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Protein Serine / Threonine Phosphatases / Related Products
You are here: Product Lines > Signal Transduction > Phosphatases / Related Products > Protein Serine / Threonine Phosphatases / Related Products
 
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ALX-430-031 Revised 11-Jan-07
Allethrin
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SYNONYMS (R,S)-3-Allyl-2-methyl-4-oxocyclopent-2-enyl-(1R,S)-cis,trans-chrysanthemate
Allylcinerin
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-031-M010   10 mg 30.00 USD Add To Cart
ALX-430-031-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C19H26O3
MW: 302.4
CAS NUMBER: 584-79-2
MERCK INDEX: 14: 260
RTECS: GZ1925000
PURITY: ≥95% (HPLC)
APPEARANCE: Clear or whitish film.
SOLUBILITY: Soluble in DMSO or 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Avoid alkalis.
HAZARD: HARMFUL.

Product Description
Type I pyrethroid, useful as a very weakly active "negative" control for inhibition of calcineurin (protein phosphatase 2B) by type II pyrethroids.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol 43, 1777 (1992) Abstract
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; TIPS 13, 236 (1992), (Review) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-151-019 Revised 15-Dec-04
cAMP-dependent Protein Kinase Substrate
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SYNONYMS PKA Substrate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKA Substrates
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ALX-151-019-MC05   0.5 mg 95.00 USD Add To Cart
ALX-151-019-M001   1 mg 165.00 USD Add To Cart
Product Specification
SEQUENCE: H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH
FORMULA: C92H150N28O29
MW: 2112.4
PURITY: ≥95%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Derived from the RII subunit of cAMP-dependent protein kinase (PKA). Substrate for PKA. Has been used in a non-radioactive assay of calcineurin (protein phosphatase 2B) for screening purposes.
Product Specific Literature References
Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity: D.K. Blumenthal, et al.; J. Biol. Chem. 261, 8140 (1986) Abstract; Full Text
Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate: A. Enz, et al.; Anal. Biochem. 216, 147 (1994) Abstract
Further Categories Containing This Product:
PP2B [Calcineurin] / Related Products • Peptides
 
 
ALX-380-005 Revised 03-Apr-08
Ascomycin
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SYNONYMS Immunomycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Immunomodulators
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ALX-380-005-M001   1 mg 125.00 USD Add To Cart
ALX-380-005-M005   5 mg 540.00 USD Add To Cart
Product Specification
FORMULA: C43H69NO12
MW: 792.0
CAS NUMBER: 11011-38-4
RTECS: CI75700000
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Antibiotic. Ethyl analog of FK506 (Prod. No. ALX-380-008) with similar immunosuppressant properties. Inhibits calcineurin phosphatase.
Product Specific Literature References
Ascomycin, an antifungal antibiotic: T. Arai, et al.; J. Antibiot. (Tokyo) 15, 23 (1962) Abstract
NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein: A.M. Petros, et al.; J. Med. Chem. 35, 2467 (1992) Abstract
Structure-activity profiles of macrolactam immunosuppressant FK-506 analogues: M. Kawai, et al.; FEBS Lett. 316, 107 (1993) Abstract
Enzymatic synthesis and immunosuppressive activity of novel desmethylated immunomycins (ascomycins): A. Shafiee, et al.; J. Antibiot. (Tokyo) 46, 1397 (1993) Abstract
Further Categories Containing This Product:
PP2B [Calcineurin] / Related Products • Antibiotics - Other Signal Transduction Pathway Modulators
 
 
ALX-430-032 Revised 24-Feb-05
Bioallethrin
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SYNONYMS D-trans-Allethrin
(S)-3-Allyl-2-methyl-4-oxocyclopent-2-enyl-(1R,3R)-2,2-dimethyl-3-(2-methyl-prop-1-enyl)cyclopropancarboxylate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
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ALX-430-032-M025   25 mg 90.00 USD Add To Cart
ALX-430-032-M100   100 mg 270.00 USD Add To Cart
Product Specification
FORMULA: C19H26O3
MW: 302.4
CAS NUMBER: 22431-63-6
PURITY: ≥97%
SOLUBILITY: Soluble in hot water, diluted acids or alkaline solutions; hardly soluble in cold water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Avoid alkalies.
HAZARD: HARMFUL.

