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Adaptor Proteins in T Cell Signal Transduction / Related Products
You are here: Product Lines > Oxidative Stress > Adaptor Proteins in T Cell Signal Transduction / Related Products
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Items 17 of 17
ALX-804-438 Revised 22-Jul-08
Monoclonal Antibody to EBP50 (human) (EBP-10)
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SYNONYMS anti-ERM (Ezrin/Radixin/Moesin)-binding Phosphoprotein of 50kDa (human) MAb (EPB-10)
anti-Na+/H+ Exchanger Regulatory Factor (human) MAb (EBP-10)
anti-NHERF (human) MAb (EBP-10)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-438-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: EBP-10
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant full length human EBP50 (ERM (ezrin/radixin/moesin)-binding phosphoprotein of 50kDa).
SPECIFICITY: Recognizes human EBP50.
APPLICATION: Immunoprecipitation
Western Blot (2μg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton: N. Bridickova, et al.; FEBS Lett. 507, 133 (2001) Abstract; Full Text
Down-regulation of Na+/H+ Exchanger Regulatory Factor 1 Increases Expression and Function of Multidrug Resistance Protein 4: Md. Tozammel Hoque & S.P.C. Cole; Cancer Res. 68, 4802 (2008) Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-456 Revised 20-Feb-07
Monoclonal Antibody to LAT (human) (LAT-01)
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SYNONYMS anti-Linker of Activated T Cells (human) MAb (LAT-01)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-456-C100   100 µg 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: LAT-01
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. Protein A affinity purified antibody in PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant human LAT (linker of activated T cells) cytoplasmic domain.
SPECIFICITY: Recognizes human LAT. Does not well recognize tyrosine phosphorylated LAT. Does not cross-react with mouse LAT.
APPLICATION: Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Autoimmunity & Self Tolerance Other Products • Monoclonal Antibodies
 
 
ALX-805-717 Revised 03-Nov-06
Monoclonal Antibody to LAT (LAT-1D1)
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PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-805-717-C100   100 µg 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
CLONE: LAT-1D1
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant rat LAT.
SPECIFICITY: Recognizes mouse and rat LAT. Does not cross-react with human LAT.
APPLICATION: Western Blot (1:100)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
New monoclonal antibodies recognizing the adaptor protein LAT: P. Tolar, et al.; Folia Biol. (Praha) 47, 215 (2001) Abstract
Dynamic recruitment of the adaptor protein LAT: LAT exists in two distinct intracellular pools and controls its own recruitment: G. Bonello, et al.; J. Cell Sci. 117, 1009 (2004) Abstract
Further Categories Containing This Product:
Autoimmunity & Self Tolerance Other Products • Monoclonal Antibodies
 
 
ALX-804-561 Revised 29-Nov-04
Monoclonal Antibody to Lck-interacting Molecule (human) (LIME-10)
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SYNONYMS anti-LIME (human) MAb (LIME-10)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-804-561-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: LIME-10
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml.
PURITY: >95% (SDS-PAGE).
FORMULATION: Liquid. Protein A affinity purified antibody in PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 281-296 of human LIME (Lck-interacting molecule).
SPECIFICITY: Recognizes human LIME.
APPLICATION: Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling: N. Brdickova, et al.; J. Exp. Med. 198, 1453 (2003) Abstract
Further Categories Containing This Product:
Src Family Kinases / Related Products • Monoclonal Antibodies
 
 
ALX-804-560 Revised 30-May-05
Monoclonal Antibody to Lck-interacting Molecule (human) (LIME-06)
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SYNONYMS anti-LIME (human) MAb (LIME-06)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-804-560-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: LIME-06
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE).
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant intracellular fragment corresponding to aa 141-295 of human LIME (Lck-interacting molecule).
SPECIFICITY: Recognizes human LIME.
APPLICATION: Immunoprecipitation
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling: N. Brdickova, et al.; J. Exp. Med. 198, 1453 (2003) Abstract
Further Categories Containing This Product:
Src Family Kinases / Related Products • Monoclonal Antibodies
 
