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ALX-610-025 Revised 03-Feb-05
Calcein
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SYNONYMS 3,3'-bis[N,N-bis(Carboxymethyl)aminomethyl]fluorescein
PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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ALX-610-025-G001   1 g 38.00 USD Add To Cart
Product Specification
FORMULA: C30H26N2O13
MW: 622.5
CAS NUMBER: 1461-15-0
PURITY: ≥95%
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
For fluorometric determination of calcium and EDTA titration in presence of magnesium.
Product Specific Literature References
Indicator for titration of calcium in presence of magnesium with disodium dihydrogen ethylene diaminetetraacetate: H. Diehl & J.L. Ellingboe; Anal. Chem. 28, 882 (1956)
D.F.H. Wallach, et al.; Anal. Chem. 31, 456 (1959)
Further Categories Containing This Product:
P-glycoprotein [Pgp] / Related Products • MDR-associated Proteins [MRPs] / Related Products • Calcium Indicators / Probes
 
 
ALX-610-026 Revised 03-Oct-08
Calcein AM
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SYNONYMS 3',6'-Di(O-acetyl-2',7'-bis[N,N-bis(carboxymethyl)-aminomethyl]fluorescein tetraacetoxymethyl ester
PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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ALX-610-026-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C46H46N2O23
MW: 994.9
CAS NUMBER: 148504-34-1
PURITY: ≥95% (HPLC)
APPEARANCE: White to yellow powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture. Packaged under inert gas.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Cell permeable derivative of calcein (Prod. No. ALX-610-025). When it permeates into the cytoplasm, it is hydrolyzed by esterases into the parent calcein which remains inside the cell. Has been used in a functional assay to measure P-glycoprotein (Pgp) and multidrug resistance protein (MRP) activities.
Product Specific Literature References
Kinetic analysis of calcein and calcein-acetoxymethylester efflux mediated by the multidrug resistance protein and P-glycoprotein: M. Essodaigui, et al.; Biochemistry 37, 2243 (1998) Abstract
Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients: O. Legrand, et al.; Blood 91, 4480 (1998) Abstract; Full Text
Simultaneous activity of MRP1 and Pgp is correlated with in vitro resistance to daunorubicin and with in vivo resistance in adult acute myeloid leukemia: O. Legrand, et al.; Blood 94, 1046 (1999) Abstract; Full Text
Both Pgp and MRP1 activities using calcein-AM contribute to drug resistance in AML: O. Legrand, et al.; Adv. Exp. Med. Biol. 457, 161 (1999) Abstract
Further Categories Containing This Product:
P-glycoprotein [Pgp] / Related Products • MDR-associated Proteins [MRPs] / Related Products • Calcium Indicators / Probes
 
 
ALX-450-015 Revised 03-Feb-05
2',7'-bis(2-Carboxyethyl)-5(6)-carboxyfluorescein
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SYNONYMS BCECF
PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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ALX-450-015-M001   1 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C27H20O11
MW: 520.5
CAS NUMBER: 85138-49-4
PURITY: Mixture of isomers
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Fluorescent indicator for the measurement of cytoplasmic pH in lymphocytes. For the cell permeable form, see BCECF-AM (2',7'-bis(2-Carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester) (Prod. No. ALX-450-016).
 
 
ALX-450-016 Revised 03-Feb-05
2',7'-bis(2-Carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester
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SYNONYMS BCECF-AM
PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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ALX-450-016-M001   1 mg 70.00 USD Add To Cart
Product Specification
CAS NUMBER: 117464-70-7
PURITY: Mixture of isomers and lactones
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
Product Description
Fluorescent cell permeable indicator for the measurement of cytoplasmic pH in lymphocytes.
 
