogenic acid
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SYNONYMS 1,3,4,5-Tetrahydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate)
3-O-Caffeoylquinic acid
Heriguard
NSC 407296
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Chemopreventive Agents
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ALX-350-353-M500   500 mg 35.00 USD Add To Cart
ALX-350-353-G001   1 g 65.00 USD Add To Cart
Product Specification
FORMULA: C16H18O9
MW: 354.3
CAS NUMBER: 327-97-9
MERCK INDEX: 14: 2142
RTECS: GU8480000
SOURCE/HOST: Isolated from the leaves and fruits of dicotyledonous plants (e.g. coffee beans).
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: 25mg/ml soluble in 100% ethanol, DMSO, dimethyl formamide or PBS (pH 7.2).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: We do not recommend storing the aqueous solution for more than one day.

Product Description
Analog of caffeic acid (Prod. No. ALX-270-231). Shows antioxidant, analgesic, antipyretic and chemopreventive activity. Inhibits Bcr-Abl tyrosine kinase and triggers MAP kinases p38-dependent apoptosis. Inhibitor of the tumor promoting activity of phorbol esters.
Product Specific Literature References
[Chlorogenic acid in coffee beans and their change during the roasting process. Report 1. Qualitative studies]: R. Krasemann; Arch. Pharm. 293, 721 (1960) Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes: Y. Kimura, et al.; J. Nat. Prod. 50, 392 (1987) Abstract
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate: M.T. Huang, et al.; Cancer Res. 48, 5941 (1988) Abstract; Full Text
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin: A.H. Conney, et al.; Adv. Enzyme Regul. 31, 385 (1991) Abstract
Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells: G. Bandyopadhyay, et al.; Blood 104, 2514 (2004) Abstract; Full Text
Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid: R. Feng, et al.; J. Biol. Chem. 280, 27888 (2005) Abstract; Full Text
The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression: A. Belkaid, et al.; Cancer Cell Int. 6, 7 (2006) Abstract; Full Text
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid: M.D. dos Santos, et al.; Biol. Pharm. Bull. 29, 2236 (2006) Abstract; Full Text
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols: W.J. Lee & B.T. Zhu; Carcinogenesis 27, 269 (2006) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • MAPK Pathway Activators • Tyrosine Kinase Inhibitors • Natural Products - Protein Kinase Inhibitors • Natural Products - Antioxidants • Natural Products for Neurological Research • Natural Products - Apoptosis Inducers & Inhibitors • Analgesic / Anti-nociceptive Agents / Related Products • Phenolic Acids
 
 
ALX-550-345 Revised 20-Nov-02
(-)-Eseroline . fumarate
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Acetylcholine Esterase / Related Products
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ALX-550-345-M010   10 mg 30.00 USD Add To Cart
ALX-550-345-M050   50 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C13H18N2O . C4H4O4
MW: 218.3 . 116.1
CAS NUMBER: 104015-29-4
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or DMSO. Slightly soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Hygroscopic.

Product Description
Metabolite of physostigmine (eserine) (Prod. No. ALX-550-364). Potent analgesic.
Product Specific Literature References
Direct evidence that eseroline possesses morphine-like effects: S. Fürst, et al.; Eur. J. Pharmacol. 83, 233 (1982) Abstract
Reversible inhibition of acetylcholinesterase by eseroline, an opioid agonist structurally related to physostigmine (eserine) and morphine: A. Galli, et al.; Biochem. Pharmacol. 31, 1233 (1982) Abstract
In-vitro and in-vivo protection of acetylcholinesterase by eseroline against inactivation by diisopropyl fluorophosphate and carbamates: A. Galli, et al.; J. Pharm. Pharmacol. 37, 42 (1985) Abstract
Further Categories Containing This Product:
Analgesic / Anti-nociceptive Agents / Related Products
 
