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ALX-270-407
Revised 24-Jul-08
4-Oxo-2-nonenal
SYNONYMS
4-ONE
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Lipid Peroxidation
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-407-M001
1 mg
108.00 USD
ALX-270-407-M005
5 mg
483.00 USD
Product Specification
FORMULA:
C
9
H
14
O
2
MW:
154.2
CAS NUMBER:
103560-62-9
CONCENTRATION:
10mg/ml
PURITY:
≥
98%
FORMULATION:
Liquid. Solution in methyl acetate.
SOLUBILITY:
50mg/ml soluble in 100% ethanol, dimethyl formamide or DMSO; sparingly soluble in PBS, pH 7.2 (0.5mg/ml).
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -80°C. Keep aqueous solutions on ice and use within 12 hours.
Product Description
Lipid peroxidation product. Modifies histidine and lysine residues in proteins and causes protein cross-linking, modifies 2'-deoxyguanosine, and implicates lipid peroxidation in mutagenesis and carcinogenesis.
Product Specific Literature References
Covalent modifications to 2'-deoxyguanosine by 4-oxo-2-nonenal, a novel product of lipid peroxidation
:
D. Rindgen, et al.; Chem. Res. Toxicol.
12
, 1195 (1999)
Abstract
Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation
:
S.H. Lee, et al.; Chem. Res. Toxicol.
13
, 698 (2000)
Abstract
Aldehydic lipid peroxidation products derived from linoleic acid
:
P. Spiteller, et al.; Biochem. Biophys. Acta
1531
, 188 (2001)
Abstract
Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal
:
Z. Liu, et al.; Chem. Res. Toxicol.
16
, 901 (2003)
Abstract
Model studies on protein side chain modification by 4-oxo-2-nonenal
:
W.H. Zhang, et al.; Chem. Res Toxicol.
16
, 512 (2003)
Abstract
Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation
:
J.D. West, et al.; Chem. Res. Toxicol.
17
, 453 (2004)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments.
ALX-210-881
Revised 04-Mar-05
Polyclonal Antibody to Acrolein
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Lipid Peroxidation
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-881-C100
100 µg
450.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized.
IMMUNOGEN:
Acrolein conjugated to a carrier protein.
SPECIFICITY:
Recognizes acrolein adducts. Slightly cross-reacts with malondialdehyde-BSA (cross-reactivity ratio=1:55 as determined with competitive ELISA test).
APPLICATION:
ELISA (1:2'000-1:5'000).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Lyophilized powder is stable at least 2 years if stored at -20°C. Reconstitute with 100µl of distilled water if solution will be used entirely within 8 hours.
If stored at +4°C (stable for 2 months) reconstitute with 100µl distilled water containing 0.1% merthiolate.
If stored at -20°C (stable for at least 1 year) reconstitute with a mixture of distilled water/glycerol (v/v).
Antibody can be prediluted 10x in PBS containing 0.1% merthiolate.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-882
Revised 04-Mar-05
Polyclonal Antibody to Formaldehyde
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Lipid Peroxidation
Ordering Information
Product Numbers:
Format:
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ALX-210-882-R100
100 µl
450.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Others
SOURCE/HOST:
From rat.
IMMUNOGEN:
Formaldeyde conjuated to a carrier protein.
SPECIFICITY:
Recognizes formaldehyde adducts.
APPLICATION:
ELISA (1:2'000-1:5'000).
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-767
Revised 30-Sep-08
Polyclonal Antibody to (E)-4-Hydroxynonenal
SYNONYMS
anti-HNE PAb
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Oxidative Stress Markers & Reagents / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-210-767-R100
100 µl
495.00 USD
Product Specification
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized. Neat serum containing 0.05% sodium azide.
RECONSTITUTION:
Reconstitute with 100µl PBS.
IMMUNOGEN:
Free recombinant HNE (E)-4-hydroxynonenal.
SPECIFICITY:
Recognizes HNE-adducts.
APPLICATION:
ELISA (1:1'000-1:10'000)
Immunohistochemistry (1:500-1:1'000)
Western Blot (1:500-1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes:
K. Uchida, et al.; PNAS
90
, 8742 (1993)
Abstract
Formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma:
K. Okamoto, et al.; Int. J. Cancer
58
, 825 (1994)
Abstract
Immunocytochemical detection of lipid peroxidation in phagosomes of human neutrophils: correlation with expression of flavocytochrome b:
M.T. Quinn, et al.; J. Leukoc. Biol.
57
, 415 (1995)
Abstract
Characterization of epitopes recognized by 4-hydroxy-2-nonenal specific antibodies:
K. Uchida, et al.; Arch. Biochem. Biophys.
324
, 241 (1995)
Abstract
Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease:
A. Yoritaka, et al.; PNAS
93
, 2696 (1996)
Abstract
alpha-Phenyl-n-tert-butyl-nitrone attenuates hypoxic-ischemic white matter injury in the neonatal rat brain
:
S. Lin, et al.; Brain Res.
1007
, 132 (2004)
Abstract
Acquired Resistance to Acetaminophen Hepatotoxicity is Associated with Induction of Multidrug Resistance-Associated Protein 4 (Mrp4) in Proliferating Hepatocytes:
L.M. Aleksunes, et al.; Toxicol. Sci.
