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Oxidative Stress
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 Items 280-300 of 337 Page 15 of 17 Select Page: << 11 12 13 14 15 16 17  >>  
ALX-850-312 Revised 14-Jan-08
Protein Carbonyl ELISA Kit (BioCell)
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
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ALX-850-312-KI01   1 Kit 590.00 USD Add To Cart
Product Specification
QUANTITY: 96 wells (~80 tests)
APPLICATION: For quantitative detection of carbonylated protein levels in plasma, other body fluids, cell and tissue extracts.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
USE/STABILITY: Remove box containing components G, K, and L and store at -20°C! For longer storage than 3 months store at -80°C!
HANDLING: Do not freeze.
Product Description

Antibody-based detection set. Advantages over colorimetric assays: Higher sensitivity - lower background - less labour-intensive - handles more samples per day.
Product Specific Literature References
[1] Protein carbonyl measurement by a sensitive ELISA method: H. Buss, et al.; Free Radic. Biol. Med. 23, 361 (1997) Abstract
[2] Elevated protein carbonyls and lipid peroxidation products correlating with myeloperoxidase in tracheal aspirates from premature infants: I.H. Buss, et al.; Pediatr. Res. 47, 640 (2000) Abstract; Full Text
[3] Protein carbonyls and lipid peroxidation products as oxidation markers in preterm infant plasma: associations with chronic lung disease and retinopathy and effects of selenium supplementation: C.C. Winterbourn, et al.; Pediatr. Res. 48, 84 (2000) Abstract; Full Text
[4] Protein carbonyl measurements show evidence of early oxidative stress in critically ill patients: C.C. Winterbourn, et al.; Crit. Care Med. 28, 143 (2000) Abstract
[5] Protein oxidative stress in dialysis patients: T. Donate, et al.; Adv. Perit. Dial. 18, 15 (2002) Abstract
[6] Protein carbonyl groups as biomarkers of oxidative stress: I. Dalle-Donne, et al.; Clin. Chim. Acta 329, 23 (2003) Abstract
[7] Elevated protein carbonyls as plasma markers of oxidative stress in acute pancreatitis: C.C. Winterbourn, et al.; Pancreatology 3, 375 (2003) Abstract
[8] Oxidative stress is increased in critically ill patients with acute renal failure: J. Himmelfarb, et al.; J. Am. Soc. Nephrol. 15, 2449 (2004) Abstract; Full Text
[9] Oxidative damage in eelpout (Zoarces viviparus), measured as protein carbonyls and TBARS, as biomarkers: B.C. Almroth, et al.; Aquat. Toxicol. 73, 171 (2005) Abstract
[10] Oxidative stress and high density lipoprotein function in type 1 diabetes and end stage renal disease: G. Kalogerakis, et al.; Clin. Sci. (Lond) 108, 497 (2005) Abstract
[11] Activated neutrophils inhibit nucleotide excision repair in human pulmonary epithelial cells: role of myeloperoxidase: N. Gungor, et al.; FASEB J. 21, 2359 (2007) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Biocell.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-430-041 Revised 17-Sep-08
Protoporphyrin IX (free acid)
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SYNONYMS 8,13-Divinyl-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Porphyrins
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ALX-430-041-M300   300 mg 50.00 USD Add To Cart
ALX-430-041-G001   1 g 90.00 USD Add To Cart
Product Specification
FORMULA: C34H34N4O4
MW: 562.6
CAS NUMBER: 553-12-8
MERCK INDEX: 14: 7897
PURITY: ≥97% (HPLC)
APPEARANCE: Purple to dark brown solid.
SOLUBILITY: Soluble in conc. HCl, DMSO (10mg/ml) or 100% ethanol (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.
IDENTITY: Identity determined by NMR.

Product Description
Protoporphyrin IX free acid, as distinct from its zinc salt (which inhibits heme oxygenase), activates soluble guanylyl cyclase (sGC) by binding directly to the enzyme. A useful reagent in cases where the use of nitric oxide (NO) or nitric oxide donors is undesirable.
Product Specific Literature References
H. Verweij & J. Van Steveninck; Photochem. Photobiol. 35, 265 (1982)
Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme: M.S. Wolin, et al.; J. Biol. Chem. 257, 13312 (1982) Abstract; Full Text
Porphyrins and chlorophylls as probes for fluoroimmunoassays [letter]: J.L. Hendrix; Clin. Chem. 29, 1003 (1983) Abstract
Photodynamic intramolecular crosslinking of myoglobin: J. van Steveninck and T.M.A.R. Dubbelman; Biochim. Biophys. Acta 791, 98 (1984)
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
 