 
ALX-610-030 Revised 23-Aug-06
CFSE
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SYNONYMS 5(6)-(N-Succinimidyloxycarbonyl)-3',6',0,0'-diacetylfluorescein
5(6)-Carboxyfluorescein diacetate, N-succinimidyl ester-
PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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ALX-610-030-M025   25 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C29H19NO11
MW: 557.5
CAS NUMBER: 150347-59-4
PURITY: ≥95%
APPEARANCE: White or slightly yellow powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Non-toxic cell permeable fluorescent dye that reacts with amine compounds. Readily accumulates inside viable cells. Hardly leaks from cells when covalently attached to intracellular proteins. Hydrolyzed CFSE emits fluorescence (Ex(max): 495nm; Em(max): 519nm). Therefore, CFSE is utilized for the long-term observation of cell activities by fluorescent microscopy as well as for viable cell detection.
Product Specific Literature References
New fluorescent dyes for lymphocyte migration studies. Analysis by flow cytometry and fluorescence microscopy: S.A. Weston & C.R. Parish; J. Immunol. Methods 133, 87 (1990) Abstract
Use of fluorescent dyes in the determination of adherence of human leucocytes to endothelial cells and the effect of fluorochromes on cellular function: L.S. De Clerck, et al.; J. Immunol. Methods 172, 115 (1994) Abstract
A simple method for evaluating the rejection of grafted spleen cells by flow cytometry and tracing adoptively transferred cells by light microscopy: S. Oehen, et al.; J Immunol Methods 207, 33 (1997) Abstract
Divided we stand: tracking cell proliferation with carboxyfluorescein diacetate succinimidyl ester: A.B. Lyons; Immunol. Cell Biol. 77, 509 (1998) Abstract
The use of carboxyfluorescein diacetate succinimidyl ester to determine the site, duration and cell type responsible for antigen presentation in vivo: J. Mintern, et al.; Immunol. Cell Biol. 77, 539 (1999) Abstract
Carboxyfluorescein diacetate succinimidyl ester and the virgin lymphocyte: a marriage made in heaven: B.F. de St Groth, et al.; Immunol. Cell Biol. 77, 530 (1999) Abstract
Optimization of 5-(and-6)-carboxyfluorescein diacetate succinimidyl ester for labeling human intervertebral disc cells in vitro: H.E. Gruber, et al.; Biotech. Histochem. 75, 118 (2000) Abstract
Flow cytometric cell division tracking using nuclei: J. Hasbold & P.D. Hodgkin; Cytometry 40, 230 (2000) Abstract
Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution: A.B. Lyons; J. Immunol. Methods 243, 147 (2000) Abstract
Flow cytometry analysis of the effect of allopurinol and the dinitroaniline compound (Chloralin) on the viability and proliferation of Leishmania infantum promastigotes: S.W. Kamau, et al.; BMC Pharmacol. 1, 1 (2001) Abstract
Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question: E.J. Suchin, et al.; J. Immunol. 166, 973 (2001) Abstract
 
 
ALX-350-238 Revised 03-Apr-08
Chlortetracycline . hydrochloride
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SYNONYMS Aureomycin . HCI
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-350-238-G001   1 g 20.00 USD Add To Cart
ALX-350-238-G005   5 g 35.00 USD Add To Cart
Product Specification
FORMULA: C22H23ClN2O8. HCl
MW: 478.9 . 36.5
CAS NUMBER: 64-72-2
MERCK INDEX: 14: 2192
SOURCE/HOST: Isolated from Streptomyces aureofaciens.
PURITY: ~80%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antibiotic. Inhibits protein synthesis in prokaryotes and eukaryotes. Inhibits binding of aminoacyl-tRNA to ribosomes. Used as a fluorescent Ca2+ probe.
Product Specific Literature References
Inhibition of thrombin-induced secretion from platelets by chlortetracycline and its analogs: E.H. Murer and E. Siojo; Thromb. Haemost. 47, 62 (1982) Abstract
Characterization of chlortetracycline (aureomycin) as a calcium ionophore: J.R. White & F.L. Pearce; Biochemistry 21, 6309 (1982) Abstract
Effect of bile acids on intracellular calcium in isolated rat hepatocyte couplets: N. Thibault & F. Ballett; Biochem. Pharmacol. 45, 289 (1993) Abstract
Chlortetracycline, oxytetracycline, and tetracycline in edible animal tissues, liquid chromatographic method: collaborative study: J.D. MacNeil, et al.; J. AOAC Int. 79, 405 (1996) Abstract
The effect of chlortetracycline treatment and its subsequent withdrawal on multi-resistant Salmonella enterica serovar Typhimurium DT104 and commensal Escherichia coli in the pig: A.A. Delsol, et al.; J. Appl. Microbiol. 95, 1226 (2003) Abstract
Further Categories Containing This Product:
tRNA / Related Products • Calcium Indicators / Probes • Dyes / Stains / Fluorescent Probes / Fluorescent Labels
 