104
, 261 (2008)
Abstract
Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes:
K. Stadler, et al.; Free Radic. Biol. Med.
Epub ahead of print
, (2008)
Abstract
Related Products
ALX-270-245
(E)-4-Hydroxynonenal
Further Categories Containing This Product:
Lipid Peroxidation
•
Polyclonal Antibodies
ALX-210-879
Revised 18-Jul-07
Polyclonal Antibody to Malondialdehyde
SYNONYMS
anti-MDA PAb
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Lipid Peroxidation
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-879-R100
100 µl
590.00 USD
Product Specification
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized.
IMMUNOGEN:
Malondialdehyde (MDA) conjugated to a carrier protein.
SPECIFICITY:
Recognizes MDA adducts.
APPLICATION:
ELISA (1:1’000-1:10’000)
Immunohistochemistry (1:500-1:1’000)
Western blot (1:500-1:1’000)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Do not freeze, thaw or store diluted working solutions.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-350-252
Revised 02-Oct-07
Pyrrolostatin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antioxidants
Ordering Information
Product Numbers:
Format:
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ALX-350-252-C100
100 µg
45.00 USD
ALX-350-252-M001
1 mg
110.00 USD
Product Specification
FORMULA:
C
15
H
21
NO
2
MW:
247.2
CAS NUMBER:
144314-68-1
SOURCE/HOST:
Isolated from
Streptomyces chrestomyceticus
.
PURITY:
≥99%
APPEARANCE:
Yellowish powder.
SOLUBILITY:
Soluble in methanol, abs. ethanol or DMSO. Insoluble in water.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Potent inhibitor of lipid peroxidation (IC
50
=49µM; inhibition of lipid peroxidation in rat brain homogenate). Free radical scavenger. Improves angiogenesis.
Product Specific Literature References
Pyrrolostatin, a novel lipid peroxidation inhibitor from Streptomyces chrestomyceticus. Taxonomy, fermentation, isolation, structure elucidation and biological properties:
S. Kato, et al.; J. Antibiot. (Tokyo)
46
, 892 (1993)
Abstract
Biodesign of a skeletal muscle flap as a model for cardiac assistance:
V.V. Nikolaychik, et al.; Artif. Organs
24
, 137 (2000)
Abstract
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
•
Natural Products for Angiogenesis Research
•
Lipid Peroxidation
ALX-270-253
Revised 18-Mar-08
Rosmarinic acid
SYNONYMS
(R)-α-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2E-propenyl]oxy]-3,4-dihydroxy-benzenepropanoic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antioxidants
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ALX-270-253-M010
10 mg
20.00 USD
ALX-270-253-M050
50 mg
80.00 USD
Product Specification
FORMULA:
C
18
H
16
O
8
MW:
360.3
CAS NUMBER:
537-15-5, 20283-92-5
SOURCE/HOST:
Isolated from
Rosmarinus officinalis.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to brown solid.
SOLUBILITY:
Soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in PBS.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Naturally occurring polyphenolic compound with antioxidant and anti-inflammatory properties. Anticarcinogenic. Inhibitor of lipid peroxidation, TCR-induced T cell activation and proliferation.
Product Specific Literature References
Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid:
H. Bult, et al.; Br. J. Pharmacol.
84
, 317 (1985)
Abstract
Complement-dependent stimulation of prostacyclin biosynthesis: inhibition by rosmarinic acid:
M. Rampart, et al.; Biochem. Pharmacol.
35
, 1397 (1986)
Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes:
Y. Kimura, et al.; J. Nat. Prod.
50
, 392 (1987)
Abstract
Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes:
G.T. Liu, et al.; Biochem. Pharmacol.
43
, 147 (1992)
Abstract
Metabolism of rosmarinic acid in rats:
T. Nakazawa & K. Ohsawa; J. Nat. Prod.
61
, 993 (1998)
Abstract
Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner
:
J. Won, et al.; Eur. J. Immunol.
33
, 870 (2003)
Abstract
Rosmarinic acid inhibits Ca2+-dependent pathways of T-cell antigen receptor-mediated signaling by inhibiting the PLC-gamma 1 and Itk activity
:
M.A. Kang, et al.; Blood
101
, 3534 (2003)
Abstract
Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model:
N. Osakabe, et al.; Carcinogenesis
25
, 549 (2004)
Abstract
Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2):
C. Renzulli, et al.; J. Appl. Toxicol.
24
, 289 (2004)
Abstract
Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro:
S.S. Huang & R.L. Zheng; Cancer Lett.
