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ALX-460-036
Revised 17-Jan-05
Alfacalcidol
SYNONYMS
Hydroxyvitamin D
3
1-Hydroxycholecalciferol
(1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3-diol
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Vitamin D3 & Vitamin D3 Receptor / Related Products
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ALX-460-036-M001
1 mg
75.00 USD
Product Specification
FORMULA:
C
27
H
44
O
2
MW:
400.6
CAS NUMBER:
41294-56-8
RTECS:
VS2851000
PURITY:
≥97%
APPEARANCE:
White to off white crystals.
SOLUBILITY:
Soluble in ethanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Converts to active calcitriol (1α,25-dihydroxyvitamin D3; Prod. No.
ALX-460-032
)
in vivo
. Inhibits bone resorption.
Further Categories Containing This Product:
Vitamins
ALX-460-001
Revised 13-Mar-06
L-(+)-Ascorbic acid
SYNONYMS
Vitamin C
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Vitamins
Ordering Information
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ALX-460-001-G010
10 g
20.00 USD
Product Specification
FORMULA:
C
6
H
8
O
6
MW:
176.1
CAS NUMBER:
50-81-7
MERCK INDEX:
14:
830
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water, 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
USE/STABILITY:
Aqueous solutions are easily oxidized. Stable at pH 5.0-6.0.
Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors
•
Natural Products - Chemopreventive Agents
•
Natural Products - Antioxidants
•
Active Substances from Fruit and Vegetables
ALX-460-002
Revised 13-Mar-06
D-(+)-Biotin
SYNONYMS
Vitamin H
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Vitamins
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ALX-460-002-G001
1 g
30.00 USD
ALX-460-002-G005
5 g
140.00 USD
Product Specification
FORMULA:
C
10
H
16
N
2
O
3
S
MW:
244.3
CAS NUMBER:
58-85-5
MERCK INDEX:
14:
1231
PURITY:
≥98%
SOLUBILITY:
Soluble in hot water, diluted acids and alkaline solutions; hardly soluble in cold water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
MAY BE CARCINOGENIC.
ALX-460-032
Revised 18-Dec-07
Calcitriol
SYNONYMS
Vitamin D
3
, 1α,25-Dihydroxy-
1α,25-Dihydroxyvitamin D
3
1,25(OH)
2
D
3
1α,25-Dihydroxycholecalciferol
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Vitamin D3 & Vitamin D3 Receptor / Related Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-460-032-C100
100 µg
150.00 USD
ALX-460-032-M001
1 mg
350.00 USD
Product Specification
FORMULA:
C
27
H
44
O
3
MW:
416.7
CAS NUMBER:
32222-06-3
MERCK INDEX:
14:
1644
RTECS:
FZ4645000
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Slightly soluble in methanol, 100% ethanol, ethyl acetate or tetrahydrofuran.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC. MAY BE TERATOGENIC.
Product Description
Osteotropic hormone that up-regulates RANKL level and down-regulates OPG level. Biologically active form of vitamin D
3
in intestinal calcium transport and bone calcium resorption.
Product Specific Literature References
A rapidly acting metabolite of vitamin D3:
Haussler, et al.; PNAS
68
, 177 (1971)
Abstract
1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture:
Raisz, et al.; Science
175
, 768 (1972)
Abstract
Further Categories Containing This Product:
Vitamins
ALX-460-003
Revised 11-Feb-08
Calcium D-(+)-pantothenate
SYNONYMS
D-(+)-Pantothenic acid hemicalcium salt
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Vitamins
Ordering Information
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ALX-460-003-G010
10 g
15.00 USD
Product Specification
FORMULA:
C
18
H
32
CaN
2
O
10
MW:
476.5
CAS NUMBER:
137-08-6
MERCK INDEX:
14:
7015
RTECS:
RU4375000
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water. Also soluble in glycerol; slightly soluble in 100% ethanol or methanol; insoluble in acetone or ether.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Precursor for coenzyme A biosynthesis .
Product Specific Literature References
Biosynthesis of riboflavin, folic acid, thiamine, and pantothenic acid:
Adv .Enzymol.; G.M. Brown & J.M. Williamson
53
, 345 (1982)
Abstract
ALX-460-004
Revised 11-Jul-07
β-Carotene
SYNONYMS
Provitamin A
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Retinol [Vitamin A] & Retinol Derivatives / Related Products
Ordering Information
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ALX-460-004-G005
5 g
65.00 USD
Product Specification
FORMULA:
C
40
H
56
MW:
536.9
CAS NUMBER:
7235-40-7
MERCK INDEX:
14:
1853
SOURCE/HOST:
Synthetic.
PURITY:
≥97%
APPEARANCE:
Red powder.
SOLUBILITY:
Soluble in DMSO, n-hexane, carbon disulfide, benzene or vegetable oils; slightly soluble in ether, petroleum ether or oils; almost insoluble in 100% ethanol, methanol, water, diluted acidic or alkaline solutions.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Absorbs oxygen from air. Keep under inert gas.
