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ALX-350-109 Revised 29-Nov-07
Panepoxydone
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-109-MC05   0.5 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C11H14O4
MW: 210.2
SOURCE/HOST: Isolated from Lentinus crinitus.
PURITY: >95% (HPLC)
FORMULATION: Yellow oil
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Protect from light. Keep cool and dry.
HAZARD: TOXIC.

Product Description
Antibiotic. Inhibitor of NF-κB activation by preventing the phosphorylation of IκB protein and thereby interrupts the signalling pathway. Strongly inhibits the expression of several NF-κB dependent pro-inflammatory genes.
Product Specific Literature References
Inhibition of NF-kappa B activation by panepoxydone: G. Erkel, et al.; BBRC 226, 214 (1996) Abstract
Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1 and NF-kappaB-signaling pathways: H. Kleinert, et al.; Br. J. Pharmacol. 125, 193 (1998) Abstract
Naturally occurring and synthetic inhibitors of NF-kappaB functions: K. Umezawa, et al.; Anticancer Drug Des. 15, 239 (2000) Abstract
Inhibitors of NF-kappaB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent: J.B. Shotwell, et al.; Bioorg. Med. Chem. Lett. 12, 3463 (2002) Abstract
Molecular design and biological activities of NF-kappaB inhibitors: K. Umezawa & C. Chaicharoenpong; Mol. Cells 14, 163 (2002) Abstract
Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells: G. Erkel, et al.; Int. Immunopharmacol. 7, 612 (2007) Abstract
Further Categories Containing This Product:
NF-kB Pathway Inhibitors • Natural Products - Anti-inflammatory Agents • Natural Products with Antibiotic Activity
 
 
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