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ALX-430-158 Revised 03-Apr-08 New product
PTC124
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SYNONYMS 3-[5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl]-benzoic acid
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Protein Synthesis Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-158-M002   2 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C15H9FN2O3
MW: 284.2
CAS NUMBER: 775304-57-9
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Orally bioavailable 284 D-1,2,4-oxadiazole. Promotes readthrough of premature translation termination codons. Targets genetic disorders caused by nonsense mutations. Shows no concomitant effects on normal termination or mRNA decay.
Product Specific Literature References
PTC124 targets genetic disorders caused by nonsense mutations: E.M. Welch, et al.; Nature 447, 87 (2007) Abstract
PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model: M. Du, et al.; PNAS 105, 2064 (2008) Abstract
 
 
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