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Oxidative Stress
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ALX-270-466 Revised 14-Sep-07
Fluvastatin . sodium salt
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Statins / Related Products
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ALX-270-466-M010   10 mg 48.00 USD Add To Cart
ALX-270-466-M050   50 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C24H25FNO4 . Na
MW: 410.5 . 23.0
CAS NUMBER: 93957-54-1
MERCK INDEX: 14: 4218
RTECS: MJ9675050
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Off-white to light yellow solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING: Protect from light.
HAZARD: TOXIC. MAY BE TERATOGENIC.

Product Description
Anticholesterol agent. HMG-CoA reductase inhibitor and antioxidant.
Product Specific Literature References
Folate and carcinogenesis: an integrated scheme: S.W. Choi and J.B. Mason; J. Nutr. 130, 129 (2000) Abstract; Full Text
Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on nitric oxide-induced hydroxyl radical generation in the rat heart: T. Obata, et al.; Biochim. Biophys. Acta 1536, 55 (2001) Abstract
Antioxidative effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes: A. Yamamoto, et al.; J. Pharm. Pharmacol. 53, 227 (2001) Abstract
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Obesity & Diabetes Other Products
 
 
ALX-270-312 Revised 03-Jan-08
Formononetin (high purity)
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SYNONYMS 7-Hydroxy-4’-methoxyisoflavone (high purity)
7-Hydroxy-3-(4’-methoxyphenyl)-4H-benzopyran-4-one (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Isoflavones
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ALX-270-312-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C16H12O4
MW: 268.3
CAS NUMBER: 485-72-3
MERCK INDEX: 14: 4244
PURITY: ≥97%
APPEARANCE: White to greyish powder.
SOLUBILITY: Soluble in DMSO (200mg/ml) or methanol (2mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Place in a desiccator under vacuum for 48 hours before use.
HANDLING: Protect from light.

Product Description
Interacts with human estrogen receptors with low potency. Enhances IL-4 production in a dose-dependent manner. Inhibits lecithin peroxidation induced by hydroxyl radicals. Selective inhibitor of the γ-isoform of alcohol dehydrogenase. Antioxidant.
Product Specific Literature References
Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor: R.J. Miksicek; J. Steroid Biochem. Mol. Biol. 49, 153 (1994) Abstract
Dietary estrogenic isoflavones are potent inhibitors of beta-hydroxysteroid dehydrogenase of P. testosteronii: W.M. Keung; BBRC 215, 1137 (1995) Abstract
Proliferative response of mammary glandular tissue to formononetin: W. Wang, et al.; Nutr. Cancer 23, 131 (1995) Abstract
Antioxidant activity of phytoestrogenic isoflavones: M.B. Ruiz-Larrea, et al.; Free Radic. Res. 26, 63 (1997) Abstract
Inhibitory effects of isoflavones on lipid peroxidation by reactive oxygen species: S. Toda and Y. Shirataki; Phytother. Res. 13, 163 (1999) Abstract
Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells: B.L. Pool-Zobel, et al.; Carcinogenesis 21, 1247 (2000) Abstract
Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates: X. Jia, et al.; J. Pharmacol. Exp. Ther. 310, 1103 (2004) Abstract
Formononetin, a phyto-oestrogen, and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity: J. Park, et al.; Immunology 116, 71 (2005) Abstract
Further Categories Containing This Product:
Estrogen & Estrogen Receptors / Related Products • Interleukins Other Products • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables • Other Natural Products for Inflammation Research
 
 
ALX-270-418 Revised 16-Jun-08
Gallotannin
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SYNONYMS Tannic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-270-418-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C76H52O46
MW: 1701.2
CAS NUMBER: 1401-55-4
MERCK INDEX: 14: 9052
RTECS: WW5075000
SOURCE/HOST: Occurs in the bark and fruit of many plants, notably in the bark of the oak species, in sumac and myrobalan.
PURITY: >95%
APPEARANCE: Beige to light brown powder.
SOLUBILITY: Soluble in water, 100% ethanol, acetone or warm glycerol.
SHIPPING: AMBIENT
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Inhibitor of poly(ADP-ribose) glycohydrolase (PARG). Cytoprotective in oxidatively stressed cells. Inhibitor of endothelial nitric oxide synthase (eNOS; NOS III) and weak inhibitor of inducible (iNOS; NOS II) and neuronal nitric oxide synthase (nNOS; NOS I). Induces cyclooxygenase-2 (COX-2) expression. Free radical scavenger.
Product Specific Literature References
Inhibition of constitutive endothelial NO-synthase activity by tannin and quercetin: M. Chiesi & R. Schwaller; Biochem. Pharmacol. 49, 495 (1995) Abstract
The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death: W. Ying, et al.; Neuroreport 11, 1385 (2000) Abstract
Green tea polyphenols and tannic acid act as potent inhibitors of phorbol ester-induced nitric oxide generation in rat hepatocytes independent of their antioxidant properties: R.C. Srivastava, et al.; Cancer Lett. 153, 1 (2000) Abstract
Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes: E. Rapizzi, et al.; Mol. Pharmacol. 66, 890 (2004) Abstract
Tannic acid in plant dust causes airway obstruction: D. Taubert, et al.; Thorax 60, 789 (2005) Abstract
Prominent free radicals scavenging activity of tannic acid in lead-induced oxidative stress in experimental mice: I.H. El-Sayed, et al.; Toxicol. Ind. Health 22, 157 (2006) Abstract
The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells: C.H. Chen, et al.; Mol. Nutr. Food Res. 51, 962 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • PARG / Related Products • DNA Repair Other Products • Free Radical Scavengers • Natural Products - Nitric Oxide Pathway Modulators • Phenolic Acids
 