239
, 271 (2006)
Abstract
Further Categories Containing This Product:
T Cell Regulation Other Products
•
Lipid Peroxidation
•
Active Substances from Fruit and Vegetables
•
Natural Products - Anti-inflammatory Agents
•
Polyphenols Other Products
•
Natural Products - Antitumor Reagents
•
Antitumor Agents (Anti-proliferative)
ALX-350-324
Revised 30-May-07
Rubellin D
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Plant Research Reagents
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ALX-350-324-M001
1 mg
110.00 USD
Product Specification
FORMULA:
C
30
H
22
O
10
MW:
542.5
SOURCE/HOST:
Isolated from fungus
Ramularia collo-cygni
.
PURITY:
≥98% (HPLC)
APPEARANCE:
Red powder.
SOLUBILITY:
Soluble in tetrahydrofuran, n-propanol, methanol, ethyl acetate, DMSO or chloroform.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Phytotoxin. Triggers the light-dependent production of reactive oxygen species and α-linolenic acid peroxidation.
Product Specific Literature References
Secondary mould metabolites. XX. The structure of rubellins C and D, two novel anthraquinone metabolites from Mycosphae-rella rubella:
A. Arnone et al.; Gazz. Chim. Ital.
119
, 35 (1989)
Photodynamic oxygen activation by rubellin D, a phytotoxin produced by Ramularia collo-cygni (Sutton et Waller):
I. Heiser et al.; Physiol. Mol. Plant Pathol.
62
, 29 (2003)
The phytopathogenic fungus Ramularia collo-cygni produces biologically active rubellins on infected barley leaves:
S. Miethbauer et al.; J. Phytopathol.
151
, 665 (2003)
Fatty acid peroxidation by rubellin B, C, and D, phytotoxins produced by Ramularia collo-cygni (Sutton et Waller):
I. Heiser et al.; Physiol. Mol. Plant Pathol.
64
, 135 (2004)
Biosynthesis of photodynamically active rubellins and structure elucidation of new anthraquinone derivatives produced by Ramularia collo-cygni:
S. Miethbauer, et al.; Phytochemistry
67
, 1206 (2006)
Abstract
Further Categories Containing This Product:
Other Toxins
•
Lipid Peroxidation
•
Lipid Peroxidation
•
Plant Research Reagents / Related Products
ALX-550-361
Revised 18-Dec-07
(Z)-4-Hydroxytamoxifen
SYNONYMS
(Z)-4-[1-(p-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl]phenol
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Antitumor Agents (Hormone-related)
Ordering Information
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Format:
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ALX-550-361-M001
1 mg
40.00 USD
ALX-550-361-M005
5 mg
145.00 USD
Product Specification
FORMULA:
C
26
H
29
NO
2
MW:
387.5
CAS NUMBER:
68047-06-3, 65213-48-1
PURITY:
≥98% (Z-isomer)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in 100% ethanol (20mg/ml) or methanol (10mg/ml); insoluble water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. TOXIC.
Product Description
Metabolite of tamoxifen (Prod. No.
ALX-550-095
). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Has antioxidant properties. Intramembranous inhibitor of lipid peroxidation.
Product Specific Literature References
The antioxidant action of tamoxifen and its metabolites. Inhibition of lipid peroxidation:
H. Wiseman, et al.; FEBS Lett.
263
, 192 (1990)
Abstract
Mechanism of inhibition of lipid peroxidation by tamoxifen and 4-hydroxytamoxifen introduced into liposomes. Similarity to cholesterol and ergosterol:
H. Wiseman, et al.; FEBS Lett.
274
, 107 (1990)
Abstract
Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?:
H. Wiseman, et al.; Biochem. J.
292
, 635 (1993)
Abstract
Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation. Evidence for peroxyl radical scavenging activity:
J.B. Custódio, et al.; Biochem. Pharmacol.
47
, 1989 (1994)
Abstract
Peroxidase-catalyzed pro- versus antioxidant effects of 4-hydroxytamoxifen: enzyme specificity and biochemical sequelae:
B.W. Day, et al.; Chem. Res. Toxicol.
12
, 28 (1999)
Abstract
Estrogen and tamoxifen metabolites protect smooth muscle cell membrane phospholipids against peroxidation and inhibit cell growth:
R.K. Dubey, et al.; Circ. Res.
84
, 229 (1999)
Abstract
Further Categories Containing This Product:
Lipid Peroxidation
•
Estrogen & Estrogen Receptors / Related Products
•
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
ALX-400-046
Revised 01-Dec-06
Taurine
SYNONYMS
2-Aminoethanesulfonic acid
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Chemopreventive Agents Other Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-400-046-G010
10 g
25.00 USD
Product Specification
FORMULA:
C
2
H
7
NO
3
S
MW:
125.2
CAS NUMBER:
107-35-7
MERCK INDEX:
14:
9074
RTECS:
WX0175000
PURITY:
≥99%
SOLUBILITY:
50mg/ml soluble in water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HAZARD:
IRRITANT.
Product Description
Inhibitor of lipid peroxidation. Inhibits diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis.
Further Categories Containing This Product:
Lipid Peroxidation
ALX-270-265
Revised 29-Jan-05
U-74389G
SYNONYMS
21-(4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-pregna-1,4,9(11)-triene-3,20-dione . (Z)-2-butenedioate
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Lipid Peroxidation
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-265-M010
10 mg
15.00 USD
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