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Oxidative Stress
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ALX-201-430 Revised 12-Aug-08 New product
Sirtuin 2 (human) (recombinant) (His)
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SYNONYMS Sirt2 (human) (recombinant) (His)
SIR2-like Protein 2 (human) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Sirtuins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-430-C010   10 µg 300.00 USD Add To Cart
ALX-201-430-C050   50 µg 470.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The mature peptide of human sirtuin 2 (aa 2-389) is fused at the N-terminus to a His-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in 50mM TRIS-Cl, pH 8.2, containing 100mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q8IXJ6: SIRT2 (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • NAD+ Metabolism / Related Products • p53 Other Products
 
 
ALX-430-114 Revised 28-Aug-07
(±)-Sulfinpyrazone
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SYNONYMS 1,2-Diphenyl-4-(phenylsulfinylethyl)-3,5-pyrazolidinedione
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Antioxidants, Flavonoids & Free Radical Scavengers Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-114-G001   1 g 16.00 USD Add To Cart
Product Specification
FORMULA: C23H20N2O3S
MW: 404.5
CAS NUMBER: 57-96-5
MERCK INDEX: 14: 8949
RTECS: UQ8575000
PURITY: ≥99% (Sodium Hydroxide Titration)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: HARMFUL.
IDENTITY: Determined by IR.

Product Description
Potent uricosuric drug. Inhibitor of organic anion transporters. Substrate for MRP2. Has free radical scavenging properties.
Product Specific Literature References
Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export: R. Evers, et al.; Br. J. Cancer 83, 375 (2000) Abstract
Free radical scavenging properties of sulfinpyrazone: M.L. Yang, et al.; Free Radic. Res. 36, 685 (2002) Abstract
Further Categories Containing This Product:
MDR Other Products
 
 
ALX-350-232 Revised 06-Oct-08
DL-Sulforaphane
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SYNONYMS R,S-Sulforaphane
1-Isothiocyanato-4-methylsulfinyl-butane
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-232-M025   25 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C6H11NOS2
MW: 177.3
CAS NUMBER: 142825-10-3; 4478-93-7 (unspecified stereo)
MERCK INDEX: 14: 8962
SOURCE/HOST: Synthetic.
PURITY: ≥98% (UPLC)
APPEARANCE: Slightly yellowish liquid.
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats. Inhibits LPS-induced HMGB1 (high mobility group box 1) secretion.
Product Specific Literature References
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure: Y. Zhang, et al.; PNAS 89, 2399 (1992) Abstract; Full Text
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates: Y. Zhang, et al.; PNAS 91, 3147 (1994) Abstract; Full Text
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase: M.C. Myzak, et al.; Cancer Res. 64, 5767 (2004) Abstract; Full Text
The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells: M.E. Killeen, et al.; J. Pharmacol. Exp. Ther. 316, 1070 (2006) Abstract
Sulforaphane targets pancreatic tumor-initiating cells by NF-{kappa}B-induced anti-apoptotic signaling: G. Kallifatidis, et al.; Gut Epub ahead of print, (2008) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Cytochrome P450 [CYP450] / Related Products • Glutathione S-Transferase • Respiratory Chain Other Products • Active Substances from Fruit and Vegetables • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-350-230 Revised 03-Nov-08
L-Sulforaphane
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SYNONYMS R-Sulforaphane
(-)-1-Isothiocyanato-(4R)-(methylsulfinyl)butane
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-230-M010   10 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C6H11NOS2
MW: 177.3
CAS NUMBER: 142825-10-3; 4478-93-7
MERCK INDEX: 14: 8962
SOURCE/HOST: Chiral natural product isolated from broccoli.
PURITY: ≥98% (UPLC)
APPEARANCE: Slightly yellowish liquid.
SOLUBILITY: Soluble in methanol, 100% ethanol, DMSO or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats.
Product Specific Literature References
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure: Y. Zhang, et al.; PNAS 89, 2399 (1992) Abstract; Full Text
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates: Y. Zhang, et al.; PNAS 91, 3147 (1994) Abstract; Full Text
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors: J.W. Fahey, et al.; PNAS 99, 7610 (2002) Abstract; Full Text
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase: M.C. Myzak ,et al.; Cancer Res. 64, 5767 (2004) Abstract; Full Text
Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex: M.L. Kerns, et al.; PNAS 104, 14460 (2007) Abstract
Sulforaphane targets pancreatic tumor-initiating cells by NF-{kappa}B-induced anti-apoptotic signaling: G. Kallifatidis, et al.; Gut Epub ahead of print, (2008) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Cytochrome P450 [CYP450] / Related Products • Glutathione S-Transferase • Respiratory Chain Other Products • Active Substances from Fruit and Vegetables • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-550-361 Revised 18-Dec-07
(Z)-4-Hydroxytamoxifen
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SYNONYMS (Z)-4-[1-(p-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl]phenol
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Hormone-related)
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ALX-550-361-M001   1 mg 40.00 USD Add To Cart
ALX-550-361-M005   5 mg 145.00 USD Add To Cart
Product Specification
FORMULA: C26H29NO2
MW: 387.5
CAS NUMBER: 68047-06-3, 65213-48-1
PURITY: ≥98% (Z-isomer)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol (20mg/ml) or methanol (10mg/ml); insoluble water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. TOXIC.