Further Categories Containing This Product:
Natural Products - Antioxidants
•
Active Substances from Fruit and Vegetables
•
Vitamins
ALX-350-335
Revised 14-Nov-07
Cochlioquinone A
SYNONYMS
Luteoleersin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
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ALX-350-335-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
30
H
44
O
8
MW:
532.7
CAS NUMBER:
32450-25-2
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Shows antiangiogenic and nematocidal activities. Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of diacylglycerol acyltransferase, diacylglycerol kinase and NADH-ubiquinone reductase.
Product Specific Literature References
Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites:
J.M. Schaeffer, et al.; J. Antibiot. (Tokyo)
43
, 1179 (1990)
Abstract
Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi:
T. Fujioka, et al.; J. Antibiot. (Tokyo)
49
, 409 (1996)
Abstract
Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola:
H.J. Jung, et al.; Bioorg. Med. Chem.
11
, 4743 (2003)
Abstract
Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1:
H.B. Lee, et al.; J. Antibiot. (Tokyo)
56
, 967 (2003)
Abstract
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products
•
NAD+ Metabolism / Related Products
•
Vitamins
ALX-350-341
Revised 14-Nov-07
Cochlioquinone B
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
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ALX-350-341-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
28
H
40
O
6
MW:
472.6
CAS NUMBER:
32450-26-3
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of NADH-ubiquinone reductase. Phytotoxic agent inhibiting root growth.
Product Specific Literature References
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products
•
NAD+ Metabolism / Related Products
•
Vitamins
ALX-460-006
Revised 08-Oct-07
Folic acid
SYNONYMS
Pteroylglutamic acid
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Folic Acid & Folate Receptors / Related Products
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ALX-460-006-G010
10 g
28.00 USD
Product Specification
FORMULA:
C
19
H
19
N
7
O
6
MW:
441.4
CAS NUMBER:
59-30-3
MERCK INDEX:
14:
4221
PURITY:
≥97%
APPEARANCE:
Yellow to orange powder.
SOLUBILITY:
Soluble in diluted acids or alkaline solutions; slightly soluble in water or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Alkaline solutions are reasonably stable. Other solutions may be light and heat sensitive.
Further Categories Containing This Product:
Natural Products - Chemopreventive Agents
•
Active Substances from Fruit and Vegetables
•
Vitamins
ALX-460-007
Revised 02-Feb-07
Menadione
SYNONYMS
Vitamin K
3
2-Methyl-1,4-naphthoquinone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Vitamins
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ALX-460-007-G010
10 g
10.00 USD
Product Specification
FORMULA:
C
11
H
8
O
2
MW:
172.2
CAS NUMBER:
58-27-5
MERCK INDEX:
14:
5831
RTECS:
QL9100000
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow crystals.
SOLUBILITY:
Soluble in 96% ethanol (16mg/ml) or DMSO (1mg/ml); almost insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
HAZARD:
HARMFUL.
Product Description
Cytotoxic in various cell lines. Induces apoptosis via elevation of peroxide and superoxide radical levels. Affects gap-junctional intercellular communication by mediation of tyrosine phosphorylation.
Product Specific Literature References
Vitamin K3 induces cell cycle arrest and cell death by inhibiting Cdc25 phosphatase:
F.Y. Wu and T.P.; Eur. J. Cancer
35
, 1388 (1999)
Abstract
Apoptosis-inducing activity of vitamin C and vitamin K:
H. Sakagami, et al.; Cell Mol. Biol.
46
, 129 (2000)
Abstract
Cytotoxic effect through fas/APO-1 expression due to vitamin K in human glioma cells:
L.K. Sun, et al.; J. Neurooncol.
47
, 31 (2000)
Abstract
Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines:
H. Okayasu, et al.; Anticancer Res.
21
, 2387 (2001)
Abstract
2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade:
L.O. Klotz, et al.; Cancer Res.
62
, 4922 (2002)
Abstract
;
Full Text
Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy:
J. Mauzeroll, et al.; PNAS
101
, 17582 (2004)
Abstract
;
Full Text
Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells:
D.N. Criddle, et al.; J. Biol. Chem.
281
, 40485 (2006)
Abstract
;
Full Text
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation)
•
Antitumor Agents (Apoptosis Inducers)
•
Cell Stress, Oxidative Stress & Redox Signalling Other Products
ALX-460-008
Revised 02-Jun-06
Nicotinamide
SYNONYMS
Niacinamide
3-Pyridinecarboxylic amide
Vitamin PP
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NAD+ Metabolism / Related Products
Ordering Information
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ALX-460-008-G010
10 g
10.00 USD
Product Specification
FORMULA:
C
6
H
6
N
2
O
MW:
122.1
CAS NUMBER:
98-92-0
MERCK INDEX:
14:
6523
PURITY:
≥99%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water; also soluble in 100 % ethanol or glycerol; slightly soluble in chloroform; almost insoluble in ether or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
USE/STABILITY:
Susceptible to hydrolysis in acidic or alkaline solution.
HANDLING:
Protect from light.
HAZARD:
IRRITANT. MAY BE MUTAGENIC.
Further Categories Containing This Product:
Vitamins
•
DNA Repair Other Products
•
PARP Inhibitors
ALX-460-009
Revised 08-Jan-03
Nicotinic acid
SYNONYMS
Niacin
3-Pyridinecarboxylic acid
Vitamin B
