ALEXIS Biochemicals: PD 184,352

ALX-270-471

Revised 06-Aug-07

PD 184,352
SYNONYMS	2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide CI-1040
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	MAPK Pathway Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-471-M001		1 mg	95.00 USD
ALX-270-471-M005		5 mg	380.00 USD

Product Specification

FORMULA:	C₁₇H₁₄ClF₂IN₂O₂
MW:	478.7
CAS NUMBER:	212631-79-3
SOURCE/HOST:	Synthetic.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Potent and selective inhibitor of MAPK (ERK kinase 1; MEK1) activation (IC₅₀=300nM in vitro, IC₅₀=2nM in vivo). Suppresses activation of MAPK but does not block its activity. Strongly suppresses growth of human implanted colon tumors in mice.

Product Specific Literature References

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo: J.S. Sebolt-Leopold, et al.; Nat. Med. 5, 810 (1999) Abstract
Specificity and mechanism of action of some commonly used protein kinase inhibitors: S.P. Davies, et al.; Biochem. J. 351, 95 (2000) Abstract; Full Text
Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352: A.M. Delaney, et al.; Mol. Cell. Biol. 22, 7593 (2002) Abstract; Full Text
Effects of the MEK inhibitor CI-1040 (PD 184352) on progenitor growth from normal and myelodysplastic marrow: D.P. Steensma, et al.; Haematologica 88, 1072 (2003) Abstract
The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer: P.J. Klein, et al.; Neoplasia 8, 1 (2006) Abstract; Full Text

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