 
ALX-620-063 Revised 03-Feb-05
Coelenterazine
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SYNONYMS 2-[(4-Hydroxyphenyl)methyl]-6-(4-hydroxyphenyl)-8-(phenylmethyl)-imidazo [1,2-a] pyrazin-3-(7H)-one
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Peroxynitrite / Scavengers / Detection
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ALX-620-063-C050   50 µg 110.00 USD Add To Cart
Product Specification
FORMULA: C26H21N3O3
MW: 423.5
CAS NUMBER: 55779-48-1
PURITY: ≥95%
APPEARANCE: Brown solid.
SOLUBILITY: Slightly soluble in methanol or ethanol. Avoid DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas. Keep calcium free when stored in solution.

Product Description
Cell permeable, very sensitive and specific chemiluminescence probe of the superoxide anion and peroxynitrite. When oxidized by oxygen it emits blue light at 446nm when Ca2+ binds to the complex. Powerful antioxidant. See also 2-(4-Dehydroxy)coelenterazine (Prod. No. ALX-620-062).
Product Specific Literature References
Use of calcium-regulated photoproteins as intracellular Ca2+ indicators: J.R. Blinks; Meth. Enzymol. 172, 164 (1989) Abstract
Slow calcium waves accompany cytokinesis in medaka fish eggs: R.A. Fluck, et al.; J. Cell Biol. 115, 1259 (1991) Abstract
Coelenterazine is a superoxide anion-sensitive chemiluminescent probe: its usefulness in the assay of respiratory burst in neutrophils: M. Lucas & F. Solano; Anal. Biochem. 206, 273 (1992) Abstract
Aequorin-expressing mammalian cell lines used to report Ca2+ mobilization: D. Button & M. Brownstein; Cell Calcium 14, 663 (1993) Abstract
Imaging [Ca2+]i with aequorin using a photon imaging detector: A.L. Miller, et al.; Meth. Cell Biol. 40, 305 (1994) Abstract
Intracellular free calcium level and its response to cAMP stimulation in developing Dictyostelium cells transformed with jellyfish apoaequorin cDNA: S. Saran, et al.; FEBS Lett. 337, 43 (1994) Abstract
The origins of marine bioluminescence: turning oxygen defence mechanisms into deep-sea communication tools: J.F. Rees, et al.; J. Exp. Biol. 201, 1211 (1998) Abstract; Full Text
Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation: M.M. Tarpey, et al.; Circ. Res. 84, 1203 (1999) Abstract
Further Categories Containing This Product:
Calcium Indicators / Probes • Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Luciferin & Luciferase / Related Products • Dyes / Stains / Fluorescent Probes / Fluorescent Labels • Oxidative Stress Markers & Reagents / Related Products
 
 
ALX-270-082 Revised 28-Jan-05
Conduritol B epoxide
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Glycosidases / Related Products
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ALX-270-082-M005   5 mg 35.00 USD Add To Cart
ALX-270-082-M025   25 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C6H10O5
MW: 162.1
CAS NUMBER: 6090-95-5
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from moisture.

Product Description
Irreversible, high-potency inhibitor of various plant β-glucosidases and mammalian glucocerebrosidase. Used in vitro and animal models for study of Gaucher's disease.
Product Specific Literature References
[Mechanism of action of glycoside-splitting enzymes. V. Labelling of the active center of beta-glucosidases A and B from sweet almond emulsin with (3H)6-bromo-6-deoxyconduritol B epoxide]: G. Legler; Hoppe-Seyler's Z. Physiol. Chem. 351, 25 (1970) Abstract
The Gaucher mouse: differential action of conduritol B epoxide and reversibility of its effects: M.C. Stephens, et al.; J. Neurochem. 30, 1023 (1978) Abstract
Destruction and resynthesis of mouse beta-glucosidases: A. Hara & N.S. Radin; Biochim. Biophys. Acta 582, 412 (1979) Abstract
beta-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell: D.S. Newburg, et al.; Biochim. Biophys. Acta 877, 121 (1986) Abstract
Normalization of liver glucosylceramide levels in the "Gaucher" mouse by phosphatidylserine injection: S.C. Datta and N.S. Radin; BBRC 152, 155 (1988) Abstract
Further Categories Containing This Product:
Plant Research Reagents / Related Products
 