 
ALX-350-123 Revised 25-Apr-08
Eugenol (high purity)
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SYNONYMS 2-Methoxy-4-(2-propenyl)phenol (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-350-123-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C10H12O2
MW: 164.2
CAS NUMBER: 97-53-0
MERCK INDEX: 14: 3898
RTECS: SJ4375000
SOURCE/HOST: Isolated from clove oil, nutmeg, cinnamon and bay leaf.
APPEARANCE: Colorless to pale yellow liquid.
SOLUBILITY: Soluble in 100% ethanol, ether, oils; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: PROTECT FROM AIR!
HAZARD: HARMFUL. MAY BE CARCINOGENIC.

Product Description
TRPV1 agonist. Analgesic. Has antifungal, antimicrobial and antioxidant properties.
Product Specific Literature References
Activation of vanilloid receptor 1 (VR1) by eugenol: B.H. Yang, et al.; J. Dent. Res. 82, 781 (2003) Abstract
Study of anticandidal activity of carvacrol and eugenol in vitro and in vivo: N. Chami, et al.; Oral. Microbiol. Immunol. 20, 106 (2005) Abstract
A comparative study of the antioxidant/prooxidant activities of eugenol and isoeugenol with various concentrations and oxidation conditions: T. Atsumi, et al.; Toxicol. In Vitro 19, 1025 (2005) Abstract
Pharmacokinetics and anesthetic activity of eugenol in male Sprague-Dawley rats: S.A. Guenette, et al.; J. Vet. Pharmacol. Ther. 29, 265 (2006) Abstract
In vitro activity of eugenol against Candida albicans biofilms: M. He, et al.; Mycopathologia 163, 137 (2007) Abstract
Antimicrobial efficacy of eugenol microemulsions in milk against Listeria monocytogenes and Escherichia coli O157:H7: S. Gaysinsky, et al.; J. Food Prot. 70, 2631 (2007) Abstract
Further Categories Containing This Product:
TRPV1 Agonists and Antagonists / Related Products • Analgesic / Anti-nociceptive Agents / Related Products • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables • Natural Products - Antifungal Agents
 
 
ALX-270-086 Revised 07-May-08
Indomethacin
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-086-G005   5 g 30.00 USD Add To Cart
ALX-270-086-G025   25 g 80.00 USD Add To Cart
Product Specification
FORMULA: C19H16ClNO4
MW: 357.8
CAS NUMBER: 53-86-1
MERCK INDEX: 14: 4968
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in acetone or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: VERY TOXIC.

Product Description
Non-steroidal anti-inflammatory and analgesic agent. Inhibits prostaglandin synthesis. Far more potent for inhibition of cyclooxygenases (COX) than for inhibition of lipoxygenases.
Product Specific Literature References
Chemical and biological studies on indomethacin, sulindac and their analogs: T.Y. Shen, et al.; Adv. Drug Res. 12, 90 (1977) Abstract
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostagl. Leukotr. Med. 13, 53 (1984) Abstract
Effects of indomethacin on fetal renal function, renal and umbilicoplacental blood flow and lung liquid production: K.M. Stevenson & E.R. Lumbers; J. Dev. Physiol. 17, 257 (1992) Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins 47, 55 (1994) Abstract
Further Categories Containing This Product:
Analgesic / Anti-nociceptive Agents / Related Products • COX Inhibitors
 
