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Stress & Heat Shock Proteins
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ALX-804-024 Revised 07-Aug-07
Monoclonal Antibody to Hip (2G6)
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SYNONYMS anti-HSC70-interacting Protein MAb (2G6)
anti-p48 MAb (2G6)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Co-Chaperones & HSP-interacting Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-024-C125   125 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
CLONE: 2G6
ISOTYPE: Mouse IgG
CONCENTRATION: 2.5mg/ml
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Recombinant human Hip (HSC70-interacting protein; p48).
SPECIFICITY: Recognizes human, rabbit and chicken Hip. Detects a band of ~48kDa by Western blot.
APPLICATION: Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Sequence and characterization of cytoplasmic nuclear protein import factor p97: N.C. Chi, et al.; J. Cell. Biol. 130, 265 (1995) Abstract
Nucleocytoplasmic transport: D. Gorlich & I.W. Mattaj; Science 271, 1513 (1996) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-382 Revised 21-Feb-08
Monoclonal Antibody to Hrs and Hrs-2 (A-5)
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SYNONYMS anti-HGS MAb (A-5)
anti-Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate MAb (A-5)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Hepatocyte Growth Factor [HGF] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-382-C050   50 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Monkey
CLONE: A-5
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS containing 10% glycerol.
IMMUNOGEN: Recombinant full length rat Hrs-2 (hepatocyte growth factor-regulated tyrosine kinase substrate).
SPECIFICITY: Recognizes human, mouse, rat and monkey Hrs (HGS) and Hrs-2.
APPLICATION: Immunohistochemistry (1:100-1:1'000)
Immunoprecipitation (2µg/ml)
Western Blot (1:2'000-1:3'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 3 months when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Isoform-specific exocytotic protein mRNA expression in hypothalamic magnocellular neurons: regulation after osmotic challenge: G. Jacobsson, et al.; Neuroendocrinology 70, 392 (1999) Abstract
The cellular and developmental expression of hrs-2 in rat: S. Tsujimoto, et al.; Eur. J. Neurosci. 11, 3047 (1999) Abstract
Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15: A.J. Bean, et al.; J. Biol. Chem. 275, 15271 (2000) Abstract; Full Text
Distinct protein domains are responsible for the interaction of Hrs-2 with SNAP-25. The role of Hrs-2 in 7 S complex formation: S. Tsujimoto & A.J. Bean; J. Biol. Chem. 275, 2938 (2000) Abstract; Full Text
SNAP-25-associated Hrs-2 protein colocalizes with AQP2 in rat kidney collecting duct principal cells: A. Shukla, et al.; Am. J. Physiol. Renal. Physiol. 281, F546 (2001) Abstract; Full Text
CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling: Q. Yan, et al.; Mol. Biol. Cell 16, 2470 (2005) Abstract; Full Text
Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK: S.K. Rayala, et al.; J. Biol. Chem. 281, 4395 (2006) Abstract; Full Text
General Information
Hrs/Hgs (hepatocyte growth factor-regulated tyrosine kinase substrate) is a tyrosine-phosphorylated member of a protein family characterized by a conserved 3´-phosphoinositide-interacting RING zinc finger domain, the so called FYVE finger. A variant of Hrs, Hrs-2 is an ATPase that has been shown to play a regulatory role in the docking and/or fusion of synaptic vesicles to plasma membranes through a calcium-regulated interaction with SNAP-25. Hrs-2 physically interacts with Eps15, a protein required for receptor-mediated endocytosis. The Hrs-2/Eps15 interaction is calcium dependent, inhibited by SNAP-25 and alpha-adaptin, and results in the inhibition of receptor-mediated endocytosis. Immunoelectron microscopy reveals Hrs-2 localization on the limiting membrane of multivesicular bodies, organelles in the endosomal pathway. Recent data suggest that Hrs-2 acts to provide communication between endo- and exocytic processes.
Further Categories Containing This Product:
Vesicles & Membrane Trafficking Other Products • Monoclonal Antibodies • Autophagy-related Proteins [APG; ATG] / Related Products
 
 
ALX-804-067 Revised 23-Aug-07
Monoclonal Antibody to HSC70 (13D3)
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SYNONYMS anti-Heat Shock Cognate Protein 70 MAb (13D3)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY HSP70 / DnaK / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-067-R050   50 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 13D3
ISOTYPE: Mouse IgM
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Mouse spermatogenic cell protein.
SPECIFICITY: Recognizes human and mouse HSC70 (heat shock cognate protein 70). Detects a band of ~70kDa by Western blot.
CROSSREACTIVITY PROTEINS: Slightly cross-reacts with HSP70.
