• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Natural Products / Antibiotics
You are here: Product Lines > Natural Products / Antibiotics
 
Toolbar - View Selection
 
 Items 140-160 of 722 Page 8 of 37 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-350-141 Revised 22-Aug-07
Rocaglamide C
Add to Clipboard
SYNONYMS 3’-Hydroxyrocaglamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-141-C050   50 µg 160.00 USD Add To Cart
Product Specification
FORMULA: C29H31NO8
MW: 521.6
CAS NUMBER: 189322-67-6
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties.
Product Specific Literature References
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982)
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000)
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000)
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001)
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006) Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006)
Related Products
Further Categories Containing This Product:
Natural Products - Immunomodulators • TNF-alpha & TNF Receptors Other Products • Other Natural Products - DNA Regulation / Transcription • Nuclear Factor of Activated T Cells [NF-AT] • NF-kB Pathway Inhibitors
 
 
ALX-350-142 Revised 22-Aug-07
Rocaglamide I
Add to Clipboard
SYNONYMS 1-Acetyl-3’-hydroxyrocaglamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-142-C050   50 µg 160.00 USD Add To Cart
Product Specification
FORMULA: C31H33NO9
MW: 563.6
CAS NUMBER: 189322-68-7
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties.
Product Specific Literature References
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982)
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000)
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000)
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001)
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006) Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006)
Related Products
Further Categories Containing This Product:
Natural Products - Immunomodulators • TNF-alpha & TNF Receptors Other Products • Other Natural Products - DNA Regulation / Transcription • Nuclear Factor of Activated T Cells [NF-AT] • NF-kB Pathway Inhibitors
 
 
ALX-350-143 Revised 22-Aug-07
Rocaglamide J
Add to Clipboard
SYNONYMS Aglafolin
2-Methylrocaglate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-143-C050   50 µg 160.00 USD Add To Cart
Product Specification
FORMULA: C28H28O8
MW: 492.5
CAS NUMBER: 147059-47-0
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties.
Product Specific Literature References
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982)
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000) Abstract
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000) Abstract
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001) Abstract
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006) Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Natural Products - Immunomodulators • TNF-alpha & TNF Receptors Other Products • Other Natural Products - DNA Regulation / Transcription • Nuclear Factor of Activated T Cells [NF-AT] • NF-kB Pathway Inhibitors
 
 
ALX-350-144 Revised 03-Apr-08
Bakuchiol
Add to Clipboard
SYNONYMS 4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-144-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C18H24O
MW: 256.4
CAS NUMBER: 10309-37-2
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow to brownish oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibitor of protein tyrosine phosphatase 1B (PTB1B). Antioxidant. Inhibitor of mitochondrial lipid peroxidation. Inhibitor of inducible nitric oxide synthase (iNOS; NOS II) expression. DNA polymerase inhibitor. Shows antimicrobial and cytotoxic activity.
Product Specific Literature References
Plant antimutagenic agents, 2. Flavonoids: M.E. Wall, et al.; J. Nat. Prod. 51, 1084 (1988) Abstract
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998) Abstract
Inhibition of mitochondrial lipid peroxidation by Bakuchiol, a meroterpene from Psoralea corylifolia: H. Haraguchi, et al.; Planta Med. 66, 569 (2000) Abstract
Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities: C.N. Backhouse, et al.; J. Ethnopharmacol. 78, 27 (2001) Abstract
Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells: H. Cho, et al.; Planta Med. 67, 750 (2001) Abstract
In vitro antimicrobial activities of bakuchiol against oral microorganisms: H. Katsura, et al.; Antimicrob. Agents Chemother. 45, 3009 (2001) Abstract; Full Text
Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappaB in RAW 264.7 macrophages: H.O. Pae, et al.; Int. Immunopharmacol. 1, 1849 (2001) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis: S.M. Newton, et al.; J. Ethnopharmacol. 79, 57 (2002) Abstract
Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain: S. Adhikari, et al.; Chem. Res. Toxicol. 16, 1062 (2003) Abstract
Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent: K. Bapat, et al.; Appl. Radiat. Isot. 62, 389 (2005) Abstract
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia: Y.C. Kim, et al.; Planta Med. 71, 87 (2005) Abstract
Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo: E.J. Park, et al.; Planta Med. 71, 508 (2005) Abstract
Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts: E.J. Park, et al.; Eur. J. Pharmacol. 559, 115 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - DNA Replication Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Topoisomerase Inhibitors • Natural Products with Antibiotic Activity • Protein Tyrosine Phosphatases Other Products • Lipid Peroxidation • Natural Products - Antioxidants
 