 
ALX-804-478 Revised 21-May-08
Monoclonal Antibody to PAG/Cbp (PAG-C1)
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SYNONYMS anti-Phosphoprotein Associated with GEMS MAb (PAG-C1)
anti-Csk-binding Protein MAb (PAG-C1)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-804-478-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE: PAG-C1
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE)
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to C-terminal (last 15 aa) human PAG/Cbp (phosphoprotein associated with GEMS/Csk-binding protein).
SPECIFICITY: Recognizes human, mouse, rat and bovine PAG/Cbp.
APPLICATION: Immunoprecipitation
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-437 Revised 13-Feb-07
Monoclonal Antibody to PAG/Cbp (human) (MEM-255)
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SYNONYMS anti-Phosphoprotein Associated with GEMS (human) MAb (MEM-255)
anti-Csk-binding Protein (human) MAb (MEM-255)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-804-437-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MEM-255
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant human PAG/Cbp (phosphoprotein associated with GEMS/Csk-binding protein) intracellular domain (aa 97-432).
SPECIFICITY: Recognizes human PAG/Cbp. Does not cross-react with mouse, rat and bovine PAG/Cbp. Detects a band of ~80kDa by Western blot (see below).
APPLICATION: Flow Cytometry (Intracellular staining, permeabilization required (2µg/ml))
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation: T. Brdicka, et al.; J. Exp. Med. 191, 1591 (2000) Abstract; Full Text
Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton: N. Brdickova, et al.; FEBS Lett. 507, 133 (2001) Abstract; Full Text
Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts: K.M. Torgersen, et al.; J. Biol. Chem. 276, 29313 (2001) Abstract; Full Text
Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling: T. Vang, et al.; J. Biol. Chem. 278, 17597 (2003) Abstract; Full Text
Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor: D. Davidson, et al.; Mol. Cell Biol. 23, 2017 (2003) Abstract
Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes: M. Baumgartner, et al.; Blood 101, 1874 (2003) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Note: PAG/Cbp is an ubiquitously expressed ~46kDa transmembrane adapter protein present in microdomains (rafts), which however migrates on SDS-PAGE gels anomalously as an ~80kDa molecule.
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-436 Revised 09-Nov-04
Monoclonal Antibody to SIT (human) (SIT-01)
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SYNONYMS anti-SHP2-interacting Transmembrane Adapter Protein (human) MAb (SIT-01)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-804-436-C100   100 µg 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: SIT-01
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. Protein A affinity purified antibody in PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant peptide from the intracellular domain of human SIT (SHP2-interacting transmembrane adapter protein).
SPECIFICITY: Recognizes human SIT.
APPLICATION: Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-562 Revised 31-Oct-06
Monoclonal Antibody to SLP-76 (SLP-76/03)
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SYNONYMS anti-SH2 Domain-containing Leukocyte Protein (76kDa) MAb (SLP-76/03)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-804-562-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Pig
CLONE: SLP-76/03
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE).
PURITY DETAIL: Protein G affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant human SLP-76 (SH2 domain-containing leukocyte protein (76kDa)) (aa 216-434).
SPECIFICITY: Recognizes human, mouse and pig SLP-76.
APPLICATION: Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Autoimmunity & Self Tolerance Other Products • Monoclonal Antibodies
 
 
ALX-804-435 Revised 08-Mar-07
Monoclonal Antibody to T Cell Receptor-interacting Molecule (human) (TRIM-04)
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SYNONYMS anti-TRIM (human) MAb (TRIM-04)
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-804-435-C100   100 µg 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: TRIM-04
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. Protein A affinity purified antibody in PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant human TRIM (T cell receptor-interacting molecule) (aa 29-186).
SPECIFICITY: Recognizes human TRIM.
APPLICATION: Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain: H. Kirchgessner, et al.; J. Exp. Med. 193, 1269 (2001) Abstract; Full Text
Developmentally regulated expression of the transmembrane adaptor protein trim in fetal and adult T cells: T. Huynh, et al.; Scand. J. Immunol. 54, 146 (2001) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-210-564 Revised 29-Nov-04
Polyclonal Antibody to Lck-interacting Molecule (human)
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SYNONYMS anti-LIME (human) PAb
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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