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ALX-430-082 Revised 06-Dec-07
PBN
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SYNONYMS N-tert-Butyl-α-phenylnitrone
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-082-G001   1 g 38.00 USD Add To Cart
Product Specification
FORMULA: C11H15NO
MW: 177.3
CAS NUMBER: 3376-24-7
MERCK INDEX: 14: 7056
PURITY: ≥98%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol; slightly soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cell permeable spin trap for both in vivo and in vitro studies.
Product Specific Literature References
Iron supplementation generates hydroxyl radical in vivo. An ESR spin- trapping investigation: M.B. Kadiiska, et al.; J. Clin. Invest. 96, 1653 (1995) Abstract
The spin trap alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone stimulates peroxidase-mediated oxidation of deferoxamine. Implications for pharmacological use of spin-trapping agents: M.L. McCormick, et al.; J. Biol. Chem. 270, 29265 (1995) Abstract
N-tert-butyl-alpha-phenylnitrone: a free radical trap with unanticipated effects on diaphragm function: K.A. Andersen, et al.; J. Appl. Physiol. 80, 862 (1996) Abstract
Optimal time and dosage of phenyl N-tert-butyl nitrone (PBN) for the inhibition of nitric oxide synthase induction in mice: T. Miyajima & Y. Kotake; Free Radic. Biol. Med. 22, 463 (1997) Abstract
Evidence for a novel pentyl radical adduct of the cyclic nitrone spin trap MDL 101,002: J.L. Dage, et al.; Free Radic. Biol. Med. 22, 807 (1997) Abstract
The structure of free radical metabolites detected by EPR spin trapping and mass spectroscopy from halocarbons in rat liver microsomes: H. Sang, et al.; Free Radic. Biol. Med. 22, 843 (1997) Abstract
Necrosis of the substantia nigra, pars reticulate, in flurothyl-induced status epilepticus is ameliorated by the spin trap alpha phenyl-N-tert-butyl nitrone: Q.P. He, et al.; Free Radic. Biol. Med. 22, 917 (1997) Abstract
Protective action of nitrone-based free radical traps against oxidative damage to the central nervous system: R.A. Floyd; Adv. Pharmacol. 38, 361 (1997) Abstract
PBN spin trapping of free radicals in the reperfusion-injured heart. Limitations for pharmacological investigations: N. Vrbjar, et al.; Mol. Cell. Biochem. 186, 107 (1998) Abstract
Release of nitric oxide from a spin trap, N-tert-butyl-alpha-phenylnitrone, under various oxidative conditions: K. Saito, et al.; Biol. Pharm. Bull. 21, 401 (1998) Abstract
Pharmacologic properties of phenyl N-tert-butylnitrone: Y. Kotake; Antioxid. Redox Signal. 1, 481 (1999), Review Abstract
Alpha-phenyl-tert-butylnitrone (PBN) inhibits NFkappaB activation offering protection against chemically induced diabetes: E. Ho, et al.; Free Radic. Biol. Med. 28, 604 (2000) Abstract
Pharmacological effects of the spin trap agents N-t-butyl-phenylnitrone (PBN) and 2,2,6, 6-tetramethylpiperidine-N-oxyl (TEMPO) in a rabbit thromboembolic stroke model: combination studies with the thrombolytic tissue plasminogen activa: P.A. Lapchak, et al.; Stroke 32, 147 (2001) Abstract; Full Text
Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059: K.R. Maples, et al.; Free Radic. Res. 34, 417 (2001) Abstract
The nitrone spin trap PBN alters the cellular response to H(2)O(2): activation of the EGF receptor/ERK pathway: W.N. Hassan, et al.; Free Radic. Biol. Med. 32, 551 (2002) Abstract
The spin trapping agent PBN stimulates H2O2 -induced Erk and Src kinase activity in human neuroblastoma cells: P. Kelicen, et al.; Neuroreport 13, 1057 (2002) Abstract
Protective effect of spin trap agent, N-tert-butyl-alpha-phenylnitrone on hyperoxia-induced oxidative stress and its potential as a nitric oxide donor: K. Saito & H. Yoshioka; Free Radic. Res. 36, 143 (2002) Abstract
In vivo detection of free radicals induced by diethylnitrosamine in rat liver tissue: K. Yamada, et al.; Free Radic. Biol. Med. 40, 2040 (2006) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION For selected literature references on spin trapping and beer please click here.
 
 

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