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Ca2+-ATPase / Related Products
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ALX-270-061 Revised 30-Oct-08
t-Butylhydroquinone
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SYNONYMS tBHQ
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+-ATPase / Related Products
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ALX-270-061-G010   10 g 30.00 USD Add To Cart
Product Specification
FORMULA: C10H14O2
MW: 166.2
CAS NUMBER: 1948-33-0
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
IDENTITY: Identity determined by IR.

Product Description
Inhibitor of the endoplasmic reticulum Ca2+-ATPase. Activates extracellular signal-regulated protein kinase 2 (ERK2).
Product Specific Literature References
Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants: R. Yu, et al.; J. Biol. Chem. 272, 28962 (1997) Abstract; Full Text
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MAPK Pathway Activators
 
 
ALX-350-023 Revised 03-Jun-08
Cyclopiazonic acid
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SYNONYMS CPA
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
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ALX-350-023-M005   5 mg 42.00 USD Add To Cart
ALX-350-023-M025   25 mg 145.00 USD Add To Cart
ALX-350-023-M100   100 mg 460.00 USD Add To Cart
Product Specification
FORMULA: C20H20N2O3
MW: 336.4
CAS NUMBER: 18172-33-3
RTECS: UY8587000
SOURCE/HOST: Isolated from Penicillium griseofulvum.
PURITY: ≥98% (TLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in DMSO (50mg/ml), methylene chloride or methanol (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Mycotoxin. Cell permeable, reversible inhibitor of Ca2+-ATPases.
Product Specific Literature References
Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum: N.W. Seidler, et al.; J. Biol. Chem. 264, 17816 (1989) Abstract; Full Text
Acetylcholine Ca2+ stores refilling directly involves a dihydropyridine- sensitive channel in dog trachea: J.P. Bourreau, et al.; Am. J. Physiol. 261, C497 (1991) Abstract
Discrimination of Ca(2+)-ATPase activity of the sarcoplasmic reticulum from actomyosin-type ATPase activity of myofibrils in skinned mammalian skeletal muscle fibres: distinct effects of cyclopiazonic acid on the two ATPase activities: N. Kurebayashi & Y. Ogawa; J. Muscle Res. Cell Motility 12, 355 (1991) Abstract
Coupling between intracellular Ca2+ stores and the Ca2+ permeability of the plasma membrane. Comparison of the effects of thapsigargin, 2,5-di- (tert-butyl)-1,4-hydroquinone, and cyclopiazonic acid in rat thymic lymphocytes: M.J. Mason, et al.; J. Biol. Chem. 266, 20856 (1991) Abstract; Full Text
Cyclopiazonic acid depletes intracellular Ca2+ stores and activates an influx pathway for divalent cations in HL-60 cells: N. Demaurex, et al.; J. Biol. Chem. 267, 2318 (1992) Abstract; Full Text
Cyclopiazonic acid, an inhibitor of the sarcoplasmic reticulum Ca(2+)- pump, reduces Ca(2+)-dependent K+ currents in guinea-pig smooth muscle cells: M. Suzuki, et al.; Br. J. Pharmacol. 107, 134 (1992) Abstract
Effects of cyclopiazonic acid, a novel Ca(2+)-ATPase inhibitor, on contractile responses in skinned ileal smooth muscle: Y. Uyama, et al.; Br. J. Pharmacol. 106, 208 (1992) Abstract
Effects of cyclopiazonic acid and ryanodine on cytosolic calcium and contraction in vascular smooth muscle: F. Abe, et al.; Br. J. Pharmacol. 118, 1711 (1996) Abstract
Natural and in vitro coproduction of cyclopiazonic acid and aflatoxins: M.L. Martins & H.M. Martins; J. Food Prot. 62, 292 (1999) Abstract
Recent advances in analytical methodology for cyclopiazonic acid: J.W. Dorner; Adv. Exp. Med. Biol. 504, 107 (2002), Review Abstract
Cyclopiazonic acid reduces the coupling factor of the Ca2+-ATPase acting on Ca2+ binding: F. Martinez-Azorin; FEBS Lett. 576, 73 (2004) Abstract
Further Categories Containing This Product:
Ca2+-ATPase / Related Products • Neurotoxins • Mycotoxins
 
 
ALX-270-093 Revised 03-Feb-05
2,5-Di-t-butylhydroquinone
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SYNONYMS DBHQ
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+-ATPase / Related Products
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ALX-270-093-G001   1 g 16.00 USD Add To Cart
Product Specification
FORMULA: C14H22O2
MW: 222.3
CAS NUMBER: 88-58-4
PURITY: ≥99%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
SERCA pump inhibitor. Induces the release of Ca2+ from agonist-sensitive and agonist-insensitive intracellular stores without increasing IP3 levels. Inhibitor of liver microsomal calcium ion sequestration.
