ALEXIS Biochemicals: Compound A

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ALX-385-029

Revised 07-Oct-08

4’-Bromoflavone
SYNONYMS	4’-Bromo-2-phenylbenzopyran 4’-Bromo-2-phenyl-4H-1-benzopyran-4-one
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavones

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-029-G001		1 g	90.00 USD

Product Specification

FORMULA:	C₁₅H₉BrO₂
MW:	301.1
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	IRRITANT.

Product Description

Chemopreventive compound. Potent inducer of phase II detoxifying enzymes.

Product Specific Literature References

Simple vs. complex inheritance of inducible aryl hydrocarbon hydroxylase in mouse tissues: K. Burki, et al.; Biochem. Genet. 13, 417 (1975) Abstract
Cancer chemopreventive activity mediated by 4’-bromoflavone, a potent inducer of phase II detoxification enzymes: L.L. Song, et al.; Cancer Res. 59, 578 (1999) Abstract

Further Categories Containing This Product:

Natural Products - Chemopreventive Agents • Respiratory Chain Other Products

ALX-385-031

Revised 07-Oct-08

Diosmin
SYNONYMS	3’,5,7-Trihydroxy-4’-methoxyflavone 7-rutinoside
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavones

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-031-G005		5 g	30.00 USD
ALX-385-031-G025		25 g	90.00 USD

Product Specification

FORMULA:	C₂₈H₃₂O₁₅
MW:	608.5
CAS NUMBER:	520-27-4
MERCK INDEX:	14: 3297
SOURCE/HOST:	Isolated from Citrus aurantium L. and Citrus reticulate Blanca.
PURITY:	≥90% (HPLC)
APPEARANCE:	Light yellow to brown yellow powder.
SOLUBILITY:	Soluble in DMSO (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
IDENTITY:	Determined by IR.

Product Description

Flavonoid glycoside. Reduces venous hyperpressure. Reduces capillary hyperpermeability and the expression of endothelial adhesion molecules (ICAM1, VCAM1). Effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in cells. Anti-inflammatory.

Product Specific Literature References

Clinical trial of oral diosmin (Daflon) in the treatment of hemorrhoids: W. Thanapongsathorn & T. Vajrabukka; Dis. Colon Rectum 35, 1085 (1992) Abstract
Amine uptake inhibition by diosmin and diosmetin in human neuronal and neuroendocrine cell lines: E. Sher, et al.; Pharmacol. Res. 26, 395 (1992) Abstract
Antioxidant activity of micronized diosmin on oxygen species from stimulated human neutrophils: B. Cypriani, et al.; Biochem. Pharmacol. 45, 1531 (1993) Abstract
Diosmin-induced increase in sensitivity to Ca2+ of the smooth muscle contractile apparatus in the rat isolated femoral vein: J.P. Savineau & R. Marthan; Br. J. Pharmacol. 111, 978 (1994) Abstract; Full Text
Venous elasticity after treatment with Daflon 500 mg: V. Ibegbuna, et al.; Angiology 48, 45 (1997) Abstract
Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary-bladder carcinogenesis in male ICR mice: M. Yang, et al.; Int. J. Cancer 73, 719 (1997) Abstract
Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity: H.P. Ciolino, et al.; Cancer Res. 58, 2754 (1998) Abstract; Full Text
Modulation by phytochemicals of cytochrome P450-linked enzyme activity: R.W. Teel & H. Huynh; Cancer Lett. 133, 135 (1998) Abstract
Inhibition of lipopolysaccharide (LPS)-induced endothelial cytotoxicity by diosmin: M.F. Melzig & R. Loose; Pharmazie 54, 298 (1999) Abstract
Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS: M.E. Crespo, et al.; Planta Med. 65, 651 (1999) Abstract
Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells: Q. Zheng, et al.; J. Cancer Res. Clin. Oncol. 128, 539 (2002) Abstract
The effect of diosmin hesperidin on intestinal ischaemia--reperfusion injury: M. Pehlivan, et al.; Acta Chir. Belg. 104, 715 (2004) Abstract
Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin: C. Martinez Conesa, et al.; J. Agric. Food Chem. 53, 6791 (2005) Abstract

