ALEXIS Biochemicals: Piericidin A

ALX-380-235

Revised 20-Jun-08

Piericidin A
SYNONYMS	Piericidin A1 Shaoguanmycin B Antibiotic MT 1882-I Antibiotic SN 198E Antibiotic IT 143D
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-235-M002		2 mg	140.00 USD

Product Specification

FORMULA:	C₂₅H₃₇NO₄
MW:	415.6
CAS NUMBER:	2738-64-9
RTECS:	YD4588000
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS5364.
PURITY:	≥95% (HPLC)
APPEARANCE:	Pale yellow oil.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	VERY TOXIC.

Product Description

Antibiotic. Specific and potent inhibitor of NADH-ubiquinone oxidoreductase (complex I) that binds to ubiquinone binding site(s). Inhibits both mitochondrial and bacterial NADH ubiquinone oxidoreductase. Anticancer agent that prevents up-regulation of GRP78, and exhibits cytotoxic activity for etoposide resistant cancer cells under glucose-deprived conditions.

Product Specific Literature References

Piericidin A: a new inhibitor of mitochondrial electron transport: C. Hall, et al.; BBRC 25, 373 (1966) Abstract
Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase: T. Friedrich, et al.; Eur. J. Biochem. 219, 691 (1994) Abstract
The 49-kDa subunit of NADH-ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone-related inhibitors: E. Darrouzet, et al.; FEBS Lett. 431, 34 (1998) Abstract; Full Text
Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I: I. Prieur, et al.; Biochim. Biophys. Acta 1504, 173 (2001) Abstract
Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator: J.H. Hwang, et al.; J. Cell. Physiol. 215, 243 (2008) Abstract

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