Product Specific Literature References
2,5-Di(tert-butyl)-1,4-benzohydroquinone--a novel inhibitor of liver microsomal Ca2+ sequestration: G.A. Moore, et al.; FEBS Lett. 224, 331 (1987) Abstract
2,5-Di-(tert-butyl)-1,4-benzohydroquinone rapidly elevates cytosolic Ca2+ concentration by mobilizing the inositol 1,4,5-trisphosphate- sensitive Ca2+ pool: G.E. Kass, et al.; J. Biol. Chem. 264, 15192 (1989) Abstract; Full Text
Agonist-sensitive and -insensitive intracellular Ca2+ pools. Separate Ca(2+)-releasing mechanisms revealed by manoalide and benzohydroquinone: S. Muallem, et al.; Biochem. J. 279, 367 (1991) Abstract
Cyclopiazonic acid depletes intracellular Ca2+ stores and activates an influx pathway for divalent cations in HL-60 cells: N. Demaurex, et al.; J. Biol. Chem. 267, 2318 (1992) Abstract; Full Text
 
 
ALX-804-049 Revised 02-Oct-08
Monoclonal Antibody to PMCA ATPase (5F10)
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SYNONYMS anti-Plasma Membrane Calcium Pump ATPase MAb (5F10)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+-ATPase / Related Products
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ALX-804-049-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Dog
Monkey
Others
CLONE: 5F10
ISOTYPE: Mouse IgG2a
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Purified human erythrocyte PMCA ATPase (plasma membrane calcium pump ATPase).
SPECIFICITY: Recognizes all known (currently four) isoforms of  human, rat, mouse, sheep, dog, monkey, rabbit, cat and chicken plasma membrane PMCA ATPase. Detects a band of ~140kDa by Western blot. Also detects bands at ~95kDa and ~180kDa which may represent aggregation and/or natural proteolytic products of PMCA ATPase. Recognizes an epitope between aa 724-783 of human PMCA ATPase.
APPLICATION: Immunocytochemistry
Immunohistochemistry (frozen sections (1:500), paraffin sections (1:500))
Immunoprecipitation
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Plasma membrane calcium pump and 28-kDa calcium binding protein in cells of rat kidney distal tubules: J.L. Borke, et al.; Am. J. Physiol. 257, F842 (1989) Abstract
Plasma membrane Ca2+ pump in rat brain. Patterns of alternative splices seen by isoform-specific antibodies: A.G. Filoteo, et al.; J. Biol. Chem. 272, 23741 (1997) Abstract; Full Text
Localization of alkaline phosphatase and Ca2+-ATPase in the cat placenta: E.E. Champion, et al.; Placenta 24, 453 (2003) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-086 Revised 26-Oct-04
Monoclonal Antibody to SERCA1 ATPase (IIH11)
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SYNONYMS anti-Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 1 MAb (IIH11)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+-ATPase / Related Products
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ALX-804-086-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Dog
Others
CLONE: IIH11
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Purified rabbit skeletal muscle sarcoplasmic reticulum.
SPECIFICITY: Recognizes SERCA1 ATPase (sarcoplasmic/endoplasmic reticulum calcium ATPase 1) in mouse, rat, dog, rabbit and guinea pig type II (fast) skeletal muscle. Detects a band of ~110kDa by Western blot. Does not cross-react with human SERCA1 ATPase.