Further Categories Containing This Product:

Natural Products - Anti-inflammatory Agents • Active Substances from Fruit and Vegetables • Natural Products - Chemopreventive Agents • CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3] / Related Products • MDR Other Products

ALX-460-001

Revised 13-Mar-06

L-(+)-Ascorbic acid
SYNONYMS	Vitamin C
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Vitamins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-460-001-G010		10 g	20.00 USD

Product Specification

FORMULA:	C₆H₈O₆
MW:	176.1
CAS NUMBER:	50-81-7
MERCK INDEX:	14: 830
PURITY:	≥97%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water, 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
USE/STABILITY:	Aqueous solutions are easily oxidized. Stable at pH 5.0-6.0.

Further Categories Containing This Product:

Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Chemopreventive Agents • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables

ALX-460-006

Revised 08-Oct-07

Folic acid
SYNONYMS	Pteroylglutamic acid
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Folic Acid & Folate Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-460-006-G010		10 g	28.00 USD

Product Specification

FORMULA:	C₁₉H₁₉N₇O₆
MW:	441.4
CAS NUMBER:	59-30-3
MERCK INDEX:	14: 4221
PURITY:	≥97%
APPEARANCE:	Yellow to orange powder.
SOLUBILITY:	Soluble in diluted acids or alkaline solutions; slightly soluble in water or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Alkaline solutions are reasonably stable. Other solutions may be light and heat sensitive.

Further Categories Containing This Product:

Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables • Vitamins

ALX-460-028

Revised 24-Oct-07

Rutin . trihydrate
SYNONYMS	Quercetin-3-rutinoside . 3H₂O Vitamin P 3,3',4',5,7-Pentahydroxyflavone-3-rutinoside . 3H₂O
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavonols

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-460-028-G005		5 g	15.00 USD

Product Specification

FORMULA:	C₂₇H₃₀O₁₆ . 3H₂O
MW:	610.5 . 54.0
CAS NUMBER:	153-18-4
MERCK INDEX:	14: 8304
PURITY:	≥99% (Assay)
APPEARANCE:	Off-white to yellow powder.
SOLUBILITY:	Soluble in pyridine or alkaline solutions; slightly soluble in 100% ethanol; very slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.

Product Description

Antioxidant flavonoid. Nitric oxide (NO) scavenger.

Product Specific Literature References

Flavonoids as scavengers of nitric oxide radical: S.A.B.E. Acker, et al.; BBRC 214, 755 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Antioxidant and chelating properties of flavonoids
: L.G. Korkina and I.B. Afanas´ev; Adv. Pharmacol. 38, 151 (1997) Abstract
Antimicrobial activity of flavonoids: T. P. Cushnie & A. J. Lamb; Int. J. Antimicrob. Agents 26, 343 (2005) Abstract

Further Categories Containing This Product:

Natural Products - Nitric Oxide Pathway Modulators • Nitric Oxide Scavengers • Natural Products - Chemopreventive Agents • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables

ALX-480-062

Revised 24-Oct-07

Theophylline
SYNONYMS	1,3-Dimethylxanthine
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Adenosine Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-062-G005		5 g	5.00 USD
ALX-480-062-G025		25 g	15.00 USD

Product Specification

FORMULA:	C₇H₈N₄O₂
MW:	180.2
CAS NUMBER:	58-55-9
MERCK INDEX:	14: 9285
PURITY:	≥98%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in dilute aqueous acid, dilute aqueous base or 100% ethanol; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	TOXIC.

Product Description

Cyclic phosphodiesterase inhibitor. Weakly inhibits alkaline phosphodiesterases and 5’-nucleotidase. Muscle relaxant, cardiac stimulant and diuretic. Used for the treatment of asthma.