Product Description
Metabolite of tamoxifen (Prod. No. ALX-550-095). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Has antioxidant properties. Intramembranous inhibitor of lipid peroxidation.
Product Specific Literature References
The antioxidant action of tamoxifen and its metabolites. Inhibition of lipid peroxidation: H. Wiseman, et al.; FEBS Lett. 263, 192 (1990) Abstract
Mechanism of inhibition of lipid peroxidation by tamoxifen and 4-hydroxytamoxifen introduced into liposomes. Similarity to cholesterol and ergosterol: H. Wiseman, et al.; FEBS Lett. 274, 107 (1990) Abstract
Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?: H. Wiseman, et al.; Biochem. J. 292, 635 (1993) Abstract
Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation. Evidence for peroxyl radical scavenging activity: J.B. Custódio, et al.; Biochem. Pharmacol. 47, 1989 (1994) Abstract
Peroxidase-catalyzed pro- versus antioxidant effects of 4-hydroxytamoxifen: enzyme specificity and biochemical sequelae: B.W. Day, et al.; Chem. Res. Toxicol. 12, 28 (1999) Abstract
Estrogen and tamoxifen metabolites protect smooth muscle cell membrane phospholipids against peroxidation and inhibit cell growth: R.K. Dubey, et al.; Circ. Res. 84, 229 (1999) Abstract
Further Categories Containing This Product:
Lipid Peroxidation • Estrogen & Estrogen Receptors / Related Products • Antioxidants, Flavonoids & Free Radical Scavengers Other Products
 
 
ALX-385-027 Revised 08-Feb-08
Tangeretin
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SYNONYMS 2-(4-Methoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benz-1-benzopyran-4-one
4’,5,6,7,8-Pentamethoxyflavone
Ponkanetin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavones
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ALX-385-027-M010   10 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C20H20O7
MW: 372.4
CAS NUMBER: 481-53-8
RTECS: DJ3102725
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Flavonoid found in the peel of citrus fruits where it provides natural resistance to fungi. Induces G1 cell cycle arrest in cancer cells. Counteracts tumor promoter-induced inhibition of intercellular communication and inhibits cell proliferation in several cancer lines. Reduces elevation of blood pressure and plasma glucose levels.
Product Specific Literature References
Nobiletin Is Main Fungistat in Tangerines Resistant to Mal Secco: A. Ben-Aziz; Science 155, 1026 (1967) Abstract
Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells: C. Chaumontet, et al.; Cancer Lett. 114, 207 (1997) Abstract
Antiproliferative activity of flavonoids on several cancer cell lines: S. Kawaii; Biosci. Biotechnol. Biochem. 63, 896 (1999) Abstract
Tangeretin inhibits extracellular-signal-regulated kinase (ERK) phosphorylation: S. Van Slambrouck, et al.; FEBS Lett. 579, 1665 (2005) Abstract
Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells: K.L. Morley, et al.; Cancer Lett. 251, 168 (2007) Abstract
Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells: K.H. Chen, et al.; Biochem. Pharmacol. 73, 215 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Natural Products - Antitumor Reagents • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products for Cell Cycle Research • Natural Products - Antifungal Agents
 
