ALEXIS Biochemicals: Phenylmethylsulfonyl fluoride

ALX-270-184

Revised 26-May-08

Phenylmethylsulfonyl fluoride
SYNONYMS	PMSF Benzylsulfonyl fluoride
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Proteases Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-184-G001		1 g	25.00 USD
ALX-270-184-G005		5 g	50.00 USD
ALX-270-184-G025		25 g	135.00 USD

Product Specification

FORMULA:	C₇H₇FO₂S
MW:	174.2
CAS NUMBER:	329-98-6
RTECS:	XT8040000
PURITY:	≥99% (HPLC)
APPEARANCE:	White to off-white needle crystals.
SOLUBILITY:	Soluble in 100% ethanol, methanol or isopropanol; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	CORROSIVE. HARMFUL.

Product Description

Irreversible inhibitor of serine proteases. Widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB₁ receptor activity. Spleen membranes used for CB₂ studies do not require this pretreatment, as FAAH activity is absent in these cells. Inhibits also cysteine proteases like papain (reversible by DTT treatment, Prod. No. ALX-280-001), as well as internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor see AEBSF (Prod. No. ALX-270-022).

Product Specific Literature References

Kinetic analysis of differences in brain acetylcholinesterase from fish or mammalian sources: D.E. Moss & D.E. Fahrney; Biochem. Pharmacol. 27, 2693 (1978) Abstract
Inactivation of the protease inhibitor phenylmethylsulfonyl fluoride in buffers: G.T. James; Anal. Biochem. 86, 574 (1978) Abstract
Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist: D.G. Deutsch & S.A. Chin; Biochem. Pharmacol. 46, 791 (1993) Abstract

Further Categories Containing This Product:

Acetylcholine Esterase / Related Products • Fatty Acid Amide Hydrolase [FAAH] / Related Products

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