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Chemical Synthesis - Reagents & Intermediates
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ALX-350-031 Revised 07-Apr-08
Ingenol (high purity)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-031-M001   1 mg 45.00 USD Add To Cart
ALX-350-031-M005   5 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C20H28O5
MW: 348.4
CAS NUMBER: 30220-46-3
PURITY: ≥98%
APPEARANCE: Solid.
SOLUBILITY: Soluble in DMSO and 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Extremely weak protein kinase C (PKC) activator. Starting material for synthesis of ingenol derivatives.
Product Specific Literature References
Specific binding to protein kinase C by ingenol and its induction of biological responses: C.M. Hasler, et al.; Cancer Res. 52, 202 (1992) Abstract
Preconditioning of isolated rabbit cardiomyocytes: effects of glycolytic blockade, phorbol esters, and ischaemia: S. Armstrong & C.E. Gonote; Cardiovasc. Res. 28, 1700 (1994) Abstract
Total synthesis of ingenol: I. Kuwajima & K. Tanino; Chem. Rev. 105, 4661 (2005), (Review) Abstract
Further Categories Containing This Product:
PKC Activators • Chemical Synthesis - Reagents & Intermediates
 
 
ALX-307-001 Revised 18-Feb-08
L-Quebrachitol
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SYNONYMS 1L-2-O-Methyl-chiro-inositol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-307-001-G001   1 g 40.00 USD Add To Cart
Product Specification
FORMULA: C7H14O6
MW: 194.2
CAS NUMBER: 642-38-6
SOURCE/HOST: Isolated from rubber tree.
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Key starting material for the synthesis of optically active inositol phosphates.
Product Specific Literature References
Synthesis of 1D-3-deoxy-, 1D-2,3-dideoxy-, and 1D-2,3,6-trideoxy-myo-inositol 1,4,5-trisphosphate from quebrachitol, their binding affinities, and calcium release activity: A.P. Kozikowski, et al.; JACS 115, 4429 (1993)
Synthesis and Biological Activity of the D-3-Deoxy-3-fluoro and D-3-Chloro-3-deoxy Analogs of Phosphatidylinositol: A.P. Kozikowski, et al.; J. Org. Chem. 59, 963 (1994)
Quebrachitol: A Versatile Building Block in the Construction of Naturally
Occurring Bioactive Materials: J.J. Kiddle; Chem. Rev. 95, 2189 (1995), (Review) Abstract
A versatile approach to PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 from L-(-)-quebrachitol: L. Qiao, et al.; Org. Lett. 2, 115 (2000) Abstract
Further Categories Containing This Product:
Chiral Compounds (Organic) • Chemical Synthesis - Reagents & Intermediates • Inositols & Inositolphosphates / Related Products
 
 
ALX-350-074 Revised 15-Nov-07
Resiniferonol 9,13,14-ortho-phenylacetate
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SYNONYMS ROPA
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-074-M005   5 mg 150.00 USD Add To Cart
ALX-350-074-M100   100 mg 1'800.00 USD Add To Cart
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Product Specification
FORMULA: C28H32O6
MW: 464.6
CAS NUMBER: 57852-42-3
PURITY: ≥98%
APPEARANCE: White to light yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HIGHLY IRRITANT.

Product Description
20-Deacylated derivative of resiniferatoxin (Prod. No. ALX-550-179) and tinyatoxin. Not active as a capsaicin analog. Binds with high potency to protein kinase C (PKC), activating the enzyme. Useful as starting material for synthesis of resiniferatoxin analogs.
Product Specific Literature References
Cell cycle- and protein kinase C-specific effects of resiniferatoxin and resiniferonol 9,13,14-ortho-phenylacetate in intestinal epithelial cells: M.R. Frey, et al.; Biochem. Pharmacol. 67, 1873 (2004) Abstract
Further Categories Containing This Product:
PKC Activators • Resiniferatoxin-type Phorboid Vanilloids • TRPV1 Agonists and Antagonists / Related Products • Natural Products - Other Signal Transduction Pathway Modulators • Chemical Synthesis - Reagents & Intermediates
 
 
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