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ALX-105-005
Revised 20-May-08
N-Acetyl-L-cysteine
SYNONYMS
LNAL
N-Acetyl-3-mercaptoalanine
L-α-Acetamido-β-mercaptopropionic acid
NAC
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
Ordering Information
Product Numbers:
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Unit Price:
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ALX-105-005-G001
1 g
16.00 USD
ALX-105-005-G005
5 g
27.00 USD
Product Specification
FORMULA:
C
5
H
9
NO
3
S
MW:
163.2
CAS NUMBER:
616-91-1
MERCK INDEX:
14:
88
RTECS:
HA1660000
PURITY:
≥99%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in 5M hydrochloric acid (hot) (100mg/ml); also soluble in water or 100% ethanol; insoluble in chloroform or ether.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Modulation of platelet function by free radicals and free-radical scavengers:
D. Salvemini & R. Botting; TIPS
14
, 36 (1993), (Review)
Abstract
Conversion of glyceryl trinitrate to nitric oxide in tolerant and non- tolerant smooth muscle and endothelial cells:
D. Salvemini, et al.; Br. J. Pharmacol.
108
, 162 (1993)
Abstract
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1:
H. Schenk, et al.; PNAS
91
, 1672 (1994)
Abstract
Induction of apoptosis by pyrrolidinedithiocarbamate and N- acetylcysteine in vascular smooth muscle cells:
J.C. Tsai, et al.; J. Biol. Chem.
271
, 3667 (1996)
Abstract
;
Full Text
Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice:
E. Ho, et al.; Faseb. J.
13
, 1845 (1999)
Abstract
Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells:
A. Iseki, et al.; Biochem. Biophys. Res. Commun.
276
, 88 (2000)
Abstract
Suppression of NF-kappaB activation and cytokine production by N- acetylcysteine in pancreatic acinar cells:
H. Kim, et al.; Free Radic. Biol. Med.
29
, 674 (2000)
Abstract
Further Categories Containing This Product:
Special Amino Acids
ALX-101-003
Revised 07-May-03
β-Alanine
SYNONYMS
3-Aminopropionic acid
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
Special Amino Acids
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ALX-101-003-G001
1 g
15.00 USD
Product Specification
FORMULA:
C
3
H
7
NO
2
MW:
89.1
CAS NUMBER:
107-95-9
MERCK INDEX:
14:
205
PURITY:
≥99%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
ALX-106-027
Revised 07-May-03
D-α-Aminoadipic acid
SYNONYMS
D-2-Aminohexanedioic acid
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
Special Amino Acids
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ALX-106-027-M050
50 mg
20.00 USD
ALX-106-027-M250
250 mg
70.00 USD
Product Specification
FORMULA:
C
6
H
11
NO
4
MW:
161.2
CAS NUMBER:
7620-28-2
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Amino acid antagonist. Glutamine synthethase inhibitor
in vivo
.
ALX-106-026
Revised 11-Jul-07
L-α-Aminoadipic acid
SYNONYMS
L-2-Aminohexanedioic acid
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
Special Amino Acids
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ALX-106-026-M050
50 mg
10.00 USD
ALX-106-026-M250
250 mg
30.00 USD
Product Specification
FORMULA:
C
6
H
11
NO
4
MW:
161.2
CAS NUMBER:
1118-90-7
MERCK INDEX:
14:
416
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in 1N HCl.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Increases intracellular free Ca
2+
concentration. Competitive inhibitor of glutamine synthase and γ-glutamylcysteine synthase. Competitive glutamate receptor antagonist.
Product Specific Literature References
Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors:
J.W. Ferkany, et al.; Nature
298
, 757 (1982)
Abstract
Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, alpha aminoadipate:
G.J. McBean; Br. J. Pharmacol.
113
, 536 (1994)
Abstract
ALX-106-025
Revised 07-May-03
γ-Aminobutyric acid
SYNONYMS
GABA
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
GABA-ergics & GABA Receptors / Related Products
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ALX-106-025-G010
10 g
7.00 USD
Product Specification
FORMULA:
C
4
H
9
NO
2
MW:
103.1
CAS NUMBER:
56-12-2
MERCK INDEX:
14:
430
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water; slightly soluble in ethanol; insoluble in most organic solvents.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Further Categories Containing This Product:
Special Amino Acids
ALX-550-016
Revised 08-Nov-07
(S)-AMPA
SYNONYMS
(S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
AMPA Receptors / Related Products
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ALX-550-016-M005
5 mg
95.00 USD
ALX-550-016-M025
25 mg
380.00 USD
Product Specification
FORMULA:
C
7
H
10
N
2
O
4
MW:
186.2
CAS NUMBER:
83643-88-3
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Hygroscopic.