 
ALX-350-323 Revised 20-Jun-08
Psoralidin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-323-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C20H16O5
MW: 336.3
CAS NUMBER: 18642-23-4
SOURCE/HOST: Isolated from Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Antineoplastic compound. Cytotoxic against stomach cancer cell lines. Shows antibacterial activity against Shigella sonnei and S. flexneri. Shows strong antioxidant activity and inhibits tyrosine phosphatase 1B (PTP1B) activity. Was shown to possess potent antidepressant properties.
Product Specific Literature References
Influence of nitrogen on accumulation of isosojagol (a newly detected coumestan in soybean) and associated isoflavonoids in roots and nodules of mycorrhizal and non-mycorrhizal soybean: D. Morandi and J.L. Le Quere; New Phytol. 117, 75 (1991) Full Text
The cytotoxicity of psoralidin from Psoralea corylifolia: Y.M. Yang, et al.; Planta Med. 62, 353 (1996) Abstract
Coumarins: A. Estevez-Braun and A.G. Gonzalez; Nat. Prod. Rep. 14, 465 (1997) Abstract
Cytotoxic constituents of Psoralea corylifolia: W. Mar, et al.; Arch. Pharm. Res. 24, 211 (2001) Abstract
Antibacterial compounds from the seeds of Psoralea corylifolia: N.A. Khatune, et al.; Fitoterapia 75, 228 (2004) Abstract
Inducible flavone in oats (Avena sativa) is a novel defense against plant-parasitic nematodes: I. R. Soriano, et al.; Nematology 94, 1207 (2004) Full Text
Antioxidants from a Chinese medicinal herb - Psoralea corylifolia L.: G. Jiangning, et al.; Food Chem. 91, 287 (2005)
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia: Y.C. Kim, et al.; Planta Med. 71, 87 (2005) Abstract
Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice: L.T. Yi, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry 32, 510 (2008) Abstract
Further Categories Containing This Product:
Monoamine Neurotransmitters & Receptors Other Products • Antitumor Agents (Anti-proliferative) • Natural Products with Antibiotic Activity • Natural Products - Antioxidants • Natural Products - Other Signal Transduction Pathway Modulators • Protein Tyrosine Phosphatases Other Products
 
 
ALX-385-034 Revised 07-Oct-08 New product
Pterostilbene
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SYNONYMS trans-3,5-Dimethoxy-4’-hydroxystilbene
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-034-M025   25 mg 90.00 USD Add To Cart
ALX-385-034-M100   100 mg 270.00 USD Add To Cart
ALX-385-034-M500   500 mg 750.00 USD Add To Cart
Product Specification
FORMULA: C16H16O3
MW: 256.3
CAS NUMBER: 537-42-8
SOURCE/HOST: Synthetic.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to light brown powder.
SOLUBILITY: Soluble in DMSO (20mg/ml) or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and oxygen.
HAZARD: IRRITANT.
IDENTITY: Identity determined by MS and 1H-NMR.
MELTINGPOINT: 92.7-94.6°C

