ALEXIS Biochemicals: PPAHV

ALX-550-355

Revised 30-Jun-08

PPAHV
SYNONYMS	Phorbol 12-phenylacetate 13-acetate 20-homovanillate
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Phorbols/Phorbol Esters

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-355-M001		1 mg	65.00 USD
ALX-550-355-M005		5 mg	260.00 USD

Product Specification

FORMULA:	C₃₉H₄₄O₁₁
MW:	688.8
CAS NUMBER:	175796-50-6
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in methanol, 100% ethanol or DMSO; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.

Product Description

Non-pungent resiniferatoxin-type phorboid vanilloid. Agonist at rat TRPV1 (EC₅₀ between 3 and 10µM) but virtually inactive at human TRPV1 (EC₅₀>10µM). Induces apoptosis through a TRPV-independent mechanism. Tumor promotor.

Product Specific Literature References

Synthesis and evaluation of phorboid 20-homovanillates: discovery of a class of ligands binding to the vanilloid (capsaicin) receptor with different degrees of cooperativity: G. Appendino, et al.; J. Med. Chem. 39, 3123 (1996) Abstract
A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor: A. Szallasi, et al.; Eur. J. Pharmacol. 299, 221 (1996) Abstract
A non-pungent resiniferatoxin analogue, phorbol 12-phenylacetate 13 acetate 20-homovanillate, reveals vanilloid receptor subtypes on rat trigeminal ganglion neurons: L. Liu, et al.; Neuroscience 84, 569 (1998) Abstract
Functional and desensitizing effects of the novel synthetic vanilloid- like agent 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) in the perfused rat hindlimb: C.D. Griffiths, et al.; Br. J. Pharmacol. 131, 1408 (2000) Abstract
Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology: J.C. Jerman, et al.; Br. J. Pharmacol. 130, 916 (2000) Abstract
Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism: A. Macho, et al.; Chem. Biol. 7, 483 (2000) Abstract
Pharmacological differences between the human and rat vanilloid receptor 1 (VR1): P. McIntyre, et al.; Br. J. Pharmacol. 132, 1084 (2001) Abstract
Differences in sensitivity of vanilloid receptor 1 transfected to human embryonic kidney cells and capsaicin-activated channels in cultured rat dorsal root ganglion neurons to capsaicin receptor agonists: J.S. Shin, et al.; Neurosci. Lett. 299, 135 (2001) Abstract
Respiratory actions of vanilloid receptor agonists in the nucleus of the solitary tract: comparison of resiniferatoxin with non-pungent agents and anandamide: D.P. Geraghty, et al.; Br. J. Pharmacol. 137, 919 (2002) Abstract
Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1: E. Phillips, et al.; J. Biol. Chem. 279, 17165 (2004) Abstract

Further Categories Containing This Product:

TRPV1 Agonists and Antagonists/Related Products • Apoptosis Inducers & Inhibitors Other Products • Resiniferatoxin-type Phorboid Vanilloids • Natural Products for Neurological Research

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