ALEXIS Biochemicals: Penitrem A

ALX-630-020

Revised 29-Oct-07

Penitrem A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Neurotoxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-630-020-M001		1 mg	30.00 USD
ALX-630-020-M005		5 mg	120.00 USD

Product Specification

FORMULA:	C₃₇H₄₄NO₆Cl
MW:	634.2
CAS NUMBER:	12627-35-9
SOURCE/HOST:	Isolated from Penicillium palitans.
PURITY:	≥98%
SOLUBILITY:	Must first be dissolved in organic solvents such as methanol, acetone or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	POTENT NEUROTOXIN.

Product Description

Fungal mycotoxin, which increases the spontaneous release of GABA and aspartate from cerebrocortical synaptosomes in rat neuromuscular junction. Specific and potent blocker of smooth muscle high-conductance Ca²⁺-activated K⁺ channels.

Product Specific Literature References

Effects of a fungus tremorgenic toxin (penitrem A) on transmission in rat phrenic nerve-diaphragm preparations: B.J. Wilson, et al.; Brain Res. 40, 540 (1972) Abstract
Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels: H.G. Knaus, et al.; Biochemistry 33, 5819 (1994) Abstract
Brain neurotoxicity of Penitrem A: electrophysiological, behavioral and histopathological study: P. Breton, et al.; Toxicon 36, 645 (1998) Abstract

Further Categories Containing This Product:

Mycotoxins • K+ Channel Blockers & Inhibitors • GABA-ergics & GABA Receptors/Related Products • Alkaloids

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