 
ALX-350-225 Revised 29-Sep-08
Limonin
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SYNONYMS Limonoic acid di-δ-lactone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-225-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C26H30O8
MW: 470.5
CAS NUMBER: 1180-71-8
MERCK INDEX: 14: 5494
SOURCE/HOST: Isolated from grapefruit seed.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol or glacial acetic acid; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Bitter principle of citrus fruits. Inhibits chemically induced carcinogenesis. Inhibits HIV-1 replication. Shows antinociceptive effect. Does not possess any inherent antioxidant activity.
Product Specific Literature References
V.P. Maier, et al.; ACS Symposium Series 143, 63 (1980)
J.A. Klocke & I. Kubo; Ent. Exp. & Appl. 32, 299 (1982)
R.L. Rouseff; J. Agric. Food Chem. 30, 504 (1982)
M.A. Altieri, et al.; Protect. Ecol. 6, 91 (1984)
The effect of citrus limonoids on hamster buccal pouch carcinogenesis: E.G. Miller, et al.; Carcinogenesis 10, 1535 (1989) Abstract
L.K.T. Lam, et al.; ACS Symposium Series 546, 209 (1994)
Antinociceptive and anti-inflammatory activities of limonin isolated from the fruits of Evodia rutaecarpa var. bodinieri: H. Matsuda, et al.; Planta Med. 64, 339 (1998) Abstract
Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats: T. Tanaka, et al.; Biofactors 13, 213 (2000) Abstract
Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells: L. Battinelli, et al.; Planta Med. 69, 910 (2003) Abstract
Evaluation of the antioxidant capacity of limonin, nomilin, and limonin glucoside: A.P. Breksa, 3rd & G.D. Manners; J. Agric. Food Chem. 54, 3827 (2006) Abstract
Further Categories Containing This Product:
Natural Products - Antiviral / anti-HIV Agents • Natural Products for Neurological Research • Analgesic / Anti-nociceptive Agents / Related Products • Active Substances from Fruit and Vegetables
 
 
ALX-300-146 Revised 20-Jun-08
Palmitoylethanolamide
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SYNONYMS PEA
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Endocannabinoids
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ALX-300-146-M010   10 mg 20.00 USD Add To Cart
Product Specification
FORMULA: C18H37NO2
MW: 299.5
CAS NUMBER: 544-31-0
PURITY: ≥99%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO, chloroform or THF (30°C).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Endogenous cannabinoid. Weak ligand of CB1 (Ki=23.8µM) and CB2 (Ki=13.9µM) receptor. Inhibits fatty acid amide hydrolase (FAAH) (IC50=5.1µM). Immunosuppressant, anti-inflammatory, anti-nociceptive and anti-convulsant in vivo. The exact mode of action has not yet been revealed. It has been suggested that PEA: i) binds to a yet to be discovered cannabinoid receptor similar to CB2; ii) administered in vivo elicits the synthesis of endogenous agonists of CB2; iii) acts as an "entourage" compound by enhancing the activity and/or by influencing the turnover of endogenous agonists of CB2, possibly but not uniquely, by inhibiting their degradation.
Product Specific Literature References
Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide: L. Facci, et al.; PNAS 92, 3376 (1995) Abstract
Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP: H. Cadas, et al.; J. Neurosci. 16, 3934 (1996) Abstract
N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation: S. Mazzari, et al.; Eur. J. Pharmacol. 300, 227 (1996) Abstract
The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons: S.D. Skaper, et al.; PNAS 93, 3984 (1996) Abstract
Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors: D.M. Lambert, et al.; Biochim. Biophys. Acta 1440, 266 (1999) Abstract
Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide: K.O. Jonsson, et al.; Br. J. Pharmacol. 133, 1263 (2001) Abstract
The palmitoylethanolamide family: a new class of anti-inflammatory agents?: D.M. Lambert, et al.; Curr. Med. Chem. 9, 663 (2002) Abstract
Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems: L. De Petrocellis, et al.; Clin. Pharmacol. 16, 297 (2002) Abstract
Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: Potential use in companion animals.
: G. Re, et al.; Vet. J. 173, 21 (2007), Review Abstract
Further Categories Containing This Product:
Anandamide & Anandamide Analogs • Analgesic / Anti-nociceptive Agents / Related Products • Immunomodulators Other Products • Anti-inflammatory Agents Other Products • Fatty Acid Amide Hydrolase [FAAH] / Related Products
 
 
ALX-550-395 Revised 08-Dec-05
SU-154