ALEXIS Biochemicals: Pifithrin-α (cyclic) . hydrobromide

ALX-270-287

Revised 26-Jun-08

Pifithrin-α (cyclic) . hydrobromide
SYNONYMS	2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole . HBr
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	p53 Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-287-M010		10 mg	170.00 USD

Product Specification

FORMULA:	C₁₆H₁₆N₂S . HBr
MW:	268.4 . 80.9
CAS NUMBER:	60477-34-1
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO (100mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light and moisture. Keep under inert gas.

Product Description

Stable analog of pifithrin-α (Prod. No. ALX-270-270), with biological properties similar to its parent compound, but with reduced cytotoxicity. Inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Potent STAT6 transcriptional inhibitor.

Product Specific Literature References

Cancer research. A new way to combat therapy side effects: D. Ferber; Science 285, 1651 (1999) Abstract
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy: P.G. Komarov, et al.; Science 285, 1733 (1999) Abstract
Suppression of p53: a new approach to overcome side effects of antitumor therapy: E.A. Komarova, et al.; Biochemistry 65, 41 (2000) Abstract; Full Text
Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation: P.J. Murphy, et al.; J Biol Chem 279, 30195 (2004) Abstract