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ALX-430-156
Revised 21-Apr-08
6BIO
SYNONYMS
(2’Z,3’E)-6-Bromoindirubin-3’-oxime
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
GSK-3 Inhibitors
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ALX-430-156-M001
1 mg
40.00 USD
Product Specification
FORMULA:
C
16
H
10
BrN
3
O
2
MW:
356.2
CAS NUMBER:
667463-62-9
PURITY:
≥98%
APPEARANCE:
Dark red solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
Product Description
Inhibitor of phosphoinositide-dependent kinase 1 (PDK1). Potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β).
Product Specific Literature References
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases:
P. Polychronopoulos, et al.; J. Med. Chem.
47
, 935 (2004)
Abstract
7-Bromoindirubin-3’-oxime induces caspase-independent cell death:
J. Ribas, et al.; Oncogene
25
, 6304 (2006)
Abstract
Inverse in silico screening for identification of kinase inhibitor targets:
S. Zahler, et al.; Chem. Biol.
14
, 1207 (2007)
Abstract
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins:
V. Myrianthopoulos, et al.; J. Med. Chem.
50
, 4027 (2007)
Abstract
Related Products
ALX-270-271
Indirubin-3'-monoxime
ALX-430-149
7BIO
ALX-430-157
Me-7BIO
ALX-270-296
Indirubin-5-sulfonic acid . sodium salt
ALX-270-361
Indirubin
ALX-270-424
5-Iodo-indirubin-3'-monoxime
Further Categories Containing This Product:
PI(3)K-Akt-mTOR Pathway Other Products
ALX-151-026
Revised 20-Jun-08
N-Acetyl-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
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ALX-151-026-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
39
H
57
N
7
O
14
S
MW:
880.0
PURITY:
≥96% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (1mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Peptide is very unstable.
Product Description
Peptide containing a phosphotyrosyl mimetic. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides:
B. Ye, et al.; J. Med. Chem.
38
, 4270 (1995)
Abstract
Further Categories Containing This Product:
Peptides
•
Phosphoinositide 3-kinase [PI(3)K] / Related Products
ALX-151-027
Revised 17-Jan-05
N-Acetyl-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
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ALX-151-027-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
36
H
57
N
7
O
13
SP
MW:
858.9
PURITY:
≥96%
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Phosphotyrosine containing peptide. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides:
B. Ye, et al.; J. Med. Chem.
38
, 4270 (1995)
Abstract
Further Categories Containing This Product:
Peptides
•
Phosphoinositide 3-kinase [PI(3)K] / Related Products
ALX-340-063
Revised 19-Apr-07
N-Arachidonoyl-L-serine
SYNONYMS
N-[(5Z,8Z,11Z,14Z)-1-Oxo-5,8,11,14-eicosatetraenyl)]-L-serine
ARA-S
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Endocannabinoids
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ALX-340-063-M010
10 mg
90.00 USD
Product Specification
FORMULA:
C
23
H
37
NO
4
MW:
391.5
CAS NUMBER:
187224-29-9
PURITY:
≥98%
APPEARANCE:
Waxy solid.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; sparingly soluble in water.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
Product Description
Endocannabinoid-like brain constituent with similar biological profile like abnormal cannabidiol. Binds weakly to CB
1
and CB
2
receptors and TRPV1. Produces endothelium-dependent vasodilation. Increases phosphorylation of Akt and mitogen-activated protein kinase (MAPK) in HUVEC.
Product Specific Literature References
N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties:
G. Milman, et al.; PNAS
103
, 2428 (2006)
Abstract
;
Full Text
Further Categories Containing This Product:
MAPK Pathway Activators
•
Endovanilloids
•
PI(3)K-Akt-mTOR Pathway Other Products
ALX-270-465
Revised 22-May-07
AS-252424
SYNONYMS
5-[5-(4-Fluoro-2-hydroxyphenyl)-furan-2-ylmethylene)]-thiazolidine-2,4-dione
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphoinositide 3-kinase [PI(3)K] / Related Products
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Product Numbers:
Format:
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Unit Price:
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ALX-270-465-M001
1 mg
30.00 USD
ALX-270-465-M005
5 mg
120.00 USD
ALX-270-465-M025
25 mg
480.00 USD
Product Specification
FORMULA:
C
14
H
8
FNO
4
S
MW:
305.3
CAS NUMBER:
900515-16-4
PURITY:
≥98% (
1
H-NMR)
APPEARANCE:
Yellow to brown crystalline solid.
SOLUBILITY:
Soluble in 100% ethanol (10mg/ml), DMSO (20mg/ml) or dimethyl formamide; also soluble in a 1:1 solution of DMSO:PBS, pH 7.4, (0.5mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 2 years after receip when stored at -20°C.
Product Description
Potent and selective phosphoinositide 3-kinase (PI(3)K) p110γ inhibitor shown to be selective for class IB PI(3)K-mediated cellular effects.
Product Specific Literature References
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils:
A.M. Condliffe, et al.; Blood
106
, 1432 (2005)
Abstract
;
Full Text
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma:
V. Pomel, et al.; J. Med. Chem.
49
, 3857 (2006)
Abstract
;
Full Text
ALX-270-461
Revised 25-May-07
AS-604850
SYNONYMS
5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphoinositide 3-kinase [PI(3)K] / Related Products
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Format:
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ALX-270-461-M001
1 mg
35.00 USD
ALX-270-461-M005
5 mg
130.00 USD
ALX-270-461-M025
25 mg
520.00 USD
Product Specification
FORMULA:
C
11
H
5
F
2
NO
4
S
MW:
285.2
PURITY:
≥98% (HPLC)
APPEARANCE:
Off-white to yellow solid.
