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Lipid Peroxidation
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ALX-385-028 Revised 03-Apr-08
Delphinidin chloride (high purity)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Anthocyanidins
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ALX-385-028-M010   10 mg 460.00 USD Add To Cart
Product Specification
FORMULA: C15H11ClO7
MW: 338.7
CAS NUMBER: 528-53-0
RTECS: DK1310000
PURITY: ≥97% (HPLC)
APPEARANCE: Red to dark brown powder.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture.

Product Description

Anthocyanidin with antioxidant effect found in pigmented fruits and vegetables. Shown to inhibit angiogenesis and endothelial cell apoptosis by stimulating nitric oxide (NO) production. Inhibits solar radiation (UVB)-mediated oxidative stress, reducing DNA damage.
Product Specific Literature References
Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis: S. Martin, et al.; Br. J. Pharmacol. 139, 1095 (2003) Abstract; Full Text
Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines: M.C. Lazzč; Carcinogenesis 25, 1427 (2004) Abstract; Full Text
DNA interaction with naturally occurring antioxidant flavonoids quercetin, kaempferol, and delphinidin: C.D. Kanakis, et al.; J. Biomol. Struct. Dyn. 22, 719 (2005) Abstract
Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK: M.H. Oak, et al.; Br. J. Pharmacol. 149, 283 (2006) Abstract; Full Text
Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation: S. Lamy, et al.; Carcinogenesis 27, 989 (2006) Abstract; Full Text
Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis: F. Afaq, et al.; J. Invest. Dermatol. 127, 222 (2007) Abstract; Full Text
Further Categories Containing This Product:
Natural Products for Angiogenesis Research • Active Substances from Fruit and Vegetables • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antioxidants • Lipid Peroxidation
 
 
ALX-400-046 Revised 01-Dec-06
Taurine
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SYNONYMS 2-Aminoethanesulfonic acid
PRODUCT LINE Cancer
PRODUCT CATEGORY Chemopreventive Agents Other Products
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ALX-400-046-G010   10 g 25.00 USD Add To Cart
Product Specification
FORMULA: C2H7NO3S
MW: 125.2
CAS NUMBER: 107-35-7
MERCK INDEX: 14: 9074
RTECS: WX0175000
PURITY: ≥99%
SOLUBILITY: 50mg/ml soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Inhibitor of lipid peroxidation. Inhibits diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis.
Further Categories Containing This Product:
Lipid Peroxidation
 
 
ALX-550-361 Revised 18-Dec-07
(Z)-4-Hydroxytamoxifen
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SYNONYMS (Z)-4-[1-(p-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl]phenol
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Hormone-related)
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ALX-550-361-M001   1 mg 40.00 USD Add To Cart
ALX-550-361-M005   5 mg 145.00 USD Add To Cart
Product Specification
FORMULA: C26H29NO2
MW: 387.5
CAS NUMBER: 68047-06-3, 65213-48-1
PURITY: ≥98% (Z-isomer)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol (20mg/ml) or methanol (10mg/ml); insoluble water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. TOXIC.

Product Description
Metabolite of tamoxifen (Prod. No. ALX-550-095). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Has antioxidant properties. Intramembranous inhibitor of lipid peroxidation.
Product Specific Literature References
The antioxidant action of tamoxifen and its metabolites. Inhibition of lipid peroxidation: H. Wiseman, et al.; FEBS Lett. 263, 192 (1990) Abstract
Mechanism of inhibition of lipid peroxidation by tamoxifen and 4-hydroxytamoxifen introduced into liposomes. Similarity to cholesterol and ergosterol: H. Wiseman, et al.; FEBS Lett. 274, 107 (1990) Abstract
Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?: H. Wiseman, et al.; Biochem. J. 292, 635 (1993) Abstract
Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation. Evidence for peroxyl radical scavenging activity: J.B. Custódio, et al.; Biochem. Pharmacol. 47, 1989 (1994) Abstract
Peroxidase-catalyzed pro- versus antioxidant effects of 4-hydroxytamoxifen: enzyme specificity and biochemical sequelae: B.W. Day, et al.; Chem. Res. Toxicol. 12, 28 (1999) Abstract
Estrogen and tamoxifen metabolites protect smooth muscle cell membrane phospholipids against peroxidation and inhibit cell growth: R.K. Dubey, et al.; Circ. Res. 84, 229 (1999) Abstract
Further Categories Containing This Product:
Lipid Peroxidation • Estrogen & Estrogen Receptors / Related Products • Antioxidants, Flavonoids & Free Radical Scavengers Other Products
 
 
ALX-630-089 Revised 16-Sep-08
Ochratoxin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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ALX-630-089-M001   1 mg 40.00 USD Add To Cart
ALX-630-089-M005   5 mg 150.00 USD Add To Cart
ALX-630-089-M025   25 mg 590.00 USD Add To Cart
Product Specification
FORMULA: C20H18ClNO6
MW: 403.8
CAS NUMBER: 303-47-9
MERCK INDEX: 14: 6740
RTECS: AY4375000
SOURCE/HOST: Isolated from Aspergillus ochraceus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystalline powder.
SOLUBILITY: Soluble in methanol (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: VERY TOXIC. MAY BE CARCINOGENIC. MAY BE TERATOGENIC. MAY BE MUTAGENIC.