Product Description
Cell permeable natural methoxylated analog of resveratrol (Prod. No. ALX-270-125). Antioxidant, antiproliferative, anti-inflammatory, anti-hyperglycemic and anti-diabetic agent. Induces apoptosis. Inhibits activator protein 1 (AP-1) and NF-κB activation. Moderately inhibits COX-1 and COX-2 (IC50=19.8μM and 83.9μM).
Product Specific Literature References
Antihyperglycemic activity of phenolics from Pterocarpus marsupium: M Manickam, et al.; J. Nat. Prod. 60, 609 (1997) Abstract
Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol: A.M. Rimando, et al.; J. Agric. Food Chem. 50, 3453 (2002) Abstract
Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents: M. Roberti, et al.; J. Med. Chem. 46, 3546 (2003) Abstract
Antioxidant activity of hydroxystilbene derivatives in homogeneous solution: R. Amorati, et al.; J. Org. Chem. 69, 7101 (2004) Abstract
Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma: P. Ferrer, et al.; Neoplasia 7, 37 (2005) Abstract; Full Text
Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters: A.M. Rimando, et al.; J. Agric. Food Chem. 53, 3403 (2005) Abstract
Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers: S. Hougee, et al.; Planta Med. 71, 387 (2005) Abstract
Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats: L. Pari & M.A. Satheesh; Life Sci. 79, 641 (2006) Abstract
Effect of natural analogues of trans-resveratrol on cytochromes P4501A2 and 2E1 catalytic activities: R. Mikstacka, et al.; Xenobiotica 36, 269 (2006) Abstract
The antioxidant role of pterostilbene in streptozotocin-nicotinamide-induced type 2 diabetes mellitus in Wistar rats: M. Amarnath Satheesh & L. Pari; J. Pharm. Pharmacol. 58, 1483 (2006) Abstract
Pharmacometrics of stilbenes: seguing towards the clinic: K.A. Roupe, et al.; Curr. Clin. Pharmacol. 1, 81 (2006) Abstract
Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma: P. Ferrer, et al.; J. Biol. Chem. 282, 2880 (2007) Abstract; Full Text
Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats: N. Suh, et al.; Clin. Cancer Res. 13, 350 (2007) Abstract; Full Text
Pterostilbene induces apoptosis and cell cycle arrest in human gastric carcinoma cells: M.H. Pan, et al.; J. Agric. Food Chem. 55, 7777 (2007) Abstract
Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity: C.M. Remsberg, et al.; Phytother. Res. 22, 169 (2008) Abstract
Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol: Z. Pan, et al.; BMC Med. Genomics 1, 7 (2008) Abstract; Full Text
Pterostilbene is equally potent as resveratrol in inhibiting 12-O-tetradecanoylphorbol-13-acetate activated NFkappaB, AP-1, COX-2, and iNOS in mouse epidermis: M. Cichocki, et al.; Mol. Nutr. Food Res. 52, S62 (2008) Abstract
Pterostilbene suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages: M.H. Pan, et al.; J. Agric. Food Chem. 56, 7502 (2008) Abstract
In Vitro evaluation of the cytotoxic and anti-proliferative properties of resveratrol and several of its analogs: B. Billack, et al.; Cell. Mol. Biol. Lett. Epub ahead of print, (2008) Abstract
Related Products
Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Antidiabetic Agents / Related Products • Natural Products - Anti-inflammatory Agents • COX Inhibitors • Natural Products - NF-kB Pathway Inhibitors • Stilbenoids
 
 
ALX-430-145 Revised 25-Apr-07
PTMIO, free radical
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SYNONYMS 4-Phenyl-2,2,5,5-tetramethyl-3-imidazoline-1-oxyl nitroxide
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Free Radicals / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-145-M050   50 mg 45.00 USD Add To Cart
ALX-430-145-M250   250 mg 180.00 USD Add To Cart
ALX-430-145-G001   1 g 510.00 USD Add To Cart
Product Specification
FORMULA: C13H17N2O
MW: 217.3
CAS NUMBER: 39753-69-0
PURITY: ≥99% (1H-NMR, EPR)
APPEARANCE: Orange solid.
PURITY DETAIL: No paramagnectic impurities detected by EPR.
SOLUBILITY: Soluble in 100% ethanol, DMSO, acetone, chloroform or hexane. Insoluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description

Free radical similar to 4-Amino-TEMPO (Prod. No. ALX-400-019) and 3-Carboxy-2,2,5,5-tetramethyl-1-
pyrrolidine-1-oxyl (Prod. No. ALX-400-018), but more lipophilic than the former compounds. May be useful for membrane dynamic studies.
Product Specific Literature References
Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents: F. Hyodo, et al.; Cancer Res. 66, 9921 (2006) Abstract
General Literature References
Neuroprotective effects of the stable nitroxide compound Tempol on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the Nerve Growth Factor-differentiated model of pheochromocytoma PC12 cells: T. Lipman, et al.; Eur. J. Pharmacol. 549, 50 (2006) Abstract
Determining the topology of integral membrane peptides using EPR spectroscopy: J.J. Inbaraj, et al.; J. Am. Chem. Soc. 128, 9549 (2006) Abstract
Further Categories Containing This Product:
Spin Traps, Spin Probes & Spin Labels
 