SOLUBILITY:
Soluble in acetonitrile (6mg/ml), DMSO (50mg/ml), methanol (9mg/ml) or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
MELTINGPOINT:
200-202°C
Product Description
Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms.
Product Specific Literature References
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis:
M. Camps, et al.; Nat. Med.
11
, 936 (2005)
Abstract
Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells:
A. Bilancio, et al.; Blood
107
, 642 (2006)
Abstract
;
Full Text
ALX-270-462
Revised 09-Oct-07
AS-605240
SYNONYMS
5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphoinositide 3-kinase [PI(3)K] / Related Products
Ordering Information
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Format:
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ALX-270-462-M001
1 mg
25.00 USD
ALX-270-462-M005
5 mg
80.00 USD
ALX-270-462-M025
25 mg
320.00 USD
Product Specification
FORMULA:
C
12
H
7
N
3
O
2
S
MW:
257.3
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
Pink to reddish brown solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Packaged under inert gas.
Product Description
Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms.
Product Specific Literature References
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis:
M. Camps, et al.; Nat. Med.
11
, 936 (2005)
Abstract
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus:
D.F. Barber, et al.; Nat. Med.
11
, 933 (2005)
Abstract
ALX-270-455
Revised 18-Dec-06
Compound 15e
SYNONYMS
3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphoinositide 3-kinase [PI(3)K] / Related Products
Ordering Information
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Format:
Size:
Unit Price:
Quantity:
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ALX-270-455-M001
1 mg
50.00 USD
ALX-270-455-M005
5 mg
190.00 USD
Product Specification
FORMULA:
C
16
H
15
N
3
O
2
S
MW:
313.4
CAS NUMBER:
371943-05-4
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO or dioxane.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent and specific inhibitor of phosphoinositide 3-kinase p110α isoform. Inhibits proliferation of A375 melanoma cells (IC
50
=0.58µM).
Product Specific Literature References
Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors:
M. Hayakawa, et al.; Bioorg. Med. Chem.
14
, 6847 (2006)
Abstract
Further Categories Containing This Product:
Antitumor Agents (Anti-proliferative)
ALX-350-118
Revised 22-Sep-08
Deguelin
SYNONYMS
[-]-Deguelin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
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ALX-350-118-M005
5 mg
60.00 USD
ALX-350-118-M025
25 mg
240.00 USD
Product Specification
FORMULA:
C
23
H
22
O
6
MW:
394.4
CAS NUMBER:
522-17-8
MERCK INDEX:
14:
2863
RTECS:
DX1500000
PURITY:
≥95%
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in acetone, acetonitrile or DMSO. Slightly soluble in 100% ethanol. Insoluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Inhibitor of Akt (protein kinase B; PKB) in an
in vitro
lung carcinogenesis progression model. Inhibits cell proliferation - cells accumulate in the G2-M phase of the cell cycle. Induces apoptosis. Exhibits a marked inhibitory effect on mouse skin tumor promotion in an
in vivo
two-stage carcinogenesis test. Inhibits cyclooxygenase-2 (COX-2) expression.
Product Specific Literature References
Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest:
G. Murillo, et al.; Eur. J. Cancer
38
, 2446 (2002)
Abstract
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells
:
K.H. Chun, et al.; J. Natl. Cancer Inst.
95
, 291 (2003)
Abstract
;
Full Text
Cancer Chemopreventive Activity of Rotenoids from Derris trifoliata
:
C. Ito, et al.; Planta Med.
70
, 8 (2004)
Abstract
Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics.
:
N. Hail, et al.; Apoptosis
9
, 437 (2004)
Abstract
Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells:
H.Y. Lee, et al.; Clin. Cancer Res.
10
, 1074 (2004)
Abstract
Further Categories Containing This Product:
Phosphoinositide 3-kinase [PI(3)K] / Related Products
•
Antitumor Agents (Apoptosis Inducers)
•
Natural Products - Antitumor Reagents
•
Antitumor Agents (Enzyme Inhibitors)
•
COX Inhibitors
•
Antitumor Agents (Anti-proliferative)
•
Natural Products - Apoptosis Inducers & Inhibitors
ALX-307-018
Revised 04-Mar-05
3-Deoxy-3-bromo-D-myo-inositol 1,4,5-trisphosphate . hexasodium salt
SYNONYMS
3-Br-Deoxy-Ins(1,4,5)P
3
. 6Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates / Related Products
Ordering Information
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ALX-307-018-M001
1 mg
80.00 USD
Product Specification
FORMULA:
C
6
H
8
BrO
14
P
3
. 6Na
MW:
477.0 . 137.9
PURITY:
≥95%
APPEARANCE:
Brown solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Very hygroscopic.
ALX-307-021
Revised 20-Feb-08
3-Deoxy-3-fluoro-D-myo-inositol 1,4,5-trisphosphate . hexasodium salt
SYNONYMS
3-F-Deoxy-Ins(1,4,5)P
3
. 6Na