Product Description
Mycotoxin. Natural contaminant of mouldy food and feed. It has a number of toxic effects, the most prominent being nephrotoxicity. Immunosuppressive, genotoxic, teratogenic and carcinogenic. Stimulates lipid peroxidation. Induces oxidative DNA lesions coupled with direct DNA adducts via quinone formation.
Product Specific Literature References
Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh: K.J. van der Merwe, et al.; Nature 205, 112 (1965) Abstract
Lipid peroxidation as a possible cause of ochratoxin A toxicity: A.D. Rahimtula, et al.; Biochem. Pharmacol. 37, 4469 (1988) Abstract
Mechanism of ochratoxin A stimulated lipid peroxidation: R.F. Omar, et al.; Biochem. Pharmacol. 40, 1183 (1990) Abstract
Role of cytochrome P-450 in ochratoxin A-stimulated lipid peroxidation: R.F. Omar, et al.; J. Biochem. Toxicol. 6, 203 (1991) Abstract
Effect of superoxide dismutase and catalase on the nephrotoxicity induced by subchronical administration of ochratoxin A in rats: I. Baudrimont, et al.; Toxicology 89, 101 (1994) Abstract
Toxicity and metabolism of ochratoxin A: J. Fink-Gremmels, et al.; Nat. Toxins 3, 214 (1995) Abstract
How aspartame prevents the toxicity of ochratoxin A: E.E. Creppy, et al.; J. Toxicol. Sci. 23 Supp. 2, 165 (1998) Abstract
Toxicokinetics and toxicodynamics of ochratoxin A, an update: D. Ringot, et al.; Chem. Biol. Interact. 159, 18 (2006), (Review) Abstract
Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans: A. Pfohl-Leszkowicz & R. A. Manderville; Mol. Nutr. Food Res. 51, 61 (2007), (Review) Abstract
Further Categories Containing This Product:
Lipid Peroxidation • Plant Research Reagents / Related Products • Oxidative Stress Markers & Reagents / Related Products
 
 
ALX-840-041 Revised 03-Jul-08
HNE-histidine FINE Standard
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
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ALX-840-041-1   1 Vial 110.00 USD Add To Cart
Product Specification
KIT/SET CONTAINS: 8 vials with ELISA FINE standard (F1-F8), 200μl each. Standards contain 35mg/ml BSA and variable amounts of HNE:
F1:     0 pmol/mg HNE
F2:     7 pmol/mg HNE
F3:   14 pmol/mg HNE
F4:   29 pmol/mg HNE
F5:   57 pmol/mg HNE
F6:   86 pmol/mg HNE
F7: 114 pmol/mg HNE
F8: 143 pmol/mg HNE
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After thawing, keep standards for 30 min. at +4°C before further use. Vortex and mix vigorously before use.
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Product Description
Standard for the HNE-histidine FINE ELISA Kit (Prod. No. ALX-850-320).
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Further Categories Containing This Product:
Lipid Peroxidation
 
 
ALX-840-042 Revised 03-Jul-08
HNE-histidine STRESS Standard
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
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ALX-840-042-1   1 Vial 110.00 USD Add To Cart
Product Specification
KIT/SET CONTAINS: 8 vials with ELISA STRESS standard (S1-S8), 200μl each. Standards contain 35mg/ml BSA and variable amounts of HNE:
S1: 0.000 nmol/mg HNE
S2: 0.143 nmol/mg HNE
S3: 0.286 nmol/mg HNE
S4: 0.571 nmol/mg HNE
S5: 0.857 nmol/mg HNE
S6: 1.143 nmol/mg HNE
S7: 1.429 nmol/mg HNE
S8: 1.714 nmol/mg HNE
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After thawing, keep standards for 30 min. at +4°C before further use. Vortex and mix vigorously before use.
Product Images
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Product Description
Standard for the HNE-histidine STRESS ELISA Kit (Prod. No. ALX-850-322).
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Further Categories Containing This Product:
Lipid Peroxidation
 
 
ALX-850-026 Revised 28-Apr-08
Lipid Hydroperoxide (LPO) Assay Kit (100 determinations)
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-850-026-KI01   1 Kit 368.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.25-5nmole
QUANTITY: 100 tests.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
Product Description
Unlike other methods of lipid peroxidation measurement that rely on decomposition products, such as malondialdehyde (Prod. No. ALX-280-018) and 4-hydroxynonenal (Prod. No. ALX-270-245), this new assay features direct measurement of lipid hydroperoxides via a redox reaction. Any sample containing lipid hydroperoxide can be easily and reliably quantified spectrophotometrically using either glass or quartz cuvettes (λmax: 500nm; ε: 16,667M-1cm-1).
Further Categories Containing This Product:
Quantification Kits
 