APPLICATION: Immunocytochemistry (1:500)
Western Blot (1:2'500)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
A monoclonal antibody to the Ca2+ ATPase of cardiac sarcoplasmic reticulum cross-reacts with slow type I but not with fast type II canine skeletal muscle fibers: an immunocytochemical study: A.O. Jorgensen, et al.; Cell Motil. Cytoskeleton 9, 164 (1988) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-087 Revised 11-Jan-05
Monoclonal Antibody to SERCA1 ATPase (VE121G9)
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SYNONYMS anti-Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 1 MAb (VE121G9)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+-ATPase / Related Products
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ALX-804-087-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Dog
Others
CLONE: VE121G9
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Antibody in PBS containing 0.05% sodium azide.
IMMUNOGEN: Purified rabbit skeletal muscle sarcoplasmic reticulum.
SPECIFICITY: Recognizes SERCA1 ATPase (sarcoplasmic/endoplasmic reticulum calcium ATPase 1) in human, mouse, dog and rabbit type II (fast) skeletal muscle. Detects a band of ~110kDa by Western blot.
APPLICATION: Immunohistochemistry (1:500)
Western Blot (1:2'500)
Functional Application (inhibits the crystallization of SERCA1 ATPase induced by vanadate)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
A monoclonal antibody to the Ca2+ ATPase of cardiac sarcoplasmic reticulum cross-reacts with slow type I but not with fast type II canine skeletal muscle fibers: an immunocytochemical study: A.O. Jorgensen, et al.; Cell Motil. Cytoskeleton 9, 164 (1988) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-088 Revised 26-Jan-05
Monoclonal Antibody to SERCA2 ATPase (2A7-A1)
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SYNONYMS anti-Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 MAb (2A7-A1)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+-ATPase / Related Products
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ALX-804-088-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Others
CLONE: 2A7-A1
ISOTYPE: Mouse IgG2a
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Purified dog cardiac sarcoplasmic reticulum vesicles.
SPECIFICITY: Recognizes human, mouse, rat, dog, rabbit, and guinea pig SERCA2 ATPase (sarcoplasmic/endoplasmic reticulum calcium ATPase 2). Detects a band of ~110kDa by Western blot.
APPLICATION: Immunoprecipitation
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
A novel interaction mechanism accounting for different acylphosphatase effects on cardiac and fast twitch skeletal muscle sarcoplasmic reticulum calcium pumps: C. Nediani, et al.; FEBS Lett. 443, 308 (1999) Abstract; Full Text
General Information
ATP dependent calcium pumps are responsible in part for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are comprised of a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium (SERCA) ATPases. The SERCA2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA2a muscle-specific isoform expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA2b isoform expressed in all cell types. The SERCA3 gene is not as well characterized and is found in non-muscle cells.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-048 Revised 29-Sep-05
Monoclonal Antibody to SERCA2 ATPase (IID8)
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SYNONYMS anti-Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 MAb (IID8)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+-ATPase / Related Products
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ALX-804-048-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Dog
Pig
Others
CLONE: IID8
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Purified dog cardiac sarcoplasmic reticulum.
SPECIFICITY: Recognizes the SERCA2a (sarcoplasmic/endoplasmic reticulum calcium ATPase 2a) and SERCA2b isoforms in human, rat, dog, pig, bovine and rat tissues. Detects a band of ~110kDa by Western blot.