Product Description
Active enantiomer of (R,S)-AMPA (Prod. No.
ALX-550-023
).
Product Specific Literature References
Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid:
J.J. Hansen, et al.; J. Med. Chem.
26
, 901 (1983)
Abstract
Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors:
J. Lauridsen, et al.; J. Med. Chem.
28
, 668 (1985)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp, et al.; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
Further Categories Containing This Product:
Special Amino Acids
ALX-101-005
Revised 22-Nov-06
D-Arginine
SYNONYMS
H-D-Arg-OH
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
D-Amino Acids
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ALX-101-005-G005
5 g
62.00 USD
Product Specification
FORMULA:
C
6
H
14
N
4
O
2
MW:
174.2
CAS NUMBER:
157-06-2
PURITY:
≥99.0%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Further Categories Containing This Product:
Arginine & Arginases / Related Products
ALX-101-004
Revised 03-Aug-07
L-Arginine
SYNONYMS
H-L-Arg-OH
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
L-Amino Acids
Ordering Information
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ALX-101-004-G025
25 g
17.00 USD
Product Specification
FORMULA:
C
6
H
14
N
4
O
2
MW:
174.2
CAS NUMBER:
74-79-3
MERCK INDEX:
14:
780
RTECS:
CF1934200
PURITY:
≥98%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Specific Literature References
L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation:
R.M.J. Palmer, et al.; BBRC
153
, 1251 (1988)
Abstract
Vascular endothelial cells synthesize nitric oxide from L-arginine:
R.M.J. Palmer, et al.; Nature
333
, 664 (1988)
Abstract
Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides:
H.H.H.W. Schmidt, et al.; Science
255
, 721 (1992)
Abstract
The importance of L-arginine metabolism in melanoma: an hypothesis for the role of nitric oxide and polyamines in tumor angiogenesis:
M. Joshi; Free Radic. Biol. Med.
22
, 573 (1997), (Review)
Abstract
L-arginine increases UVA cytotoxicity in irradiated human keratinocyte cell line: potential role of nitric oxide:
C. Didier, et al.; FASEB J.
13
, 1817 (1999)
Abstract
;
Full Text
L-Arginine supplementation enhances diabetic wound healing: involvement of the nitric oxide synthase and arginase pathways:
M.B. Witte, et al.; Metabolism
51
, 1269 (2002)
Abstract
Pharmacokinetics and pharmacodynamics of L-arginine in rats: a model of stimulated neuronal nitric oxide synthesis:
E.L. Heinzen & G.M. Pollack; Brain Res.
989
, 67 (2003)
Abstract
L-arginine regulates neuronal nitric oxide synthase production of superoxide and hydrogen peroxide:
P. Tsai, et al.; Biochem. Pharmacol.
69
, 971 (2005)
Abstract
Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide:
S. Saleh & E. El-Demerdash; Basic Clin. Pharmacol. Toxicol.
97
, 91 (2005)
Abstract
General Information
Physiological precursor for the formation of nitric oxide (NO) by nitric oxide synthase (NOS). Enhances the release of NO.
Further Categories Containing This Product:
Arginine & Arginases / Related Products
•
Nitric Oxide Donors
ALX-101-011
Revised 22-Nov-06
D-Aspartic acid
SYNONYMS
H-D-Asp-OH
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
D-Amino Acids
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ALX-101-011-G001
1 g
12.00 USD
Product Specification
FORMULA:
C
4
H
7
NO
4
MW:
133.1
CAS NUMBER:
1783-96-6
MERCK INDEX:
14:
840
RTECS:
CI9097500
PURITY:
≥99%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Further Categories Containing This Product:
Excitatory Amino Acids
•
NMDA Receptors / Related Products
ALX-101-010
Revised 11-Sep-07
L-Aspartic acid
SYNONYMS
H-L-Asp-OH
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
L-Amino Acids
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ALX-101-010-G001
1 g
12.00 USD
Product Specification
FORMULA:
C
4
H
7
NO
4
MW:
133.1
CAS NUMBER:
56-84-8
MERCK INDEX:
14:
840
RTECS:
CI9098500
PURITY:
≥99.5%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Further Categories Containing This Product:
NMDA Receptors / Related Products
•
Excitatory Amino Acids
ALX-106-031
Revised 06-Dec-04
p-Chloro-L-phenylalanine
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
Special Amino Acids
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ALX-106-031-M050
50 mg
15.00 USD
ALX-106-031-M250
250 mg
45.00 USD
Product Specification
FORMULA:
C
9
H
10
ClN
2
O
2
MW:
199.6
CAS NUMBER:
14173-39-8
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
ALX-106-030
Revised 01-Jul-03
p-Chloro-DL-phenylalanine
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
Special Amino Acids
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ALX-106-030-G001
1 g