APPLICATION: Immunohistochemistry (1:100)
Immunoprecipitation
Western Blot (1:5'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Heat-shock cognate protein (hsc71) and related proteins in mouse spermatogenic cells: M. Maekawa, et al.; Biol. Reprod. 40, 843 (1989) Abstract
Further Categories Containing This Product:
Chaperone-mediated Autophagy [CMA] • Monoclonal Antibodies
 
 
ALX-804-810 Revised 24-Mar-05
Monoclonal Antibody to HSP70 (BB70)
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SYNONYMS anti-Heat Shock Protein 70 MAb (BB70)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY HSP70 / DnaK / Related Products
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ALX-804-810-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Dog
Pig
Monkey
Others
CLONE: BB70
ISOTYPE: Mouse IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE)
FORMULATION: Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: Chicken HSP70 (heat shock protein 70)/HSP90 (heat shock protein 90) complex.
SPECIFICITY: Recognizes both free and complexed human, mouse, rat, sheep, dog, pig, monkey, fish, guinea pig, hamster, rabbit, chicken, xenopus, drosophila and yeast HSP70 and HSC70. Detects bands of ~72 and ~73 kDa by Western blot, corresponding to HSP70 and HSC70, respectively.
APPLICATION: Immunohistochemistry (works on endogenous)
Immunoprecipitation (works on endogenous)
Western Blot (works on endogenous)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least one year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70: D.F. Smith, et al.; Mol. Cell. Biol. 13, 869 (1993) Abstract; Full Text
Mutational analysis of the hsp70-interacting protein Hip: V. Prapapanich, et al.; Mol. Cell. Biol. 16, 6200 (1996) Abstract; Full Text
Mutation of Hip's carboxy-terminal region inhibits a transitional stage of progesterone receptor assembly: V. Prapapanich, et al.; Mol. Cell. Biol. 18, 944 (1998) Abstract; Full Text
Hop modulates Hsp70/Hsp90 interactions in protein folding: B.D. Johnson, et al.; J. Biol. Chem. 273, 3679 (1998) Abstract; Full Text
A role for heat shock protein 27 in CTL-mediated cell death: P.J. Beresford, et al.; J. Immunol. 161, 161 (1998) Abstract; Full Text
Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery: S. Chen & D.F. Smith; J. Biol. Chem. 273, 35194 (1998) Abstract; Full Text
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1: J. Zou, et al.; Cell 94, 471 (1998) Abstract; Full Text
Identification of genes that modify ataxin-1-induced neurodegeneration: P. Fernandez-Funez, et al.; Nature 408, 101 (2000) Abstract; Full Text
Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents: R. Bagatell, et al.; Clin. Cancer Res. 6, 3312 (2000) Abstract; Full Text
Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes: D.L. Fisher, et al.; EMBO J. 19, 1516 (2000) Abstract
Mutations in Drosophila heat shock cognate 4 are enhancers of Polycomb: R. Mollaaghababa, et al.; PNAS 98, 3958 (2001) Abstract; Full Text
Modulation of Drosophila heat shock transcription factor activity by the molecular chaperone DROJ1: G. Marchler & C. Wu; EMBO J. 20, 499 (2001) Abstract
Co-translational folding of caspase-activated DNase with Hsp70, Hsp40, and inhibitor of caspase-activated DNase: H. Sakahira & S. Nagata; J. Biol. Chem. 277, 3364 (2002) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome: J. Luders, et al.; J. Biol. Chem. 275, 4613 (2000) Abstract; Full Text
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • Monoclonal Antibodies
 
 
ALX-804-068 Revised 31-Aug-07
Monoclonal Antibody to HSP27 (G3.1)
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SYNONYMS anti-Heat Shock Protein 27 MAb (G3.1)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Small Heat Shock Proteins / Related Products
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ALX-804-068-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Dog
CLONE: G3.1
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Partially purified HSP27 (heat shock protein 27).
SPECIFICITY: Recognizes human, mouse (weak), rat and dog HSP27. Detects a band of ~24kDa by Western blot.