 
ALX-400-046 Revised 01-Dec-06
Taurine
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SYNONYMS 2-Aminoethanesulfonic acid
PRODUCT LINE Cancer
PRODUCT CATEGORY Chemopreventive Agents Other Products
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ALX-400-046-G010   10 g 25.00 USD Add To Cart
Product Specification
FORMULA: C2H7NO3S
MW: 125.2
CAS NUMBER: 107-35-7
MERCK INDEX: 14: 9074
RTECS: WX0175000
PURITY: ≥99%
SOLUBILITY: 50mg/ml soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Inhibitor of lipid peroxidation. Inhibits diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis.
Further Categories Containing This Product:
Lipid Peroxidation
 
 
ALX-385-018 Revised 03-Dec-07
(+)-Taxifolin
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SYNONYMS (+)-Dihydroquercetin
(+)-3,3',4',5,7-Pentahydroxyflavanone
Taxifoliol
Distylin
Catechin hydrate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavanones
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ALX-385-018-M010   10 mg 35.00 USD Add To Cart
ALX-385-018-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C15H12O7
MW: 304.3
CAS NUMBER: 17654-26-1
PURITY: ≥96%
APPEARANCE: Light yellow to brown powder.
SOLUBILITY: Soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Antioxidant flavonoid. Anti-inflammatory compound. Chemopreventive agent. Decreases hepatic lipid synthesis.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid: A. Theriault, et al.; J. Lipid Res. 41, 1969 (2000) Abstract
Prevention of macrophage adhesion molecule-1 (Mac-1)-dependent neutrophil firm adhesion by taxifolin through impairment of protein kinase-dependent NADPH oxidase activation and antagonism of G protein-mediated calcium influx: Y.H. Wang, et al.; Biochem. Pharmacol. 67, 2251 (2004) Abstract
The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation: S.B. Lee, et al.; Biol. Pharm. Bull. 30, 1074 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Chemopreventive Agents • Natural Products - Antioxidants • Natural Products - Anti-inflammatory Agents
 
 
ALX-385-006 Revised 03-Dec-07
(±)-Taxifolin
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SYNONYMS (±)-Dihydroquercetin
(±)-3,3',4',5,7-Pentahydroxyflavanone
Taxifoliol
Distylin
Catechin hydrate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavanones
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-006-M010   10 mg 50.00 USD Add To Cart
ALX-385-006-M050   50 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C15H12O7
MW: 304.3
CAS NUMBER: 480-18-2
RTECS: LK6920000
PURITY: ≥90%
APPEARANCE: White to faintly yellow powder.
SOLUBILITY: Soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Antioxidant flavonoid.
Product Specific Literature References
Suppression of active oxygen-induced cytotoxicity by flavonoids: T. Nakayama, et al.; Biochem. Pharmacol. 45, 265 (1993) Abstract
Suppression of hydroperoxide-induced cytotoxicity by polyphenols: T. Nakayama; Cancer Res. 54, 1991s (1994) Abstract
Interaction of flavonoids with ascorbate and determination of their univalent redox potentials: a pulse radiolysis study: W. Bors, et al.; Free Radic. Biol. Med. 19, 45 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid: A. Theriault, et al.; J. Lipid Res. 41, 1969 (2000) Abstract
Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretionInhibitory activity of diacylglycero: A. Casaschi, et al.; Atherosclerosis 176, 247 (2004) Abstract
Further Categories Containing This Product:
Natural Products - Antioxidants
 
 
ALX-430-081 Revised 22-May-08
TEMPOL