 
ALX-400-016 Revised 28-Nov-04
Galvinoxyl, free radical
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SYNONYMS 2,6-di-t-Butyl-α-(3,5-di-t-butyl-4-oxo-2,5-cyclohexadien-1-ylidene)-p-tolyloxy, free radical
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Free Radicals / Related Products
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ALX-400-016-M010   10 mg 15.00 USD Add To Cart
ALX-400-016-M050   50 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C29H41O2
MW: 421.6
CAS NUMBER: 2370-18-5
PURITY: ≥95%
APPEARANCE: Dark brownish crystalline powder.
SOLUBILITY: Soluble in chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Free radical compound.
 
 
ALX-350-006 Revised 05-Apr-08
Genistein (synthetic)
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SYNONYMS 4',5,7-Trihydroxyisoflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-006-M010   10 mg 25.00 USD Add To Cart
ALX-350-006-M025   25 mg 50.00 USD Add To Cart
ALX-350-006-M050   50 mg 90.00 USD Add To Cart
ALX-350-006-M100   100 mg 150.00 USD Add To Cart
ALX-350-006-G001   1 g 480.00 USD Add To Cart
Product Specification
FORMULA: C15H10O5
MW: 270.2
CAS NUMBER: 446-72-0
MERCK INDEX: 14: 4391
RTECS: NR2392000
SOURCE/HOST: Synthetic.
PURITY: ≥99% (HPLC)
APPEARANCE: White to yellow crystalline powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or dilute aqueous base; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Tyrosine protein kinase inhibitor. Inhibits phosphorylation of EGFR kinase. Inhibits tumor cell proliferation and induces tumor cell differentiation. Inhibits topoisomerase II activity in vivo. Produces cell cycle arrest and apoptosis. Direct inhibitor of insulin-induced glucose uptake in adipocytes (IC50=20µM).
Product Specific Literature References
Genistein, a specific inhibitor of tyrosine-specific protein kinases: T. Akiyama, et al.; J. Biol. Chem. 262, 5592 (1987) Abstract; Full Text
Erbstatin blocks platelet activating factor-induced protein-tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets: H. Salari, et al.; FEBS Lett. 263, 104 (1990) Abstract
Mechanisms of cancer chemoprevention by soy isoflavone genistein: F.H. Sarkar & Y. Li; Cancer Metastasis Rev. 21, 265 (2002) Abstract
Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy: N. Dijsselbloem, et al.; Biochem. Pharmacol. 68, 1171 (2004), Review Abstract
Genistein affects testosterone secretion by Leydig cells in roosters (Gallus gallus domesticus): M. Opalka, et al.; Reprod. Biol. 4, 185 (2004) Abstract
Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes: M. Bazuine, et al.; BBRC 325, 511 (2005) Abstract
Decreased circulating levels of tumor necrosis factor-alpha in postmenopausal women during consumption of soy-containing isoflavones: Y. Huang, et al.; J. Clin. Endocrinol. Metab. 90, 3956 (2005) Abstract
Phytoestrogens and lipoproteins in women: C.N. Bairey Merz, et al.; J. Clin. Endocrinol. Metab. 91, 2209 (2006) Abstract
Clinical review: a critical evaluation of the role of soy protein and isoflavone supplementation in the control of plasma cholesterol concentrations: A. Dewell, et al.; J. Clin. Endocrinol. Metab. 91, 772 (2006), Review Abstract
The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy: F.H. Sarkar, et al.; Mini Rev. Med. Chem. 6, 401 (2006), Review Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • TNF-alpha & TNF Receptors Other Products • Cell Cycle Blockers & Inhibitors / Related Products • EGFR Kinase Inhibitors • Natural Products - Topoisomerase Inhibitors • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Antitumor Reagents • Active Substances from Fruit and Vegetables • Antitumor Agents (Apoptosis Inducers) • Natural Products for Cell Cycle Research • Natural Products for Angiogenesis Research • Natural Products - Apoptosis Inducers & Inhibitors • Isoflavones • Antitumor Agents (Anti-proliferative)
 