APPLICATION: ELISA
Immunohistochemistry (paraffin sections (1:500))
Immunoprecipitation
Western Blot (1:500)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Detection of a Mr 24,000 estrogen-related protein in human breast cancer by monoclonal antibodies: D.J. Adams, et al.; Cancer Res. 43, 4297 (1983) Abstract
General Information
HSP27 also referred to as the Estrogen-Regulated 24K protein and HSP28, is one of several small heat shock proteins (HSP) produced by all organisms studied. HSP27 synthesis is induced by elevated temperature, as well as estrogen in hormone responsive cells. Interestingly, human HSP27 also shares greater than 50% homology with low molecular weight Drosophila HSP's and mammalian a-crystalline lens protein. Because of the estrogen responsive nature of HSP27, this protein has been studied extensively in human estrogen responsive tissues such as cervix, endometrium and breast tissue. This work has led to the suggestion that HSP27 may be a useful marker in classifying various hormone sensitive tumors.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-588 Revised 20-Nov-07
Monoclonal Antibody to HSP27 (phosphorylated) (pSer82) (5B9)
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SYNONYMS anti-Heat Shock Protein 27 (phosphorylated) (pSer82) MAb (5B9)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Small Heat Shock Proteins / Related Products
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ALX-804-588-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
CLONE: 5B9
ISOTYPE: Mouse IgG2a
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN: Synthetic peptide corresponding to aa 79-85 (R79QLpSSGV85) of human HSP27 (heat shock protein 27) phosphorylated at Ser82.
SPECIFICITY: Recognizes human, mouse, rat and dog phosphorylated HSP27.
APPLICATION: Immunohistochemistry
Western Blot (0.5µg/ml for HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and freeze in liquid nitrogen.
POSITIVE CONTROL: Yes (Prod. No. ALX-840-031).
Further Categories Containing This Product:
Phospho-specific Antibodies • Monoclonal Antibodies
 
 
ALX-804-584 Revised 31-Oct-06
Monoclonal Antibody to HSP65 (mycobacterial) (4H11)
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SYNONYMS anti-Heat Shock Protein 65 (mycobacterial) MAb (4H11)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY HSP60 / GroEL / Related Products
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ALX-804-584-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Others
CLONE: 4H11
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.2, containing 0.1mM PMSF and 50% glycerol.
IMMUNOGEN: Recombinant Mycobacterium bovis BCG HSP65 (heat shock protein 65).
SPECIFICITY: Recognizes M. bovis and M. leprae HSP65. Detects a band of ~65kDa by Western blot. Does not cross-react with the mammalian HSP60 homologs from human, mouse, rat and monkey.
APPLICATION: Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 2-4 weeks when stored at +4°C.
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-075 Revised 24-Sep-07
Monoclonal Antibody to HSP70 (2A4)
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SYNONYMS anti-Heat Shock Protein 70 MAb (2A4)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY HSP70 / DnaK / Related Products
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ALX-804-075-R050   50 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Others
CLONE: 2A4
ISOTYPE: Mouse IgM
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Human HSP70 (heat shock protein 70).
SPECIFICITY: Recognizes HSP70, HSC70, and following heat shock, HSP72 from a broad range of species including human, mouse, avian, frog, fish, drosophila, yeast and wheat HSP70. Detects bands from ~70 to ~72kDa by Western blot, representing different members of the HSP70 family.
CROSSREACTIVITY PROTEINS: HSP70, HSC70, HSP72 (following heat shock)
APPLICATION: Immunocytochemistry (1:100)
Immunohistochemistry (paraffin sections)
Western Blot (1:5’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION 2D-gel electrophoresis is required to resolve the heat induced form of these proteins from their constitutively expressed counterparts.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-076 Revised 01-Oct-07
Monoclonal Antibody to HSP70 (human) (4G4)
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SYNONYMS anti-Heat Shock Protein 70 (human) MAb (4G4)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY HSP70 / DnaK / Related Products
Ordering Information
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ALX-804-076-R050   50 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 4G4
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Ascites diluted in PBS.
IMMUNOGEN: Recombinant human HSP70 (heat shock protein 70).
SPECIFICITY: Recognizes human HSP70.
APPLICATION: Immunoprecipitation
Western Blot (1:5'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-586 Revised 31-Oct-06
Monoclonal Antibody to HSP71 (mycobacterial) (5A8)
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SYNONYMS anti-Heat Shock Protein 71 (mycobacterial) MAb (5A8)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY HSP70 / DnaK / Related Products
Ordering Information
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ALX-804-586-C200   200 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Others
CLONE: 5A8
ISOTYPE: Mouse IgG1
PURITY DETAIL: Protein G-affinity purified antibody.
FORMULATION: Liquid. Protein G purfied antibody in PBS, pH 7.2, containing 0.1mM PMSF and 50% glycerol.
IMMUNOGEN: Recombinant Mycobacterium tuberculosis HSP71 (heat shock protein 71).
SPECIFICITY: Recognizes M. bovis and M. leprae HSP71. Detects a band of ~71kDa by Western blot. Does not cross-react with eukaryotic HSC70, HSP70 or DnaK from E. coli.
APPLICATION: Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stability at +4°C: 2-4 weeks.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
POSITIVE CONTROL: M. bovis or M. leprae samples can be used as positive control.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-078 Revised 29-Jul-08