ALEXIS Biochemicals: PD 150,606

ALX-270-234

Revised 29-Jan-05

PD 150,606
SYNONYMS	3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Calpains / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-234-M005		5 mg	65.00 USD

Product Specification

FORMULA:	C₉H₇IO₂S
MW:	306.1
PURITY:	≥95%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in DMSO or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light. Keep under inert gas.

Product Description

Cell permeable, selective, and non-peptide calpain inhibitor directed towards the calcium binding sites of calpain. Exhibits high specificity for calpains relative to other proteases such as cathepsin B and cathepsin L. Prevents dexamethasone-induced apoptosis in thymocytes.

Product Specific Literature References

Modulation of hypoxia-induced calpain activity in rat renal proximal tubules: C.L. Edelstein, et al.; Kidney Int. 50, 1150 (1996) Abstract
An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective: K.K. Wang, et al.; PNAS 93, 6687 (1996) Abstract
Alpha-mercaptoacrylic acid derivatives as novel selective calpain inhibitors: K.K. Wang, et al.; Adv. Exp. Med. Biol. 389, 95 (1996) Abstract
Crystal structure of calcium bound domain VI of calpain at 1.9A resolution and its role in enzyme assembly, regulation, and inhibitor binding: G.D. Lin, et al.; Nat. Struct. Biol. 4, 539 (1997) Abstract
Calpains mediate calcium and chloride influx during the late phase of cell injury: S.L. Waters, et al.; J. Pharmacol. Exp. Ther. 283, 1177 (1997) Abstract

Further Categories Containing This Product:

Apoptosis Inducers & Inhibitors Other Products

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