ALEXIS Biochemicals: PD 169,316

ALX-270-258

Revised 22-Jun-05

PD 169,316
SYNONYMS	4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	MAPK Pathway Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-258-M001		1 mg	82.00 USD
ALX-270-258-M005		5 mg	310.00 USD
ALX-270-258-M050		50 mg	1'300.00 USD

Product Specification

FORMULA:	C₂₀H₁₃FN₄O₂
MW:	360.3
PURITY:	≥98%
APPEARANCE:	Yellow to orange solid.
SOLUBILITY:	Soluble in DMSO; slightly soluble in methanol. Insoluble in water, ethyl acetate or diethyl ether.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Potent, cell permeable and selective inhibitor of p38 (SAPK2a).

Product Specific Literature References

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase: T.F. Gallagher, et al.; Bioorg. Med. Chem. 5, 49 (1997) Abstract
Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase: J.L. Kummer, et al.; J. Biol. Chem. 272, 20490 (1997) Abstract; Full Text
The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin: Z. Assefa, et al.; J. Biol. Chem. 274, 8788 (1999) Abstract; Full Text

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