 
ALX-850-203 Revised 28-Apr-08
Lipid Hydroperoxide (LPO) Assay Kit (96 wells)
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-850-203-KI01   1 Kit 582.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.25-5nmole
QUANTITY: 96 wells (~80 tests).
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
Product Description
Unlike other methods of lipid peroxidation measurement that rely on decomposition products, such as malondialdehyde (Prod. No. ALX-280-018) and 4-hydroxynonenal (Prod. No. ALX-270-245), this new assay features direct measurement of lipid hydroperoxides via a redox reaction. Any sample containing lipid hydroperoxide can be easily and reliably quantified spectrophotometrically using either glass or quartz cuvettes (λmax: 500nm; ε: 16,667M-1cm-1). Contains a reusable glass 96 well plate (for use of organic solvents).
Further Categories Containing This Product:
Quantification Kits
 
 
ALX-850-287 Revised 16-Jul-08
OXI-TEK TBARS Assay Kit
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
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ALX-850-287-KI01   1 Kit 416.00 USD Add To Cart
Product Specification
QUANTITY: 160 tests
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Description
The sensitivity of measuring thiobarbituric acid reactive substances (TBARS) has made this assay the method of choice for screening and monitoring lipid peroxidation, which is a major indication of oxidative stress. Malondialdehyde (MDA) forms a 1:2 adduct with thiobarbituric acid; the adduct can be measured by fluorometry. Biological specimens contain a mixture of TBARS, including lipid hydroperoxides and aldehydes. In practice, TBARS are expressed in equivalent numbers to MDA.
Product Specific Literature References
The role of junctional adhesion molecule-C (JAM-C) in oxidized LDL-mediated leukocyte recruitment: T. Keiper, et al.; FASEB J. 19, 2078 (2005) Abstract; Full Text
Adiponectin mediates the suppressive effect of rosiglitazone on plasminogen activator inhibitor-1 production: R. L. Hoo, et al.; Arterioscler. Thromb. Vasc. Biol. 27, 2777 (2007) Abstract
Dyslipidemia inhibits Toll-like receptor-induced activation of CD8alpha-negative dendritic cells and protective Th1 type immunity: A.T. Shamshiev, et al.; J. Exp. Med. 204, 441 (2007) Abstract; Full Text
Tea catechin ingestion combined with habitual exercise suppresses the aging-associated decline in physical performance in senescence-accelerated mice: T. Murase, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 295, R281 (2008) Abstract
General Information
MANUFACTURER Manufactured by Zeptometrix Corporation.
Further Categories Containing This Product:
Lipid Peroxidation • Quantification Kits
 
 
ALX-850-320 Revised 03-Jul-08
HNE-histidine FINE ELISA Kit
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
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ALX-850-320-KI01   1 Kit 750.00 USD Add To Cart
Product Specification
SENSITIVITY: 8.1nmol/mg (7.1 to 143pmol/mg)
QUANTITY: 2x96 wells
APPLICATION: For the quantitative determination of HNE-histidine conjugates in human cell lysates induced by mild oxidative stress.
SHIPPING: SHIPPED ON BLUE ICE
HANDLING: Store standards at -80°C. Store rest of the kit at +4°C.
Product Description

- Quantitative determination of HNE-histidine in human cell lysates
- Indirect enzyme immunoassay
- Based on a well described monoclonal antibody used in ICC, IHC & WB
- Range of detection between 7.1pmol/mg and 143pmol/mg
- Human plasma spiking tested
- Tissue homogenates have not been tested yet

(E)-4-Hydroxynonenal (HNE) is one of the most important breakdown products and reliable marker of lipid peroxidation (LPO). This indirect enzyme immunoassay (EIA) allows for the first time the quantitative determination of HNE-histidine conjugates from lysates of human cells which were exposed to mild oxidative stress.
Product Specific Literature References
Enzyme-linked immunosorbent assay for 4-hydroxynonenal-histidine conjugates: S. Borovic, et al.; Free Radic. Res. 40, 809 (2006) Abstract
Differential sensitivity to 4-hydroxynonenal for normal and malignant mesenchymal cells: S. Borovic, et al.; Redox Rep. 12, 50 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Do not use serum free cell culture supernatants. Running duplicate wells for samples and standards is recommended.
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Further Categories Containing This Product:
Lipid Peroxidation • ELISA & EIA Kits
 
 
ALX-850-322 Revised 03-Jul-08
HNE-histidine STRESS ELISA Kit
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products