Product Description
Although bioallethrin is a type I pyrethroid, its effects on calcineurin (protein phosphatase 2B) resembles those of type II pyrethrins. Unlike most type I pyrethrins, which are very weak, bioallethrin is a potent calcineurin inhibitor.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-202-034 Revised 13-Dec-04
Calcineurin (bovine brain)
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SYNONYMS Calmodulin Binding Protein (bovine brain)
Protein Phosphatase 2B (bovine brain)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
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ALX-202-034-U100   100 U 590.00 USD Add To Cart
Product Specification
CAS NUMBER: 9025-75-6
EC: 3.1.3.16
MERCK INDEX: 14: 1640
SOURCE/HOST: Isolated from bovine brain.
FORMULATION: Lyophilized powder containing ~1% protein (Lowry) and 0.5% EGTA, buffer salts and stabilizers.
SPECIFIC ACTIVITY: ~2'500-5'000U/mg protein. One unit causes a 50% inhibition of the activated phosphodiesterase activity when assayed with 2 units of activator and 0.1mM Ca2+ in an enzyme coupled system at 30°C, pH 7.5.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Enzymes • Natural Proteins • Nitric Oxide Pathway Other Products
 
 
ALX-350-014 Revised 03-Apr-08
Calyculin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-014-C010   10 µg 65.00 USD Add To Cart
ALX-350-014-C025   25 µg 110.00 USD Add To Cart
ALX-350-014-C050   50 µg 190.00 USD Add To Cart
ALX-350-014-C100   100 µg 320.00 USD Add To Cart
Product Specification
FORMULA: C50H81N4O15P
MW: 1009.2
CAS NUMBER: 101932-71-2
SOURCE/HOST: Isolated from Discodermia calyx.
PURITY: ≥95%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol, acetonitrile, chloroform, methylene chloride or benzene. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: May by subject to isomerization when in solution. Biological activity is not affected by isomerization.
HANDLING: Protect from light and moisture.
HAZARD: TOXIC. MAY BE CARCINOGENIC.

Product Description
Potent cell permeable inhibitor with high specificity for protein phosphatase 1 (PP1) and 2A (PP2A). Inhibits p130cas tyrosine phosphorylation. Enhances the phosphorylation level of NF-κB. Affects intracellular signalling processes that require 14-3-3. Potent non-phorbol type tumor promoter. Prevents γ-radiation induced apoptosis.
Product Specific Literature References
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate- type tumor promoter: M. Suganuma, et al.; PNAS 85, 1768 (1988) Abstract
Protein phosphatases come of age: P.Cohen & P.T. Cohen; J. Biol. Chem. 264, 21435 (1989) Abstract; Full Text
Calyculin A and okadaic acid: inhibitors of protein phosphatase activity: H. Ishihara, et al.; BBRC 159, 871 (1989) Abstract
The structure and regulation of protein phosphatases: P. Cohen; Ann. Rev. Biochem. 58, 453 (1989) Abstract
Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin: M. Suganuma, et al.; Cancer Res. 50, 3521 (1990) Abstract
Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C: R. Gopalakrishna; BBRC 189, 950 (1992) Abstract
Comparative effects of protein phosphatase inhibitors (okadaic acid and calyculin A) on human leukemia HL60, HL60/ADR and K562 cells: K. Sakurada, et al.; BBRC 187, 488 (1992) Abstract
Calyculin A, a potent inhibitor of phosphatases-1 and -2A, prevents apoptosis: Q. Song & M.F. Lavin; BBRC 190, 47 (1993) Abstract
Enhancement of AMPA-mediated synaptic transmission by the protein phosphatase inhibitor calyculin A in rat hippocampal slices: A. Figurov, et al.; Eur. J. Neurosci. 5, 1035 (1993) Abstract
Calyculin A, a non-phorbol ester type tumor promotor, induced oxidative DNA damage in stimulated human neutrophil-like cells: T. Takeuchi, et al.; BBRC 205, 1803 (1994) Abstract
Potassium and calcium channel involvement in induction of long-lasting synaptic enhancement by calyculin A, a protein phosphatase inhibitor, in rat hippocampal CA1 region: N. Murakami, et al.; Neurosci. Lett. 176, 181 (1994) Abstract
Differential toxicity of the protein phosphatase inhibitors microcystin and calyculin A: M.T. Runnegar, et al.; J. Pharmacol. Exp. Ther. 273, 545 (1995) Abstract
Inhibition of p130cas tyrosine phosphorylation by calyculin A: W. Qiu, et al.; J. Leukoc. Biol. 63, 631 (1998) Abstract
Unique features of the okadaic acid activity class of tumor promoters: H. Fujiki & M. Suganuma; J. Cancer Res. Clin. Oncol. 125, 150 (1999), Review Abstract
Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo: G. Tzivion, et al.; J. Biol. Chem. 275, 29772 (2000) Abstract
Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells: H. Tanaka, et al.; Int. J. Oncol. 31, 389 (2007) Abstract
Further Categories Containing This Product:
PP2A / Related Products • PP1 / Related Products • Natural Products - Other Tumor Promoters • 14-3-3 Proteins / Related Products • Carcinogens & Tumor Promoters Other Products • NF-kB Pathway Modulators • Natural Products - Apoptosis Inducers & Inhibitors • Marine Natural Products
 