APPLICATION: Immunocytochemistry
Immunohistochemistry (frozen sections (1:500))
Western Blot (1:2’500)
Note: For detection of rat SERCA2 ATPase use MAb to SERCA2 ATPase (2A7-A1) (Prod. No. ALX-804-088)).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
A monoclonal antibody to the Ca2+ ATPase of cardiac sarcoplasmic reticulum cross-reacts with slow type I but not with fast type II canine skeletal muscle fibers: an immunocytochemical study: A.O. Jorgensen, et al.; Cell Motil. Cytoskeleton 9, 164 (1988) Abstract
Identification and characterization of proteins in sarcoplasmic reticulum from normal and failing human left ventricles: M.A. Movsesian, et al.; J. Mol. Cell. Cardiol. 22, 1477 (1990) Abstract
Ca-ATPase isozyme expression in sarcoplasmic reticulum is altered by chronic stimulation of skeletal muscle: F.N. Briggs, et al.; FEBS Lett. 259, 269 (1990) Abstract
A study of the organellar Ca2(+)-transport ATPase isozymes in pig cerebellar Purkinje neurons: L. Plessers, et al.; J. Neurosci. 11, 650 (1991) Abstract; Full Text
Immunological relatedness of the sarcoplasmic reticulum Ca(2+)-ATPase and the Na+,K(+)-ATPase: E. Molnar, et al.; Biochim. Biophys. Acta 1103, 281 (1992) Abstract
In situ hybridization and immunocytochemical localization of SERCA2 encoded Ca2+ pump in rabbit heart and stomach: K.M. Mearow, et al.; Mol. Cell. Biochem. 121, 155 (1993) Abstract
Correlated expression of the 97 kDa sarcoendoplasmic reticulum Ca(2+)-ATPase and Rap1B in platelets and various cell lines: C. Magnier, et al.; Biochem. J. 297, 343 (1994) Abstract
Transcriptional regulation of phospholamban gene and translational regulation of SERCA2 gene produces coordinate expression of these two sarcoplasmic reticulum proteins during skeletal muscle phenotype switching: P. Hu, et al.; J. Biol. Chem. 270, 11619 (1995) Abstract; Full Text
Functional characterization of alternatively spliced human SERCA3 transcripts: E. Poch, et al.; Am. J. Physiol. 275, C1449 (1998) Abstract; Full Text
Control of sarcoplasmic/endoplasmic-reticulum Ca2+ pump expression in cardiac and smooth muscle: C.M. Misquitta, et al.; Biochem. J. 338, 167 (1999) Abstract; Full Text
Biogenesis of endoplasmic reticulum proteins involved in Ca2+ signalling during megakaryocytic differentiation: an in vitro study: C. Lacabaratz-Porret, et al.; Biochem. J. 350, 723 (2000) Abstract; Full Text
Localization of endoplasmic reticulum and plasma membrane Ca2+-ATPases in subcellular fractions and sections of pig cerebellum: M.R. Sepulveda, et al.; Eur. J. Neurosci. 19, 542 (2004) Abstract
Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility: I.L. Ennis, et al.; J. Clin. Invest. 109, 393 (2002) Abstract; Full Text
General Information
ATP dependent calcium pumps are responsible, in part, for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are encoded by a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium (SERCA) ATPases. The SERCA1 gene is exclusively expressed in type II (fast) skeletal muscle. The SERCA2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA2a muscle-specific form expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA2b isoform expressed in all cell types. The SERCA3 gene is not as well characterized and is found in non-muscle cells.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-210-167/1 Revised 28-Jul-05
Polyclonal Antibody to SERCA3 ATPase
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SYNONYMS anti-Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 3 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+-ATPase / Related Products
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ALX-210-167/1-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Epitope affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 29-39 (V29TDARERYGPN39) of rat SERCA3 ATPase (sarcoplasmic/endoplasmic reticulum calcium ATPase 3).
SPECIFICITY: Recognizes mouse and rat SERCA3 ATPase. Detects a band of ~97kDa by Western blot. Does not cross-react with other SERCA ATPase isoforms.
APPLICATION: Western Blot (1:500)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-167-011.
Related Products
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-550-295 Revised 08-Jul-08
Ruthenium red
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PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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ALX-550-295-M500   500 mg 60.00 USD Add To Cart
ALX-550-295-G001   1 g 90.00 USD Add To Cart
Product Specification
SEQUENCE: [(NH3)5RuORu(NH3)4ORu(NH3)5]6+ 6Cl-
FORMULA: Cl6H42N14O2Ru3 . 4H20
MW: 786.4 . 72.1
CAS NUMBER: 11103-72-3
MERCK INDEX: 14: 8300
RTECS: VM2656500
PURITY: ≥90% (contains 5-10% water)
APPEARANCE: Dark red to purple crystalline solid.
SOLUBILITY: Soluble in water (10mg/ml) or ammonia.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
Product Description
Blocks TRPV1. Capsaicin and calcium antagonist. Inhibitor of Ca2+/Mg2+-ATPase.