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ALX-270-022
Revised 09-Jan-08
AEBSF . hydrochloride
SYNONYMS
4-(2-Aminoethyl)benzenesulfonylfluoride . HCl
Pefabloc
®
SC
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Proteases Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-022-M050
50 mg
40.00 USD
ALX-270-022-M250
250 mg
145.00 USD
ALX-270-022-G001
1 g
360.00 USD
Product Specification
FORMULA:
C
8
H
10
FNO
2
S . HCl
MW:
203.2 . 36.5
CAS NUMBER:
30827-99-7
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from moisture.
Product Description
Specific irreversible inhibitor of serine proteases including trypsin, chymotrypsin, plasmin, plasma kallikrein, and thrombin. Stable, non-toxic alternative to PMSF (Prod. No.
ALX-270-184
). Inhibitor of NAD(P)H oxidase. Activator of MAP kinases JNK and p38.
Product Specific Literature References
Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide:
B.R. Baker & H.J. Cory; J. Med. Chem.
14
, 119 (1971)
Abstract
Serine protease inhibitors block priming of monocytes for enhanced release of superoxide:
P. Megyeri, et al.; Immunology
86
, 629 (1995)
Abstract
;
Full Text
Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF:
M. Citron, et al.; Neuron
17
, 171 (1996)
Abstract
Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor:
Y. Nakabo & M.J. Pabst; J. Leukoc. Biol.
60
, 328 (1996)
Abstract
;
Full Text
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds:
V. Diatchuk, et al.; J. Biol. Chem.
272
, 13292 (1997)
Abstract
;
Full Text
4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-alpha-induced blood-brain barrier opening:
P. Megyeri, et al.; Eur. J. Pharmacol.
374
, 207 (1999)
Abstract
Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis:
R. Buitrago-Rey, et al.; J. Antimicrob. Chemother.
49
, 871 (2002)
Abstract
;
Full Text
Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes:
N. Wijayanti, et al.; J. Biol. Chem.
280
, 21820 (2005)
Abstract
;
Full Text
Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression:
T. Hosoi, et al.; Eur. J. Pharmacol.
554
, 8 (2007)
Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
•
Cell Stress, Oxidative Stress & Redox Signalling Other Products
•
MAPK Pathway Activators
•
Fatty Acid Amide Hydrolase [FAAH] / Related Products
ALX-430-048
Revised 03-Oct-08
Copper(II) Protoporphyrin IX (free acid)
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
Ordering Information
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Format:
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Unit Price:
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ALX-430-048-M025
25 mg
75.00 USD
Product Specification
FORMULA:
C
34
H
32
CuN
4
O
4
MW:
624.2
PURITY:
≥95%
APPEARANCE:
Red to brown solid.
SOLUBILITY:
Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base; slightly soluble in aqueous base/organic solvent mixtures.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 3 years after receipt when stored at -20°C. Product may be unstable in solution if exposed to light.
HANDLING:
Protect from light and moisture.
Product Description
Negative control for the heme oxygenase inhibitor zinc protoporphyrin IX (Prod. No.
ALX-430-049
).
Product Specific Literature References
Sensitivity of human tissue heme oxygenase to a new synthetic metalloporphyrin:
R.J. Chernick, et al.; Hepatology
10
, 365 (1989)
Abstract
Zinc protoporphyrin-IX blocks the effects of metabotropic glutamate receptor activation in the rat nucleus tractus solitarii:
S.R. Glaum & R.J. Miller; Mol. Pharmacol.
43
, 965 (1993)
Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
ALX-430-049
Revised 25-May-07
Zinc(II) Protoporphyrin IX
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-430-049-M005
5 mg
20.00 USD
ALX-430-049-M025
25 mg
60.00 USD
ALX-430-049-M100
100 mg
180.00 USD
Product Specification
FORMULA:
C
34
H
32
N
4
O
4
Zn
MW:
626.0
CAS NUMBER:
15442-64-5
PURITY:
≥95% (TLC)
APPEARANCE:
Dark red solid.
SOLUBILITY:
Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base; slightly soluble in aqueous base/organic solvent mixtures.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 3 years after receipt when stored at -20°C. Product may be unstable in solution if exposed to light.
HANDLING:
Protect from light and moisture.
Product Description
Potent and selective inhibitor of heme oxygenase, the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC
50
=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier.
Product Specific Literature References
Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase:
B. Brune & V. Ullrich; Mol. Pharmacol.
32
, 497 (1987)
Abstract
Does endogenous zinc protoporphyrin modulate carbon monoxide formation from heme? Implications for long-term potentiation, memory, and cognitive function:
G.S. Marks, et al.; Can. J. Physiol.Pharmacol.
71
, 753 (1993)
Abstract
Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus:
M. Zhuo, et al; Science
260
, 1946 (1993)
Abstract
Preischemic but not postischemic zinc protoporphyrin treatment reduces infarct size and edema accumulation after temporary focal cerebral ischemia in rats:
C. Kadoya, et al.; Stroke
26
, 1035 (1995)
Abstract
;
Full Text
Inhibition by zinc protoporphyrin-IX of receptor-mediated relaxation of the rat aorta in a manner distinct from inhibition of haem oxygenase:
L. Ny, et al.; Br. J. Pharmacol.
115
, 186 (1995)
Abstract
Heme oxygenase inhibitor zinc protoporphyrin IX causes an activation of nitric oxide synthase in the rabbit internal anal sphincter:
S. Chakder, et al.; J. Pharmacol. Exp. Ther.
277
, 1376 (1996)
Abstract
Inhibition of nitric oxide synthase isoforms by porphyrins:
D.J. Wolff, et al.; Arch. Biochem. Biophys.