Product Specific Literature References

1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors: J.W. Daly, et al.; J. Med. Chem. 28, 487 (1985) Abstract
Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes: R.F. Bruns, et al.; Mol. Pharmacol. 29, 331 (1986) Abstract
Theophylline: new perspectives for an old drug: P.J. Barnes; Am. J. Respir. Crit. Care Med. 167, 813 (2003), (Review) Abstract

Further Categories Containing This Product:

Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables • Alkaloids • Phosphodiesterases / Related Products

ALX-550-322

Revised 11-Nov-08

Caffeine
SYNONYMS	1,3,7-Trimethylxanthine 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Neurological Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-322-G005		5 g	10.00 USD

Product Specification

FORMULA:	C₈H₁₀N₄O₂
MW:	194.2
CAS NUMBER:	58-08-2
MERCK INDEX:	14: 1636
SOURCE/HOST:	Found in tea leaves, coffee beans, cocoa beans, maté leaves, guarana paste and kola nuts.
PURITY:	≥99%
APPEARANCE:	White to colorless powder.
SOLUBILITY:	Soluble in chloroform, 100% alcohol or hot water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	HARMFUL.
IDENTITY:	Identity determined by NIR.

Product Description

CNS stimulant. Blocks adenosine A1 and A2A receptors. cAMP phosphodiesterase inhibitor. Interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by various chemicals. Inhibits cellular DNA repair mechanisms. Anti-inflammatory.

Product Specific Literature References

Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors: J.W. Daly, et al.; J. Med. Chem. 29, 1305 (1986) Abstract
Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action: J. Sawynok & T.L. Yaksh; Pharmacol. Rev. 45, 43 (1993) Abstract
Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells: F. Traganos, et al.; Cancer Res. 53, 4613 (1993) Abstract
Multiple effects of caffeine on calcium current in rat ventricular myocytes: I. Zahradnik & P. Palade; Pfluegers Arch. 424, 129 (1993) Abstract
Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressures: T.G. Papaioannou, et al.; Am. J. Hypertens. 18, 129 (2005), (Review) Abstract
Caffeine and the dopaminergic system: O. Cauli & M. Morelli; Behav. Pharmacol. 16, 63 (2005), (Review) Abstract
Immunomodulatory effects of caffeine: friend or foe: L. A. Horrigan, et al.; Pharmacol. Ther. 111, 877 (2006), (Review) Abstract
Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in animal models of Parkinson’s disease: A. Kalda, et al.; J. Neurol. Sci. 248, 9 (2006), (Review) Abstract
The enigmatic effects of caffeine in cell cycle and cancer: A. M. & Bode and Z. Dong; Cancer Lett. 247, 26 (2007), (Review) Abstract

Further Categories Containing This Product:

Natural Products - Other Signal Transduction Pathway Modulators • Ca2+ Modulators • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Chemopreventive Agents • Neuroactive Agents Other Products • Alkaloids • Active Substances from Fruit and Vegetables • Natural Products - Anti-inflammatory Agents • DNA Repair Other Products • Other Natural Products - DNA Regulation / Transcription • Natural Products for Cell Cycle Research • Phosphodiesterases / Related Products

ALX-550-516

Revised 21-May-08

Compound A
SYNONYMS	CpdA 2-((4-Acetophenyl)-2-chloro-N-methyl)ethylammonium chloride
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Anti-inflammatory Agents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-516-M005		5 mg	40.00 USD
ALX-550-516-M025		25 mg	120.00 USD

Product Specification

FORMULA:	C₁₁H₁₄ClNO₂ . HCl
MW:	227.7 . 36.5
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or water.
SHIPPING:	SHIPPED ON DRY ICE
LONG TERM STORAGE:	-80°C
USE/STABILITY:	Stock solutions in ethanol are stable for up to 1 month when stored at -80°C.
HANDLING:	Protect from moisture. After reconstitution, prepare aliquots and store at -80°C.

Product Description

Cell permeable, nonsteroidal glucocorticoid receptor modulator with high binding affinity. Exerts anti-inflammatory potential by down-modulating TNF-induced pro-inflammatory gene expression, such as IL-6 and E-selectin. Unlike dexamethasone (Prod. No. ALX-370-002) it does not enhance glucocorticoid response element (GRE)-driven gene expression or induce glucocorticoid receptor (GR) binding to GRE-dependent genes in vivo.

Product Specific Literature References

A fully dissociated compound of plant origin for inflammatory gene repression: K. De Bosscher, et al.; PNAS 102, 15827 (2005) Abstract
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis: P. Dewint, et al.; J. Immunol. 180, 2608 (2008) Abstract