ALEXIS Biochemicals: Pepstatin A (synthetic)

ALX-260-085

Revised 23-Jan-07

Pepstatin A (synthetic)
SYNONYMS	i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA Iva-Val-Val-Sta-Ala-Sta
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Cathepsin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-085-M005		5 mg	35.00 USD
ALX-260-085-M025		25 mg	95.00 USD
ALX-260-085-M100		100 mg	290.00 USD

Product Specification

SEQUENCE:	i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA (AHMHA = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid)
FORMULA:	C₃₄H₆₃N₅O₉
MW:	685.9
CAS NUMBER:	26305-03-3
MERCK INDEX:	14: 7147
RTECS:	SC6155000
SOURCE/HOST:	Synthetic.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO, methanol or acetic acid.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 2 years after receipt when stored at -20°C.
HANDLING:	Protect from light.

Product Description

Inhibitor of aspartate (acid) proteases, including pepsin, cathepsin D, renin, chymosin, bacterial aspartic proteinases and HIV proteases. Efficiently inhibits Fcγ receptor induction by IFN-γ. Blocks the endocytic pathway followed by an antibody when it enters the cell at the level of early endosomal compartments, resulting in inhibition of autoantigen presentation or viral transmission.

Product Specific Literature References

Localization of pepstatin's inhibitory action during Fc-mediated antibody internalization: possible implications for antibody-mediated viral transmission: I. Athanassakis, et al.; Cell. Immunol. 199, 81 (2000) Abstract
Pepstatin, a new pepsin inhibitor produced by Actinomycetes: H. Umezawa, et al.; J. Antibiot. 23, 259 (1970) Abstract

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Proteases Other Products • Autophagy Other Products

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