333
, 27 (1996)
Abstract
Pitfalls using metalloporphyrins in carbon monoxide research:
L. Grundemar and L. Ny; TIPS
18
, 193 (1997), (Review)
Abstract
Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock:
S.F. Yet, et al.; J. Biol. Chem.
272
, 4295 (1997)
Abstract
;
Full Text
Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity:
L. Serfass and J.N. Burstyn; Arch. Biochem. Biophys.
359
, 8 (1998)
Abstract
Mechanism of inhibition of VIP-induced LES relaxation by heme oxygenase inhibitor zinc protoporphyrin IX:
S. Rattan, et al.; Am. J. Physiol.
276
, G138 (1999)
Abstract
;
Full Text
Further Categories Containing This Product:
Heme Oxygenase / Related Products
•
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
ALX-430-050
Revised 13-Jun-03
Zinc(II) Deuteroporphyrin IX-2,4-bisethyleneglycol
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-430-050-M001
1 mg
30.00 USD
ALX-430-050-M005
5 mg
90.00 USD
ALX-430-050-M010
10 mg
150.00 USD
Product Specification
FORMULA:
C
34
H
36
N
4
O
8
Zn
MW:
694.1
PURITY:
≥85%
APPEARANCE:
Dark purple solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Extremely potent inhibitor of heme oxygenase, the enzyme that generates carbon monoxide (CO).
Product Specific Literature References
Sensitivity of human tissue heme oxygenase to a new synthetic metalloporphyrin:
R.J. Chernick, et al.; Hepatology
10
, 365 (1989)
Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
ALX-430-051
Revised 03-Oct-08
Tin Protoporphyrin IX . dichloride
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-430-051-M005
5 mg
45.00 USD
ALX-430-051-M025
25 mg
180.00 USD
Product Specification
FORMULA:
C
34
H
32
N
4
O
4
Sn . 2Cl
MW:
750.3
PURITY:
≥95% (TLC)
APPEARANCE:
Dark red solid.
SOLUBILITY:
Soluble in aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
Product Description
Potent inhibitor of heme oxygenase.
Product Specific Literature References
Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation:
G.S. Drummond & A. Kappas; PNAS
78
, 6466 (1981)
Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
ALX-210-116
Revised 29-Sep-08
Polyclonal Antibody to Heme Oxygenase-1
SYNONYMS
anti-HO-1 PAb
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Heme Oxygenase / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-210-116-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Monkey
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-30 (M
1
ERPQLDSMSQDL
SEALKEATKEVHIRAEN
30
) of N-terminal rat HO-1 (heme oxygenase-1).
SPECIFICITY:
Recognizes human, mouse, rat, monkey and bovine HO-1. Detects a band of ~32kDa by Western blot. Does not cross-react with HO-2.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (paraffin sections (1:100))
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease:
M.A. Smith, et al.; Am. J. Pathol.
145
, 42 (1994)
Abstract
RT-PCR assay for heme oxygenase-1 and heme oxygenase-2: a sensitive method to estimate cellular oxidative damage:
R.K. Kutty, et al.; Ann. N. Y. Acad. Sci.
738
, 427 (1994)
Abstract
Increased expression of heme oxygenase-1 in human retinal pigment epithelial cells by transforming growth factor-beta:
R.K. Kutty, et al.; J. Cell. Physiol.
159
, 371 (1994)
Abstract
Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylthiourea:
R.K. Kutty, et al.; PNAS
92
, 1177 (1995)
Abstract
Heme oxygenase is downregulated in stress-triggered and interleukin-12-mediated murine abortion:
A.C. Zenclussen, et al.; Scand. J. Immunol.
55
, 560 (2002)
Abstract
Protection from abortion by heme oxygenase-1 up-regulation is associated with increased levels of Bag-1 and neuropilin-1 at the fetal-maternal interface:
A. Sollwedel, et al.; J. Immunol.
175
, 4875 (2005)
Abstract
Heme oxygenase as a therapeutic target in immunological pregnancy complications:
A.C. Zenclussen, et al.; Int. Immunopharmacol.
5
, 41 (2005)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Immunohistochemical staining of HO-1 in Alzheimer's diseased human brain with Prod. No.
ALX-210-116
results in staining of the neurofibrillary tangles, senile plaque neurites and neurophil threads.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-523
Revised 30-Oct-06
Polyclonal Antibody to Biliverdin-IX α-Reductase (human)
SYNONYMS
anti-BLVRA (human) PAb
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Heme Oxygenase / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-523-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From chicken.
PURITY DETAIL:
Epitope-affinity purified IgY.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human BLVRA (biliverdin-IX α-reductase).
SPECIFICITY:
Recognizes human BLVRA. Detects a band of ~40kDa by Western blot.
APPLICATION:
Western Blot (0.1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
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