 
ALX-350-247 Revised 27-Oct-08
Genistin
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SYNONYMS Genistein-7-O-glucoside
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-247-M010   10 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C21H20O10
MW: 432.4
CAS NUMBER: 529-59-9
MERCK INDEX: 14: 4391
RTECS: DJ3093000
PURITY: ≥98%
APPEARANCE: Off-white to light yellow powder.
SOLUBILITY: Soluble in DMSO or dilute aqueous base; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Glucoside of genistein (Prod. No. ALX-350-006) found in soy beans. Useful as a negative control for genistein and other tyrosine kinase inhibitors. Selective inhibitor of terminal deoxyribonucleotidyltransferase (TdT). Displays antioxidant and anticarcinogenic properties.
Product Specific Literature References
Soybean isoflavones, genistein and genistin, inhibit rat myoblast proliferation, fusion and myotube protein synthesis: S. Ji, et al.; J. Nutr. 129, 1291 (1999) Abstract
Daidzein and genistein but not their glucosides are absorbed from the rat stomach: M.K. Piskula, et al.; FEBS Lett. 447, 287 (1999) Abstract
Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones: H.G. Shertzer, et al.; Chem. Biol. Interact. 123, 31 (1999) Abstract
Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): baicalin and genistin: Y. Uchiyama, et al.; Biochim. Biophys. Acta 1725, 298 (2005) Abstract
Genistin inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells: A. Russo, et al.; J. Nutr. Biochem. 17, 103 (2006) Abstract
Pro-apoptotic effect and cytotoxicity of genistein and genistin in human ovarian cancer SK-OV-3 cells: E.J. Choi, et al.; Life Sci. 80, 1403 (2007) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • Natural Products - Topoisomerase Inhibitors • Natural Products - Chemopreventive Agents • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables • Isoflavones
 
 
ALX-350-239 Revised 22-Apr-08
Gliotoxin
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SYNONYMS [3R-(3α, 5aβ,6β,10aα)]-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epi-dithiopyrazino[1,2-a]indole-1,4-dione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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ALX-350-239-M001   1 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C13H14N2O4S2
MW: 326.4
CAS NUMBER: 67-99-2
MERCK INDEX: 14: 4441
RTECS: KB4725000
SOURCE/HOST: Isolated from Gladiocladium fimbriatum.
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow solid.
SOLUBILITY: Soluble in DMSO or methanol (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HAZARD: TOXIC.

Product Description
Immunomodulating mycotoxin which acts by blocking membrane thiol groups. Causes apoptotic cell death in macrophages and thymocytes. Induces Ca2+ release from intact rat liver mitochondria. Inhibits the activation of transcription factor NF-κB. Antioxidant.
Product Specific Literature References
Identification of an agent in cultures of Aspergillus fumigatus displaying anti-phagocytic and immunomodulating activity in vitro: A. Müllbacher, et al.; J. Gen. Microbiol. 131, 1251 (1985) Abstract
R.J. Jones & J.G. Hancock; J. Gen. Microbiol. 134, 2067 (1988)
Gliotoxin stimulates Ca2+ release from intact rat liver mitochondria: M. Schweizer & C. Richter; Biochemistry 33, 13401 (1994) Abstract
Extracellular calcium is not required for gliotoxin or dexamethasone- induced DNA fragmentation: a reappraisal of the use of EGTA: P. Waring & A. Sjaarda; Int. J. Immunopharmacol. 17, 403 (1995) Abstract
Gliotoxin and related epipolythiodioxopiperazines: P. Waring & J. Beaver; Gen. Pharmacol. 27, 1311 (1996), Review Abstract
The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB: H.L. Pahl, et al.; J.Exp. Med. 183, 1829 (1996) Abstract
Aspergillus fumigatus suppresses the human cellular immune response via gliotoxin-mediated apoptosis of monocytes: M. Stanzani, et al.; Blood 105, 2258 (2005) Abstract
Discovery of gliotoxin as a new small molecule targeting thioredoxin redox system: H.S. Choi, et al.; BBRC 359, 523 (2007) Abstract
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Natural Products - NF-kB Pathway Inhibitors • Mycotoxins • Antibiotics - Immunomodulators
 
 
ALX-850-038 Revised 28-Aug-06
Glutathione Assay Kit
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Glutathione / Related Products
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ALX-850-038-KI01   1 Kit 349.00 USD Add To Cart
Product Specification
SENSITIVITY: 0-16µM GSH (or 0-8µM GSSG)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the measurement of glutathione (GSH) in plasma, tissue samples and cultured cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues: F. Tietze; Anal. Biochem. 27, 502 (1969) Abstract
Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine: O.W. Griffith; Anal. Biochem. 106, 207 (1980) Abstract
Evaluation of the micromethod for determination of glutathione using enzymatic cycling and Ellman's reagent: P. Eyer & D. Podhradsky; Anal. Biochem. 153, 57 (1986) Abstract
Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples: M.A. Baker, et al.; Anal. Biochem. 190, 360 (1990) Abstract
Further Categories Containing This Product:
Quantification Kits
 
 
ALX-157-001 Revised 26-May-03
L-Glutathione (oxidized form)
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SYNONYMS GSSG
(γ-Glu-Cys-Gly)2
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Glutathione / Related Products
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ALX-157-001-M250   250 mg 25.00 USD Add To Cart
ALX-157-001-G001   1 g 50.00 USD Add To Cart
ALX-157-001-G005   5 g 190.00 USD Add To Cart
Product Specification
FORMULA: C20H32N6O12S2
MW: 612.6
CAS NUMBER: 27025-41-8
MERCK INDEX: 14: 4475
PURITY: </