 
ALX-350-145 Revised 28-Mar-07
Isobavachalcone
Add to Clipboard
SYNONYMS 2’,4’,4-Trihydroxy-3’-[3’’-methylbut-3’’-enyl]chalcone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-145-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C20H20O4
MW: 324.4
CAS NUMBER: 20784-50-3
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibits platelet aggregation. Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Shows antifungal activity.
Product Specific Literature References
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects: T. Akihisa, et al.; Cancer Lett. 201, 133 (2003) Abstract
Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa: N.O. Omisore, et al.; Braz. J. Med. Biol. Res. 38, 1087 (2005) Abstract
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects: T. Akihisa, et al.; J. Nat. Prod. 69, 38 (2006) Abstract
Inhibition of matrix metalloproteinase-2 secretion by chalcones from the twigs of Dorstenia barteri Bureau.: B. Ngameni, et al.; Arkivoc ix, 91 (2007) Full Text
Further Categories Containing This Product:
Other Natural Products - DNA Regulation / Transcription • Chalcones • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • MMP Inhibitors • Epstein Barr Virus / Related Products • Antitumor Agents (Anti-proliferative) • Natural Products - Antifungal Agents
 
 
ALX-350-146 Revised 03-Oct-07
Neobavaisoflavone
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-146-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C20H18O4
MW: 322.4
CAS NUMBER: 41060-15-5
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibits platelet aggregation. DNA polymerase inhibitor. Shows antifungal activity.
Product Specific Literature References
Prenylated isoflavanone from the roots of Erythrina sigmoidea: A.E. Nkengfack, et al.; Phytochemistry 36, 1047 (1994) Abstract
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998) Abstract
Studies on the chemical constituents of Psoralea corylifolia L.: B. Ruan, et al.; J. Asian Nat. Prod. Res. 9, 41 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Topoisomerase Inhibitors • Natural Products - DNA Replication Inhibitors • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Natural Products - Antifungal Agents • DNA Replication Inhibitors • Isoflavones
 
 
ALX-350-147 Revised 03-Oct-07
Bavachin
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-147-MC05   0.5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C20H20O4
MW: 324.4
CAS NUMBER: 19879-32-4
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Weak antioxidant. Antimutagenic. Stimulates bone formation and has potential activity against osteoporosis. Shows inhibitory activities against the antigen-induced degranulation and weak estrogen-like activity.
Product Specific Literature References
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
Osteoblastic proliferation stimulating activity of Psoralea corylifolia extracts and two of its flavonoids: D. Wang, et al.; Planta Med. 67, 748 (2001) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia: H. Matsuda, et al.; Chem. Pharm. Bull. (Tokyo) 55, 106 (2007) Abstract
Synthesis of four natural prenylflavonoids and their estrogen-like activities: X. Dong, et al.; Arch. Pharm. (Weinheim) 340, 372 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Immunomodulators • Estrogen & Estrogen Receptors / Related Products • Flavanones • Bone Metabolism Other Products
 
 
ALX-350-148 Revised 06-Jun-08
Microcystin-LY
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Microcystins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-148-C025   25 µg 135.00 USD Add To Cart
ALX-350-148-C100   100 µg 390.00 USD Add To Cart
Product Specification
FORMULA: C52H71N7O13
MW: 1002.2
SOURCE/HOST: Isolated from Microcystis aeruginosa.
PURITY: ≥95% (HPLC)
APPEARANCE: Whitish film adhered to inside of the vial.
SOLUBILITY: Soluble in 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at -20°C. Unstable at pH>7.7.
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap.
HAZARD: MAY BE CARCINOGENIC. VERY TOXIC. HIGHLY IRRITANT.
IDENTITY: Identity determined by MS.

Product Description
Analog of microcystin-LR (Prod. No. ALX-350-012) with Tyr substituted in place of Arg. Its toxicity is intermediate between the more toxic microcystin-LF and the less toxic microcystin-LR.
Product Specific Literature References
The effects of single L-amino acid substitutions on the lethal potencies of the microcystins: R.D. Stoner, et al.; Toxicon 27, 825 (1989)
Identification and characterization of microcystin-LY from Microcystis aeruginosa (strain 298): S. Rudolph-Bohner, et al.; Biol. Chem. Hoppe Seyler 374, 635 (1993) Abstract
Comparative toxicity of four microcystins of different hydrophobicities to the protozoan, Tetrahymena pyriformis: C.J. Ward & G.A. Codd; J. Appl. Microbiol. 86, 874 (1999) Abstract
Related Products
Further Categories Containing This Product:
Other Toxins • Marine Natural Products
 
 
ALX-350-149 Revised 23-Oct-07
Cylindrospermopsin