 
ALX-350-100 Revised 03-Apr-08
Convulxin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
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ALX-350-100-C050   50 µg 565.00 USD Add To Cart
Product Specification
MW: ~84kDa.
CAS NUMBER: 37206-04-5
SOURCE/HOST: Isolated from Crotalus durissus terrificus snake venom.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in organic buffer (HEPES).
ACTIVITY: <50ng/ml (minimal concentration to induce maximum activation of washed human platelets).
APPLICATION: Studies on platelet receptors.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for 8 hours at +20°C, for 2 days at +4°C or for 1 month when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
HAZARD: TOXIC.
Product Description
Heterodimeric C-type lectin. Activates mammalian platelets via binding and clustering of p62/GPVI-receptors under physiological conditions.
Product Specific Literature References
Convulxin, a new toxin from the venom of the South American rattlesnake Crotalus durissus terrificus: J. Prado-Franceschi & O.V. Brazil; Toxicon 19, 875 (1981) Abstract
Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor: J. Polgar, et al.; J. Biol. Chem. 272, 13576 (1997) Abstract
Convulxin-induced platelet adhesion and aggregation: involvement of glycoproteins VI and IaIIa: M. Jandrot-Perrus, et al.; Platelets 9, 207 (1998) Abstract
Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases: M. Cicmil, et al.; J. Biol. Chem. 275, 27339 (2000) Abstract
Convulxin binds to native, human glycoprotein Ib alpha: S. Kanaji, et al.; J. Biol. Chem. 278, 39452 (2003) Abstract
Structure of the snake-venom toxin convulxin: T. Batuwangala, et al.; Acta Crystallogr. D. Biol. Crystallogr. 60, 46 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Assay performed in aggregometer:
- Incubate 485µl platelets suspension (5x108 platelets/ml) for 1-2 minutes at 37°C until base line is stable.
- Add 5µl 200mM CaCl2.
- Add 5µl 200mM MgCl2.
- Wait until baseline is stable.
- Add 5µl collagen solution (0.5mg/ml) for positive control OR add 5µl convulxin (0.1µg/ml in HEPES).
- Measure aggregation at 37°C.
Further Categories Containing This Product:
Unconjugated Lectins • Platelet Activating Factors [PAF] & Receptors / Related Products
 
 
ALX-620-079 Revised 11-Aug-06
CPF4
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SYNONYMS Coumarin phosphodiester-linked fluorescein
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
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ALX-620-079-C250   250 µg 381.00 USD Add To Cart
ALX-620-079-C500   500 µg 667.00 USD Add To Cart
Product Specification
FORMULA: C44H28ClN2O14P
MW: 875.1
PURITY: ≥99% (1H-NMR)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO (10mM) or in aqueous buffers, pH>8.5.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Keep cool and dry.
Product Images
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Product Description
Enzyme-cleavable FRET sensor molecule for the ratiometric measurement of phosphodiesterase activity. This is an effective method for the monitoring of phosphodiesterase activity in real time with high sensitivity; a large spectral shift in the emission spectrum is noticed after hydrolysis of the phosphodiester linker by phosphodiesterase I (Ex(max): 370nm; Em(max) uncleaved: 515nm; Em(max) cleaved: 450nm). The role of NPPs (pyrophosphatases/phosphodiesterases) can also be investigated.
Product Specific Literature References
Design and synthesis of an enzyme-cleavable sensor molecule for phosphodiesterase activity based on fluorescence resonance energy transfer: H. Takakusa, et al.; J. Am. Chem. Soc. 124, 1653 (2002) Abstract
Design and Synthesis of Intramolecular Resonance-Energy Transfer Probes for Use in Ratiometric Measurements in Aqueous Solution: Y. Kawanishi, et al.; Angew. Chem. Int. Ed. Engl. 39, 3438 (2000) Abstract