 
ALX-270-062 Revised 03-Feb-05
Cantharidic acid . disodium salt
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2A / Related Products
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ALX-270-062-M010   10 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C10H12O5 . 2Na
MW: 212.2 . 46.0
CAS NUMBER: 28874-45-5
PURITY: ≥95%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water; slightly soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent protein phosphatase 2A inhibitor.
Product Specific Literature References
M. Matsuzawa, et al.; J. Agric. Food Chem. 35, 823 (1987)
Partial characterization of specific cantharidin binding sites in mouse tissues: M.J. Graziano, et al.; Mol. Pharmacol. 33, 706 (1989) Abstract
Cantharidin-binding protein: identification as protein phosphatase 2A: Y.-M. Li & J.E. Casida; PNAS 89, 11867 (1992) Abstract
 
 
ALX-270-063 Revised 03-Apr-08
Cantharidin
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SYNONYMS Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-270-063-M025   25 mg 50.00 USD Add To Cart
ALX-270-063-M100   100 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C10H12O4
MW: 196.2
CAS NUMBER: 56-25-7
MERCK INDEX: 14: 1752
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetone, DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Potent protein phosphatase 2A (PP2A) inhibitor. At higher concentrations, also inhibits protein phosphatase 1 (PP1).
Product Specific Literature References
Partial characterization of specific cantharidin binding sites in mouse tissues: M.J. Graziano, et al.; Mol. Pharmacol. 33, 706 (1988) Abstract
Cantharidin-binding protein: identification as protein phosphatase 2A: Y.-M. Li and J.E. Casida; PNAS 89, 11867 (1992) Abstract
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues: Y.-M. Li, et al.; Biochem. Pharmacol. 46, 1435 (1993) Abstract
Further Categories Containing This Product:
PP2A / Related Products
 
 
ALX-430-044 Revised 29-Feb-08
Cypermethrin
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SYNONYMS Alphamethrine
(R,S)-α-Cyano-(3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
Pestanal
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-044-M010   10 mg 40.00 USD Add To Cart
ALX-430-044-M025   25 mg 80.00 USD Add To Cart
ALX-430-044-M100   100 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C22H19Cl2NO3
MW: 416.3
CAS NUMBER: 52315-07-8
MERCK INDEX: 14: 2767
RTECS: GZ1250000
PURITY: ≥95% (HPLC)
FORMULATION: Clear or whitish film adhered to inside of vial.
SOLUBILITY: Soluble in methanol or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE MUTAGENIC. TOXIC.
IDENTITY: Determined by 1H-NMR.

Product Description
Synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B).
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) Abstract
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; TIPS 13, 236 (1992), (Review) Abstract
Inhibition of phosphatase 2B prevents expression of hippocampal long- term potentiation: J.H. Wang & A. Stelzer; Neuroreport 5, 2377 (1994) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-430-045 Revised 24-Feb-05
Deltamethrin
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SYNONYMS (S)-α-Cyano-(3-phenoxybenzyl (1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
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ALX-430-045-M010   10 mg 45.00 USD Add To Cart
ALX-430-045-M025   25 mg 96.00 USD Add To Cart