 
ALX-350-249 Revised 07-Oct-08
Puerarin
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SYNONYMS 8-(β-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one
NPI-031G
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-249-M005   5 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C21H20O9
MW: 416.4
CAS NUMBER: 3681-99-0
RTECS: UO5216000
SOURCE/HOST: Isolated from Kudzu root.
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Biologically active isoflavone. Affects serotonin levels and platelet aggregation in blood cells. 5-HT2c antagonist. Antibacterial. Displays cardioprotective effects. Induces apoptosis.
Product Specific Literature References
Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria: W.M. Keung & B.L. Vallee; PNAS 95, 2198 (1998) Abstract
Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity: D.H. Kim, et al.; Biol. Pharm. Bull. 21, 628 (1998) Abstract
NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists: D.H. Overstreet, et al.; Pharmacol. Biochem. Behav. 75, 619 (2003) Abstract
Puerarin reduces increased c-fos, c-jun, and type IV collagen expression caused by high glucose in glomerular mesangial cells: C.P. Mao & Z.L. Gu; Acta Pharmacol. Sin. 26, 982 (2005) Abstract
Contrasting effects of puerarin and daidzin on glucose homeostasis in mice: E. Meezan, et al.; J. Agric. Food Chem. 53, 8760 (2005) Abstract
Induction of apoptosis by puerarin in colon cancer HT-29 cells: Z. Yu & W. L; Cancer Lett. 238, 53 (2006) Abstract
Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin: 574, 179 (2007)
: Q. Gao, et al.; Eur. J. Pharmacol. 574, 179 (2007) Abstract
Further Categories Containing This Product:
Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Natural Products with Antibiotic Activity • Natural Products for Neurological Research • Serotonergics & Serotonin Receptors / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Isoflavones
 
 
ALX-350-252 Revised 02-Oct-07
Pyrrolostatin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-252-C100   100 µg 45.00 USD Add To Cart
ALX-350-252-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C15H21NO2
MW: 247.2
CAS NUMBER: 144314-68-1
SOURCE/HOST: Isolated from Streptomyces chrestomyceticus.
PURITY: ≥99%
APPEARANCE: Yellowish powder.
SOLUBILITY: Soluble in methanol, abs. ethanol or DMSO. Insoluble in water.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Potent inhibitor of lipid peroxidation (IC50=49µM; inhibition of lipid peroxidation in rat brain homogenate). Free radical scavenger. Improves angiogenesis.
Product Specific Literature References
Pyrrolostatin, a novel lipid peroxidation inhibitor from Streptomyces chrestomyceticus. Taxonomy, fermentation, isolation, structure elucidation and biological properties: S. Kato, et al.; J. Antibiot. (Tokyo) 46, 892 (1993) Abstract
Biodesign of a skeletal muscle flap as a model for cardiac assistance: V.V. Nikolaychik, et al.; Artif. Organs 24, 137 (2000) Abstract
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Natural Products for Angiogenesis Research • Lipid Peroxidation
 
 
ALX-385-001 Revised 08-Apr-08
Quercetin . dihydrate
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SYNONYMS 3,3',4',5,7-Pentahydroxyflavone . 2H2O
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-001-G005   5 g 15.00 USD Add To Cart
ALX-385-001-G025   25 g 45.00 USD Add To Cart
Product Specification
FORMULA: C15H10O7 . 2H2O
MW: 302.2 . 36.0
CAS NUMBER: 6151-25-3
MERCK INDEX: 14: 8034
RTECS: LK8950000
SOURCE/HOST: Isolated from Sophora japonica L.
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow powder with a green or brown cast.
SOLUBILITY: Soluble in 100% ethanol or 1M sodium hydroxide; almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE MUTAGENIC. TOXIC.

Product Description
Antioxidant flavonoid. Inhibitor of mitochondrial ATPase, cAMP- and cGMP-phosphodiesterases. Inhibitor of protein tyrosine kinases and protein kinase C (PKC). Induces apoptosis. Blocks cells at the G0/G1 interface. Activator of human deacetylase SIRT1. Reversible inhibitor of fatty acid synthase (FAS). Inhibits the production of the inflammatory mediators nitric oxide (NO), TNF-α and IL-12 in activated macrophages.
Product Specific Literature References
Effects of quercetin and F1 inhibitor on mitochondrial ATPase and energy-linked reactions in submitochondrial particles: D.R. Lang & E. Racker; Biochim. Biophys. Acta 333, 180 (1974)
Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase: A. Beretz, et al.; Experientia 34, 1054 (1978) Abstract
Flavonoids are selective cyclic GMP phosphodiesterase inhibitors: M. Ruckstuhl, et al.; Biochem. Pharmacol. 28, 535 (1979) Abstract
The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo: Y. Graziani, et al.; Eur. J. Biochem. 135, 583 (1983) Abstract
Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin: M. Gschwendt, et al.; BBRC 117, 444 (1983) Abstract
Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin: J. Levy, et al.; BBRC 123, 1227 (1984) Abstract
The phospholipid- and calcium-dependent protein kinase as a target in tumor chemotherapy: H. Grunicke, et al.; Adv. Enzyme Regul. 28, 201 (1989) Abstract
Induction of apoptosis by quercetin: involvement of heat shock protein: Y.Q. Wei, et al.; Cancer Res. 54, 4952 (1994)